ID E9Q631_MOUSE Unreviewed; 185 AA.
AC E9Q631;
DT 05-APR-2011, integrated into UniProtKB/TrEMBL.
DT 05-APR-2011, sequence version 1.
DT 27-MAR-2024, entry version 78.
DE RecName: Full=Prolactin receptor {ECO:0000256|RuleBase:RU365035};
DE Short=PRL-R {ECO:0000256|RuleBase:RU365035};
DE Flags: Fragment;
GN Name=Prlr {ECO:0000313|Ensembl:ENSMUSP00000116211.2,
GN ECO:0000313|MGI:MGI:97763};
GN Synonyms=PRLR {ECO:0000256|RuleBase:RU365035};
OS Mus musculus (Mouse).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae;
OC Murinae; Mus; Mus.
OX NCBI_TaxID=10090 {ECO:0000313|Ensembl:ENSMUSP00000116211.2, ECO:0000313|Proteomes:UP000000589};
RN [1] {ECO:0000313|Ensembl:ENSMUSP00000116211.2, ECO:0000313|Proteomes:UP000000589}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=C57BL/6J {ECO:0000313|Ensembl:ENSMUSP00000116211.2,
RC ECO:0000313|Proteomes:UP000000589};
RX PubMed=19468303; DOI=10.1371/journal.pbio.1000112;
RA Church D.M., Goodstadt L., Hillier L.W., Zody M.C., Goldstein S., She X.,
RA Bult C.J., Agarwala R., Cherry J.L., DiCuccio M., Hlavina W., Kapustin Y.,
RA Meric P., Maglott D., Birtle Z., Marques A.C., Graves T., Zhou S.,
RA Teague B., Potamousis K., Churas C., Place M., Herschleb J., Runnheim R.,
RA Forrest D., Amos-Landgraf J., Schwartz D.C., Cheng Z., Lindblad-Toh K.,
RA Eichler E.E., Ponting C.P.;
RT "Lineage-specific biology revealed by a finished genome assembly of the
RT mouse.";
RL PLoS Biol. 7:E1000112-E1000112(2009).
RN [2] {ECO:0000313|Ensembl:ENSMUSP00000116211.2}
RP IDENTIFICATION.
RC STRAIN=C57BL/6J {ECO:0000313|Ensembl:ENSMUSP00000116211.2};
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- FUNCTION: This is a receptor for the anterior pituitary hormone
CC prolactin. {ECO:0000256|RuleBase:RU365035}.
CC -!- SUBUNIT: Interacts with SMARCA1. Interacts with NEK3 and VAV2 and this
CC interaction is prolactin-dependent. {ECO:0000256|RuleBase:RU365035}.
CC -!- SUBCELLULAR LOCATION: Membrane {ECO:0000256|RuleBase:RU365035}; Single-
CC pass type I membrane protein {ECO:0000256|RuleBase:RU365035}.
CC -!- DOMAIN: The WSXWS motif appears to be necessary for proper protein
CC folding and thereby efficient intracellular transport and cell-surface
CC receptor binding. {ECO:0000256|RuleBase:RU365035}.
CC -!- DOMAIN: The box 1 motif is required for JAK interaction and/or
CC activation. {ECO:0000256|RuleBase:RU365035}.
CC -!- SIMILARITY: Belongs to the type I cytokine receptor family. Type 1
CC subfamily. {ECO:0000256|RuleBase:RU365035}.
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DR AlphaFoldDB; E9Q631; -.
DR SMR; E9Q631; -.
DR ProteomicsDB; 361082; -.
DR Ensembl; ENSMUST00000127467.3; ENSMUSP00000116211.2; ENSMUSG00000005268.21.
DR AGR; MGI:97763; -.
DR MGI; MGI:97763; Prlr.
DR VEuPathDB; HostDB:ENSMUSG00000005268; -.
DR GeneTree; ENSGT00940000154851; -.
DR ChiTaRS; Prlr; mouse.
DR Proteomes; UP000000589; Chromosome 15.
DR Bgee; ENSMUSG00000005268; Expressed in choroid plexus epithelium and 151 other cell types or tissues.
DR ExpressionAtlas; E9Q631; baseline and differential.
DR GO; GO:0016020; C:membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
DR CDD; cd00063; FN3; 1.
DR Gene3D; 2.60.40.10; Immunoglobulins; 1.
DR InterPro; IPR003961; FN3_dom.
DR InterPro; IPR036116; FN3_sf.
DR InterPro; IPR015152; Growth/epo_recpt_lig-bind.
DR InterPro; IPR013783; Ig-like_fold.
DR PANTHER; PTHR23036; CYTOKINE RECEPTOR; 1.
DR PANTHER; PTHR23036:SF86; PROLACTIN RECEPTOR; 1.
DR Pfam; PF09067; EpoR_lig-bind; 1.
DR SUPFAM; SSF49265; Fibronectin type III; 1.
DR PROSITE; PS50853; FN3; 1.
PE 1: Evidence at protein level;
KW Disulfide bond {ECO:0000256|ARBA:ARBA00023157,
KW ECO:0000256|RuleBase:RU365035};
KW Metal-binding {ECO:0000256|RuleBase:RU365035};
KW Proteomics identification {ECO:0007829|ProteomicsDB:E9Q631};
KW Receptor {ECO:0000256|RuleBase:RU365035};
KW Reference proteome {ECO:0000313|Proteomes:UP000000589};
KW Zinc {ECO:0000256|RuleBase:RU365035}.
FT DOMAIN 58..158
FT /note="Fibronectin type-III"
FT /evidence="ECO:0000259|PROSITE:PS50853"
FT NON_TER 185
FT /evidence="ECO:0000313|Ensembl:ENSMUSP00000116211.2"
SQ SEQUENCE 185 AA; 20921 MW; 074CA0267BBD3BF1 CRC64;
MCLSGCHLTN VTWCFLFQGA SDLLPVARRR ASLKQNMSSA LAYMLLVLSI SLLNGQSPPG
KPEIHKCRSP DKETFTCWWN PGSDGGLPTN YSLTYSKEGE KNTYECPDYK TSGPNSCFFS
KQYTSIWKIY IITVNATNEM GSSTSDPLYV DVTYIVEPEP PRNLTLEVKQ LKDKKTYLWV
KWLPP
//
