ID E9Q892_MOUSE Unreviewed; 624 AA.
AC E9Q892;
DT 05-APR-2011, integrated into UniProtKB/TrEMBL.
DT 05-APR-2011, sequence version 1.
DT 27-MAR-2024, entry version 74.
DE SubName: Full=Leucine-rich repeats and calponin homology (CH) domain containing 3 {ECO:0000313|Ensembl:ENSMUSP00000130009.2};
GN Name=Lrch3 {ECO:0000313|Ensembl:ENSMUSP00000130009.2,
GN ECO:0000313|MGI:MGI:1917394};
OS Mus musculus (Mouse).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae;
OC Murinae; Mus; Mus.
OX NCBI_TaxID=10090 {ECO:0000313|Ensembl:ENSMUSP00000130009.2, ECO:0000313|Proteomes:UP000000589};
RN [1] {ECO:0000313|Ensembl:ENSMUSP00000130009.2, ECO:0000313|Proteomes:UP000000589}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=C57BL/6J {ECO:0000313|Ensembl:ENSMUSP00000130009.2,
RC ECO:0000313|Proteomes:UP000000589};
RX PubMed=19468303; DOI=10.1371/journal.pbio.1000112;
RA Church D.M., Goodstadt L., Hillier L.W., Zody M.C., Goldstein S., She X.,
RA Bult C.J., Agarwala R., Cherry J.L., DiCuccio M., Hlavina W., Kapustin Y.,
RA Meric P., Maglott D., Birtle Z., Marques A.C., Graves T., Zhou S.,
RA Teague B., Potamousis K., Churas C., Place M., Herschleb J., Runnheim R.,
RA Forrest D., Amos-Landgraf J., Schwartz D.C., Cheng Z., Lindblad-Toh K.,
RA Eichler E.E., Ponting C.P.;
RT "Lineage-specific biology revealed by a finished genome assembly of the
RT mouse.";
RL PLoS Biol. 7:E1000112-E1000112(2009).
RN [2] {ECO:0007829|PubMed:21183079}
RP IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
RX PubMed=21183079; DOI=10.1016/j.cell.2010.12.001;
RA Huttlin E.L., Jedrychowski M.P., Elias J.E., Goswami T., Rad R.,
RA Beausoleil S.A., Villen J., Haas W., Sowa M.E., Gygi S.P.;
RT "A tissue-specific atlas of mouse protein phosphorylation and expression.";
RL Cell 143:1174-1189(2010).
RN [3] {ECO:0000313|Ensembl:ENSMUSP00000130009.2}
RP IDENTIFICATION.
RC STRAIN=C57BL/6J {ECO:0000313|Ensembl:ENSMUSP00000130009.2};
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
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DR AlphaFoldDB; E9Q892; -.
DR SMR; E9Q892; -.
DR jPOST; E9Q892; -.
DR MaxQB; E9Q892; -.
DR PeptideAtlas; E9Q892; -.
DR ProteomicsDB; 361070; -.
DR Antibodypedia; 2704; 113 antibodies from 18 providers.
DR Ensembl; ENSMUST00000165616.8; ENSMUSP00000130009.2; ENSMUSG00000022801.14.
DR AGR; MGI:1917394; -.
DR MGI; MGI:1917394; Lrch3.
DR VEuPathDB; HostDB:ENSMUSG00000022801; -.
DR GeneTree; ENSGT00940000158330; -.
DR ChiTaRS; Lrch3; mouse.
DR Proteomes; UP000000589; Chromosome 16.
DR Bgee; ENSMUSG00000022801; Expressed in manus and 231 other cell types or tissues.
DR ExpressionAtlas; E9Q892; baseline and differential.
DR CDD; cd21272; CH_LRCH3; 1.
DR Gene3D; 1.10.418.10; Calponin-like domain; 1.
DR Gene3D; 3.80.10.10; Ribonuclease Inhibitor; 1.
DR InterPro; IPR001715; CH_dom.
DR InterPro; IPR036872; CH_dom_sf.
DR InterPro; IPR032675; LRR_dom_sf.
DR PANTHER; PTHR48051; -; 1.
DR PANTHER; PTHR48051:SF44; LEUCINE RICH REPEATS AND CALPONIN HOMOLOGY DOMAIN CONTAINING 3; 1.
DR Pfam; PF00307; CH; 1.
DR SMART; SM00033; CH; 1.
DR SUPFAM; SSF47576; Calponin-homology domain, CH-domain; 1.
DR SUPFAM; SSF52058; L domain-like; 1.
DR PROSITE; PS50021; CH; 1.
PE 1: Evidence at protein level;
KW Proteomics identification {ECO:0007829|EPD:E9Q892,
KW ECO:0007829|MaxQB:E9Q892};
KW Reference proteome {ECO:0000313|Proteomes:UP000000589}.
FT DOMAIN 491..604
FT /note="Calponin-homology (CH)"
FT /evidence="ECO:0000259|PROSITE:PS50021"
FT REGION 357..382
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 604..624
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 359..382
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 624 AA; 68694 MW; BF31BC2F6419EDB2 CRC64;
MAAAGLVAVV AAAEYSGPVA SGGNLSGATC GPSPGLGPGP GPGSWSRSVD RALEEAAVTG
VLSLSGRKLR EFPRGAANHD LTDTTRAELA EVPLIRLDFS CNKITVIPVC YRNLRHLQVI
TLDNNPLQSP PAQICIKGKI HIFKYLNIQA CKIAPDLPDY ERRPLGFGSC HEELYSGRPY
GALDSGFNSV DSGDKRWSGN EPTDEFSDLP LRVAEITKEQ RLRRESQYQE NRSSVAVTNG
GVEHDLDQID YIDSCTTEEE ENDVSPVKPI AVREFQKTED MKRYSHQNRV PVEPSLVLSM
PPSHNQLSHS DLELHQRREQ SIECTRREAQ LAALQYEEEK IRTKQIQRDA VLDFVKQKAS
HNPQRQQPPG NGECSFPSRR SQHTDDSALL VSLSGLDGVS CVATRPHSSA FTPLKSENRV
DVTSSFPMTE TVHHSPAYSF PAATQRNQPQ RPESFLFRAA VRAEANKGRA SPLLLSSAPA
TDPTDAITRQ REEELKLIDQ LRKHIEYRLK VSLPCDLGAA LTDGVVLCHL ANHVRPRSVP
SIHVPSPAVP KLTMAKCRRN VENFLDACRK IGVPQEQLCL PLHILEEKGL GQVAVTVQAL
LELAPPKQPP PQQPQQQQPQ LSAV
//
