ID E9Q8P5_MOUSE Unreviewed; 239 AA.
AC E9Q8P5;
DT 05-APR-2011, integrated into UniProtKB/TrEMBL.
DT 03-OCT-2012, sequence version 2.
DT 27-MAR-2024, entry version 82.
DE SubName: Full=PDZ and LIM domain 5 {ECO:0000313|Ensembl:ENSMUSP00000128752.3};
GN Name=Pdlim5 {ECO:0000313|Ensembl:ENSMUSP00000128752.3,
GN ECO:0000313|MGI:MGI:1927489};
OS Mus musculus (Mouse).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae;
OC Murinae; Mus; Mus.
OX NCBI_TaxID=10090 {ECO:0000313|Ensembl:ENSMUSP00000128752.3, ECO:0000313|Proteomes:UP000000589};
RN [1] {ECO:0000313|Ensembl:ENSMUSP00000128752.3, ECO:0000313|Proteomes:UP000000589}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=C57BL/6J {ECO:0000313|Ensembl:ENSMUSP00000128752.3,
RC ECO:0000313|Proteomes:UP000000589};
RX PubMed=19468303; DOI=10.1371/journal.pbio.1000112;
RA Church D.M., Goodstadt L., Hillier L.W., Zody M.C., Goldstein S., She X.,
RA Bult C.J., Agarwala R., Cherry J.L., DiCuccio M., Hlavina W., Kapustin Y.,
RA Meric P., Maglott D., Birtle Z., Marques A.C., Graves T., Zhou S.,
RA Teague B., Potamousis K., Churas C., Place M., Herschleb J., Runnheim R.,
RA Forrest D., Amos-Landgraf J., Schwartz D.C., Cheng Z., Lindblad-Toh K.,
RA Eichler E.E., Ponting C.P.;
RT "Lineage-specific biology revealed by a finished genome assembly of the
RT mouse.";
RL PLoS Biol. 7:E1000112-E1000112(2009).
RN [2] {ECO:0007829|PubMed:21183079}
RP IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
RX PubMed=21183079; DOI=10.1016/j.cell.2010.12.001;
RA Huttlin E.L., Jedrychowski M.P., Elias J.E., Goswami T., Rad R.,
RA Beausoleil S.A., Villen J., Haas W., Sowa M.E., Gygi S.P.;
RT "A tissue-specific atlas of mouse protein phosphorylation and expression.";
RL Cell 143:1174-1189(2010).
RN [3] {ECO:0007829|PubMed:23806337}
RP IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
RX PubMed=23806337; DOI=10.1016/j.molcel.2013.06.001;
RA Park J., Chen Y., Tishkoff D.X., Peng C., Tan M., Dai L., Xie Z., Zhang Y.,
RA Zwaans B.M., Skinner M.E., Lombard D.B., Zhao Y.;
RT "SIRT5-mediated lysine desuccinylation impacts diverse metabolic
RT pathways.";
RL Mol. Cell 50:919-930(2013).
RN [4] {ECO:0000313|Ensembl:ENSMUSP00000128752.3}
RP IDENTIFICATION.
RC STRAIN=C57BL/6J {ECO:0000313|Ensembl:ENSMUSP00000128752.3};
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
CC ---------------------------------------------------------------------------
CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC ---------------------------------------------------------------------------
DR RefSeq; NP_072048.2; NM_022554.3.
DR RefSeq; XP_006501813.1; XM_006501750.2.
DR AlphaFoldDB; E9Q8P5; -.
DR SMR; E9Q8P5; -.
DR iPTMnet; E9Q8P5; -.
DR MaxQB; E9Q8P5; -.
DR ProteomicsDB; 357531; -.
DR Antibodypedia; 4614; 464 antibodies from 30 providers.
DR DNASU; 56376; -.
DR Ensembl; ENSMUST00000170361.9; ENSMUSP00000128752.3; ENSMUSG00000028273.16.
DR GeneID; 56376; -.
DR UCSC; uc012cyt.1; mouse.
DR AGR; MGI:1927489; -.
DR CTD; 10611; -.
DR MGI; MGI:1927489; Pdlim5.
DR VEuPathDB; HostDB:ENSMUSG00000028273; -.
DR GeneTree; ENSGT00940000155292; -.
DR OrthoDB; 370973at2759; -.
DR BioGRID-ORCS; 56376; 1 hit in 77 CRISPR screens.
DR Proteomes; UP000000589; Chromosome 3.
DR Bgee; ENSMUSG00000028273; Expressed in soleus muscle and 263 other cell types or tissues.
DR ExpressionAtlas; E9Q8P5; baseline and differential.
DR GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
DR CDD; cd00992; PDZ_signaling; 1.
DR Gene3D; 2.30.42.10; -; 1.
DR InterPro; IPR001478; PDZ.
DR InterPro; IPR036034; PDZ_sf.
DR PANTHER; PTHR24214:SF32; PDZ AND LIM DOMAIN PROTEIN 5; 1.
DR PANTHER; PTHR24214; PDZ AND LIM DOMAIN PROTEIN ZASP; 1.
DR Pfam; PF00595; PDZ; 1.
DR SMART; SM00228; PDZ; 1.
DR SUPFAM; SSF50156; PDZ domain-like; 1.
DR PROSITE; PS50106; PDZ; 1.
PE 1: Evidence at protein level;
KW Proteomics identification {ECO:0007829|EPD:E9Q8P5,
KW ECO:0007829|MaxQB:E9Q8P5};
KW Reference proteome {ECO:0000313|Proteomes:UP000000589}.
FT DOMAIN 10..85
FT /note="PDZ"
FT /evidence="ECO:0000259|PROSITE:PS50106"
FT REGION 111..142
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 111..132
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 239 AA; 26356 MW; 13C38516E6BF80DA CRC64;
MSNYSVSLVG PAPWGFRLQG GKDFNMPLTI SSLKDGGKAS QAHVRIGDVV LSIDGISAQG
MTHLEAQNKI KACTGSLNMT LQRASAAAKS EPVSVQKPTV TSVCSESAQE LAEGQRRGSQ
GDIKQQNGNP GTVKIPPKRP PRKHIVERNT EFYHIPTHSD ASKKRLIEDT EDWRPRTGTT
QSRSFRILAQ ITGTEHLTES ENDNTKKAKE KIPLHVFSPK YTKLRDWHHE VSARALNVQ
//
