ID E9Q921_MOUSE Unreviewed; 1226 AA.
AC E9Q921;
DT 05-APR-2011, integrated into UniProtKB/TrEMBL.
DT 05-APR-2011, sequence version 1.
DT 27-MAR-2024, entry version 81.
DE SubName: Full=AF4/FMR2 family, member 1 {ECO:0000313|Ensembl:ENSMUSP00000031256.6};
GN Name=Aff1 {ECO:0000313|Ensembl:ENSMUSP00000031256.6,
GN ECO:0000313|MGI:MGI:1100819};
OS Mus musculus (Mouse).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae;
OC Murinae; Mus; Mus.
OX NCBI_TaxID=10090 {ECO:0000313|Ensembl:ENSMUSP00000031256.6, ECO:0000313|Proteomes:UP000000589};
RN [1] {ECO:0000313|Ensembl:ENSMUSP00000031256.6, ECO:0000313|Proteomes:UP000000589}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=C57BL/6J {ECO:0000313|Ensembl:ENSMUSP00000031256.6,
RC ECO:0000313|Proteomes:UP000000589};
RX PubMed=19468303; DOI=10.1371/journal.pbio.1000112;
RA Church D.M., Goodstadt L., Hillier L.W., Zody M.C., Goldstein S., She X.,
RA Bult C.J., Agarwala R., Cherry J.L., DiCuccio M., Hlavina W., Kapustin Y.,
RA Meric P., Maglott D., Birtle Z., Marques A.C., Graves T., Zhou S.,
RA Teague B., Potamousis K., Churas C., Place M., Herschleb J., Runnheim R.,
RA Forrest D., Amos-Landgraf J., Schwartz D.C., Cheng Z., Lindblad-Toh K.,
RA Eichler E.E., Ponting C.P.;
RT "Lineage-specific biology revealed by a finished genome assembly of the
RT mouse.";
RL PLoS Biol. 7:E1000112-E1000112(2009).
RN [2] {ECO:0007829|PubMed:21183079}
RP IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
RX PubMed=21183079; DOI=10.1016/j.cell.2010.12.001;
RA Huttlin E.L., Jedrychowski M.P., Elias J.E., Goswami T., Rad R.,
RA Beausoleil S.A., Villen J., Haas W., Sowa M.E., Gygi S.P.;
RT "A tissue-specific atlas of mouse protein phosphorylation and expression.";
RL Cell 143:1174-1189(2010).
RN [3] {ECO:0000313|Ensembl:ENSMUSP00000031256.6}
RP IDENTIFICATION.
RC STRAIN=C57BL/6J {ECO:0000313|Ensembl:ENSMUSP00000031256.6};
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- SIMILARITY: Belongs to the AF4 family. {ECO:0000256|ARBA:ARBA00007354}.
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DR RefSeq; NP_001074267.1; NM_001080798.2.
DR AlphaFoldDB; E9Q921; -.
DR SMR; E9Q921; -.
DR jPOST; E9Q921; -.
DR MaxQB; E9Q921; -.
DR ProteomicsDB; 317987; -.
DR Antibodypedia; 25387; 292 antibodies from 31 providers.
DR DNASU; 17355; -.
DR Ensembl; ENSMUST00000031256.6; ENSMUSP00000031256.6; ENSMUSG00000029313.19.
DR GeneID; 17355; -.
DR KEGG; mmu:17355; -.
DR UCSC; uc008yju.1; mouse.
DR AGR; MGI:1100819; -.
DR CTD; 4299; -.
DR MGI; MGI:1100819; Aff1.
DR VEuPathDB; HostDB:ENSMUSG00000029313; -.
DR GeneTree; ENSGT00950000182974; -.
DR OMA; KFTMSLK; -.
DR OrthoDB; 4254515at2759; -.
DR PhylomeDB; E9Q921; -.
DR BioGRID-ORCS; 17355; 5 hits in 80 CRISPR screens.
DR ChiTaRS; Aff1; mouse.
DR Proteomes; UP000000589; Chromosome 5.
DR Bgee; ENSMUSG00000029313; Expressed in lacrimal gland and 239 other cell types or tissues.
DR ExpressionAtlas; E9Q921; baseline and differential.
DR Genevisible; E9Q921; MM.
DR GO; GO:0008023; C:transcription elongation factor complex; IEA:Ensembl.
DR GO; GO:0010468; P:regulation of gene expression; IEA:InterPro.
DR Gene3D; 6.10.250.2670; -; 1.
DR InterPro; IPR007797; AF4/FMR2.
DR InterPro; IPR043640; AF4/FMR2_CHD.
DR InterPro; IPR043639; AF4_int.
DR PANTHER; PTHR10528; AF4/FMR2 FAMILY MEMBER; 1.
DR PANTHER; PTHR10528:SF6; AF4_FMR2 FAMILY MEMBER 1; 1.
DR Pfam; PF05110; AF-4; 1.
DR Pfam; PF18875; AF4_int; 1.
DR Pfam; PF18876; AFF4_CHD; 1.
DR PRINTS; PR01217; PRICHEXTENSN.
PE 1: Evidence at protein level;
KW Nucleus {ECO:0000256|ARBA:ARBA00023242};
KW Proteomics identification {ECO:0007829|EPD:E9Q921,
KW ECO:0007829|MaxQB:E9Q921};
KW Reference proteome {ECO:0000313|Proteomes:UP000000589}.
FT DOMAIN 964..1224
FT /note="AF4/FMR2 C-terminal homology"
FT /evidence="ECO:0000259|Pfam:PF18876"
FT REGION 28..60
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 76..112
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 124..147
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 162..225
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 257..283
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 360..737
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 786..980
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1104..1135
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 28..45
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 76..101
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 168..186
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 208..225
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 262..277
FT /note="Pro residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 388..419
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 436..450
FT /note="Pro residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 452..478
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 479..494
FT /note="Acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 505..548
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 656..674
FT /note="Pro residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 711..737
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 795..846
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 847..896
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 910..925
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 926..940
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 1226 AA; 132548 MW; A30074D8FF8D908D CRC64;
METRILPRES GGACLYNEDR NLLRIREKER RNQEAHQEKE AFPEKAPLFP EPYKTAKGDE
LSSRIQTMLG DYEEMKEFLS SKSHPHRLDG SEDRPGKPRY PLGHDRGNGA ASSSLRTHVY
HQPIHTSAPG SRPVGNISHS PKMAQPRMEP SLHTKIYDGP RLTQDHLSQG HCSRKCDRRA
EGDSAPERKL SPLISSLPSP VPPLSPVHSR LQGTSKAHSS GVSSKSCCVA KSSKDLVAKA
QDKETPHDGL VAVTSLGSAP PQPPCQTFPP PPLPSKSAAM QQKPTAYVRP MDGQDQAPSE
SPELKLPLED YGQQSFEKPD LKVPAKAKLT RLRMPSQSVE QPYSNEVHCV EEILKEMTHS
WPPPLTAIHT PSTAEPSRFP FPTKDPLHVS PATQSQKQYD TPSKTHPNPQ QGTSMLEDDL
QLSDSEDSDT EQATEKPPSP PAPPSAPQTL PEPVASAHSS SGESESSESD SSSDSESESS
SSDSEEEEEN EPLETRAPEP EPPTTNKWQL DNWLTKVNQP SVPLDGRGST ESPQWRQESK
GVAEGSSDQQ HPDSKDPLPK SSSKTLRGPS EGPQPGKRGC PKSPAQQEPP PRQTVGSKQP
RKPAKGSGQA EPQASSQAES EVGPLPYGSK EQTSKDRPKV KTKGRPRAVG SREPKPEVPA
PTPQAAVPRP KPPVPTPSEK RKHKSSTAPS KAPSAPQPPK DSAGDRNPEH SALVSLTQSQ
GPSHSSRGSS GSVRTSGCRQ AVIAQGDGCK DKLLLPLRDT KLLSPLRDSP PPTSLVVKIT
LDLLTRIPQP LGKGSRPRKA EDKQLSAGKK QDSETKSCDS SSRVTKKRKG DPEKEHSNKR
HKLDKSQTAS SSSSHTESSR TKAPRSSSEN SRKEMLPPAS ASSVSSSSSS QKPSRPAQKR
PRPDEDTCSQ EPPRSASSTK SSSTDPPAPK HRKVQARGSE HKGSSGDAAN AANPFPVPSL
PNGNAKPGKP QVKSDRQQAD FHMKEAKKLK CKAETMVDKA GKAFKYLEAV LSFIECGMAS
ESESSAKSAY AVYSETIDLI RYVMSLKCFS DNTMPAQEKI FAVLCLRCQS LLNMAMFRCK
KDTVMKYSRT LSEHFKSTSK VAQAPSPCTA RSTGVPSPLS PMPSPASSVG SQSSAGSSMG
SVGVTATVST PVSIQNMTSS YVTITSHVLT AFSLWEQAEA LTRKNKEFFA QLSTKVRVLA
LNSSLVDLVH YTRQGLQRLK QSPKGP
//
