ID E9Q9Q2_MOUSE Unreviewed; 1135 AA.
AC E9Q9Q2;
DT 05-APR-2011, integrated into UniProtKB/TrEMBL.
DT 05-APR-2011, sequence version 1.
DT 27-MAR-2024, entry version 83.
DE SubName: Full=R3H domain containing 1 {ECO:0000313|Ensembl:ENSMUSP00000043103.5};
GN Name=R3hdm1 {ECO:0000313|Ensembl:ENSMUSP00000043103.5,
GN ECO:0000313|MGI:MGI:2448514};
OS Mus musculus (Mouse).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae;
OC Murinae; Mus; Mus.
OX NCBI_TaxID=10090 {ECO:0000313|Ensembl:ENSMUSP00000043103.5, ECO:0000313|Proteomes:UP000000589};
RN [1] {ECO:0007829|PubMed:19144319}
RP IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
RX PubMed=19144319; DOI=10.1016/j.immuni.2008.11.006;
RA Trost M., English L., Lemieux S., Courcelles M., Desjardins M.,
RA Thibault P.;
RT "The phagosomal proteome in interferon-gamma-activated macrophages.";
RL Immunity 30:143-154(2009).
RN [2] {ECO:0000313|Ensembl:ENSMUSP00000043103.5, ECO:0000313|Proteomes:UP000000589}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=C57BL/6J {ECO:0000313|Ensembl:ENSMUSP00000043103.5,
RC ECO:0000313|Proteomes:UP000000589};
RX PubMed=19468303; DOI=10.1371/journal.pbio.1000112;
RA Church D.M., Goodstadt L., Hillier L.W., Zody M.C., Goldstein S., She X.,
RA Bult C.J., Agarwala R., Cherry J.L., DiCuccio M., Hlavina W., Kapustin Y.,
RA Meric P., Maglott D., Birtle Z., Marques A.C., Graves T., Zhou S.,
RA Teague B., Potamousis K., Churas C., Place M., Herschleb J., Runnheim R.,
RA Forrest D., Amos-Landgraf J., Schwartz D.C., Cheng Z., Lindblad-Toh K.,
RA Eichler E.E., Ponting C.P.;
RT "Lineage-specific biology revealed by a finished genome assembly of the
RT mouse.";
RL PLoS Biol. 7:E1000112-E1000112(2009).
RN [3] {ECO:0007829|PubMed:21183079}
RP IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
RX PubMed=21183079; DOI=10.1016/j.cell.2010.12.001;
RA Huttlin E.L., Jedrychowski M.P., Elias J.E., Goswami T., Rad R.,
RA Beausoleil S.A., Villen J., Haas W., Sowa M.E., Gygi S.P.;
RT "A tissue-specific atlas of mouse protein phosphorylation and expression.";
RL Cell 143:1174-1189(2010).
RN [4] {ECO:0007829|PubMed:24129315}
RP IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
RX PubMed=24129315;
RA Guo A., Gu H., Zhou J., Mulhern D., Wang Y., Lee K.A., Yang V., Aguiar M.,
RA Kornhauser J., Jia X., Ren J., Beausoleil S.A., Silva J.C., Vemulapalli V.,
RA Bedford M.T., Comb M.J.;
RT "Immunoaffinity enrichment and mass spectrometry analysis of protein
RT methylation.";
RL Mol. Cell. Proteomics 13:372-387(2014).
RN [5] {ECO:0000313|Ensembl:ENSMUSP00000043103.5}
RP IDENTIFICATION.
RC STRAIN=C57BL/6J {ECO:0000313|Ensembl:ENSMUSP00000043103.5};
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
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DR RefSeq; NP_861415.2; NM_181750.2.
DR RefSeq; XP_011246284.1; XM_011247982.2.
DR AlphaFoldDB; E9Q9Q2; -.
DR SMR; E9Q9Q2; -.
DR STRING; 10090.ENSMUSP00000043103; -.
DR GlyGen; E9Q9Q2; 1 site, 1 O-linked glycan (1 site).
DR iPTMnet; E9Q9Q2; -.
DR PhosphoSitePlus; E9Q9Q2; -.
DR jPOST; E9Q9Q2; -.
DR MaxQB; E9Q9Q2; -.
DR PaxDb; 10090-ENSMUSP00000043103; -.
DR ProteomicsDB; 353291; -.
DR Antibodypedia; 51003; 17 antibodies from 10 providers.
DR DNASU; 226412; -.
DR Ensembl; ENSMUST00000036288.11; ENSMUSP00000043103.5; ENSMUSG00000056211.14.
DR GeneID; 226412; -.
DR UCSC; uc007clj.1; mouse.
DR AGR; MGI:2448514; -.
DR CTD; 23518; -.
DR MGI; MGI:2448514; R3hdm1.
DR VEuPathDB; HostDB:ENSMUSG00000056211; -.
DR eggNOG; KOG2953; Eukaryota.
DR GeneTree; ENSGT00940000156095; -.
DR HOGENOM; CLU_007817_0_0_1; -.
DR InParanoid; E9Q9Q2; -.
DR OMA; ACYCAPS; -.
DR OrthoDB; 91945at2759; -.
DR PhylomeDB; E9Q9Q2; -.
DR TreeFam; TF315915; -.
DR BioGRID-ORCS; 226412; 1 hit in 78 CRISPR screens.
DR ChiTaRS; R3hdm1; mouse.
DR Proteomes; UP000000589; Chromosome 1.
DR RNAct; E9Q9Q2; Protein.
DR Bgee; ENSMUSG00000056211; Expressed in metanephric ureteric bud and 258 other cell types or tissues.
DR ExpressionAtlas; E9Q9Q2; baseline and differential.
DR Genevisible; E9Q9Q2; MM.
DR GO; GO:0003676; F:nucleic acid binding; IEA:UniProtKB-UniRule.
DR CDD; cd02642; R3H_encore_like; 1.
DR Gene3D; 3.30.1370.50; R3H-like domain; 1.
DR InterPro; IPR001374; R3H_dom.
DR InterPro; IPR036867; R3H_dom_sf.
DR InterPro; IPR024771; SUZ.
DR PANTHER; PTHR15672; CAMP-REGULATED PHOSPHOPROTEIN 21 RELATED R3H DOMAIN CONTAINING PROTEIN; 1.
DR PANTHER; PTHR15672:SF12; R3H DOMAIN-CONTAINING PROTEIN 1; 1.
DR Pfam; PF01424; R3H; 1.
DR Pfam; PF12752; SUZ; 1.
DR SMART; SM00393; R3H; 1.
DR SUPFAM; SSF82708; R3H domain; 1.
DR PROSITE; PS51061; R3H; 1.
DR PROSITE; PS51673; SUZ; 1.
PE 1: Evidence at protein level;
KW Phosphoprotein {ECO:0000256|ARBA:ARBA00022553};
KW Proteomics identification {ECO:0007829|EPD:E9Q9Q2,
KW ECO:0007829|MaxQB:E9Q9Q2};
KW Reference proteome {ECO:0000313|Proteomes:UP000000589}.
FT DOMAIN 168..231
FT /note="R3H"
FT /evidence="ECO:0000259|PROSITE:PS51061"
FT DOMAIN 232..302
FT /note="SUZ"
FT /evidence="ECO:0000259|PROSITE:PS51673"
FT REGION 54..75
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 110..146
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 330..370
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 387..439
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 484..572
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 618..659
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 975..1010
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 55..72
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 110..141
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 514..536
FT /note="Pro residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 537..556
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 622..644
FT /note="Pro residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 645..659
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 1135 AA; 124387 MW; 7D8321F5BB5B52AC CRC64;
MRMSDIVIIK DETETMKDLE AEMRDTTRVE NLIKSENYGK ISAEKNEHCI DNNIDLQRPP
QSFGQTGKRS KSSSKLKLVR SLAVCEESPP PPAAEISQET QEKIQIQLTQ SFEKEEKPSK
DETDKEKASD KLPRKMLSRD SSQEYTDSTG IDLHEFLVNT LKNNPRDRMM LLKLEQEILD
FIGNNESPRK KFPPMTSYHR MLLHRVAAYF GLDHNVDQSG KSVIVNKTSN TRIPDQKFNE
HIKDDRGEDF QKRYILKRDN SSFDKDDSQM RIRLKDDRRS KSIEEREEEY QRARDRIFSQ
DSLCSQENYI IDKRIQDEDT IGTQQRRQIF RVNKDASGRS TNSHQSSTEN ELKYSEPRPW
SSTDSDSSLR NLKPAVTKAS SFSGISVLTR GDSSGSSKSI GRLSKTGSES SGSVGSSTGS
LSHTQQPLPG SALSQSSHGA PVIYPAASNH SSLSFDGGLS GQGASPSTSF LLLPLEATGI
PPGSILINPQ TGQPFLNPDG SPVVYNPPMT QQPVRTQVPG PPQPPLPPPP PQQPAASHMF
SQPVGPLQSS SQPVQCSPAP YPSPLLPVSP TQQYSVDNLG AQFSHMSLAR QPSADGSDPH
ATMFQSTVVL QSPQQSGYIV TTAPPHPPPP PPPPPPPPSL PPGQSVPTAS FSASGHPVSQ
PVLQQQGFLP QPSPQMPACY CAPGHYHSSQ PQYRPIPSVH HSSHLNQPLP QPAQHTGYQV
MPNQQQNYQG IVGVQSPQSQ SLMGGQPNST GPHIQGVVIP YPSVPSYQVS LPQGSQGIAH
QTYQQPVVFP NQSNQGSLPT TGMPVYYSVI PPGQQSNLSS AVGYLQHPGS EQVQFPRTTS
PCSSQQLQGH QCAAVPQQPP GGGMVMMQLN LPNNPQSRTH SPPQWKQNKH YCDHQRGQKC
MDFSNMDNIV QPSPQLSSPI LSPVQSPAPA QLSTLKTIRP SGPPLSIMSQ FARPFVPGQG
DARYPLLGQP LQYNPPTLLH GHIPHQQGQS GSRHGNRGRR QAKKAASTDL GAGEAVVGKV
LEITELPDGI TRVEAEKLFG ELFKIGAKIR WLRDPQSQPQ LRRHALCCGS GDNTVNPEHS
KPSDLASTYT VLATFPSISA AQSALKKQIH SVNKFKLRMS KKHYDFHILE RASSQ
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