ID E9QAU9_MOUSE Unreviewed; 796 AA.
AC E9QAU9;
DT 05-APR-2011, integrated into UniProtKB/TrEMBL.
DT 05-APR-2011, sequence version 1.
DT 27-MAR-2024, entry version 92.
DE SubName: Full=Leucine-rich repeats and calponin homology (CH) domain containing 3 {ECO:0000313|Ensembl:ENSMUSP00000130708.2};
GN Name=Lrch3 {ECO:0000313|Ensembl:ENSMUSP00000130708.2,
GN ECO:0000313|MGI:MGI:1917394};
OS Mus musculus (Mouse).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae;
OC Murinae; Mus; Mus.
OX NCBI_TaxID=10090 {ECO:0000313|Ensembl:ENSMUSP00000130708.2, ECO:0000313|Proteomes:UP000000589};
RN [1] {ECO:0000313|Ensembl:ENSMUSP00000130708.2, ECO:0000313|Proteomes:UP000000589}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=C57BL/6J {ECO:0000313|Ensembl:ENSMUSP00000130708.2,
RC ECO:0000313|Proteomes:UP000000589};
RX PubMed=19468303; DOI=10.1371/journal.pbio.1000112;
RA Church D.M., Goodstadt L., Hillier L.W., Zody M.C., Goldstein S., She X.,
RA Bult C.J., Agarwala R., Cherry J.L., DiCuccio M., Hlavina W., Kapustin Y.,
RA Meric P., Maglott D., Birtle Z., Marques A.C., Graves T., Zhou S.,
RA Teague B., Potamousis K., Churas C., Place M., Herschleb J., Runnheim R.,
RA Forrest D., Amos-Landgraf J., Schwartz D.C., Cheng Z., Lindblad-Toh K.,
RA Eichler E.E., Ponting C.P.;
RT "Lineage-specific biology revealed by a finished genome assembly of the
RT mouse.";
RL PLoS Biol. 7:E1000112-E1000112(2009).
RN [2] {ECO:0007829|PubMed:21183079}
RP IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
RX PubMed=21183079; DOI=10.1016/j.cell.2010.12.001;
RA Huttlin E.L., Jedrychowski M.P., Elias J.E., Goswami T., Rad R.,
RA Beausoleil S.A., Villen J., Haas W., Sowa M.E., Gygi S.P.;
RT "A tissue-specific atlas of mouse protein phosphorylation and expression.";
RL Cell 143:1174-1189(2010).
RN [3] {ECO:0000313|Ensembl:ENSMUSP00000130708.2}
RP IDENTIFICATION.
RC STRAIN=C57BL/6J {ECO:0000313|Ensembl:ENSMUSP00000130708.2};
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
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DR RefSeq; NP_001297603.1; NM_001310674.1.
DR RefSeq; XP_006522587.1; XM_006522524.3.
DR AlphaFoldDB; E9QAU9; -.
DR SMR; E9QAU9; -.
DR jPOST; E9QAU9; -.
DR MaxQB; E9QAU9; -.
DR PeptideAtlas; E9QAU9; -.
DR ProteomicsDB; 361384; -.
DR Antibodypedia; 2704; 113 antibodies from 18 providers.
DR Ensembl; ENSMUST00000135193.9; ENSMUSP00000130708.2; ENSMUSG00000022801.14.
DR GeneID; 70144; -.
DR AGR; MGI:1917394; -.
DR CTD; 84859; -.
DR MGI; MGI:1917394; Lrch3.
DR VEuPathDB; HostDB:ENSMUSG00000022801; -.
DR GeneTree; ENSGT00940000158330; -.
DR OMA; LYSWIFP; -.
DR OrthoDB; 2956716at2759; -.
DR PhylomeDB; E9QAU9; -.
DR BioGRID-ORCS; 70144; 3 hits in 77 CRISPR screens.
DR ChiTaRS; Lrch3; mouse.
DR Proteomes; UP000000589; Chromosome 16.
DR Bgee; ENSMUSG00000022801; Expressed in manus and 231 other cell types or tissues.
DR ExpressionAtlas; E9QAU9; baseline and differential.
DR GO; GO:0005829; C:cytosol; IEA:Ensembl.
DR GO; GO:0016020; C:membrane; IEA:UniProtKB-KW.
DR GO; GO:0032185; P:septin cytoskeleton organization; IEA:Ensembl.
DR Gene3D; 1.10.418.10; Calponin-like domain; 1.
DR Gene3D; 3.80.10.10; Ribonuclease Inhibitor; 1.
DR InterPro; IPR001715; CH_dom.
DR InterPro; IPR036872; CH_dom_sf.
DR InterPro; IPR001611; Leu-rich_rpt.
DR InterPro; IPR003591; Leu-rich_rpt_typical-subtyp.
DR InterPro; IPR032675; LRR_dom_sf.
DR PANTHER; PTHR48051; -; 1.
DR PANTHER; PTHR48051:SF44; LEUCINE RICH REPEATS AND CALPONIN HOMOLOGY DOMAIN CONTAINING 3; 1.
DR Pfam; PF00307; CH; 1.
DR Pfam; PF13855; LRR_8; 2.
DR SMART; SM00033; CH; 1.
DR SMART; SM00364; LRR_BAC; 4.
DR SMART; SM00369; LRR_TYP; 5.
DR SUPFAM; SSF47576; Calponin-homology domain, CH-domain; 1.
DR SUPFAM; SSF52058; L domain-like; 1.
DR PROSITE; PS50021; CH; 1.
PE 1: Evidence at protein level;
KW Leucine-rich repeat {ECO:0000256|ARBA:ARBA00022614};
KW Membrane {ECO:0000256|SAM:Phobius};
KW Proteomics identification {ECO:0007829|EPD:E9QAU9,
KW ECO:0007829|MaxQB:E9QAU9};
KW Reference proteome {ECO:0000313|Proteomes:UP000000589};
KW Repeat {ECO:0000256|ARBA:ARBA00022737};
KW Transmembrane {ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|SAM:Phobius}.
FT TRANSMEM 771..790
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 645..760
FT /note="Calponin-homology (CH)"
FT /evidence="ECO:0000259|PROSITE:PS50021"
FT REGION 511..536
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 513..536
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 796 AA; 88524 MW; 73E838AABEA200A5 CRC64;
MAAAGLVAVV AAAEYSGPVA SGGNLSGATC GPSPGLGPGP GPGSWSRSVD RALEEAAVTG
VLSLSGRKLR EFPRGAANHD LTDTTRADLS RNRLSEIPME ACHFVSLESL NLYQNCIRYI
PEAVLNLQAL TFLNISRNQL STLPVHLCNL PLKVLIASNN KLVSLPEEIG HLRHLTELDV
SCNEIQTVPS QIGNLEALRD FNVRRNHLLR LPEELAEVPL IRLDFSCNKI TVIPVCYRNL
RHLQVITLDN NPLQSPPAQI CIKGKIHIFK YLNIQACKIA PDLPDYERRP LGFGSCHEEL
YSGRPYGALD SGFNSVDSGD KRWSGNEPTD EFSDLPLRVA EITKEQRLRR ESQYQENRSS
VAVTNGGVEH DLDQIDYIDS CTTEEEENDV KQPKSLDTNS LSSQFMAYIE QRRISHEVSP
VKPIAVREFQ KTEDMKRYSH QNRVPVEPSL VLSMPPSHNQ LSHSDLELHQ RREQSIECTR
REAQLAALQY EEEKIRTKQI QRDAVLDFVK QKASHNPQRQ QPPGNGECSF PSRRSQHTDD
SALLVSLSGL DGVSCVATRP HSSAFTPLKS ENRVDVTSSF PMTETVHHSP AYSFPAATQR
NQPQRPESFL FRAAVRAEAN KGRASPLLLS SAPATDPTDA ITRQREEELK LIDQLRKHIE
YRLKVSLPCD LGAALTDGVV LCHLANHVRP RSVPSIHVPS PAVPKLTMAK CRRNVENFLD
ACRKIGVPQD NLCSPSDILQ LNLSLKRTVE TLLSLGARAE ESSFVSLSVQ LLGFVAFYCS
LMLILCVLYY RVFTYS
//
