ID E9QCY1_DANRE Unreviewed; 438 AA.
AC E9QCY1; A0A8M3AX22; X1WGS6;
DT 05-APR-2011, integrated into UniProtKB/TrEMBL.
DT 05-APR-2011, sequence version 1.
DT 27-MAR-2024, entry version 81.
DE SubName: Full=Eva-1 homolog C (C. elegans) {ECO:0000313|Ensembl:ENSDARP00000104027};
DE SubName: Full=Protein eva-1 homolog C isoform X2 {ECO:0000313|RefSeq:XP_009303779.2};
GN Name=eva1c {ECO:0000313|Ensembl:ENSDARP00000104027,
GN ECO:0000313|RefSeq:XP_009303779.2,
GN ECO:0000313|ZFIN:ZDB-GENE-091204-329};
OS Danio rerio (Zebrafish) (Brachydanio rerio).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes;
OC Danionidae; Danioninae; Danio.
OX NCBI_TaxID=7955 {ECO:0000313|Ensembl:ENSDARP00000104027};
RN [1] {ECO:0000313|Ensembl:ENSDARP00000104027}
RP IDENTIFICATION.
RC STRAIN=Tuebingen {ECO:0000313|Ensembl:ENSDARP00000104027};
RG Ensembl;
RL Submitted (JUL-2011) to UniProtKB.
RN [2] {ECO:0000313|Ensembl:ENSDARP00000104027, ECO:0000313|Proteomes:UP000000437}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Tuebingen {ECO:0000313|Ensembl:ENSDARP00000104027};
RX PubMed=23594743; DOI=10.1038/nature12111;
RG Genome Reference Consortium Zebrafish;
RA Howe K., Clark M.D., Torroja C.F., Torrance J., Berthelot C., Muffato M.,
RA Collins J.E., Humphray S., McLaren K., Matthews L., McLaren S., Sealy I.,
RA Caccamo M., Churcher C., Scott C., Barrett J.C., Koch R., Rauch G.J.,
RA White S., Chow W., Kilian B., Quintais L.T., Guerra-Assuncao J.A., Zhou Y.,
RA Gu Y., Yen J., Vogel J.H., Eyre T., Redmond S., Banerjee R., Chi J., Fu B.,
RA Langley E., Maguire S.F., Laird G.K., Lloyd D., Kenyon E., Donaldson S.,
RA Sehra H., Almeida-King J., Loveland J., Trevanion S., Jones M., Quail M.,
RA Willey D., Hunt A., Burton J., Sims S., McLay K., Plumb B., Davis J.,
RA Clee C., Oliver K., Clark R., Riddle C., Elliot D., Eliott D.,
RA Threadgold G., Harden G., Ware D., Begum S., Mortimore B., Mortimer B.,
RA Kerry G., Heath P., Phillimore B., Tracey A., Corby N., Dunn M.,
RA Johnson C., Wood J., Clark S., Pelan S., Griffiths G., Smith M.,
RA Glithero R., Howden P., Barker N., Lloyd C., Stevens C., Harley J.,
RA Holt K., Panagiotidis G., Lovell J., Beasley H., Henderson C., Gordon D.,
RA Auger K., Wright D., Collins J., Raisen C., Dyer L., Leung K.,
RA Robertson L., Ambridge K., Leongamornlert D., McGuire S., Gilderthorp R.,
RA Griffiths C., Manthravadi D., Nichol S., Barker G., Whitehead S., Kay M.,
RA Brown J., Murnane C., Gray E., Humphries M., Sycamore N., Barker D.,
RA Saunders D., Wallis J., Babbage A., Hammond S., Mashreghi-Mohammadi M.,
RA Barr L., Martin S., Wray P., Ellington A., Matthews N., Ellwood M.,
RA Woodmansey R., Clark G., Cooper J., Cooper J., Tromans A., Grafham D.,
RA Skuce C., Pandian R., Andrews R., Harrison E., Kimberley A., Garnett J.,
RA Fosker N., Hall R., Garner P., Kelly D., Bird C., Palmer S., Gehring I.,
RA Berger A., Dooley C.M., Ersan-Urun Z., Eser C., Geiger H., Geisler M.,
RA Karotki L., Kirn A., Konantz J., Konantz M., Oberlander M.,
RA Rudolph-Geiger S., Teucke M., Lanz C., Raddatz G., Osoegawa K., Zhu B.,
RA Rapp A., Widaa S., Langford C., Yang F., Schuster S.C., Carter N.P.,
RA Harrow J., Ning Z., Herrero J., Searle S.M., Enright A., Geisler R.,
RA Plasterk R.H., Lee C., Westerfield M., de Jong P.J., Zon L.I.,
RA Postlethwait J.H., Nusslein-Volhard C., Hubbard T.J., Roest Crollius H.,
RA Rogers J., Stemple D.L.;
RT "The zebrafish reference genome sequence and its relationship to the human
RT genome.";
RL Nature 496:498-503(2013).
RN [3] {ECO:0000313|RefSeq:XP_009303779.2}
RP IDENTIFICATION.
RC STRAIN=Tuebingen {ECO:0000313|RefSeq:XP_009303779.2};
RG RefSeq;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- SIMILARITY: Belongs to the EVA1 family.
CC {ECO:0000256|ARBA:ARBA00006023}.
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DR EMBL; CR394538; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; CR759796; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR RefSeq; XP_009303779.2; XM_009305504.3.
DR STRING; 7955.ENSDARP00000104027; -.
DR PaxDb; 7955-ENSDARP00000104027; -.
DR Ensembl; ENSDART00000108658.4; ENSDARP00000104027.3; ENSDARG00000056024.8.
DR Ensembl; ENSDART00000155634.3; ENSDARP00000129435.2; ENSDARG00000056024.8.
DR GeneID; 564385; -.
DR AGR; ZFIN:ZDB-GENE-091204-329; -.
DR CTD; 59271; -.
DR ZFIN; ZDB-GENE-091204-329; eva1c.
DR eggNOG; KOG4729; Eukaryota.
DR OMA; LWTRRMN; -.
DR OrthoDB; 56324at2759; -.
DR TreeFam; TF328177; -.
DR Proteomes; UP000000437; Chromosome 10.
DR Bgee; ENSDARG00000056024; Expressed in swim bladder and 18 other cell types or tissues.
DR GO; GO:0016020; C:membrane; IEA:UniProtKB-KW.
DR GO; GO:0030246; F:carbohydrate binding; IEA:InterPro.
DR GO; GO:0008201; F:heparin binding; IBA:GO_Central.
DR CDD; cd22828; Gal_Rha_Lectin_EVA1_EVA1C_rpt1; 1.
DR CDD; cd22829; Gal_Rha_Lectin_EVA1_EVA1C_rpt2; 1.
DR Gene3D; 2.60.120.740; -; 2.
DR InterPro; IPR039500; EVA1_dom.
DR InterPro; IPR000922; Lectin_gal-bd_dom.
DR InterPro; IPR043159; Lectin_gal-bd_sf.
DR PANTHER; PTHR46780; PROTEIN EVA-1; 1.
DR PANTHER; PTHR46780:SF4; PROTEIN EVA-1 HOMOLOG C; 1.
DR Pfam; PF14851; FAM176; 1.
DR Pfam; PF02140; Gal_Lectin; 2.
DR PROSITE; PS50228; SUEL_LECTIN; 2.
PE 3: Inferred from homology;
KW Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|SAM:Phobius};
KW Reference proteome {ECO:0000313|Proteomes:UP000000437};
KW Transmembrane {ECO:0000256|ARBA:ARBA00022692, ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW ECO:0000256|SAM:Phobius}.
FT TRANSMEM 302..322
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 52..144
FT /note="SUEL-type lectin"
FT /evidence="ECO:0000259|PROSITE:PS50228"
FT DOMAIN 153..244
FT /note="SUEL-type lectin"
FT /evidence="ECO:0000259|PROSITE:PS50228"
FT REGION 339..372
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 351..367
FT /note="Acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 438 AA; 49599 MW; EC020E38192D3553 CRC64;
MISAQHLRSC RAPGLCLQIL YSVLILWTKE MDGLSDFSNY LFRIIKSQSA QACDGDLLIL
KCPRHSTITI QSAFYGQSET LVGLEPRMRC QWHNHSCSAS TTLQKVLSEC QGHRDCQFLV
NHQVFGKDPC PGIPKYINVS YRCKPTEHKR KVTCEGDRLL LHCKYPKVLN IYSAVYGRLL
EEEDLCSSEE QKPPYECLHH GAVDVVSNIC YGKQRCLFTV DQKHFKDPCP PGTKKYITIL
YACVPQSLLK EADPSSFLTT SMPSQSTKEE RPVIRSSKFP EGGIILSNAL MGFGYITEHP
EMAGLLFTSS VCVGLLIVLI AVSTQLTCSR HLNTPRAFRK KSRTNLEEEE PMNQDNSEEE
DDEDDKGSLM DSSNLSEIGR KVYCWEDVTY TTEAADLMER IERRELVIQE IRMNAYLNGN
TCILHSNMPT VTQNVQLL
//
