ID E9QF07_DANRE Unreviewed; 1935 AA.
AC E9QF07; A0A8M3AMS5;
DT 05-APR-2011, integrated into UniProtKB/TrEMBL.
DT 26-JUN-2013, sequence version 2.
DT 27-MAR-2024, entry version 81.
DE SubName: Full=Myosin, heavy chain 7B, cardiac muscle, beta b {ECO:0000313|Ensembl:ENSDARP00000114580};
DE SubName: Full=Myosin-7 isoform X1 {ECO:0000313|RefSeq:XP_009295034.2};
GN Name=myh7bb {ECO:0000313|Ensembl:ENSDARP00000114580,
GN ECO:0000313|RefSeq:XP_009295034.2,
GN ECO:0000313|ZFIN:ZDB-GENE-090311-5};
OS Danio rerio (Zebrafish) (Brachydanio rerio).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes;
OC Danionidae; Danioninae; Danio.
OX NCBI_TaxID=7955 {ECO:0000313|Ensembl:ENSDARP00000114580};
RN [1] {ECO:0000313|Ensembl:ENSDARP00000114580}
RP IDENTIFICATION.
RC STRAIN=Tuebingen {ECO:0000313|Ensembl:ENSDARP00000114580};
RG Ensembl;
RL Submitted (JUL-2011) to UniProtKB.
RN [2] {ECO:0000313|Ensembl:ENSDARP00000114580, ECO:0000313|Proteomes:UP000000437}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Tuebingen {ECO:0000313|Ensembl:ENSDARP00000114580};
RX PubMed=23594743; DOI=10.1038/nature12111;
RG Genome Reference Consortium Zebrafish;
RA Howe K., Clark M.D., Torroja C.F., Torrance J., Berthelot C., Muffato M.,
RA Collins J.E., Humphray S., McLaren K., Matthews L., McLaren S., Sealy I.,
RA Caccamo M., Churcher C., Scott C., Barrett J.C., Koch R., Rauch G.J.,
RA White S., Chow W., Kilian B., Quintais L.T., Guerra-Assuncao J.A., Zhou Y.,
RA Gu Y., Yen J., Vogel J.H., Eyre T., Redmond S., Banerjee R., Chi J., Fu B.,
RA Langley E., Maguire S.F., Laird G.K., Lloyd D., Kenyon E., Donaldson S.,
RA Sehra H., Almeida-King J., Loveland J., Trevanion S., Jones M., Quail M.,
RA Willey D., Hunt A., Burton J., Sims S., McLay K., Plumb B., Davis J.,
RA Clee C., Oliver K., Clark R., Riddle C., Elliot D., Eliott D.,
RA Threadgold G., Harden G., Ware D., Begum S., Mortimore B., Mortimer B.,
RA Kerry G., Heath P., Phillimore B., Tracey A., Corby N., Dunn M.,
RA Johnson C., Wood J., Clark S., Pelan S., Griffiths G., Smith M.,
RA Glithero R., Howden P., Barker N., Lloyd C., Stevens C., Harley J.,
RA Holt K., Panagiotidis G., Lovell J., Beasley H., Henderson C., Gordon D.,
RA Auger K., Wright D., Collins J., Raisen C., Dyer L., Leung K.,
RA Robertson L., Ambridge K., Leongamornlert D., McGuire S., Gilderthorp R.,
RA Griffiths C., Manthravadi D., Nichol S., Barker G., Whitehead S., Kay M.,
RA Brown J., Murnane C., Gray E., Humphries M., Sycamore N., Barker D.,
RA Saunders D., Wallis J., Babbage A., Hammond S., Mashreghi-Mohammadi M.,
RA Barr L., Martin S., Wray P., Ellington A., Matthews N., Ellwood M.,
RA Woodmansey R., Clark G., Cooper J., Cooper J., Tromans A., Grafham D.,
RA Skuce C., Pandian R., Andrews R., Harrison E., Kimberley A., Garnett J.,
RA Fosker N., Hall R., Garner P., Kelly D., Bird C., Palmer S., Gehring I.,
RA Berger A., Dooley C.M., Ersan-Urun Z., Eser C., Geiger H., Geisler M.,
RA Karotki L., Kirn A., Konantz J., Konantz M., Oberlander M.,
RA Rudolph-Geiger S., Teucke M., Lanz C., Raddatz G., Osoegawa K., Zhu B.,
RA Rapp A., Widaa S., Langford C., Yang F., Schuster S.C., Carter N.P.,
RA Harrow J., Ning Z., Herrero J., Searle S.M., Enright A., Geisler R.,
RA Plasterk R.H., Lee C., Westerfield M., de Jong P.J., Zon L.I.,
RA Postlethwait J.H., Nusslein-Volhard C., Hubbard T.J., Roest Crollius H.,
RA Rogers J., Stemple D.L.;
RT "The zebrafish reference genome sequence and its relationship to the human
RT genome.";
RL Nature 496:498-503(2013).
RN [3] {ECO:0000313|RefSeq:XP_009295034.2}
RP IDENTIFICATION.
RC STRAIN=Tuebingen {ECO:0000313|RefSeq:XP_009295034.2};
RG RefSeq;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- SIMILARITY: Belongs to the TRAFAC class myosin-kinesin ATPase
CC superfamily. Myosin family. {ECO:0000256|ARBA:ARBA00008314,
CC ECO:0000256|PROSITE-ProRule:PRU00782}.
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DR EMBL; CR847953; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR RefSeq; XP_009295034.2; XM_009296759.3.
DR Ensembl; ENSDART00000137438; ENSDARP00000114580; ENSDARG00000035322.
DR Ensembl; ENSDART00000137438.4; ENSDARP00000114580.2; ENSDARG00000035322.7.
DR GeneID; 560945; -.
DR KEGG; dre:560945; -.
DR AGR; ZFIN:ZDB-GENE-090311-5; -.
DR CTD; 560945; -.
DR ZFIN; ZDB-GENE-090311-5; myh7bb.
DR eggNOG; KOG0161; Eukaryota.
DR HOGENOM; CLU_000192_8_0_1; -.
DR OMA; ITMLQAF; -.
DR OrthoDB; 2877572at2759; -.
DR TreeFam; TF314375; -.
DR Proteomes; UP000000437; Chromosome 23.
DR Bgee; ENSDARG00000035322; Expressed in heart and 9 other cell types or tissues.
DR GO; GO:0005737; C:cytoplasm; IBA:GO_Central.
DR GO; GO:0032982; C:myosin filament; IBA:GO_Central.
DR GO; GO:0016460; C:myosin II complex; IBA:GO_Central.
DR GO; GO:0051015; F:actin filament binding; IBA:GO_Central.
DR GO; GO:0005524; F:ATP binding; IEA:UniProtKB-UniRule.
DR GO; GO:0000146; F:microfilament motor activity; IBA:GO_Central.
DR GO; GO:0048731; P:system development; IEA:UniProt.
DR Gene3D; 1.10.10.820; -; 1.
DR Gene3D; 1.20.5.340; -; 4.
DR Gene3D; 1.20.5.370; -; 5.
DR Gene3D; 1.20.5.4820; -; 1.
DR Gene3D; 1.20.58.530; -; 1.
DR Gene3D; 3.40.850.10; Kinesin motor domain; 1.
DR Gene3D; 2.30.30.360; Myosin S1 fragment, N-terminal; 1.
DR Gene3D; 1.20.120.720; Myosin VI head, motor domain, U50 subdomain; 1.
DR InterPro; IPR000048; IQ_motif_EF-hand-BS.
DR InterPro; IPR036961; Kinesin_motor_dom_sf.
DR InterPro; IPR001609; Myosin_head_motor_dom.
DR InterPro; IPR004009; Myosin_N.
DR InterPro; IPR008989; Myosin_S1_N.
DR InterPro; IPR002928; Myosin_tail.
DR InterPro; IPR027417; P-loop_NTPase.
DR InterPro; IPR014751; XRCC4-like_C.
DR PANTHER; PTHR45615; MYOSIN HEAVY CHAIN, NON-MUSCLE; 1.
DR PANTHER; PTHR45615:SF29; MYOSIN-7B; 1.
DR Pfam; PF00063; Myosin_head; 1.
DR Pfam; PF02736; Myosin_N; 1.
DR Pfam; PF01576; Myosin_tail_1; 1.
DR PRINTS; PR00193; MYOSINHEAVY.
DR SMART; SM00242; MYSc; 1.
DR SUPFAM; SSF90257; Myosin rod fragments; 5.
DR SUPFAM; SSF52540; P-loop containing nucleoside triphosphate hydrolases; 1.
DR PROSITE; PS50096; IQ; 1.
DR PROSITE; PS51456; MYOSIN_MOTOR; 1.
DR PROSITE; PS51844; SH3_LIKE; 1.
PE 1: Evidence at protein level;
KW Actin-binding {ECO:0000256|ARBA:ARBA00023203, ECO:0000256|PROSITE-
KW ProRule:PRU00782};
KW ATP-binding {ECO:0000256|ARBA:ARBA00022840, ECO:0000256|PROSITE-
KW ProRule:PRU00782};
KW Coiled coil {ECO:0000256|ARBA:ARBA00023054, ECO:0000256|SAM:Coils};
KW Motor protein {ECO:0000256|ARBA:ARBA00023175, ECO:0000256|PROSITE-
KW ProRule:PRU00782};
KW Myosin {ECO:0000256|ARBA:ARBA00023123, ECO:0000256|PROSITE-
KW ProRule:PRU00782};
KW Nucleotide-binding {ECO:0000256|ARBA:ARBA00022741, ECO:0000256|PROSITE-
KW ProRule:PRU00782};
KW Proteomics identification {ECO:0007829|PeptideAtlas:E9QF07};
KW Reference proteome {ECO:0000313|Proteomes:UP000000437}.
FT DOMAIN 33..82
FT /note="Myosin N-terminal SH3-like"
FT /evidence="ECO:0000259|PROSITE:PS51844"
FT DOMAIN 86..779
FT /note="Myosin motor"
FT /evidence="ECO:0000259|PROSITE:PS51456"
FT REGION 656..678
FT /note="Actin-binding"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00782"
FT REGION 1127..1158
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COILED 1201..1685
FT /evidence="ECO:0000256|SAM:Coils"
FT COILED 1728..1833
FT /evidence="ECO:0000256|SAM:Coils"
FT COILED 1862..1924
FT /evidence="ECO:0000256|SAM:Coils"
FT COMPBIAS 1127..1152
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT BINDING 179..186
FT /ligand="ATP"
FT /ligand_id="ChEBI:CHEBI:30616"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00782"
SQ SEQUENCE 1935 AA; 224469 MW; 70D2C50FC75C8EF6 CRC64;
MSRFMELREF GEAATFLRKT NLEQLAAQSH AFDGKKRVWI PDEKEAYIEV EIKDTDGDKV
MVETKDGRML TVKEEDIQQM NPPKFDLMED MAMLTHLNEA SVLFNLSRRY SFWMIYTYSG
LFCVTVNPYK WLPVYSSEVV AAYKGKRRSD VPPHIYSIAD NAYNDMLKNR ENQSMLITGE
SGAGKTVNTK RVIQYFAIIA ALGEAGGKKG GTLEDQIIEA NPAMEAFGNA KTLRNDNSSR
FGKFIRIHFG PTGKLASADI DIYLLEKSRV IFQQTGERSY HIYYQILSHR KPELQDMLLV
SSNPFDYHFC SQGVITVDNM DDGDELLATD HAMDTLGFTP EEKYGCYKIV GGIMHFGNMK
FKVKQREEQA EADGTESADK ASYLMGISSA DLIKGLLHPR VKVGNEYIVR GQTVEQVTYA
VGALAKATYD RMFKWLVGRI NKTLYTAIPR QFFIGVLDIA GFEIFEFNNF EQMCINFTNE
KLQQFFNHHM FILEQEEYKT EGIEWTFIDF GLDLQACIDL IEKPLGILSI LEEECMFPKA
TESSFKAKLY DNLLGKSPNF LKPRPDKKRK YDTHFELVHY AGVVPYNING WLDKNRDPLN
ETVVGIFQRS SNKLMSSLFE NFISLDSGSE AKPGSKEKRK KGASFQTVSQ LHKENLNKLM
TNLRSTQPHF VRCIIPNEAK NPGMMEPFLV LHQLRCNGVL EGIRICRKGF PNRILYAEFK
QRYRILNPLA IPEDTYVDSR KAVEKLLGSL DIDHTQYKFG HSKVFFKAGL LGQLEDMRDE
RLSKVLTLLQ AFCRGKLMRM ERKRMMKEKE ALMVIQWNIR AFYAVKNWPW MCLFFKIKPL
LRSAATEKEL ATLKEEFQKL KEALERSEVK RKELEEKQVS LVQEKNDLSL QLQAEQDNLA
DAEDRCNLLI KAKIQMEGKI KELMERLEDE EEMNATILAK KRKLEDECIE LKKDLDDLEI
TLAKVEKEKH ATENKVKNLV EEMAALDETI SRLSKEKKAL QDAHQQALED LQSEENKVNM
LSKAKIKLEQ QVDDLEGSLE QEKKVRMDLE RVKRKLEGDL KLSVESSMDL DNSKQQLEER
LKKKDHEMVQ IGAKIEEEQA LVIQLHKKIK ELQTRIEELE EELEAERAAR SKSEKQRSDV
SRELEELSER LEEAGGATTA QIEMNKKREA DFIKLRRDLE EASLHHETTI AMLRRKHADT
VAEMGEQLDN LQRVKQKLEK EKAETRMECE DLASNVEHLS RAKTTTEKMC RMYEDQLNES
KTKIEELQRQ LMDVTSQKAR AQTESAEVSR RLEEKEVLVM QLQRTKIAFS QTVEELKKQL
EEESKAKNSL AHAVQSSRHD CDLLREQFEE EQEAKSELQR ALSKANIEIA QWRTKYETDA
IQRTDELEDA KKKLVARLQG SEEAVEASNA KCASLEKTKH RLQTEIEDLM VDLERSNAVA
IALDKKQRNF DKVLSEWRQK FEETQSELEG SQKESRSLST ELFKLKNSYE EALDQLETIK
RENKNLQEEI TDLTDQISQG NKTIHELEQM KKVLDHEKCD IQAALEEAEG TLEHEESKTL
RVQLELSQTK TEVEKKLAER DEEIDNLRRN HQRTLEGMQT TLDAETRARN EAIRVKKKME
NDMNEMEIHL NHANRQAVES QKMVRNLQLQ IKDLQVELDE SMHHCEELKE QVAVTERRNT
LLSAELEELR GVAEQTDRMR KVAEHELLES SERVNLLHAQ NTVMLNQKKK LESDLSMLSG
EVDDAQQECR NAEEKAKKAI TDAAMMAEEL KKEQDTSSHL ERMKRNMEQT IKDLQNRLDE
AEQIALKGGK KQIQKMEIRV RELETELDCE QKKSAEFQKG IRKYERRIKE LTYQTEEDRK
TLLRMQDLID KLQAKVKSFK RQAEDAEEQV NCNMTRFRKI QHDLDEAEER ADMAESQVNK
LRVRTRETHV VKVVE
//
