ID E9QPQ1_MOUSE Unreviewed; 1380 AA.
AC E9QPQ1;
DT 05-APR-2011, integrated into UniProtKB/TrEMBL.
DT 05-APR-2011, sequence version 1.
DT 27-MAR-2024, entry version 90.
DE SubName: Full=Roundabout guidance receptor 3 {ECO:0000313|Ensembl:ENSMUSP00000034643.6};
GN Name=Robo3 {ECO:0000313|Ensembl:ENSMUSP00000034643.6,
GN ECO:0000313|MGI:MGI:1343102};
OS Mus musculus (Mouse).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae;
OC Murinae; Mus; Mus.
OX NCBI_TaxID=10090 {ECO:0000313|Ensembl:ENSMUSP00000034643.6, ECO:0000313|Proteomes:UP000000589};
RN [1] {ECO:0000313|Ensembl:ENSMUSP00000034643.6, ECO:0000313|Proteomes:UP000000589}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=C57BL/6J {ECO:0000313|Ensembl:ENSMUSP00000034643.6,
RC ECO:0000313|Proteomes:UP000000589};
RX PubMed=19468303; DOI=10.1371/journal.pbio.1000112;
RA Church D.M., Goodstadt L., Hillier L.W., Zody M.C., Goldstein S., She X.,
RA Bult C.J., Agarwala R., Cherry J.L., DiCuccio M., Hlavina W., Kapustin Y.,
RA Meric P., Maglott D., Birtle Z., Marques A.C., Graves T., Zhou S.,
RA Teague B., Potamousis K., Churas C., Place M., Herschleb J., Runnheim R.,
RA Forrest D., Amos-Landgraf J., Schwartz D.C., Cheng Z., Lindblad-Toh K.,
RA Eichler E.E., Ponting C.P.;
RT "Lineage-specific biology revealed by a finished genome assembly of the
RT mouse.";
RL PLoS Biol. 7:E1000112-E1000112(2009).
RN [2] {ECO:0000313|Ensembl:ENSMUSP00000034643.6}
RP IDENTIFICATION.
RC STRAIN=C57BL/6J {ECO:0000313|Ensembl:ENSMUSP00000034643.6};
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
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DR SMR; E9QPQ1; -.
DR MaxQB; E9QPQ1; -.
DR ProteomicsDB; 359038; -.
DR Antibodypedia; 2550; 223 antibodies from 33 providers.
DR Ensembl; ENSMUST00000034643.12; ENSMUSP00000034643.6; ENSMUSG00000032128.16.
DR UCSC; uc009ouw.1; mouse.
DR AGR; MGI:1343102; -.
DR MGI; MGI:1343102; Robo3.
DR VEuPathDB; HostDB:ENSMUSG00000032128; -.
DR GeneTree; ENSGT00940000155457; -.
DR ChiTaRS; Robo3; mouse.
DR Proteomes; UP000000589; Chromosome 9.
DR Bgee; ENSMUSG00000032128; Expressed in roof plate of midbrain and 70 other cell types or tissues.
DR ExpressionAtlas; E9QPQ1; baseline and differential.
DR CDD; cd00063; FN3; 3.
DR Gene3D; 2.60.40.10; Immunoglobulins; 8.
DR InterPro; IPR003961; FN3_dom.
DR InterPro; IPR036116; FN3_sf.
DR InterPro; IPR007110; Ig-like_dom.
DR InterPro; IPR036179; Ig-like_dom_sf.
DR InterPro; IPR013783; Ig-like_fold.
DR InterPro; IPR013098; Ig_I-set.
DR InterPro; IPR003599; Ig_sub.
DR InterPro; IPR003598; Ig_sub2.
DR PANTHER; PTHR44170; PROTEIN SIDEKICK; 1.
DR PANTHER; PTHR44170:SF37; ROUNDABOUT GUIDANCE RECEPTOR 3; 1.
DR Pfam; PF00041; fn3; 2.
DR Pfam; PF07679; I-set; 3.
DR Pfam; PF13927; Ig_3; 2.
DR SMART; SM00060; FN3; 3.
DR SMART; SM00409; IG; 5.
DR SMART; SM00408; IGc2; 5.
DR SUPFAM; SSF49265; Fibronectin type III; 2.
DR SUPFAM; SSF48726; Immunoglobulin; 5.
DR PROSITE; PS50853; FN3; 3.
DR PROSITE; PS50835; IG_LIKE; 5.
PE 1: Evidence at protein level;
KW Glycoprotein {ECO:0000256|ARBA:ARBA00023180};
KW Immunoglobulin domain {ECO:0000256|ARBA:ARBA00023319};
KW Proteomics identification {ECO:0007829|MaxQB:E9QPQ1};
KW Reference proteome {ECO:0000313|Proteomes:UP000000589};
KW Repeat {ECO:0000256|ARBA:ARBA00022737}.
FT DOMAIN 42..138
FT /note="Ig-like"
FT /evidence="ECO:0000259|PROSITE:PS50835"
FT DOMAIN 144..231
FT /note="Ig-like"
FT /evidence="ECO:0000259|PROSITE:PS50835"
FT DOMAIN 236..320
FT /note="Ig-like"
FT /evidence="ECO:0000259|PROSITE:PS50835"
FT DOMAIN 325..418
FT /note="Ig-like"
FT /evidence="ECO:0000259|PROSITE:PS50835"
FT DOMAIN 428..509
FT /note="Ig-like"
FT /evidence="ECO:0000259|PROSITE:PS50835"
FT DOMAIN 536..630
FT /note="Fibronectin type-III"
FT /evidence="ECO:0000259|PROSITE:PS50853"
FT DOMAIN 650..744
FT /note="Fibronectin type-III"
FT /evidence="ECO:0000259|PROSITE:PS50853"
FT DOMAIN 749..847
FT /note="Fibronectin type-III"
FT /evidence="ECO:0000259|PROSITE:PS50853"
FT REGION 1..41
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 518..539
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 617..640
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 943..967
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1010..1285
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1318..1380
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 620..634
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1012..1031
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1058..1073
FT /note="Pro residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1118..1134
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1135..1149
FT /note="Pro residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1194..1211
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1241..1256
FT /note="Pro residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1323..1369
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 1380 AA; 147285 MW; EEDEBD38E6621301 CRC64;
MSEAEGSLTL QSKPGLPPVA LPGYLELPSS PGSRVGPEDA MPRIVEQPPD LVVSRGEPAT
LPCRAEGRPR PNIEWYKNGA RVATAREDPR AHRLLLPSGA LFFPRIVHGR RSRPDEGVYT
CVARNYLGAA ASRNASLEVA VLRDDFRQSP GNVVVAVGEP AVMECVPPKG HPEPLVTWKK
GKIKLKEEEG RITIRGGKLM MSHTFKSDAG MYMCVASNMA GERESGAAEL VVLERPSFLR
RPINQVVLAD APVNFLCEVQ GDPQPNLHWR KDDGELPAGR YEIRSDHSLW IDQVSSEDEG
TYTCVAENSV GRAEASGSLS VHVPPQFVTK PQNQTVAPGA NVSFQCETKG NPPPAIFWQK
EGSQVLLFPS QSLQPMGRLL VSPRGQLNIT EVKIGDGGYY VCQAVSVAGS ILAKALLEIK
GASIDGLPPI ILQGPANQTL VLGSSVWLPC RVIGNPQPNI QWKKDERWLQ GDDSQFNLMD
NGTLHIASIQ EMDMGFYSCV AKSSIGEATW NSWLRKQEDW GASPGPATGP SNPPGPPSQP
IVTEVTANSI TLTWKPNPQS GATATSYVIE AFSQAAGNTW RTVADGVQLE TYTISGLQPN
TIYLFLVRAV GAWGLSEPSP VSEPVQTQDS SLSRPAEDPW KGQRGLAEVA VRMQEPTVLG
PRTLQVSWTV DGPVQLVQGF RVSWRIAGLD QGSWTMLDLQ SPHKQSTVLR GLPPGAQIQI
KVQVQGQEGL GAESPFVTRS IPEEAPSGPP QGVAVALGGD RNSSVTVSWE PPLPSQRNGV
ITEYQIWCLG NESRFHLNRS AAGWARSVTF SGLLPGQIYR ALVAAATSAG VGVASAPVLV
QLPFPPAAEP GPEVSEGLAE RLAKVLRKPA FLAGSSAACG ALLLGFCAAL YRRQKQRKEL
SHYTASFAYT PAVSFPHSEG LSGSSSRPPM GLGPAAYPWL ADSWPHPPRS PSAQEPRGSC
CPSNPDPDDR YYNEAGISLY LAQTARGANA SGEGPVYSTI DPVGEELQTF HGGFPQHSSG
DPSTWSQYAP PEWSEGDSGA RGGQGKLLGK PVQMPSLSWP EALPPPPPSC ELSCPEGPEE
ELKGSSDLEE WCPPVPEKSH LVGSSSSGAC MVAPAPRDTP SPTSSYGQQS TATLTPSPPD
PPQPPTDIPH LHQMPRRVPL GPSSPLSVSQ PALSSHDGRP VGLGAGPVLS YHASPSPVPS
TASSAPGRTR QVTGEMTPPL HGHRARIRKK PKALPYRREH SPGDLPPPPL PPPEEETSWP
LGLRAAGSMS SLERERSGER RVVQAVPLGA QPLGAQRGPH PDAALLGCAA EEAWLPYGRP
SFLSHGQGTS TCSTAGSNSS RGSNSSRGSR GSRGPGRSRS RSRSQSQSQR PGRNRREEPR
//
