ID EFHC2_DANRE Reviewed; 748 AA.
AC Q32TF8; Q08CU1;
DT 03-OCT-2006, integrated into UniProtKB/Swiss-Prot.
DT 21-AUG-2007, sequence version 2.
DT 27-MAR-2024, entry version 84.
DE RecName: Full=EF-hand domain-containing family member C2;
GN Name=efhc2; ORFNames=zgc:152706;
OS Danio rerio (Zebrafish) (Brachydanio rerio).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes;
OC Danionidae; Danioninae; Danio.
OX NCBI_TaxID=7955;
RN [1]
RP NUCLEOTIDE SEQUENCE [MRNA].
RA Gu W., Steinlein O.K.;
RT "The EFHC family.";
RL Submitted (OCT-2004) to the EMBL/GenBank/DDBJ databases.
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC TISSUE=Olfactory epithelium;
RG NIH - Zebrafish Gene Collection (ZGC) project;
RL Submitted (SEP-2006) to the EMBL/GenBank/DDBJ databases.
CC -!- FUNCTION: Microtubule inner protein (MIP) part of the dynein-decorated
CC doublet microtubules (DMTs) in cilia axoneme, which is required for
CC motile cilia beating. {ECO:0000250|UniProtKB:A0A3Q1N1R0}.
CC -!- SUBCELLULAR LOCATION: Cytoplasm, cytoskeleton, cilium axoneme
CC {ECO:0000250|UniProtKB:A0A3Q1N1R0}.
CC -!- SEQUENCE CAUTION:
CC Sequence=AAX08048.1; Type=Frameshift; Evidence={ECO:0000305};
CC Sequence=AAX08048.1; Type=Miscellaneous discrepancy; Note=Intron retention.; Evidence={ECO:0000305};
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DR EMBL; AY823393; AAX08048.1; ALT_SEQ; mRNA.
DR EMBL; BC124091; AAI24092.1; -; mRNA.
DR AlphaFoldDB; Q32TF8; -.
DR SMR; Q32TF8; -.
DR STRING; 7955.ENSDARP00000010992; -.
DR PaxDb; 7955-ENSDARP00000010992; -.
DR AGR; ZFIN:ZDB-GENE-031001-10; -.
DR ZFIN; ZDB-GENE-031001-10; efhc2.
DR eggNOG; KOG0043; Eukaryota.
DR InParanoid; Q32TF8; -.
DR PhylomeDB; Q32TF8; -.
DR PRO; PR:Q32TF8; -.
DR Proteomes; UP000000437; Genome assembly.
DR GO; GO:0005879; C:axonemal microtubule; ISS:UniProtKB.
DR GO; GO:1903251; P:multi-ciliated epithelial cell differentiation; IMP:ZFIN.
DR GO; GO:0010975; P:regulation of neuron projection development; IBA:GO_Central.
DR GO; GO:0039010; P:specification of pronephric distal tubule identity; IMP:ZFIN.
DR Gene3D; 2.30.29.170; -; 3.
DR Gene3D; 1.10.238.10; EF-hand; 1.
DR InterPro; IPR006602; DM10_dom.
DR InterPro; IPR011992; EF-hand-dom_pair.
DR InterPro; IPR040193; EFHC1/EFHC2/EFHB.
DR PANTHER; PTHR12086; EF-HAND DOMAIN C-TERMINAL CONTAINING PROTEIN; 1.
DR PANTHER; PTHR12086:SF11; EF-HAND DOMAIN-CONTAINING FAMILY MEMBER C2; 1.
DR Pfam; PF06565; DM10_dom; 3.
DR SMART; SM00676; DM10; 3.
DR SUPFAM; SSF47473; EF-hand; 1.
DR PROSITE; PS51336; DM10; 3.
PE 2: Evidence at transcript level;
KW Cell projection; Cytoplasm; Cytoskeleton; Reference proteome; Repeat.
FT CHAIN 1..748
FT /note="EF-hand domain-containing family member C2"
FT /id="PRO_0000251706"
FT DOMAIN 75..182
FT /note="DM10 1"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00665"
FT DOMAIN 226..366
FT /note="DM10 2"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00665"
FT DOMAIN 428..535
FT /note="DM10 3"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00665"
FT DOMAIN 556..591
FT /note="EF-hand 1"
FT DOMAIN 631..666
FT /note="EF-hand 2"
FT CONFLICT 88
FT /note="A -> D (in Ref. 1; AAX08048)"
FT /evidence="ECO:0000305"
FT CONFLICT 159
FT /note="L -> V (in Ref. 1; AAX08048)"
FT /evidence="ECO:0000305"
FT CONFLICT 179
FT /note="V -> I (in Ref. 1; AAX08048)"
FT /evidence="ECO:0000305"
FT CONFLICT 203..205
FT /note="LEE -> AK (in Ref. 1; AAX08048)"
FT /evidence="ECO:0000305"
FT CONFLICT 425
FT /note="R -> Q (in Ref. 1; AAX08048)"
FT /evidence="ECO:0000305"
FT CONFLICT 560
FT /note="T -> K (in Ref. 1; AAX08048)"
FT /evidence="ECO:0000305"
SQ SEQUENCE 748 AA; 85457 MW; 9B6C88FF54307AA3 CRC64;
MALPMLPGNS VNRNLGKDKF HKSQHFDYSN GVAMMVGTEK PGIGGDLLLG QSARAKYSRF
PKGEGSGAPA WLAFDKQVLC FDAYFNEAVP QRREEKYRVR KCKIYFYLED DTIQVVEPEF
KNSGIPQGTL IRRHRIPLPA PKDDCFYNVH HFNINQEVLF YSRNFMITDC DPFTRNFLVK
MGVRLNPPAS TPADPYTTLR QELEENMKPL RPYERLDTLK QFLEHDRQVL RFYCYWDDSE
SMFGDPRELI LHYFLADDTM EMYEVVPPNS GRDTVPKFLH RGKLPKHAPI PKRQPGEITD
RTVLNVFGPV GQGGPYILDS LKTGALEEEF YKDSDLTIGA VINVWGRRVL ICDCDYFTKE
YYRSKYGIED FPSISYKASP PPKPAKQVPP YTGFGSEEDS LCSCQGLLPK PPQKDFKKLM
EKDRRGLVSN VLRFVGKMLT DSPVDKERVF IICFYLTDDT IAVFEPPQRN SGVIGGKFLE
RGRVKKPGQE LFKSEMSEYF TAQDLYVGAH LLLNSQPFQL VDADDFTFSY MEQHADEFPK
ANIGTIISKV KSISEEQQKT VKQFFTMSDP SSTGSLPYES FRTLLADLDV ELSEHEIMTL
GRVYSVRQQP EVNVGLMLAV AQDHLKKKNF EKFSEMIQAF THEDRDRCGQ LSSKEARIIC
KAFRLPLSDD LLRALLEKFA GESEKIDYHA FLSGINWREN PVPAVLPEDT VKFDADWRGE
APEPAVKTIN YSLLLEDVFG SATNINDS
//
