GenomeNet

Database: UniProt
Entry: EHF_PANTR
LinkDB: EHF_PANTR
Original site: EHF_PANTR 
ID   EHF_PANTR               Reviewed;         300 AA.
AC   A2T737;
DT   01-MAY-2007, integrated into UniProtKB/Swiss-Prot.
DT   06-MAR-2007, sequence version 1.
DT   05-JUN-2019, entry version 91.
DE   RecName: Full=ETS homologous factor;
DE   AltName: Full=ETS domain-containing transcription factor;
GN   Name=EHF;
OS   Pan troglodytes (Chimpanzee).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
OC   Catarrhini; Hominidae; Pan.
OX   NCBI_TaxID=9598;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RA   Nickel G.C., Tefft D.L., Trevarthen K., Funt J., Adams M.D.;
RT   "Positive selection in transcription factor genes on the human
RT   lineage.";
RL   Submitted (AUG-2006) to the EMBL/GenBank/DDBJ databases.
CC   -!- FUNCTION: Transcriptional activator that may play a role in
CC       regulating epithelial cell differentiation and proliferation. May
CC       act as a repressor for a specific subset of ETS/AP-1-responsive
CC       genes, and as a modulator of the nuclear response to mitogen-
CC       activated protein kinase signaling cascades. Binds to DNA
CC       sequences containing the consensus nucleotide core sequence GGAA.
CC       Involved in regulation of TNFRSF10B/DR5 expression through Ets-
CC       binding sequences on the TNFRSF10B/DR5 promoter (By similarity).
CC       {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000255|PROSITE-
CC       ProRule:PRU00237}.
CC   -!- DOMAIN: The PNT domain acts as a transcriptional activator.
CC       {ECO:0000250}.
CC   -!- SIMILARITY: Belongs to the ETS family. {ECO:0000305}.
DR   EMBL; DQ977366; ABM91992.1; -; Genomic_DNA.
DR   RefSeq; NP_001075037.1; NM_001081568.1.
DR   RefSeq; XP_009458439.1; XM_009460164.2.
DR   STRING; 9598.ENSPTRP00000006078; -.
DR   PaxDb; A2T737; -.
DR   Ensembl; ENSPTRT00000006591; ENSPTRP00000006078; ENSPTRG00000003498.
DR   Ensembl; ENSPTRT00000098886; ENSPTRP00000076408; ENSPTRG00000003498.
DR   GeneID; 739336; -.
DR   KEGG; ptr:739336; -.
DR   CTD; 26298; -.
DR   VGNC; VGNC:1049; EHF.
DR   eggNOG; KOG3804; Eukaryota.
DR   eggNOG; ENOG4111K4J; LUCA.
DR   GeneTree; ENSGT00940000159310; -.
DR   HOGENOM; HOG000232188; -.
DR   InParanoid; A2T737; -.
DR   KO; K17102; -.
DR   OrthoDB; 837296at2759; -.
DR   TreeFam; TF318679; -.
DR   Proteomes; UP000002277; Chromosome 11.
DR   Bgee; ENSPTRG00000003498; Expressed in 2 organ(s), highest expression level in liver.
DR   GO; GO:0005634; C:nucleus; IBA:GO_Central.
DR   GO; GO:0000981; F:DNA-binding transcription factor activity, RNA polymerase II-specific; IBA:GO_Central.
DR   GO; GO:0043565; F:sequence-specific DNA binding; IEA:InterPro.
DR   GO; GO:0030154; P:cell differentiation; IBA:GO_Central.
DR   GO; GO:0030855; P:epithelial cell differentiation; IEA:InterPro.
DR   GO; GO:0050673; P:epithelial cell proliferation; IEA:InterPro.
DR   GO; GO:0006357; P:regulation of transcription by RNA polymerase II; IBA:GO_Central.
DR   GO; GO:0006366; P:transcription by RNA polymerase II; IEA:InterPro.
DR   Gene3D; 1.10.10.10; -; 1.
DR   Gene3D; 1.10.150.50; -; 1.
DR   InterPro; IPR033071; EHF.
DR   InterPro; IPR000418; Ets_dom.
DR   InterPro; IPR003118; Pointed_dom.
DR   InterPro; IPR013761; SAM/pointed_sf.
DR   InterPro; IPR036388; WH-like_DNA-bd_sf.
DR   InterPro; IPR036390; WH_DNA-bd_sf.
DR   PANTHER; PTHR11849:SF171; PTHR11849:SF171; 1.
DR   Pfam; PF00178; Ets; 1.
DR   Pfam; PF02198; SAM_PNT; 1.
DR   PRINTS; PR00454; ETSDOMAIN.
DR   SMART; SM00413; ETS; 1.
DR   SMART; SM00251; SAM_PNT; 1.
DR   SUPFAM; SSF46785; SSF46785; 1.
DR   SUPFAM; SSF47769; SSF47769; 1.
DR   PROSITE; PS50061; ETS_DOMAIN_3; 1.
DR   PROSITE; PS51433; PNT; 1.
PE   3: Inferred from homology;
KW   Complete proteome; DNA-binding; Nucleus; Reference proteome;
KW   Transcription; Transcription regulation.
FT   CHAIN         1    300       ETS homologous factor.
FT                                /FTId=PRO_0000285519.
FT   DOMAIN       29    115       PNT. {ECO:0000255|PROSITE-
FT                                ProRule:PRU00762}.
FT   DNA_BIND    207    289       ETS. {ECO:0000255|PROSITE-
FT                                ProRule:PRU00237}.
SQ   SEQUENCE   300 AA;  34833 MW;  03E64D383DDD67BE CRC64;
     MILEGGGVMN LNPGNNLLHQ PPAWTDSYST CNVSSGFFGG QWHEIHPQYW TKYQVWEWLQ
     HLLDTNQLDA SCIPFQEFDI NGEHLCSMSL QEFTRAAGTA GQLLYSNLQH LKWNGQCSSD
     LFQSTHNVIV KTEQTEPSIV NTWKDENYLY DTNYGSTVDL LDSKTFCRAQ ISMTTTSHLP
     VAESPDMKKE QDPPAKCHTK KHNPRGTHLW EFIRDILLNP DKNPGLIKWE DRSEGVFRFL
     KSEAVAQLWG KKKNNSSMTY EKLSRAMRYY YKREILERVD GRRLVYKFGK NARGWRENEN
//
DBGET integrated database retrieval system