ID EIF3M_DROWI Reviewed; 387 AA.
AC B4MY75;
DT 03-MAR-2009, integrated into UniProtKB/Swiss-Prot.
DT 23-SEP-2008, sequence version 1.
DT 24-JAN-2024, entry version 76.
DE RecName: Full=Eukaryotic translation initiation factor 3 subunit M {ECO:0000255|HAMAP-Rule:MF_03012};
DE Short=eIF3m {ECO:0000255|HAMAP-Rule:MF_03012};
DE AltName: Full=Transport and Golgi organization protein 7 {ECO:0000255|HAMAP-Rule:MF_03012};
DE Short=Tango-7 {ECO:0000255|HAMAP-Rule:MF_03012};
GN Name=Tango7 {ECO:0000255|HAMAP-Rule:MF_03012}; ORFNames=GK22125;
OS Drosophila willistoni (Fruit fly).
OC Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota;
OC Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea;
OC Drosophilidae; Drosophila; Sophophora.
OX NCBI_TaxID=7260;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Tucson 14030-0811.24;
RX PubMed=17994087; DOI=10.1038/nature06341;
RG Drosophila 12 genomes consortium;
RT "Evolution of genes and genomes on the Drosophila phylogeny.";
RL Nature 450:203-218(2007).
CC -!- FUNCTION: Component of the eukaryotic translation initiation factor 3
CC (eIF-3) complex, which is involved in protein synthesis of a
CC specialized repertoire of mRNAs and, together with other initiation
CC factors, stimulates binding of mRNA and methionyl-tRNAi to the 40S
CC ribosome. The eIF-3 complex specifically targets and initiates
CC translation of a subset of mRNAs involved in cell proliferation.
CC {ECO:0000255|HAMAP-Rule:MF_03012}.
CC -!- SUBUNIT: Component of the eukaryotic translation initiation factor 3
CC (eIF-3) complex. The eIF-3 complex interacts with pix.
CC {ECO:0000255|HAMAP-Rule:MF_03012}.
CC -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000255|HAMAP-Rule:MF_03012}.
CC Golgi apparatus {ECO:0000255|HAMAP-Rule:MF_03012}.
CC -!- SIMILARITY: Belongs to the eIF-3 subunit M family. {ECO:0000255|HAMAP-
CC Rule:MF_03012}.
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DR EMBL; CH963894; EDW77064.1; -; Genomic_DNA.
DR RefSeq; XP_002066078.1; XM_002066042.2.
DR AlphaFoldDB; B4MY75; -.
DR SMR; B4MY75; -.
DR STRING; 7260.B4MY75; -.
DR EnsemblMetazoa; FBtr0252776; FBpp0251268; FBgn0224110.
DR GeneID; 6643303; -.
DR KEGG; dwi:6643303; -.
DR eggNOG; KOG2753; Eukaryota.
DR HOGENOM; CLU_035254_1_0_1; -.
DR OMA; AQRCILA; -.
DR OrthoDB; 2875448at2759; -.
DR PhylomeDB; B4MY75; -.
DR Proteomes; UP000007798; Unassembled WGS sequence.
DR GO; GO:0005829; C:cytosol; IEA:EnsemblMetazoa.
DR GO; GO:0016282; C:eukaryotic 43S preinitiation complex; IEA:UniProtKB-UniRule.
DR GO; GO:0033290; C:eukaryotic 48S preinitiation complex; IEA:UniProtKB-UniRule.
DR GO; GO:0071541; C:eukaryotic translation initiation factor 3 complex, eIF3m; IEA:UniProtKB-UniRule.
DR GO; GO:0005794; C:Golgi apparatus; IEA:UniProtKB-SubCell.
DR GO; GO:0070865; C:investment cone; IEA:EnsemblMetazoa.
DR GO; GO:0089720; F:caspase binding; IEA:EnsemblMetazoa.
DR GO; GO:0003743; F:translation initiation factor activity; IEA:UniProtKB-UniRule.
DR GO; GO:0097202; P:activation of cysteine-type endopeptidase activity; IEA:EnsemblMetazoa.
DR GO; GO:0001732; P:formation of cytoplasmic translation initiation complex; IEA:UniProtKB-UniRule.
DR GO; GO:0007030; P:Golgi organization; IEA:EnsemblMetazoa.
DR GO; GO:2001272; P:positive regulation of cysteine-type endopeptidase activity involved in execution phase of apoptosis; IEA:EnsemblMetazoa.
DR GO; GO:0009306; P:protein secretion; IEA:EnsemblMetazoa.
DR GO; GO:0007291; P:sperm individualization; IEA:EnsemblMetazoa.
DR HAMAP; MF_03012; eIF3m; 1.
DR InterPro; IPR016024; ARM-type_fold.
DR InterPro; IPR045237; COPS7/eIF3m.
DR InterPro; IPR027528; eIF3m.
DR InterPro; IPR040750; eIF3m_C_helix.
DR InterPro; IPR000717; PCI_dom.
DR InterPro; IPR036390; WH_DNA-bd_sf.
DR PANTHER; PTHR15350; COP9 SIGNALOSOME COMPLEX SUBUNIT 7/DENDRITIC CELL PROTEIN GA17; 1.
DR PANTHER; PTHR15350:SF2; EUKARYOTIC TRANSLATION INITIATION FACTOR 3 SUBUNIT M; 1.
DR Pfam; PF18005; eIF3m_C_helix; 1.
DR Pfam; PF01399; PCI; 1.
DR SMART; SM00088; PINT; 1.
DR SUPFAM; SSF48371; ARM repeat; 1.
DR SUPFAM; SSF46785; Winged helix' DNA-binding domain; 1.
DR PROSITE; PS50250; PCI; 1.
PE 3: Inferred from homology;
KW Cytoplasm; Golgi apparatus; Initiation factor; Protein biosynthesis;
KW Reference proteome.
FT CHAIN 1..387
FT /note="Eukaryotic translation initiation factor 3 subunit
FT M"
FT /id="PRO_0000366006"
FT DOMAIN 181..340
FT /note="PCI"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU01185"
SQ SEQUENCE 387 AA; 44098 MW; E0707C95C1D0BC14 CRC64;
MTSHPVFIDL SLDEQVQELR KYFKKLGAEI SSEKSNKGVE DDLHKIIGVC DVCFKDGEPA
QIDGILNSIV SIMITIPLDR GENIVLAYCE KMTKAPNQPL AKVCLQSLWR LFNNLDTASP
LRYHVYYHLV QVAKQCDQVL EVFTGVDQLK SQFANCPPSS EQMQKLYRLL HDVTKDTNLE
RSSKVMIELL GTYTADNACV AREDAMKCIV TALADPNTFL LDPLLSLKPV RFLEGDLIHD
LLSIFVSEKL PAYVEFYEEH KEFVNSQGLN HEQNMKKMRL LTFMQLAESN AEMSFEALTK
ELQITENEVE PFVIEVLKTK LVRARLDQAN RKVHISSTMH RTFGAPQWEQ LRDLLQAWKE
NLSSVREGLT NVASAQLDLA RSQKLIH
//
