ID EMP3_BOVIN Reviewed; 163 AA.
AC Q58DR6; A0JNM3;
DT 27-JUN-2006, integrated into UniProtKB/Swiss-Prot.
DT 26-APR-2005, sequence version 1.
DT 24-JAN-2024, entry version 95.
DE RecName: Full=Epithelial membrane protein 3;
DE Short=EMP-3;
GN Name=EMP3;
OS Bos taurus (Bovine).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Laurasiatheria; Artiodactyla; Ruminantia; Pecora; Bovidae;
OC Bovinae; Bos.
OX NCBI_TaxID=9913;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RX PubMed=16305752; DOI=10.1186/1471-2164-6-166;
RA Harhay G.P., Sonstegard T.S., Keele J.W., Heaton M.P., Clawson M.L.,
RA Snelling W.M., Wiedmann R.T., Van Tassell C.P., Smith T.P.L.;
RT "Characterization of 954 bovine full-CDS cDNA sequences.";
RL BMC Genomics 6:166-166(2005).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC STRAIN=Hereford; TISSUE=Fetal medulla;
RG NIH - Mammalian Gene Collection (MGC) project;
RL Submitted (OCT-2006) to the EMBL/GenBank/DDBJ databases.
CC -!- FUNCTION: Probably involved in cell proliferation and cell-cell
CC interactions. {ECO:0000250}.
CC -!- SUBCELLULAR LOCATION: Membrane {ECO:0000250}; Multi-pass membrane
CC protein {ECO:0000250}.
CC -!- SIMILARITY: Belongs to the PMP-22/EMP/MP20 family. {ECO:0000305}.
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DR EMBL; BT021531; AAX46378.1; -; mRNA.
DR EMBL; BC126787; AAI26788.1; -; mRNA.
DR RefSeq; NP_001019733.1; NM_001024562.1.
DR RefSeq; XP_015313659.1; XM_015458173.1.
DR AlphaFoldDB; Q58DR6; -.
DR SMR; Q58DR6; -.
DR STRING; 9913.ENSBTAP00000023976; -.
DR GlyCosmos; Q58DR6; 2 sites, No reported glycans.
DR PaxDb; 9913-ENSBTAP00000023976; -.
DR Ensembl; ENSBTAT00000023976.3; ENSBTAP00000023976.2; ENSBTAG00000018013.3.
DR GeneID; 535273; -.
DR KEGG; bta:535273; -.
DR CTD; 2014; -.
DR VEuPathDB; HostDB:ENSBTAG00000018013; -.
DR VGNC; VGNC:28483; EMP3.
DR eggNOG; ENOG502RZP6; Eukaryota.
DR GeneTree; ENSGT00950000182696; -.
DR HOGENOM; CLU_138632_1_0_1; -.
DR InParanoid; Q58DR6; -.
DR OMA; QLYTMKR; -.
DR OrthoDB; 4195542at2759; -.
DR TreeFam; TF330414; -.
DR Proteomes; UP000009136; Chromosome 18.
DR Bgee; ENSBTAG00000018013; Expressed in blood and 103 other cell types or tissues.
DR GO; GO:0005886; C:plasma membrane; IBA:GO_Central.
DR GO; GO:0006915; P:apoptotic process; IEA:Ensembl.
DR GO; GO:0032060; P:bleb assembly; IEA:Ensembl.
DR Gene3D; 1.20.140.150; -; 1.
DR InterPro; IPR003934; EMP_3.
DR InterPro; IPR004031; PMP22/EMP/MP20/Claudin.
DR InterPro; IPR004032; PMP22_EMP_MP20.
DR PANTHER; PTHR10671:SF8; EPITHELIAL MEMBRANE PROTEIN 3; 1.
DR PANTHER; PTHR10671; EPITHELIAL MEMBRANE PROTEIN-RELATED; 1.
DR Pfam; PF00822; PMP22_Claudin; 1.
DR PRINTS; PR01453; EPMEMFAMILY.
DR PRINTS; PR01456; EPMEMPROT3.
DR PROSITE; PS01221; PMP22_1; 1.
DR PROSITE; PS01222; PMP22_2; 1.
PE 2: Evidence at transcript level;
KW Glycoprotein; Membrane; Reference proteome; Transmembrane;
KW Transmembrane helix.
FT CHAIN 1..163
FT /note="Epithelial membrane protein 3"
FT /id="PRO_0000244414"
FT TRANSMEM 4..24
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 66..86
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 100..120
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 139..159
FT /note="Helical"
FT /evidence="ECO:0000255"
FT CARBOHYD 49
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT CARBOHYD 56
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
SQ SEQUENCE 163 AA; 18300 MW; 6E180D986AFB2F5B CRC64;
MSLLLLVVSA LHILILILLF VATLDKSWWT LPGKESLNLW YDCTWNSDNK TWACSNVSEN
GWLKAVQVLM VLSLILCCLS FILFMFQLYT MRRGGLFYAT GFCQLCTSVA VFTGALIYAI
HAEEILADRP SGGSFGYCFA LAWVAFPLAL ASGIIYIHLR KRE
//
