ID ERV15_YEAST Reviewed; 142 AA.
AC P38312; D6VQK6;
DT 01-OCT-1994, integrated into UniProtKB/Swiss-Prot.
DT 01-OCT-1994, sequence version 1.
DT 27-MAR-2024, entry version 136.
DE RecName: Full=ER-derived vesicles protein ERV15;
GN Name=ERV15; OrderedLocusNames=YBR210W; ORFNames=YBR1457;
OS Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast).
OC Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes;
OC Saccharomycetales; Saccharomycetaceae; Saccharomyces.
OX NCBI_TaxID=559292;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=ATCC 204508 / S288c;
RX PubMed=7813418; DOI=10.1002/j.1460-2075.1994.tb06923.x;
RA Feldmann H., Aigle M., Aljinovic G., Andre B., Baclet M.C., Barthe C.,
RA Baur A., Becam A.-M., Biteau N., Boles E., Brandt T., Brendel M.,
RA Brueckner M., Bussereau F., Christiansen C., Contreras R., Crouzet M.,
RA Cziepluch C., Demolis N., Delaveau T., Doignon F., Domdey H.,
RA Duesterhus S., Dubois E., Dujon B., El Bakkoury M., Entian K.-D.,
RA Feuermann M., Fiers W., Fobo G.M., Fritz C., Gassenhuber J., Glansdorff N.,
RA Goffeau A., Grivell L.A., de Haan M., Hein C., Herbert C.J.,
RA Hollenberg C.P., Holmstroem K., Jacq C., Jacquet M., Jauniaux J.-C.,
RA Jonniaux J.-L., Kallesoee T., Kiesau P., Kirchrath L., Koetter P.,
RA Korol S., Liebl S., Logghe M., Lohan A.J.E., Louis E.J., Li Z.Y.,
RA Maat M.J., Mallet L., Mannhaupt G., Messenguy F., Miosga T., Molemans F.,
RA Mueller S., Nasr F., Obermaier B., Perea J., Pierard A., Piravandi E.,
RA Pohl F.M., Pohl T.M., Potier S., Proft M., Purnelle B., Ramezani Rad M.,
RA Rieger M., Rose M., Schaaff-Gerstenschlaeger I., Scherens B.,
RA Schwarzlose C., Skala J., Slonimski P.P., Smits P.H.M., Souciet J.-L.,
RA Steensma H.Y., Stucka R., Urrestarazu L.A., van der Aart Q.J.M.,
RA Van Dyck L., Vassarotti A., Vetter I., Vierendeels F., Vissers S.,
RA Wagner G., de Wergifosse P., Wolfe K.H., Zagulski M., Zimmermann F.K.,
RA Mewes H.-W., Kleine K.;
RT "Complete DNA sequence of yeast chromosome II.";
RL EMBO J. 13:5795-5809(1994).
RN [2]
RP GENOME REANNOTATION.
RC STRAIN=ATCC 204508 / S288c;
RX PubMed=24374639; DOI=10.1534/g3.113.008995;
RA Engel S.R., Dietrich F.S., Fisk D.G., Binkley G., Balakrishnan R.,
RA Costanzo M.C., Dwight S.S., Hitz B.C., Karra K., Nash R.S., Weng S.,
RA Wong E.D., Lloyd P., Skrzypek M.S., Miyasato S.R., Simison M., Cherry J.M.;
RT "The reference genome sequence of Saccharomyces cerevisiae: Then and now.";
RL G3 (Bethesda) 4:389-398(2014).
RN [3]
RP TOPOLOGY [LARGE SCALE ANALYSIS].
RC STRAIN=ATCC 208353 / W303-1A;
RX PubMed=16847258; DOI=10.1073/pnas.0604075103;
RA Kim H., Melen K., Oesterberg M., von Heijne G.;
RT "A global topology map of the Saccharomyces cerevisiae membrane proteome.";
RL Proc. Natl. Acad. Sci. U.S.A. 103:11142-11147(2006).
CC -!- SUBCELLULAR LOCATION: Membrane; Multi-pass membrane protein.
CC -!- SIMILARITY: Belongs to the cornichon family. {ECO:0000305}.
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DR EMBL; Z36079; CAA85174.1; -; Genomic_DNA.
DR EMBL; BK006936; DAA07326.1; -; Genomic_DNA.
DR PIR; S46084; S46084.
DR RefSeq; NP_009769.1; NM_001178558.1.
DR AlphaFoldDB; P38312; -.
DR SMR; P38312; -.
DR BioGRID; 32907; 99.
DR IntAct; P38312; 1.
DR MINT; P38312; -.
DR STRING; 4932.YBR210W; -.
DR MaxQB; P38312; -.
DR PaxDb; 4932-YBR210W; -.
DR PeptideAtlas; P38312; -.
DR EnsemblFungi; YBR210W_mRNA; YBR210W; YBR210W.
DR GeneID; 852511; -.
DR KEGG; sce:YBR210W; -.
DR AGR; SGD:S000000414; -.
DR SGD; S000000414; ERV15.
DR VEuPathDB; FungiDB:YBR210W; -.
DR eggNOG; KOG2729; Eukaryota.
DR GeneTree; ENSGT00950000182834; -.
DR HOGENOM; CLU_112942_0_0_1; -.
DR InParanoid; P38312; -.
DR OMA; CQREGWV; -.
DR OrthoDB; 2872997at2759; -.
DR BioCyc; YEAST:G3O-29147-MONOMER; -.
DR BioGRID-ORCS; 852511; 3 hits in 10 CRISPR screens.
DR PRO; PR:P38312; -.
DR Proteomes; UP000002311; Chromosome II.
DR RNAct; P38312; Protein.
DR GO; GO:0030134; C:COPII-coated ER to Golgi transport vesicle; IGI:SGD.
DR GO; GO:0005783; C:endoplasmic reticulum; HDA:SGD.
DR GO; GO:0005789; C:endoplasmic reticulum membrane; IBA:GO_Central.
DR GO; GO:0006888; P:endoplasmic reticulum to Golgi vesicle-mediated transport; IGI:SGD.
DR InterPro; IPR003377; Cornichon.
DR InterPro; IPR033466; Cornichon_conserved.
DR PANTHER; PTHR12290; CORNICHON-RELATED; 1.
DR PANTHER; PTHR12290:SF11; PROTEIN CORNICHON; 1.
DR Pfam; PF03311; Cornichon; 1.
DR SMART; SM01398; Cornichon; 1.
DR PROSITE; PS01340; CORNICHON; 1.
PE 1: Evidence at protein level;
KW Membrane; Reference proteome; Transmembrane; Transmembrane helix.
FT CHAIN 1..142
FT /note="ER-derived vesicles protein ERV15"
FT /id="PRO_0000122237"
FT TOPO_DOM 1..7
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 8..28
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TOPO_DOM 29..55
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 56..76
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TOPO_DOM 77..114
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 115..135
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TOPO_DOM 136..142
FT /note="Extracellular"
FT /evidence="ECO:0000255"
SQ SEQUENCE 142 AA; 16347 MW; E3329C122326A6A0 CRC64;
MSGTGLSLFV TGLILNCLNS ICQIYFTILY GDLEADYINS IELCKRVNRL SVPEAILQAF
ISALFLFNGY WFVFLLNVPV LAYNASKVYK KTHLLDATDI FRKLGRCKIE CFLKLGFYLL
IFFFYFYRMV TALLENDANL IS
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