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Database: UniProt
Entry: ETS2_CHICK
LinkDB: ETS2_CHICK
Original site: ETS2_CHICK 
ID   ETS2_CHICK              Reviewed;         479 AA.
AC   P10157;
DT   01-JUL-1989, integrated into UniProtKB/Swiss-Prot.
DT   01-JUL-1989, sequence version 1.
DT   16-OCT-2019, entry version 141.
DE   RecName: Full=Protein C-ets-2;
GN   Name=ETS2;
OS   Gallus gallus (Chicken).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Archelosauria; Archosauria; Dinosauria; Saurischia; Theropoda;
OC   Coelurosauria; Aves; Neognathae; Galloanserae; Galliformes;
OC   Phasianidae; Phasianinae; Gallus.
OX   NCBI_TaxID=9031;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [MRNA].
RC   TISSUE=Fibroblast;
RX   PubMed=3293999; DOI=10.1002/j.1460-2075.1988.tb02865.x;
RA   Boulukos K.E., Pognonec P., Begue A., Galibert F., Gesquiere J.C.,
RA   Stehelin D., Ghysdael J.;
RT   "Identification in chickens of an evolutionarily conserved cellular
RT   ets-2 gene (c-ets-2) encoding nuclear proteins related to the products
RT   of the c-ets proto-oncogene.";
RL   EMBO J. 7:697-705(1988).
CC   -!- FUNCTION: Probable transcription factor. {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: Nucleus.
CC   -!- SIMILARITY: Belongs to the ETS family. {ECO:0000305}.
DR   EMBL; X07202; CAA30178.1; -; mRNA.
DR   PIR; S00386; TVCHE2.
DR   RefSeq; NP_990643.1; NM_205312.1.
DR   SMR; P10157; -.
DR   STRING; 9031.ENSGALP00000025826; -.
DR   PaxDb; P10157; -.
DR   Ensembl; ENSGALT00000025873; ENSGALP00000025826; ENSGALG00000016059.
DR   Ensembl; ENSGALT00000094617; ENSGALP00000066822; ENSGALG00000016059.
DR   GeneID; 396250; -.
DR   KEGG; gga:396250; -.
DR   CTD; 2114; -.
DR   eggNOG; KOG3806; Eukaryota.
DR   eggNOG; ENOG410Z0ZF; LUCA.
DR   GeneTree; ENSGT00940000160202; -.
DR   HOGENOM; HOG000285953; -.
DR   InParanoid; P10157; -.
DR   KO; K21932; -.
DR   OMA; RSWNSQS; -.
DR   OrthoDB; 526256at2759; -.
DR   PhylomeDB; P10157; -.
DR   Reactome; R-GGA-2559585; Oncogene Induced Senescence.
DR   PRO; PR:P10157; -.
DR   Proteomes; UP000000539; Chromosome 1.
DR   Bgee; ENSGALG00000016059; Expressed in 10 organ(s), highest expression level in colon.
DR   GO; GO:0005829; C:cytosol; IEA:Ensembl.
DR   GO; GO:0005654; C:nucleoplasm; IEA:Ensembl.
DR   GO; GO:0005634; C:nucleus; IBA:GO_Central.
DR   GO; GO:0005886; C:plasma membrane; IEA:Ensembl.
DR   GO; GO:0000981; F:DNA-binding transcription factor activity, RNA polymerase II-specific; IBA:GO_Central.
DR   GO; GO:0001227; F:DNA-binding transcription repressor activity, RNA polymerase II-specific; IEA:Ensembl.
DR   GO; GO:0019904; F:protein domain specific binding; IEA:Ensembl.
DR   GO; GO:0000978; F:RNA polymerase II proximal promoter sequence-specific DNA binding; IEA:Ensembl.
DR   GO; GO:0001569; P:branching involved in blood vessel morphogenesis; TAS:DFLAT.
DR   GO; GO:0030154; P:cell differentiation; IBA:GO_Central.
DR   GO; GO:0060982; P:coronary artery morphogenesis; TAS:DFLAT.
DR   GO; GO:0001712; P:ectodermal cell fate commitment; IEA:Ensembl.
DR   GO; GO:0007498; P:mesoderm development; IEA:Ensembl.
DR   GO; GO:0045893; P:positive regulation of transcription, DNA-templated; IEA:Ensembl.
DR   GO; GO:0090009; P:primitive streak formation; IEA:Ensembl.
DR   GO; GO:0006357; P:regulation of transcription by RNA polymerase II; IBA:GO_Central.
DR   Gene3D; 1.10.10.10; -; 1.
DR   Gene3D; 1.10.150.50; -; 1.
DR   InterPro; IPR000418; Ets_dom.
DR   InterPro; IPR003118; Pointed_dom.
DR   InterPro; IPR013761; SAM/pointed_sf.
DR   InterPro; IPR016311; Transform_prot_C-ets.
DR   InterPro; IPR027276; Transform_prot_C-ets-2.
DR   InterPro; IPR036388; WH-like_DNA-bd_sf.
DR   InterPro; IPR036390; WH_DNA-bd_sf.
DR   Pfam; PF00178; Ets; 1.
DR   Pfam; PF02198; SAM_PNT; 1.
DR   PIRSF; PIRSF501032; C-ets-2; 1.
DR   PIRSF; PIRSF001698; Transforming_factor_C-ets; 1.
DR   PRINTS; PR00454; ETSDOMAIN.
DR   SMART; SM00413; ETS; 1.
DR   SMART; SM00251; SAM_PNT; 1.
DR   SUPFAM; SSF46785; SSF46785; 1.
DR   SUPFAM; SSF47769; SSF47769; 1.
DR   PROSITE; PS00345; ETS_DOMAIN_1; 1.
DR   PROSITE; PS00346; ETS_DOMAIN_2; 1.
DR   PROSITE; PS50061; ETS_DOMAIN_3; 1.
DR   PROSITE; PS51433; PNT; 1.
PE   2: Evidence at transcript level;
KW   Complete proteome; DNA-binding; Nucleus; Proto-oncogene;
KW   Reference proteome; Transcription; Transcription regulation.
FT   CHAIN         1    479       Protein C-ets-2.
FT                                /FTId=PRO_0000204076.
FT   DOMAIN       88    173       PNT. {ECO:0000255|PROSITE-
FT                                ProRule:PRU00762}.
FT   DNA_BIND    373    453       ETS. {ECO:0000255|PROSITE-
FT                                ProRule:PRU00237}.
SQ   SEQUENCE   479 AA;  54540 MW;  91BCD5206972E867 CRC64;
     MSEFAIRNMD QVAPVSNMYR GMLKRQPAFD TFDSSNSLFA GYFLSLNEDQ TLQEVPTGFD
     STSYESNNCE LPLLTPCSKA VMSQALKDTF SGFTKEQCRL GIPNNPWLWT EQHVCQWLAW
     ATNEFSLANV NIHQFLMSGQ DLCNLGKERF LELAPDYVGD ILWEHLEQMI KDSQEKTQDQ
     YVESSHLTSV PHWVNNNSLT VNVDQTPYGI QMPGYPKALS YPKPNLLSDI CQTSTGPNLL
     SPEQDFSLFP KTQVDAVSVN YCTVNQDFTR SNLNLLIDNS GKLREHESSE SGAESYESSD
     SMLQSWNSQS SLVDLQRVPS YESFEDDCSQ SLCMSKPTMS FKDYIQDRSD PVEQGKPVIP
     AAILAGFTGS GPIQLWQFLL ELLTDKSCQS FISWTGDGWE FKLADPDEVA RRWGRRKNKP
     KMNYEKLSRG LRYYYDKNII HKTSGKRYVY RFVCDLQNLL GYTAEELHAM LGVQPDTED
//
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