ID   EVA1A_DANRE             Reviewed;         153 AA.
AC   Q08CB3;
DT   20-FEB-2007, integrated into UniProtKB/Swiss-Prot.
DT   20-FEB-2007, sequence version 2.
DT   27-MAR-2024, entry version 93.
DE   RecName: Full=Protein eva-1 homolog A;
DE   AltName: Full=Protein FAM176A;
DE   AltName: Full=Transmembrane protein 166;
GN   Name=Eva1a; Synonyms=fam176a, tmem166; ORFNames=zgc:153298;
OS   Danio rerio (Zebrafish) (Brachydanio rerio).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes;
OC   Danionidae; Danioninae; Danio.
OX   NCBI_TaxID=7955;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   TISSUE=Skin;
RG   NIH - Zebrafish Gene Collection (ZGC) project;
RL   Submitted (SEP-2006) to the EMBL/GenBank/DDBJ databases.
CC   -!- FUNCTION: Acts as a regulator of programmed cell death, mediating both
CC       autophagy and apoptosis. {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: Endoplasmic reticulum membrane {ECO:0000250};
CC       Single-pass membrane protein {ECO:0000250}. Lysosome membrane
CC       {ECO:0000250}; Single-pass membrane protein {ECO:0000250}.
CC   -!- SIMILARITY: Belongs to the EVA1 family. {ECO:0000305}.
CC   -!- SEQUENCE CAUTION:
CC       Sequence=AAI24309.1; Type=Erroneous initiation; Note=Truncated N-terminus.; Evidence={ECO:0000305};
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DR   EMBL; BC124308; AAI24309.1; ALT_INIT; mRNA.
DR   RefSeq; NP_001070055.2; NM_001076587.2.
DR   RefSeq; XP_017207168.1; XM_017351679.1.
DR   AlphaFoldDB; Q08CB3; -.
DR   STRING; 7955.ENSDARP00000081999; -.
DR   PaxDb; 7955-ENSDARP00000081999; -.
DR   GeneID; 767647; -.
DR   KEGG; dre:767647; -.
DR   AGR; ZFIN:ZDB-GENE-060929-200; -.
DR   CTD; 84141; -.
DR   ZFIN; ZDB-GENE-060929-200; eva1a.
DR   eggNOG; ENOG502S091; Eukaryota.
DR   HOGENOM; CLU_104871_1_0_1; -.
DR   InParanoid; Q08CB3; -.
DR   OMA; VMKISCH; -.
DR   OrthoDB; 56324at2759; -.
DR   PhylomeDB; Q08CB3; -.
DR   TreeFam; TF352986; -.
DR   PRO; PR:Q08CB3; -.
DR   Proteomes; UP000000437; Chromosome 17.
DR   Bgee; ENSDARG00000061405; Expressed in swim bladder and 9 other cell types or tissues.
DR   GO; GO:0005789; C:endoplasmic reticulum membrane; IEA:UniProtKB-SubCell.
DR   GO; GO:0005765; C:lysosomal membrane; IEA:UniProtKB-SubCell.
DR   GO; GO:0006915; P:apoptotic process; IEA:UniProtKB-KW.
DR   GO; GO:0006914; P:autophagy; IEA:UniProtKB-KW.
DR   InterPro; IPR039500; EVA1_dom.
DR   PANTHER; PTHR48334:SF1; PROTEIN EVA-1 HOMOLOG A; 1.
DR   PANTHER; PTHR48334; PROTEIN EVA-1 HOMOLOG B-RELATED; 1.
DR   Pfam; PF14851; FAM176; 1.
PE   2: Evidence at transcript level;
KW   Apoptosis; Autophagy; Endoplasmic reticulum; Lysosome; Membrane;
KW   Reference proteome; Transmembrane; Transmembrane helix.
FT   CHAIN           1..153
FT                   /note="Protein eva-1 homolog A"
FT                   /id="PRO_0000278673"
FT   TRANSMEM        37..57
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   REGION          66..97
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        66..84
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   153 AA;  17374 MW;  439EF885B82474BB CRC64;
     MVTAFLNERQ ATTEEMALVS NALAAYSFIA DQPERAALYF VCGVCLGLVL TLIALVVQIS
     CRTDCKTQQA PKKTGKTVEN TSDTSDSDSD WDNTSDLSAR RHRRFERTLG NVFTSAEELE
     RAQRLEERER IIREIWMNGQ PDMPGTRSLN RYY
//