ID EX7L_LACAC Reviewed; 455 AA.
AC Q5FJG6;
DT 23-JAN-2007, integrated into UniProtKB/Swiss-Prot.
DT 01-MAR-2005, sequence version 1.
DT 27-MAR-2024, entry version 102.
DE RecName: Full=Exodeoxyribonuclease 7 large subunit {ECO:0000255|HAMAP-Rule:MF_00378};
DE EC=3.1.11.6 {ECO:0000255|HAMAP-Rule:MF_00378};
DE AltName: Full=Exodeoxyribonuclease VII large subunit {ECO:0000255|HAMAP-Rule:MF_00378};
DE Short=Exonuclease VII large subunit {ECO:0000255|HAMAP-Rule:MF_00378};
GN Name=xseA {ECO:0000255|HAMAP-Rule:MF_00378}; OrderedLocusNames=LBA1331;
OS Lactobacillus acidophilus (strain ATCC 700396 / NCK56 / N2 / NCFM).
OC Bacteria; Bacillota; Bacilli; Lactobacillales; Lactobacillaceae;
OC Lactobacillus.
OX NCBI_TaxID=272621;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=ATCC 700396 / NCK56 / N2 / NCFM;
RX PubMed=15671160; DOI=10.1073/pnas.0409188102;
RA Altermann E., Russell W.M., Azcarate-Peril M.A., Barrangou R., Buck B.L.,
RA McAuliffe O., Souther N., Dobson A., Duong T., Callanan M., Lick S.,
RA Hamrick A., Cano R., Klaenhammer T.R.;
RT "Complete genome sequence of the probiotic lactic acid bacterium
RT Lactobacillus acidophilus NCFM.";
RL Proc. Natl. Acad. Sci. U.S.A. 102:3906-3912(2005).
CC -!- FUNCTION: Bidirectionally degrades single-stranded DNA into large acid-
CC insoluble oligonucleotides, which are then degraded further into small
CC acid-soluble oligonucleotides. {ECO:0000255|HAMAP-Rule:MF_00378}.
CC -!- CATALYTIC ACTIVITY:
CC Reaction=Exonucleolytic cleavage in either 5'- to 3'- or 3'- to 5'-
CC direction to yield nucleoside 5'-phosphates.; EC=3.1.11.6;
CC Evidence={ECO:0000255|HAMAP-Rule:MF_00378};
CC -!- SUBUNIT: Heterooligomer composed of large and small subunits.
CC {ECO:0000255|HAMAP-Rule:MF_00378}.
CC -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000255|HAMAP-Rule:MF_00378}.
CC -!- SIMILARITY: Belongs to the XseA family. {ECO:0000255|HAMAP-
CC Rule:MF_00378}.
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DR EMBL; CP000033; AAV43158.1; -; Genomic_DNA.
DR RefSeq; WP_003547941.1; NC_006814.3.
DR RefSeq; YP_194189.1; NC_006814.3.
DR AlphaFoldDB; Q5FJG6; -.
DR SMR; Q5FJG6; -.
DR STRING; 272621.LBA1331; -.
DR GeneID; 56942915; -.
DR KEGG; lac:LBA1331; -.
DR PATRIC; fig|272621.13.peg.1259; -.
DR eggNOG; COG1570; Bacteria.
DR HOGENOM; CLU_023625_3_1_9; -.
DR OrthoDB; 9802795at2; -.
DR BioCyc; LACI272621:G1G49-1308-MONOMER; -.
DR Proteomes; UP000006381; Chromosome.
DR GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
DR GO; GO:0009318; C:exodeoxyribonuclease VII complex; IEA:InterPro.
DR GO; GO:0008855; F:exodeoxyribonuclease VII activity; IEA:UniProtKB-UniRule.
DR GO; GO:0003676; F:nucleic acid binding; IEA:InterPro.
DR GO; GO:0006308; P:DNA catabolic process; IEA:UniProtKB-UniRule.
DR CDD; cd04489; ExoVII_LU_OBF; 1.
DR HAMAP; MF_00378; Exonuc_7_L; 1.
DR InterPro; IPR003753; Exonuc_VII_L.
DR InterPro; IPR020579; Exonuc_VII_lsu_C.
DR InterPro; IPR025824; OB-fold_nuc-bd_dom.
DR NCBIfam; TIGR00237; xseA; 1.
DR PANTHER; PTHR30008; EXODEOXYRIBONUCLEASE 7 LARGE SUBUNIT; 1.
DR PANTHER; PTHR30008:SF0; EXODEOXYRIBONUCLEASE 7 LARGE SUBUNIT; 1.
DR Pfam; PF02601; Exonuc_VII_L; 1.
DR Pfam; PF13742; tRNA_anti_2; 1.
PE 3: Inferred from homology;
KW Cytoplasm; Exonuclease; Hydrolase; Nuclease; Reference proteome.
FT CHAIN 1..455
FT /note="Exodeoxyribonuclease 7 large subunit"
FT /id="PRO_0000273662"
SQ SEQUENCE 455 AA; 52602 MW; D7634B989436F987 CRC64;
MAENKYLTVT DLNYYITQKF KNDPYLHKVF LQGELSNFRY RRNSHQYFSL KDEKSKINVV
MFRSYFDKVK FKPEEGMKVY VTGYVSVYGP QGSYQFYAEN MEPAGLGALY EQLKQLQVKL
AKEGLFNPEH KKKIPRFPDR IAVVTSASGA VIHDIMVTAN RRFPHAEIDL FPAQVQGDTA
AESLVRAMRQ IAAEGDKYDV MIIGRGGGSL EDLWPFNEEE VVRQVYNMQM PVISSVGHET
DTTLCDLVAD ARAATPTAAA EYATPNLMDE LAGIHQLQSR LFSSMQTIIR QKRDRLNRIQ
NSIIMREPTR LYDQQIETVD RLKQRLQNSM QNKLDHSKQD YRLLNQRLFA VNPDKQINQM
KQQRLFLAKR LSDNMQHYLK DKRNIFAQIV QQLDDYSPLK TLERGFVYTT DRDGKTISSV
KQVNKNDSLN LHFKDGQVAA KVVEVKEEKN ANEEK
//
