ID F0F6N2_9BACT Unreviewed; 533 AA.
AC F0F6N2;
DT 03-MAY-2011, integrated into UniProtKB/TrEMBL.
DT 03-MAY-2011, sequence version 1.
DT 24-JAN-2024, entry version 47.
DE RecName: Full=beta-N-acetylhexosaminidase {ECO:0000256|ARBA:ARBA00012663};
DE EC=3.2.1.52 {ECO:0000256|ARBA:ARBA00012663};
GN Name=nagZ2 {ECO:0000313|EMBL:EGC20314.1};
GN ORFNames=HMPREF9141_1254 {ECO:0000313|EMBL:EGC20314.1};
OS Prevotella multiformis DSM 16608.
OC Bacteria; Bacteroidota; Bacteroidia; Bacteroidales; Prevotellaceae;
OC Prevotella.
OX NCBI_TaxID=888743 {ECO:0000313|EMBL:EGC20314.1, ECO:0000313|Proteomes:UP000005697};
RN [1] {ECO:0000313|EMBL:EGC20314.1, ECO:0000313|Proteomes:UP000005697}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=DSM 16608 {ECO:0000313|EMBL:EGC20314.1,
RC ECO:0000313|Proteomes:UP000005697};
RA Muzny D., Qin X., Deng J., Jiang H., Liu Y., Qu J., Song X.-Z., Zhang L.,
RA Thornton R., Coyle M., Francisco L., Jackson L., Javaid M., Korchina V.,
RA Kovar C., Mata R., Mathew T., Ngo R., Nguyen L., Nguyen N., Okwuonu G.,
RA Ongeri F., Pham C., Simmons D., Wilczek-Boney K., Hale W., Jakkamsetti A.,
RA Pham P., Ruth R., San Lucas F., Warren J., Zhang J., Zhao Z., Zhou C.,
RA Zhu D., Lee S., Bess C., Blankenburg K., Forbes L., Fu Q., Gubbala S.,
RA Hirani K., Jayaseelan J.C., Lara F., Munidasa M., Palculict T., Patil S.,
RA Pu L.-L., Saada N., Tang L., Weissenberger G., Zhu Y., Hemphill L.,
RA Shang Y., Youmans B., Ayvaz T., Ross M., Santibanez J., Aqrawi P.,
RA Gross S., Joshi V., Fowler G., Nazareth L., Reid J., Worley K.,
RA Petrosino J., Highlander S., Gibbs R.;
RL Submitted (JAN-2011) to the EMBL/GenBank/DDBJ databases.
CC -!- SIMILARITY: Belongs to the glycosyl hydrolase 20 family.
CC {ECO:0000256|ARBA:ARBA00006285}.
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:EGC20314.1}.
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DR EMBL; AEWX01000017; EGC20314.1; -; Genomic_DNA.
DR RefSeq; WP_007368783.1; NZ_GL872283.1.
DR AlphaFoldDB; F0F6N2; -.
DR STRING; 888743.HMPREF9141_1254; -.
DR eggNOG; COG3525; Bacteria.
DR HOGENOM; CLU_007082_5_1_10; -.
DR OrthoDB; 1090159at2; -.
DR Proteomes; UP000005697; Unassembled WGS sequence.
DR GO; GO:0004563; F:beta-N-acetylhexosaminidase activity; IEA:UniProtKB-EC.
DR GO; GO:0102148; F:N-acetyl-beta-D-galactosaminidase activity; IEA:UniProtKB-EC.
DR GO; GO:0005975; P:carbohydrate metabolic process; IEA:InterPro.
DR CDD; cd06563; GH20_chitobiase-like; 1.
DR Gene3D; 3.30.379.10; Chitobiase/beta-hexosaminidase domain 2-like; 1.
DR Gene3D; 3.20.20.80; Glycosidases; 1.
DR InterPro; IPR025705; Beta_hexosaminidase_sua/sub.
DR InterPro; IPR015883; Glyco_hydro_20_cat.
DR InterPro; IPR017853; Glycoside_hydrolase_SF.
DR InterPro; IPR029018; Hex-like_dom2.
DR InterPro; IPR015882; HEX_bac_N.
DR PANTHER; PTHR22600; BETA-HEXOSAMINIDASE; 1.
DR PANTHER; PTHR22600:SF21; BETA-HEXOSAMINIDASE A; 1.
DR Pfam; PF00728; Glyco_hydro_20; 1.
DR Pfam; PF02838; Glyco_hydro_20b; 1.
DR PRINTS; PR00738; GLHYDRLASE20.
DR SUPFAM; SSF51445; (Trans)glycosidases; 1.
DR SUPFAM; SSF55545; beta-N-acetylhexosaminidase-like domain; 1.
PE 3: Inferred from homology;
KW Glycosidase {ECO:0000313|EMBL:EGC20314.1};
KW Hydrolase {ECO:0000256|ARBA:ARBA00022801, ECO:0000313|EMBL:EGC20314.1};
KW Reference proteome {ECO:0000313|Proteomes:UP000005697};
KW Signal {ECO:0000256|SAM:SignalP}.
FT SIGNAL 1..19
FT /evidence="ECO:0000256|SAM:SignalP"
FT CHAIN 20..533
FT /note="beta-N-acetylhexosaminidase"
FT /evidence="ECO:0000256|SAM:SignalP"
FT /id="PRO_5003247201"
FT DOMAIN 24..149
FT /note="Beta-hexosaminidase bacterial type N-terminal"
FT /evidence="ECO:0000259|Pfam:PF02838"
FT DOMAIN 152..500
FT /note="Glycoside hydrolase family 20 catalytic"
FT /evidence="ECO:0000259|Pfam:PF00728"
FT ACT_SITE 326
FT /note="Proton donor"
FT /evidence="ECO:0000256|PIRSR:PIRSR625705-1"
SQ SEQUENCE 533 AA; 59910 MW; EDF1B08B4E568179 CRC64;
MKKILFSVAM MIACLSLHAT EANYQVVPLP QSITAGKGGA FVLDGNSVVN VVGTDEAMYR
NASFLKQYIR EATGIAVGGA DKKGTAITLK LNTGIENEEG YVITVKPKGI TVEGRTPRGV
FYGIQTLRKS LPVEQTETVG FPAVRIADHP RFSYRGTMLD CARHYFKLSF IKEFIDMLAL
HNINIFHWHL TEDQGWRVQI DRYPRLTEVG SKRAQTVIGR MTGLYDDTPY GGYYTKEDMR
EVVKYAADRY ITVIPEIDMP GHMLGALAAY PELGCTGGPY KVAEEWGVFP DILCAGNPKT
YEFVYNVLDE LLEIFPSKYI HLGGDEAPRD RWKSCPRCQA EIQRLGLKGT DGFSAEGRLQ
VCFMNRVAKH LAEKGRRIIG WDEILEGDVD KGTTVMSWRG VSGGQEAARR GLDAIMSPTA
YYYLDYYQTK NDALTLIGGL LPVETTYGYN PVPEDASPEL KQHIKGVQAN LWTEYIVGRD
LAFYQLLPRV AAVSETGWTE NGRKDFASFR EREARLNRLY RHFGWKACQD LFK
//
