ID F0GCV2_9BURK Unreviewed; 880 AA.
AC F0GCV2;
DT 03-MAY-2011, integrated into UniProtKB/TrEMBL.
DT 03-MAY-2011, sequence version 1.
DT 27-MAR-2024, entry version 49.
DE RecName: Full=cellulose synthase (UDP-forming) {ECO:0000256|ARBA:ARBA00012539};
DE EC=2.4.1.12 {ECO:0000256|ARBA:ARBA00012539};
GN ORFNames=B1M_30370 {ECO:0000313|EMBL:EGD00685.1};
OS Burkholderia sp. TJI49.
OC Bacteria; Pseudomonadota; Betaproteobacteria; Burkholderiales;
OC Burkholderiaceae; Burkholderia.
OX NCBI_TaxID=987057 {ECO:0000313|EMBL:EGD00685.1, ECO:0000313|Proteomes:UP000003049};
RN [1] {ECO:0000313|EMBL:EGD00685.1, ECO:0000313|Proteomes:UP000003049}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=TJI49 {ECO:0000313|EMBL:EGD00685.1,
RC ECO:0000313|Proteomes:UP000003049};
RX PubMed=23653265; DOI=10.1007/s11274-013-1366-5;
RA Khan A., Asif H., Studholme D.J., Khan I.A., Azim M.K.;
RT "Genome characterization of a novel Burkholderia cepacia complex genomovar
RT isolated from dieback affected mango orchards.";
RL World J. Microbiol. Biotechnol. 29:2033-2044(2013).
CC -!- SUBCELLULAR LOCATION: Membrane {ECO:0000256|ARBA:ARBA00004141}; Multi-
CC pass membrane protein {ECO:0000256|ARBA:ARBA00004141}.
CC -!- SIMILARITY: Belongs to the glycosyl hydrolase 26 family.
CC {ECO:0000256|PROSITE-ProRule:PRU01100}.
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:EGD00685.1}.
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DR EMBL; AEXE01001850; EGD00685.1; -; Genomic_DNA.
DR AlphaFoldDB; F0GCV2; -.
DR PATRIC; fig|987057.7.peg.4755; -.
DR BioCyc; BSP987057:G10O5-880-MONOMER; -.
DR Proteomes; UP000003049; Unassembled WGS sequence.
DR GO; GO:0016020; C:membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0016757; F:glycosyltransferase activity; IEA:UniProtKB-KW.
DR GO; GO:0004553; F:hydrolase activity, hydrolyzing O-glycosyl compounds; IEA:InterPro.
DR GO; GO:0030244; P:cellulose biosynthetic process; IEA:UniProtKB-KW.
DR CDD; cd06421; CESA_CelA_like; 1.
DR Gene3D; 3.20.20.80; Glycosidases; 1.
DR InterPro; IPR022790; GH26_dom.
DR InterPro; IPR001173; Glyco_trans_2-like.
DR InterPro; IPR017853; Glycoside_hydrolase_SF.
DR InterPro; IPR029044; Nucleotide-diphossugar_trans.
DR PANTHER; PTHR43867; CELLULOSE SYNTHASE CATALYTIC SUBUNIT A [UDP-FORMING]; 1.
DR PANTHER; PTHR43867:SF2; CELLULOSE SYNTHASE CATALYTIC SUBUNIT A [UDP-FORMING]; 1.
DR Pfam; PF02156; Glyco_hydro_26; 1.
DR Pfam; PF13632; Glyco_trans_2_3; 1.
DR SUPFAM; SSF51445; (Trans)glycosidases; 1.
DR SUPFAM; SSF53448; Nucleotide-diphospho-sugar transferases; 1.
DR PROSITE; PS51764; GH26; 1.
PE 3: Inferred from homology;
KW Cellulose biosynthesis {ECO:0000256|ARBA:ARBA00022916};
KW Glycosidase {ECO:0000256|ARBA:ARBA00023295, ECO:0000256|PROSITE-
KW ProRule:PRU01100};
KW Hydrolase {ECO:0000256|ARBA:ARBA00022801, ECO:0000256|PROSITE-
KW ProRule:PRU01100};
KW Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|SAM:Phobius};
KW Transferase {ECO:0000256|ARBA:ARBA00022679};
KW Transmembrane {ECO:0000256|ARBA:ARBA00022692, ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW ECO:0000256|SAM:Phobius}.
FT TRANSMEM 45..64
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 76..97
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 376..398
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 410..428
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 448..470
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 490..512
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 518..541
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 562..582
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 585..880
FT /note="GH26"
FT /evidence="ECO:0000259|PROSITE:PS51764"
FT REGION 1..21
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT ACT_SITE 712
FT /note="Proton donor"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU01100"
FT ACT_SITE 816
FT /note="Nucleophile"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU01100"
SQ SEQUENCE 880 AA; 97575 MW; 1FF81B53556F2086 CRC64;
MKKLVASLAG GPEAETGDAG AAPADTLRRE APLLVPLMDS GTKVIFQILA LCWFVALGIF
WRWWLRDEHY VDAFRFGVNG FVLFWTTFIP GYFIFIIRSA VVPNPEVAVP RDWRVAMVVT
KAPSEPFAIV RTTLLAMLDQ TYPHDTWLAD EDPTPETLEW CRQHGVRVST RRGVADYHRT
SWPRRTRCKE GNLAYFYDMY GYDNYDFVSQ LDADHVPTRT YLEEMLRPFV DPAVGYVSAP
SICDSNAAES WSARGRVNVE GPLHGTMQAG YAGGLAPLCI GSHYAVRCRA LREIGGLGPE
LAEDHSTTMI FNAKGWRGMH ALNAIANGEG PRTFADLATQ EFQWSKSVMI IMLRYTRHYF
GGLPLKLKAQ FLFCQLWYPL CALAMAGSVV IPVVALLTGR VWAHVDYLSY LTYALPLAVL
ILCVVTWATH ATQSCRPLNT KLLSWEGLSF VFARWPWVVL GCASAIVDCL RGKEFAFKVT
PKGGAIEQDA PLRVVAPYLL ISMFCSVPVV AVENAHNAAG FYLFSTLTSI LYLVIAAVVA
VNHGKEQGLA ASTLAQMFFS RLPVRNALFV FALAMLLAGI GLRAPQGWRA VTWRSDVPEL
LAPAPGQRVK QPALGAYDPD STFSADANLA FDHVFVSWNA PDLDTQIDRA YRDAQARHRS
LMVTVEPWAL DGSRKGALLD DIAQGRYDAR IAATCSALAA LQAPVFVRWG HEMETDTGRY
PWAIGDASGY VDAYRRVVTA CRAMTDKLRF VWSPAGNRNL DDYFPGRGYA DVIGLSVFDC
PRCAVWPAGG RSSAASVLRV KYARVADYGL PVMVTELGVD GSDARKRDEL DEFQRSLWRY
PLLKAVLYFN AVDTPGAWPA HYVPDWRIEP AFLPAEVVAK
//
