ID F0MAC2_PSEPM Unreviewed; 385 AA.
AC F0MAC2;
DT 03-MAY-2011, integrated into UniProtKB/TrEMBL.
DT 03-MAY-2011, sequence version 1.
DT 27-MAR-2024, entry version 60.
DE RecName: Full=3-hydroxyisobutyryl-CoA hydrolase {ECO:0000256|ARBA:ARBA00011915};
DE EC=3.1.2.4 {ECO:0000256|ARBA:ARBA00011915};
GN OrderedLocusNames=Asphe3_05230 {ECO:0000313|EMBL:ADX71735.1};
OS Pseudarthrobacter phenanthrenivorans (strain DSM 18606 / JCM 16027 / LMG
OS 23796 / Sphe3) (Arthrobacter phenanthrenivorans).
OC Bacteria; Actinomycetota; Actinomycetes; Micrococcales; Micrococcaceae;
OC Pseudarthrobacter.
OX NCBI_TaxID=930171 {ECO:0000313|EMBL:ADX71735.1, ECO:0000313|Proteomes:UP000008639};
RN [1] {ECO:0000313|EMBL:ADX71735.1, ECO:0000313|Proteomes:UP000008639}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=DSM 18606 / JCM 16027 / LMG 23796 / Sphe3
RC {ECO:0000313|Proteomes:UP000008639};
RX PubMed=21677849; DOI=10.4056/sigs.1393494;
RA Kallimanis A., Labutti K.M., Lapidus A., Clum A., Lykidis A.,
RA Mavromatis K., Pagani I., Liolios K., Ivanova N., Goodwin L., Pitluck S.,
RA Chen A., Palaniappan K., Markowitz V., Bristow J., Velentzas A.D.,
RA Perisynakis A., Ouzounis C.C., Kyrpides N.C., Koukkou A.I., Drainas C.;
RT "Complete genome sequence of Arthrobacter phenanthrenivorans type strain
RT (Sphe3).";
RL Stand. Genomic Sci. 4:123-130(2011).
CC -!- CATALYTIC ACTIVITY:
CC Reaction=3-hydroxy-2-methylpropanoyl-CoA + H2O = 3-hydroxy-2-
CC methylpropanoate + CoA + H(+); Xref=Rhea:RHEA:20888,
CC ChEBI:CHEBI:11805, ChEBI:CHEBI:15377, ChEBI:CHEBI:15378,
CC ChEBI:CHEBI:57287, ChEBI:CHEBI:57340; EC=3.1.2.4;
CC Evidence={ECO:0000256|ARBA:ARBA00001709};
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DR EMBL; CP002379; ADX71735.1; -; Genomic_DNA.
DR RefSeq; WP_013599677.1; NC_015145.1.
DR AlphaFoldDB; F0MAC2; -.
DR STRING; 930171.Asphe3_05230; -.
DR KEGG; apn:Asphe3_05230; -.
DR eggNOG; COG1024; Bacteria.
DR HOGENOM; CLU_009834_22_1_11; -.
DR Proteomes; UP000008639; Chromosome.
DR GO; GO:0003860; F:3-hydroxyisobutyryl-CoA hydrolase activity; IEA:InterPro.
DR CDD; cd06558; crotonase-like; 1.
DR InterPro; IPR029045; ClpP/crotonase-like_dom_sf.
DR InterPro; IPR045004; ECH_dom.
DR InterPro; IPR032259; HIBYL-CoA-H.
DR PANTHER; PTHR43176:SF3; 3-HYDROXYISOBUTYRYL-COA HYDROLASE, MITOCHONDRIAL; 1.
DR PANTHER; PTHR43176; 3-HYDROXYISOBUTYRYL-COA HYDROLASE-RELATED; 1.
DR Pfam; PF16113; ECH_2; 1.
DR SUPFAM; SSF52096; ClpP/crotonase; 1.
PE 4: Predicted;
KW Hydrolase {ECO:0000256|ARBA:ARBA00022801}.
FT DOMAIN 31..352
FT /note="Enoyl-CoA hydratase/isomerase"
FT /evidence="ECO:0000259|Pfam:PF16113"
SQ SEQUENCE 385 AA; 40833 MW; F62E0A160BF816C4 CRC64;
MTESAAGGMT GGGFTADGAG EVVFERRGRL GVMTLNRPRA VNALTVGMVE RLLEQLTAWA
DDDGVATVLV QGAGDRGLCA GGDIVAIYDD MLGGGDKTAH FWEAEYRLNS LISRYPKPYV
ALMDGLVLGG GVGISAHGSL RVVTERTRTG MPETTIGFAP DVGGTFLLSR APGETGTHAA
LTGAHLTGPD ALFLGLASHY VPSQKLPALV AALEAEPAEA AVGRCSEEAP PSVLQGQRQW
IDDCYASDDA EEIVRRLRAY QGAGSADAVA AAGTIEAKSP TSVKVTLASL RRIRGRTLDE
ALAQEYRVGL RFLAAPDFRE GIRAQVVDKD RTPRWDPPTL AEVLPARVEG FFEPLGSREL
DLSTVHLQPA LHFSREPNPK EPDHA
//
