ID F0T0J9_SYNGF Unreviewed; 460 AA.
AC F0T0J9;
DT 03-MAY-2011, integrated into UniProtKB/TrEMBL.
DT 03-MAY-2011, sequence version 1.
DT 27-MAR-2024, entry version 54.
DE RecName: Full=Citrate synthase {ECO:0000256|PIRNR:PIRNR001369};
GN OrderedLocusNames=Sgly_0702 {ECO:0000313|EMBL:ADY55064.1};
OS Syntrophobotulus glycolicus (strain DSM 8271 / FlGlyR).
OC Bacteria; Bacillota; Clostridia; Eubacteriales; Desulfitobacteriaceae;
OC Syntrophobotulus.
OX NCBI_TaxID=645991 {ECO:0000313|EMBL:ADY55064.1, ECO:0000313|Proteomes:UP000007488};
RN [1] {ECO:0000313|EMBL:ADY55064.1, ECO:0000313|Proteomes:UP000007488}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=DSM 8271 / FlGlyR {ECO:0000313|Proteomes:UP000007488};
RX PubMed=21886864;
RA Han C., Mwirichia R., Chertkov O., Held B., Lapidus A., Nolan M., Lucas S.,
RA Hammon N., Deshpande S., Cheng J.F., Tapia R., Goodwin L., Pitluck S.,
RA Huntemann M., Liolios K., Ivanova N., Pagani I., Mavromatis K.,
RA Ovchinikova G., Pati A., Chen A., Palaniappan K., Land M., Hauser L.,
RA Brambilla E.M., Rohde M., Spring S., Sikorski J., Goker M., Woyke T.,
RA Bristow J., Eisen J.A., Markowitz V., Hugenholtz P., Kyrpides N.C.,
RA Klenk H.P., Detter J.C.;
RT "Complete genome sequence of Syntrophobotulus glycolicus type strain
RT (FlGlyR).";
RL Stand. Genomic Sci. 4:371-380(2011).
RN [2] {ECO:0000313|Proteomes:UP000007488}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=DSM 8271 / FlGlyR {ECO:0000313|Proteomes:UP000007488};
RA Lucas S., Copeland A., Lapidus A., Bruce D., Goodwin L., Pitluck S.,
RA Kyrpides N., Mavromatis K., Pagani I., Ivanova N., Mikhailova N.,
RA Chertkov O., Held B., Detter J.C., Tapia R., Han C., Land M., Hauser L.,
RA Markowitz V., Cheng J.-F., Hugenholtz P., Woyke T., Wu D., Spring S.,
RA Schroeder M., Brambilla E., Klenk H.-P., Eisen J.A.;
RT "The complete genome of Syntrophobotulus glycolicus DSM 8271.";
RL Submitted (FEB-2011) to the EMBL/GenBank/DDBJ databases.
CC -!- CATALYTIC ACTIVITY:
CC Reaction=acetyl-CoA + H2O + oxaloacetate = citrate + CoA + H(+);
CC Xref=Rhea:RHEA:16845, ChEBI:CHEBI:15377, ChEBI:CHEBI:15378,
CC ChEBI:CHEBI:16452, ChEBI:CHEBI:16947, ChEBI:CHEBI:57287,
CC ChEBI:CHEBI:57288; EC=2.3.3.16;
CC Evidence={ECO:0000256|ARBA:ARBA00000308};
CC -!- PATHWAY: Carbohydrate metabolism; tricarboxylic acid cycle.
CC {ECO:0000256|ARBA:ARBA00005163}.
CC -!- SIMILARITY: Belongs to the citrate synthase family.
CC {ECO:0000256|ARBA:ARBA00010566, ECO:0000256|PIRNR:PIRNR001369}.
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DR EMBL; CP002547; ADY55064.1; -; Genomic_DNA.
DR RefSeq; WP_013623935.1; NC_015172.1.
DR AlphaFoldDB; F0T0J9; -.
DR STRING; 645991.Sgly_0702; -.
DR KEGG; sgy:Sgly_0702; -.
DR eggNOG; COG0372; Bacteria.
DR HOGENOM; CLU_025068_2_2_9; -.
DR OrthoDB; 9800864at2; -.
DR UniPathway; UPA00223; -.
DR Proteomes; UP000007488; Chromosome.
DR GO; GO:0036440; F:citrate synthase activity; IEA:UniProtKB-EC.
DR GO; GO:0006099; P:tricarboxylic acid cycle; IEA:UniProtKB-UniPathway.
DR Gene3D; 1.10.580.10; Citrate Synthase, domain 1; 1.
DR Gene3D; 1.10.230.10; Cytochrome P450-Terp, domain 2; 1.
DR InterPro; IPR016142; Citrate_synth-like_lrg_a-sub.
DR InterPro; IPR016143; Citrate_synth-like_sm_a-sub.
DR InterPro; IPR002020; Citrate_synthase.
DR InterPro; IPR024176; Citrate_synthase_bac-typ.
DR InterPro; IPR036969; Citrate_synthase_sf.
DR PANTHER; PTHR11739; CITRATE SYNTHASE; 1.
DR PANTHER; PTHR11739:SF4; CITRATE SYNTHASE, PEROXISOMAL; 1.
DR Pfam; PF00285; Citrate_synt; 1.
DR PIRSF; PIRSF001369; Citrate_synth; 1.
DR PRINTS; PR00143; CITRTSNTHASE.
DR SUPFAM; SSF48256; Citrate synthase; 1.
PE 3: Inferred from homology;
KW Reference proteome {ECO:0000313|Proteomes:UP000007488};
KW Transferase {ECO:0000256|PIRNR:PIRNR001369}.
FT ACT_SITE 333
FT /evidence="ECO:0000256|PIRSR:PIRSR001369-1"
FT ACT_SITE 393
FT /evidence="ECO:0000256|PIRSR:PIRSR001369-1"
SQ SEQUENCE 460 AA; 51676 MW; 539323F61F7D1585 CRC64;
MENGKFLKFE EKLLDNLCNI AQKRNYIKQD LYSKYDVKRG LRDQDGRGVL VGLTEIGDVH
SYILDENEMV PVPGRLRYRG YDVNDLVRGF MTDKRFGFEE ITYLLLFGGL PTKGELEEFV
SLLANYQRLP EEFARDMILK APSKDIMNGL ARSVLALYSY DDNPEDTSIR NVLQQCLKLI
ALFPSIVVYC FQAFSHYHGN KSLYIHSPNP QLSLAENILY MLRPDMQYTP LEADLLDLAL
VLHAEHGGGN NSSFVTHVVT STGTDTYSVI ASALGSLKGP RHGGANIKVI QMIEDIKANV
GNWEDDEELT NYLSKILSKD TFDKSGLIYG VGHAIYSISD PRALILKDYA GKLASEKGLS
KEYNLYASIE RLAPPLVIAK NNLGSKVVCA NVDFYSGFVY KMLNIPVEMF TPIFAIARIS
GWGAHRIEEI VNSGKIIRPA YKSVAPRQQY IPINQRNCAK
//
