ID F0TBI8_METLA Unreviewed; 1719 AA.
AC F0TBI8;
DT 03-MAY-2011, integrated into UniProtKB/TrEMBL.
DT 03-MAY-2011, sequence version 1.
DT 27-MAR-2024, entry version 55.
DE SubName: Full=DNA helicase related protein {ECO:0000313|EMBL:ADZ10257.1};
GN OrderedLocusNames=Metbo_2038 {ECO:0000313|EMBL:ADZ10257.1};
OS Methanobacterium lacus (strain AL-21).
OC Archaea; Euryarchaeota; Methanomada group; Methanobacteria;
OC Methanobacteriales; Methanobacteriaceae; Methanobacterium.
OX NCBI_TaxID=877455 {ECO:0000313|EMBL:ADZ10257.1, ECO:0000313|Proteomes:UP000007490};
RN [1] {ECO:0000313|Proteomes:UP000007490}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=AL-21 {ECO:0000313|Proteomes:UP000007490};
RG US DOE Joint Genome Institute;
RA Lucas S., Copeland A., Lapidus A., Cheng J.-F., Goodwin L., Pitluck S.,
RA Chertkov O., Detter J.C., Han C., Tapia R., Land M., Hauser L.,
RA Kyrpides N., Ivanova N., Mikhailova N., Pagani I., Cadillo-Quiroz H.,
RA Imachi H., Zinder S., Liu W., Woyke T.;
RT "Complete sequence of Methanobacterium sp. AL-21.";
RL Submitted (FEB-2011) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|EMBL:ADZ10257.1, ECO:0000313|Proteomes:UP000007490}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=AL-21 {ECO:0000313|EMBL:ADZ10257.1,
RC ECO:0000313|Proteomes:UP000007490};
RX PubMed=24449792; DOI=10.1099/ijs.0.059964-0;
RA Cadillo-Quiroz H., Brauer S.L., Goodson N., Yavitt J.B., Zinder S.H.;
RT "Methanobacterium paludis sp. nov. and a novel strain of Methanobacterium
RT lacus isolated from northern peatlands.";
RL Int. J. Syst. Evol. Microbiol. 64:1473-1480(2014).
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DR EMBL; CP002551; ADZ10257.1; -; Genomic_DNA.
DR RefSeq; WP_013645608.1; NC_015216.1.
DR STRING; 877455.Metbo_2038; -.
DR GeneID; 10278499; -.
DR KEGG; mel:Metbo_2038; -.
DR eggNOG; arCOG00803; Archaea.
DR HOGENOM; CLU_000788_3_2_2; -.
DR OrthoDB; 45637at2157; -.
DR Proteomes; UP000007490; Chromosome.
DR GO; GO:0004386; F:helicase activity; IEA:UniProtKB-KW.
DR CDD; cd18808; SF1_C_Upf1; 1.
DR Gene3D; 3.40.50.300; P-loop containing nucleotide triphosphate hydrolases; 3.
DR Gene3D; 3.40.960.10; VSR Endonuclease; 1.
DR InterPro; IPR045055; DNA2/NAM7-like.
DR InterPro; IPR041679; DNA2/NAM7-like_C.
DR InterPro; IPR041677; DNA2/NAM7_AAA_11.
DR InterPro; IPR021754; DUF3320.
DR InterPro; IPR025103; DUF4011.
DR InterPro; IPR027417; P-loop_NTPase.
DR InterPro; IPR011335; Restrct_endonuc-II-like.
DR InterPro; IPR049468; Restrct_endonuc-II-like_dom.
DR InterPro; IPR047187; SF1_C_Upf1.
DR PANTHER; PTHR10887; DNA2/NAM7 HELICASE FAMILY; 1.
DR PANTHER; PTHR10887:SF525; HELICASE SENATAXIN-RELATED; 1.
DR Pfam; PF13086; AAA_11; 1.
DR Pfam; PF13087; AAA_12; 1.
DR Pfam; PF11784; DUF3320; 1.
DR Pfam; PF13195; DUF4011; 1.
DR Pfam; PF18741; MTES_1575; 1.
DR SUPFAM; SSF52540; P-loop containing nucleoside triphosphate hydrolases; 1.
DR SUPFAM; SSF52980; Restriction endonuclease-like; 1.
PE 4: Predicted;
KW ATP-binding {ECO:0000313|EMBL:ADZ10257.1};
KW Helicase {ECO:0000313|EMBL:ADZ10257.1};
KW Hydrolase {ECO:0000313|EMBL:ADZ10257.1};
KW Nucleotide-binding {ECO:0000313|EMBL:ADZ10257.1};
KW Reference proteome {ECO:0000313|Proteomes:UP000007490}.
FT DOMAIN 976..1019
FT /note="DNA2/NAM7 helicase helicase"
FT /evidence="ECO:0000259|Pfam:PF13086"
FT DOMAIN 1047..1238
FT /note="DNA2/NAM7 helicase-like C-terminal"
FT /evidence="ECO:0000259|Pfam:PF13087"
FT DOMAIN 1283..1379
FT /note="Restriction endonuclease type II-like"
FT /evidence="ECO:0000259|Pfam:PF18741"
FT DOMAIN 1556..1602
FT /note="DUF3320"
FT /evidence="ECO:0000259|Pfam:PF11784"
FT REGION 1392..1450
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1468..1491
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1416..1430
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 1719 AA; 197101 MW; 6268BE17A6412160 CRC64;
MEESANINTE AKIGALRKNL LDLTMRNKLL NFKPLAKSIK VVDEIPTEIY QLMVLEDKKM
QFIPRARKPV KKDFEGNQKP EEVEEEEEEL KLKPIDITDK EASLLWKLPL PNSKVSSKHR
NLLLQTNHEA EELQKRLFYI NQQARSVLEE QGYNILYLAL GFLEWTENND LETKRKAPLI
LIPVELERKK VKGSFKLRWT GEDIIPNISL QEKLLEQGVE LPGFEMPEHK EGIYHYFESV
SDAIEPKKDW NVVYEIYLNF FSFTKFVMFK DLDPASWGGV SIAENSIIKT LFDDVESIDK
TEFNEEDVDK KLNSKDVFNV VDADSSQIAV VEEAKSGMNL VVEGPPGTGK SQTIVNLISE
LMANGKSVLF VSEKMAALEV VKTRLDSIGL GEFCLELHSH KSNKKNVLKE LERTLYSQYD
RLRPLDEEFE ELERLKLELN QYNEVLHTSI GNSGFSPFQL FGMKEDAIQH FKKVERNIPR
AHIENPESYT QKDWKNAVST LKNVTEVITP LKPISKNAWY NTEPGTILPT DSEDIAELLE
NAVLTLNDVE ADLYELIELT GIRKPLNKSE LDSSIKTALL IADPLTTNPD VLFNPVWEIG
RSEIIHIIDI MVEYDTNRKE LEKRFNKGVL NTNIQSLLDD YQETSSKFLK SFRGKYKKSK
DKIAKLYRDA VPEDDEVIIE DLKTLKSCQE LQKKLEDLNS EAKAVFGDEW KGTETDLKKI
KDLAEWVLTV KKLLKTGKIT ERTFDIIVDG PDTATINGTI QKLNKDYGSF LKVYKAIKGY
IKIDEELVFG AKMRFVRFHE LESRIENFLK GMPLLQKWSQ LTAILNETPS PIAQPIVELI
KADKINIDDI IPCLKANFAD DLLRNAFLEN HILSSFIGEI HERKIGRFID LDRQIISLNR
KRISNRIAYN RPHINTAVSR TSELGILLSE FNRKRGHMPI RKLLSNAGNL VKKIKPCFMM
SPLSVAQFID PKNSVDLRFD VVIFDEASQV KPEDSLGAFL RANQAVVMGD TRQLPPTTFF
DIILETDENE DYEIASISDM ESILHLCKGR FPTKMLRWHY RSRHESLIAL SNQEFYDNNL
LIYPSPCHET ESLGLKFEYM EDTVYDRGNT SSNRLEARRV VEAAGDHYRE HGLSKSLGIG
TFNIKQQQAI LEEVELYLRQ NPSLEKYFSN DLEEHFFVKN LETIQGDERD VIFISVGYGN
DENGHLSLNF GPLNREGGER RLNVLITRAR EKTVVFSNFR HTEINLNENA PFGLRALKSF
LKYSETKMLD TKYDSDDELN TEFEDSLYEF LRSHNYEVHK QVGCAGFRLD LAVVDPEERG
KYLVGIECDG ETYHSSPVAR DRDRLRQQIL EGLEWHIYRV WSTDWYRNRA ESEKRLLEAV
KNAKDLKPIV KLDTTPDDSE TVKPIGEYEP AYERTGTGNP ENSTLPEEET DPQTVKWESE
DLNPELSPET DPEIIADSEI VENAKFEEPE VSSEFVEEGT IPELEEPEPQ NIKKHRAANE
PLQVEEEEVS KTPAHEELEK PVIDEAVEFV DIVEDEEDSV VDYVPCTEFC IPVTGEIHEK
SAEDMARLVV QIVDEEGPIH INEIIRRIRV VWGLKRAGKR IHDSIMAGVQ LADERNNIII
RDDFVYSRSA VLRVRRRSVD PPAKINLISD EEIAKAVQIV LKTQYASPMA EIIKQTSRLF
GIKVTRGATA KRIEGIVLEL LESGSLELQA NGMINFPKS
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