ID F0UAF9_AJEC8 Unreviewed; 1656 AA.
AC F0UAF9;
DT 03-MAY-2011, integrated into UniProtKB/TrEMBL.
DT 03-MAY-2011, sequence version 1.
DT 24-JAN-2024, entry version 51.
DE SubName: Full=Sec7 domain-containing protein {ECO:0000313|EMBL:EGC42878.1};
GN ORFNames=HCEG_02093 {ECO:0000313|EMBL:EGC42878.1}, I7I53_09330
GN {ECO:0000313|EMBL:QSS49071.1};
OS Ajellomyces capsulatus (strain H88) (Darling's disease fungus) (Histoplasma
OS capsulatum).
OC Eukaryota; Fungi; Dikarya; Ascomycota; Pezizomycotina; Eurotiomycetes;
OC Eurotiomycetidae; Onygenales; Ajellomycetaceae; Histoplasma.
OX NCBI_TaxID=544711 {ECO:0000313|Proteomes:UP000008142};
RN [1] {ECO:0000313|Proteomes:UP000008142}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=H88 {ECO:0000313|Proteomes:UP000008142};
RA Champion M., Cuomo C., Ma L.-J., Henn M.R., Sil A., Goldman B., Young S.K.,
RA Kodira C.D., Zeng Q., Koehrsen M., Alvarado L., Berlin A., Borenstein D.,
RA Chen Z., Engels R., Freedman E., Gellesch M., Goldberg J., Griggs A.,
RA Gujja S., Heiman D., Hepburn T., Howarth C., Jen D., Larson L., Lewis B.,
RA Mehta T., Park D., Pearson M., Roberts A., Saif S., Shea T., Shenoy N.,
RA Sisk P., Stolte C., Sykes S., Walk T., White J., Yandava C., Klein B.,
RA McEwen J.G., Puccia R., Goldman G.H., Felipe M.S., Nino-Vega G.,
RA San-Blas G., Taylor J., Mendoza L., Galagan J., Nusbaum C., Birren B.;
RT "Annotation of Ajellomyces capsulatus strain H88.";
RL Submitted (JUL-2008) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|EMBL:EGC42878.1}
RP NUCLEOTIDE SEQUENCE.
RC STRAIN=H88 {ECO:0000313|EMBL:EGC42878.1};
RG The Broad Institute Genome Sequencing Platform;
RA Champion M., Cuomo C., Ma L.-J., Henn M.R., Sil A., Goldman B., Young S.K.,
RA Kodira C.D., Zeng Q., Koehrsen M., Alvarado L., Berlin A., Borenstein D.,
RA Chen Z., Engels R., Freedman E., Gellesch M., Goldberg J., Griggs A.,
RA Gujja S., Heiman D., Hepburn T., Howarth C., Jen D., Larson L., Lewis B.,
RA Mehta T., Park D., Pearson M., Roberts A., Saif S., Shea T., Shenoy N.,
RA Sisk P., Stolte C., Sykes S., Walk T., White J., Yandava C., Klein B.,
RA McEwen J.G., Puccia R., Goldman G.H., Felipe M.S., Nino-Vega G.,
RA San-Blas G., Taylor J., Mendoza L., Galagan J., Nusbaum C., Birren B.;
RT "Annotation of Ajellomyces capsulatus strain H88.";
RL Submitted (FEB-2011) to the EMBL/GenBank/DDBJ databases.
RN [3] {ECO:0000313|EMBL:QSS49071.1}
RP NUCLEOTIDE SEQUENCE.
RC STRAIN=H88 {ECO:0000313|EMBL:QSS49071.1};
RA Voorhies M., Cohen S., Shea T.P., Petrus S., Munoz J.F., Poplawski S.,
RA Goldman W.E., Michael T., Cuomo C.A., Sil A., Beyhan S.;
RT "Chromosome-level genome assembly of a human fungal pathogen reveals
RT clustering of transcriptionally co-regulated genes.";
RL Submitted (JAN-2021) to the EMBL/GenBank/DDBJ databases.
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DR EMBL; DS990637; EGC42878.1; -; Genomic_DNA.
DR EMBL; CP069102; QSS49071.1; -; Genomic_DNA.
DR STRING; 544711.F0UAF9; -.
DR VEuPathDB; FungiDB:I7I53_09330; -.
DR HOGENOM; CLU_001772_0_0_1; -.
DR OMA; FYTSIQK; -.
DR Proteomes; UP000008142; Unassembled WGS sequence.
DR Proteomes; UP000663419; Chromosome 1.
DR GO; GO:0005085; F:guanyl-nucleotide exchange factor activity; IEA:InterPro.
DR GO; GO:0032012; P:regulation of ARF protein signal transduction; IEA:InterPro.
DR Gene3D; 1.10.1000.11; Arf Nucleotide-binding Site Opener,domain 2; 1.
DR Gene3D; 2.30.29.30; Pleckstrin-homology domain (PH domain)/Phosphotyrosine-binding domain (PTB); 1.
DR InterPro; IPR011993; PH-like_dom_sf.
DR InterPro; IPR041681; PH_9.
DR InterPro; IPR023394; Sec7_C_sf.
DR InterPro; IPR000904; Sec7_dom.
DR InterPro; IPR035999; Sec7_dom_sf.
DR PANTHER; PTHR10663; GUANYL-NUCLEOTIDE EXCHANGE FACTOR; 1.
DR PANTHER; PTHR10663:SF373; PH AND SEC7 DOMAIN-CONTAINING PROTEIN C11E3.11C; 1.
DR Pfam; PF15410; PH_9; 1.
DR Pfam; PF01369; Sec7; 1.
DR SMART; SM00222; Sec7; 1.
DR SUPFAM; SSF50729; PH domain-like; 1.
DR SUPFAM; SSF48425; Sec7 domain; 1.
DR PROSITE; PS50190; SEC7; 1.
PE 4: Predicted;
KW Reference proteome {ECO:0000313|Proteomes:UP000008142}.
FT DOMAIN 857..1008
FT /note="SEC7"
FT /evidence="ECO:0000259|PROSITE:PS50190"
FT REGION 1..91
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 111..251
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 325..526
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 563..590
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 641..678
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 800..827
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1059..1097
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1154..1223
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1458..1509
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 72..91
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 111..189
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 200..251
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 325..365
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 437..458
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 465..502
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 648..678
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 800..820
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1179..1223
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1458..1503
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 1656 AA; 182625 MW; 363ED0AB7798E826 CRC64;
MAFEHPRPQK RAIPAYPSSS RAPQMYDTYS GESPPRTPPP QSNKYKTMRK GDWMLQPPIR
QTFLDDFPPV DNHGNPDSEE DDHDTHDLSL SPKHVTRTSV VDNMLLSLDQ FSVSDPHDNS
RLFGSSRDQE THPIYTRYSS MRTSRPRGDT FSSSISSDIE VHSEDNVGRY SSQSTRGRRS
NSNSNYHPGL RRIDSVRGVG ESMSTRNKTY DAQRGSNIAD RPPTHRTSRV GTKTSSRSSG
SSSVDFNQMT AGGRLGQYTE RRSASFDYGS TLPPSQPLMD NRGGFEDFIH YNGFHYDDID
AAPTPCIPVG PRRNISPPMR ELAYNRTAPS SSRGPALSRK RSSKSARSMY TKNGRSDTLG
TATIRGRGNE SRHHRDPIPD FPPSMPTYSL HQPAPSPTIA FHKSAYDSPQ PVINNTPPPP
TPKERPGFFR RVFGGGSSKS QPLSRSEVSA SYNQENETPR QQREQHHSAP NSSKGQKQSI
KEYSSPGNNV SSRENTPVIT KKPSSFFRRR KKSIPDHVPP PLKLSLCSSK PEHFKVDHLR
GDLGPEPSPV SSLRKVMDPY LTNTSSHEVD HDPAMDDADN EVSGGEQPSL ADFKHDPAEV
MSNEMMSANP ENNSGTQKPR MLNSLNFKSG LNLNVSSHDR DDSFLTDRSS VNEGADQAYP
SDRTRRPMTS PNTPTHMKLM PVGQSAEFIS GSHSSEKTSA NGSHASYAIS PTHLQLSQSM
HGATDGLSIS TASLSTSVSY NKSEHGSSYV QTHVLTGDNH AHPARHLQEK AWQESDSPVE
HLSDGRNKLS LPLEGPITSP RASLSTVSNY HTASNTPIIP DDENRTRDSK SQALPLIHTE
IEMERNAIDA NNDDTTILAV NEEPTAEDRQ HAQKIFDEFE DETEGKESRA AWLGSPDRSA
VRKAYMELFD WSNMNILAAL RGLCSRLALK GETQQVDRIL DAFSSRWCEC NLEHGFKATD
VVHTICYSLL LLNTDLHMAD IEQKMTRSQF IKNTMPTIQR VVLDAAPNAF ERTNPGNASS
KAQPPGANVI SGALIGKSPT LPPVRHGGHG SVDMDVPHST LSKPTESTPR TNSLSIVGTS
QNTDVSSSDS GPLVSTPFRG TQKGWEFQIE SVLRDFYNSI HKQRLPLRGA TVEAGEPHHP
SNNFLTLTGN MLRRTPSTLS KSGSDICPRG RHMENRLSTA RWSSKPRSRP RLYPSSNIGS
SRTSLDDQSS VWSPSASSTW SKHSLGKTLT SMSMDSLGSD FPRGDYQQSI GFANALSHAI
IREDSANAMS GMEDSERAAA LLEDETLELA GAPWAKEGSL KHKHHLDSVD KRSKDRNWNE
SFAVIQRGWM RLFSFNASTK SMRLKPKQRQ NGGLVVGGGN WTENAEETWK FLLRQSIASA
LPSPGYSKSR PHVWALSLPT GAVHLFQVGT PEIVKEFVSS ANYWSARLSK EPLFGGISNI
EYGWSPAVIN SALVHNSGNG ETTATGSSPT SGPQQQTAPL PQTANSSATR QSFQSSFRGS
LDHQSSVRPR LPADRIHISD WTPPQQSMMA STLSENDQLA TLRRYVKHVE EELQRHNELR
GAMSLAFTPR HPNANKALAN WERKSSYLLR EIVKFRTYID CLTTAQTLRE KIRAVSAGTN
GNGTGTSTET PTALHGLVEL KTSPIDRPRA PSLSVS
//
