ID   F0UB99_AJEC8            Unreviewed;       759 AA.
AC   F0UB99;
DT   03-MAY-2011, integrated into UniProtKB/TrEMBL.
DT   03-MAY-2011, sequence version 1.
DT   27-MAR-2024, entry version 40.
DE   SubName: Full=U-box domain-containing protein {ECO:0000313|EMBL:EGC43008.1};
GN   ORFNames=HCEG_02223 {ECO:0000313|EMBL:EGC43008.1}, I7I53_09488
GN   {ECO:0000313|EMBL:QSS49195.1};
OS   Ajellomyces capsulatus (strain H88) (Darling's disease fungus) (Histoplasma
OS   capsulatum).
OC   Eukaryota; Fungi; Dikarya; Ascomycota; Pezizomycotina; Eurotiomycetes;
OC   Eurotiomycetidae; Onygenales; Ajellomycetaceae; Histoplasma.
OX   NCBI_TaxID=544711 {ECO:0000313|Proteomes:UP000008142};
RN   [1] {ECO:0000313|Proteomes:UP000008142}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=H88 {ECO:0000313|Proteomes:UP000008142};
RA   Champion M., Cuomo C., Ma L.-J., Henn M.R., Sil A., Goldman B., Young S.K.,
RA   Kodira C.D., Zeng Q., Koehrsen M., Alvarado L., Berlin A., Borenstein D.,
RA   Chen Z., Engels R., Freedman E., Gellesch M., Goldberg J., Griggs A.,
RA   Gujja S., Heiman D., Hepburn T., Howarth C., Jen D., Larson L., Lewis B.,
RA   Mehta T., Park D., Pearson M., Roberts A., Saif S., Shea T., Shenoy N.,
RA   Sisk P., Stolte C., Sykes S., Walk T., White J., Yandava C., Klein B.,
RA   McEwen J.G., Puccia R., Goldman G.H., Felipe M.S., Nino-Vega G.,
RA   San-Blas G., Taylor J., Mendoza L., Galagan J., Nusbaum C., Birren B.;
RT   "Annotation of Ajellomyces capsulatus strain H88.";
RL   Submitted (JUL-2008) to the EMBL/GenBank/DDBJ databases.
RN   [2] {ECO:0000313|EMBL:EGC43008.1}
RP   NUCLEOTIDE SEQUENCE.
RC   STRAIN=H88 {ECO:0000313|EMBL:EGC43008.1};
RG   The Broad Institute Genome Sequencing Platform;
RA   Champion M., Cuomo C., Ma L.-J., Henn M.R., Sil A., Goldman B., Young S.K.,
RA   Kodira C.D., Zeng Q., Koehrsen M., Alvarado L., Berlin A., Borenstein D.,
RA   Chen Z., Engels R., Freedman E., Gellesch M., Goldberg J., Griggs A.,
RA   Gujja S., Heiman D., Hepburn T., Howarth C., Jen D., Larson L., Lewis B.,
RA   Mehta T., Park D., Pearson M., Roberts A., Saif S., Shea T., Shenoy N.,
RA   Sisk P., Stolte C., Sykes S., Walk T., White J., Yandava C., Klein B.,
RA   McEwen J.G., Puccia R., Goldman G.H., Felipe M.S., Nino-Vega G.,
RA   San-Blas G., Taylor J., Mendoza L., Galagan J., Nusbaum C., Birren B.;
RT   "Annotation of Ajellomyces capsulatus strain H88.";
RL   Submitted (FEB-2011) to the EMBL/GenBank/DDBJ databases.
RN   [3] {ECO:0000313|EMBL:QSS49195.1}
RP   NUCLEOTIDE SEQUENCE.
RC   STRAIN=H88 {ECO:0000313|EMBL:QSS49195.1};
RA   Voorhies M., Cohen S., Shea T.P., Petrus S., Munoz J.F., Poplawski S.,
RA   Goldman W.E., Michael T., Cuomo C.A., Sil A., Beyhan S.;
RT   "Chromosome-level genome assembly of a human fungal pathogen reveals
RT   clustering of transcriptionally co-regulated genes.";
RL   Submitted (JAN-2021) to the EMBL/GenBank/DDBJ databases.
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DR   EMBL; DS990637; EGC43008.1; -; Genomic_DNA.
DR   EMBL; CP069102; QSS49195.1; -; Genomic_DNA.
DR   AlphaFoldDB; F0UB99; -.
DR   STRING; 544711.F0UB99; -.
DR   VEuPathDB; FungiDB:I7I53_09488; -.
DR   HOGENOM; CLU_013635_0_0_1; -.
DR   OMA; QVCNSFK; -.
DR   Proteomes; UP000008142; Unassembled WGS sequence.
DR   Proteomes; UP000663419; Chromosome 1.
DR   Gene3D; 3.40.50.410; von Willebrand factor, type A domain; 1.
DR   InterPro; IPR036844; Hint_dom_sf.
DR   InterPro; IPR039510; Vint_dom.
DR   InterPro; IPR032838; Vwaint_dom.
DR   InterPro; IPR002035; VWF_A.
DR   InterPro; IPR036465; vWFA_dom_sf.
DR   PANTHER; PTHR10579; CALCIUM-ACTIVATED CHLORIDE CHANNEL REGULATOR; 1.
DR   PANTHER; PTHR10579:SF43; LOW QUALITY PROTEIN: EPITHELIAL CHLORIDE CHANNEL PROTEIN-LIKE ISOFORM X1-RELATED; 1.
DR   Pfam; PF14623; Vint; 1.
DR   Pfam; PF00092; VWA; 1.
DR   Pfam; PF14624; Vwaint; 1.
DR   SMART; SM00327; VWA; 1.
DR   SUPFAM; SSF51294; Hedgehog/intein (Hint) domain; 1.
DR   SUPFAM; SSF53300; vWA-like; 1.
DR   PROSITE; PS50234; VWFA; 1.
PE   4: Predicted;
KW   Reference proteome {ECO:0000313|Proteomes:UP000008142}.
FT   DOMAIN          75..271
FT                   /note="VWFA"
FT                   /evidence="ECO:0000259|PROSITE:PS50234"
SQ   SEQUENCE   759 AA;  83576 MW;  6F8BB6859B242E6D CRC64;
     MDSVQPAASS EDDFEIIDDQ IPIRPRLSTS TTIAGERSPN EVGVQLHPLP DTNSMILSVH
     SPLHPEKEMP HVPCDIVLCI DVSYSMQSSA PLPTTDESGE REETGLSVLD LTKHAARTII
     ETLNENDRLG IVAFSTEAEV VYKISKMNES NKKAALKAVE ALKPLSSTNL WHGLKLGLKA
     FENERRTPQS VQALYVLTDG MPNHMCPKQG YVTKLRPILQ LLGHRMPMIH TFGFGYNIRS
     GLLQAIAEVG GGTFAFIPDA GMIGTVFVHA IANLYTTFAT QAKVTFRTSG SVTLAQDLGS
     KTGLGLHEES TKDSNLTVAI GTLQYGQSRD LVIRMKNATT AATPSTAQAT LTYQFQGLLK
     SVVSDEQVLS QRTSLPVHVS DYHLSRARIC AFLRSLYPLG PDKEYTNIDE NGLKNARQQL
     DHIIKDIKQL EHTDEENDSL VRDLAGEEPE GQLRLSILVH ANFAKWGKHY LLSLLNAHTH
     QMCNSFKDPG PLQYGKNSPF FCRCREELDT CFDNLPPPKP SIIEKAPDGT VKIRPSYKMS
     RYNCRNNPCF AGHCNIRLAE RNSSLPIRDI RAGIKVWTPL GPRRVRAVLA TAVKNTILCN
     IGSLSITPWH PIQVAGDWIF PSHVSEQNVP FSGTVYSVLL DPSPVSDAHA IMVEGHVCVS
     LGHGIQGCND VRAHPFFGSY PSVVRSLASL PRDVNGILRC SGMKRNPLTG LACGFIGEGG
     FRKSINKRPF KRSAKVGLRY HFQAPITVNP RRRTACPAF
//