ID F0UIE1_AJEC8 Unreviewed; 600 AA.
AC F0UIE1;
DT 03-MAY-2011, integrated into UniProtKB/TrEMBL.
DT 03-MAY-2011, sequence version 1.
DT 27-MAR-2024, entry version 41.
DE SubName: Full=Double-strand-break repair protein {ECO:0000313|EMBL:EGC46393.1, ECO:0000313|EMBL:QSS57014.1};
GN Name=RAD21 {ECO:0000313|EMBL:QSS57014.1};
GN ORFNames=HCEG_05608 {ECO:0000313|EMBL:EGC46393.1}, I7I53_05395
GN {ECO:0000313|EMBL:QSS57014.1};
OS Ajellomyces capsulatus (strain H88) (Darling's disease fungus) (Histoplasma
OS capsulatum).
OC Eukaryota; Fungi; Dikarya; Ascomycota; Pezizomycotina; Eurotiomycetes;
OC Eurotiomycetidae; Onygenales; Ajellomycetaceae; Histoplasma.
OX NCBI_TaxID=544711 {ECO:0000313|Proteomes:UP000008142};
RN [1] {ECO:0000313|Proteomes:UP000008142}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=H88 {ECO:0000313|Proteomes:UP000008142};
RA Champion M., Cuomo C., Ma L.-J., Henn M.R., Sil A., Goldman B., Young S.K.,
RA Kodira C.D., Zeng Q., Koehrsen M., Alvarado L., Berlin A., Borenstein D.,
RA Chen Z., Engels R., Freedman E., Gellesch M., Goldberg J., Griggs A.,
RA Gujja S., Heiman D., Hepburn T., Howarth C., Jen D., Larson L., Lewis B.,
RA Mehta T., Park D., Pearson M., Roberts A., Saif S., Shea T., Shenoy N.,
RA Sisk P., Stolte C., Sykes S., Walk T., White J., Yandava C., Klein B.,
RA McEwen J.G., Puccia R., Goldman G.H., Felipe M.S., Nino-Vega G.,
RA San-Blas G., Taylor J., Mendoza L., Galagan J., Nusbaum C., Birren B.;
RT "Annotation of Ajellomyces capsulatus strain H88.";
RL Submitted (JUL-2008) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|EMBL:EGC46393.1}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=H88 {ECO:0000313|EMBL:EGC46393.1};
RG The Broad Institute Genome Sequencing Platform;
RA Champion M., Cuomo C., Ma L.-J., Henn M.R., Sil A., Goldman B., Young S.K.,
RA Kodira C.D., Zeng Q., Koehrsen M., Alvarado L., Berlin A., Borenstein D.,
RA Chen Z., Engels R., Freedman E., Gellesch M., Goldberg J., Griggs A.,
RA Gujja S., Heiman D., Hepburn T., Howarth C., Jen D., Larson L., Lewis B.,
RA Mehta T., Park D., Pearson M., Roberts A., Saif S., Shea T., Shenoy N.,
RA Sisk P., Stolte C., Sykes S., Walk T., White J., Yandava C., Klein B.,
RA McEwen J.G., Puccia R., Goldman G.H., Felipe M.S., Nino-Vega G.,
RA San-Blas G., Taylor J., Mendoza L., Galagan J., Nusbaum C., Birren B.;
RT "Annotation of Ajellomyces capsulatus strain H88.";
RL Submitted (JUL-2008) to the EMBL/GenBank/DDBJ databases.
RN [3] {ECO:0000313|EMBL:QSS57014.1}
RP NUCLEOTIDE SEQUENCE.
RC STRAIN=H88 {ECO:0000313|EMBL:QSS57014.1};
RA Voorhies M., Cohen S., Shea T.P., Petrus S., Munoz J.F., Poplawski S.,
RA Goldman W.E., Michael T., Cuomo C.A., Sil A., Beyhan S.;
RT "Chromosome-level genome assembly of a human fungal pathogen reveals
RT clustering of transcriptionally co-regulated genes.";
RL Submitted (JAN-2021) to the EMBL/GenBank/DDBJ databases.
CC -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000256|ARBA:ARBA00004123}.
CC -!- SIMILARITY: Belongs to the rad21 family.
CC {ECO:0000256|ARBA:ARBA00009870}.
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DR EMBL; DS990639; EGC46393.1; -; Genomic_DNA.
DR EMBL; CP069106; QSS57014.1; -; Genomic_DNA.
DR AlphaFoldDB; F0UIE1; -.
DR STRING; 544711.F0UIE1; -.
DR VEuPathDB; FungiDB:I7I53_05395; -.
DR HOGENOM; CLU_015775_0_1_1; -.
DR OMA; HTDLYEP; -.
DR Proteomes; UP000008142; Unassembled WGS sequence.
DR Proteomes; UP000663419; Chromosome 5.
DR GO; GO:0008278; C:cohesin complex; IEA:InterPro.
DR GO; GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
DR GO; GO:0007062; P:sister chromatid cohesion; IEA:InterPro.
DR CDD; cd21788; Rad21_Rec8_M_SpRad21p-like; 1.
DR Gene3D; 1.10.10.580; Structural maintenance of chromosome 1. Chain E; 1.
DR InterPro; IPR039781; Rad21/Rec8-like.
DR InterPro; IPR006909; Rad21/Rec8_C_eu.
DR InterPro; IPR006910; Rad21_Rec8_N.
DR InterPro; IPR023093; ScpA-like_C.
DR InterPro; IPR036390; WH_DNA-bd_sf.
DR PANTHER; PTHR12585:SF69; FI11703P; 1.
DR PANTHER; PTHR12585; SCC1 / RAD21 FAMILY MEMBER; 1.
DR Pfam; PF04824; Rad21_Rec8; 1.
DR Pfam; PF04825; Rad21_Rec8_N; 1.
DR SUPFAM; SSF46785; Winged helix' DNA-binding domain; 1.
PE 3: Inferred from homology;
KW Nucleus {ECO:0000256|ARBA:ARBA00023242};
KW Reference proteome {ECO:0000313|Proteomes:UP000008142}.
FT DOMAIN 1..100
FT /note="Rad21/Rec8-like protein N-terminal"
FT /evidence="ECO:0000259|Pfam:PF04825"
FT DOMAIN 525..563
FT /note="Rad21/Rec8-like protein C-terminal eukaryotic"
FT /evidence="ECO:0000259|Pfam:PF04824"
FT REGION 133..171
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 145..160
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 600 AA; 65918 MW; AEE758F652F98E2E CRC64;
MFYSETLLSK TGPLARVWLS ANLERKLTKS HILQSDIESS VSAIVDQGQA PMALRLSGQL
LLGVVRIYSR KTRYLLDDCN EALMKIKMAF RLTNNNDLPT SVTLPAGGIT LPDVLTESDL
FMNLDTSVLF SQPMPQVGTE GKRPASSLGW SSQLLPDSTP SRRFATPIER PHLEDDTGLV
LDLGEDDMPL GHDMSIEVGR DAPAPRPVGE DLFSDDQRAF NDDLELDHGD VGIQFNKPED
EVDAHDNVDN FLHQDDDVLM GGVEEELGVP IAEEDTTVVP AEEPSEFLRD SQSPLSSVRS
SVVRDLEDSF MYETVRQTQR VKRRKILQPD ADTVISSHQI KEQQADRSSI LKPASILPRD
PLLLTLMNMQ KNGDFVSSVM SGNNENWAPE LREMLSIDAV RQASELKRKR DSGIADMDVD
GADKMPRLDL DEDSGFLHAD EGIELGGDTT LNQQSEIHIA GDEEQAHYMS DDEVPGYQAE
GFNDSSSTVH PAESGPISLG TKHAVHLLRD RFGGEGSSRS KKSSVIFQDL LPEGTTTKSD
ATKMFFEVLV LATKDAVKVE QHHGTIGGRL KISAKQGLWG SWAETEAGGE IATQTTEVAV
//
