ID F0V7L8_NEOCL Unreviewed; 594 AA.
AC F0V7L8;
DT 03-MAY-2011, integrated into UniProtKB/TrEMBL.
DT 03-MAY-2011, sequence version 1.
DT 27-MAR-2024, entry version 48.
DE SubName: Full=Rhoptry protein 4 {ECO:0000313|EMBL:CEL64294.1};
GN ORFNames=BN1204_001970 {ECO:0000313|EMBL:CEL64294.1}, NCLIV_001970
GN {ECO:0000313|EMBL:CBZ49709.1};
OS Neospora caninum (strain Liverpool).
OC Eukaryota; Sar; Alveolata; Apicomplexa; Conoidasida; Coccidia;
OC Eucoccidiorida; Eimeriorina; Sarcocystidae; Neospora.
OX NCBI_TaxID=572307 {ECO:0000313|EMBL:CBZ49709.1, ECO:0000313|Proteomes:UP000007494};
RN [1] {ECO:0000313|EMBL:CBZ49709.1}
RP NUCLEOTIDE SEQUENCE.
RC STRAIN=Liverpool {ECO:0000313|EMBL:CBZ49709.1};
RA Aslett M.;
RL Submitted (FEB-2011) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|EMBL:CBZ49709.1}
RP NUCLEOTIDE SEQUENCE.
RC STRAIN=Liverpool {ECO:0000313|EMBL:CBZ49709.1};
RA Reid A.J., Sohal A., Harris D., Quail M., Sanders M., Berriman M.,
RA Wastling J.M., Pain A.;
RT "Comparative genomics and transcriptomics of Neospora caninum and
RT Toxoplasma gondii.";
RL Submitted (MAR-2011) to the EMBL/GenBank/DDBJ databases.
RN [3] {ECO:0000313|Proteomes:UP000007494}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Liverpool {ECO:0000313|Proteomes:UP000007494};
RX PubMed=22457617; DOI=10.1371/journal.ppat.1002567;
RA Reid A.J., Vermont S.J., Cotton J.A., Harris D., Hill-Cawthorne G.A.,
RA Konen-Waisman S., Latham S.M., Mourier T., Norton R., Quail M.A.,
RA Sanders M., Shanmugam D., Sohal A., Wasmuth J.D., Brunk B., Grigg M.E.,
RA Howard J.C., Parkinson J., Roos D.S., Trees A.J., Berriman M., Pain A.,
RA Wastling J.M.;
RT "Comparative genomics of the apicomplexan parasites Toxoplasma gondii and
RT Neospora caninum: Coccidia differing in host range and transmission
RT strategy.";
RL PLoS Pathog. 8:e1002567-e1002567(2012).
RN [4] {ECO:0000313|EMBL:CEL64294.1}
RP NUCLEOTIDE SEQUENCE.
RC STRAIN=Liverpool {ECO:0000313|EMBL:CEL64294.1};
RX PubMed=25875305; DOI=10.1371/journal.pone.0124473;
RA Ramaprasad A., Mourier T., Naeem R., Malas T.B., Moussa E., Panigrahi A.,
RA Vermont S.J., Otto T.D., Wastling J., Pain A.;
RT "Comprehensive Evaluation of Toxoplasma gondii VEG and Neospora caninum LIV
RT Genomes with Tachyzoite Stage Transcriptome and Proteome Defines Novel
RT Transcript Features.";
RL PLoS ONE 10:e0124473-e0124473(2015).
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DR EMBL; FR823380; CBZ49709.1; -; Genomic_DNA.
DR EMBL; LN714474; CEL64294.1; -; Genomic_DNA.
DR RefSeq; XP_003879744.1; XM_003879695.1.
DR AlphaFoldDB; F0V7L8; -.
DR SMR; F0V7L8; -.
DR GeneID; 13440595; -.
DR VEuPathDB; ToxoDB:NCLIV_001970; -.
DR eggNOG; KOG0575; Eukaryota.
DR InParanoid; F0V7L8; -.
DR OrthoDB; 203209at2759; -.
DR Proteomes; UP000007494; Chromosome Ia.
DR GO; GO:0005524; F:ATP binding; IEA:InterPro.
DR GO; GO:0004672; F:protein kinase activity; IEA:InterPro.
DR Gene3D; 1.10.510.10; Transferase(Phosphotransferase) domain 1; 1.
DR InterPro; IPR027916; Kinase-like_dom_Apicomplexa.
DR InterPro; IPR011009; Kinase-like_dom_sf.
DR InterPro; IPR000719; Prot_kinase_dom.
DR InterPro; IPR016815; Rhoptry_Rop2-like.
DR PANTHER; PTHR24345; SERINE/THREONINE-PROTEIN KINASE PLK; 1.
DR PANTHER; PTHR24345:SF0; SERINE_THREONINE-PROTEIN KINASE PLK1; 1.
DR Pfam; PF14531; Kinase-like; 1.
DR PIRSF; PIRSF022995; Rhoptry_ROP2; 1.
DR SMART; SM00220; S_TKc; 1.
DR SUPFAM; SSF56112; Protein kinase-like (PK-like); 1.
DR PROSITE; PS50011; PROTEIN_KINASE_DOM; 1.
PE 4: Predicted;
KW Reference proteome {ECO:0000313|Proteomes:UP000007494};
KW Signal {ECO:0000256|SAM:SignalP}.
FT SIGNAL 1..28
FT /evidence="ECO:0000256|SAM:SignalP"
FT CHAIN 29..594
FT /evidence="ECO:0000256|SAM:SignalP"
FT /id="PRO_5007654993"
FT DOMAIN 257..546
FT /note="Protein kinase"
FT /evidence="ECO:0000259|PROSITE:PS50011"
FT REGION 447..466
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 565..594
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 594 AA; 66823 MW; 68F4FA462E73E08C CRC64;
MEQSASVGPS SCLVRLAGAL LVLALCHAQR GAGILLPQSW DDSEAALSVS PVGGLMGEHR
TASAEQANFV AEEQVEDKRG GSWLQQEEVE QVPSEAQNQT DAEPGTQSST RFGRLLARLR
WRGRGRGGSA GAAQEQQRRR VPLRTRLLQH LKRGVRFLRH DIPAAAARLY RRLRPGQPRL
FPVDEVPSDV ETNPMYYHGR DSGDVILEEL FKRIPEAGQP IIYREASAYD DLVSRMLWRN
QKHFSVVSEL GEPSRTLIRG RMLGKGPSAI VFEATDRETG ETLAVSVPYF TEKPSAMDIE
GLRDEVLCIN LFPNIKNPKQ AQTYMRLLVP TDIVRARLTR LSRRGLVGQS RIWIVNRYFL
YPLMQTNLIS LIEGLSRSSD VNSNLAIHAR LQLTVQVIKL AASLHHHGVV HGNLQMSSIF
IQKNGAVFLG KLRYMVKEGE YSEFTFGRGF EPPETTDPSR QGRSYDPRKH KRYAFDAWAV
GLAIHWIWCE DLPDTESAPL GGTEWIFKRC RNIELSEPVK FLLEGFLRHD PEDRLLPLQA
TETPQFENIK EMISSVLNQY DQQGEPKLWG KGDLPTSGTT QGDDGVDETE DTRL
//
