ID F0VAD8_NEOCL Unreviewed; 637 AA.
AC F0VAD8;
DT 03-MAY-2011, integrated into UniProtKB/TrEMBL.
DT 03-MAY-2011, sequence version 1.
DT 24-JAN-2024, entry version 58.
DE SubName: Full=ATP-binding protein, Mrp/Nbp35 family, related {ECO:0000313|EMBL:CBZ50627.1, ECO:0000313|EMBL:CEL65239.1};
GN ORFNames=BN1204_010950 {ECO:0000313|EMBL:CEL65239.1}, NCLIV_010950
GN {ECO:0000313|EMBL:CBZ50627.1};
OS Neospora caninum (strain Liverpool).
OC Eukaryota; Sar; Alveolata; Apicomplexa; Conoidasida; Coccidia;
OC Eucoccidiorida; Eimeriorina; Sarcocystidae; Neospora.
OX NCBI_TaxID=572307 {ECO:0000313|EMBL:CBZ50627.1, ECO:0000313|Proteomes:UP000007494};
RN [1] {ECO:0000313|EMBL:CBZ50627.1}
RP NUCLEOTIDE SEQUENCE.
RC STRAIN=Liverpool {ECO:0000313|EMBL:CBZ50627.1};
RA Aslett M.;
RL Submitted (FEB-2011) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|EMBL:CBZ50627.1}
RP NUCLEOTIDE SEQUENCE.
RC STRAIN=Liverpool {ECO:0000313|EMBL:CBZ50627.1};
RA Reid A.J., Sohal A., Harris D., Quail M., Sanders M., Berriman M.,
RA Wastling J.M., Pain A.;
RT "Comparative genomics and transcriptomics of Neospora caninum and
RT Toxoplasma gondii.";
RL Submitted (MAR-2011) to the EMBL/GenBank/DDBJ databases.
RN [3] {ECO:0000313|Proteomes:UP000007494}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Liverpool {ECO:0000313|Proteomes:UP000007494};
RX PubMed=22457617; DOI=10.1371/journal.ppat.1002567;
RA Reid A.J., Vermont S.J., Cotton J.A., Harris D., Hill-Cawthorne G.A.,
RA Konen-Waisman S., Latham S.M., Mourier T., Norton R., Quail M.A.,
RA Sanders M., Shanmugam D., Sohal A., Wasmuth J.D., Brunk B., Grigg M.E.,
RA Howard J.C., Parkinson J., Roos D.S., Trees A.J., Berriman M., Pain A.,
RA Wastling J.M.;
RT "Comparative genomics of the apicomplexan parasites Toxoplasma gondii and
RT Neospora caninum: Coccidia differing in host range and transmission
RT strategy.";
RL PLoS Pathog. 8:e1002567-e1002567(2012).
RN [4] {ECO:0000313|EMBL:CEL65239.1}
RP NUCLEOTIDE SEQUENCE.
RC STRAIN=Liverpool {ECO:0000313|EMBL:CEL65239.1};
RX PubMed=25875305; DOI=10.1371/journal.pone.0124473;
RA Ramaprasad A., Mourier T., Naeem R., Malas T.B., Moussa E., Panigrahi A.,
RA Vermont S.J., Otto T.D., Wastling J., Pain A.;
RT "Comprehensive Evaluation of Toxoplasma gondii VEG and Neospora caninum LIV
RT Genomes with Tachyzoite Stage Transcriptome and Proteome Defines Novel
RT Transcript Features.";
RL PLoS ONE 10:e0124473-e0124473(2015).
CC -!- SIMILARITY: Belongs to the Mrp/NBP35 ATP-binding proteins family.
CC {ECO:0000256|ARBA:ARBA00024036}.
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DR EMBL; FR823384; CBZ50627.1; -; Genomic_DNA.
DR EMBL; LN714478; CEL65239.1; -; Genomic_DNA.
DR RefSeq; XP_003880660.1; XM_003880611.1.
DR AlphaFoldDB; F0VAD8; -.
DR GeneID; 13441656; -.
DR VEuPathDB; ToxoDB:NCLIV_010950; -.
DR eggNOG; KOG3022; Eukaryota.
DR InParanoid; F0VAD8; -.
DR OrthoDB; 228512at2759; -.
DR Proteomes; UP000007494; Chromosome IV.
DR GO; GO:0005524; F:ATP binding; IEA:UniProtKB-KW.
DR GO; GO:0140663; F:ATP-dependent FeS chaperone activity; IEA:InterPro.
DR GO; GO:0051536; F:iron-sulfur cluster binding; IEA:InterPro.
DR GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
DR GO; GO:0016226; P:iron-sulfur cluster assembly; IEA:InterPro.
DR CDD; cd02037; Mrp_NBP35; 1.
DR Gene3D; 3.30.2020.30; -; 1.
DR Gene3D; 3.30.300.130; Fe-S cluster assembly (FSCA); 1.
DR Gene3D; 3.40.50.300; P-loop containing nucleotide triphosphate hydrolases; 1.
DR HAMAP; MF_02040; Mrp_NBP35; 1.
DR InterPro; IPR034904; FSCA_dom_sf.
DR InterPro; IPR010376; GBBH-like_N.
DR InterPro; IPR038492; GBBH-like_N_sf.
DR InterPro; IPR002744; MIP18-like.
DR InterPro; IPR000808; Mrp-like_CS.
DR InterPro; IPR019591; Mrp/NBP35_ATP-bd.
DR InterPro; IPR044304; NUBPL-like.
DR InterPro; IPR027417; P-loop_NTPase.
DR InterPro; IPR033756; YlxH/NBP35.
DR PANTHER; PTHR42961; IRON-SULFUR PROTEIN NUBPL; 1.
DR PANTHER; PTHR42961:SF2; IRON-SULFUR PROTEIN NUBPL; 1.
DR Pfam; PF01883; FeS_assembly_P; 1.
DR Pfam; PF06155; GBBH-like_N; 1.
DR Pfam; PF10609; ParA; 2.
DR SUPFAM; SSF117916; Fe-S cluster assembly (FSCA) domain-like; 1.
DR SUPFAM; SSF52540; P-loop containing nucleoside triphosphate hydrolases; 1.
DR PROSITE; PS01215; MRP; 1.
PE 3: Inferred from homology;
KW ATP-binding {ECO:0000256|ARBA:ARBA00022840, ECO:0000313|EMBL:CBZ50627.1};
KW Iron {ECO:0000256|ARBA:ARBA00023004};
KW Metal-binding {ECO:0000256|ARBA:ARBA00022723};
KW Nucleotide-binding {ECO:0000256|ARBA:ARBA00022741};
KW Reference proteome {ECO:0000313|Proteomes:UP000007494}.
FT DOMAIN 38..110
FT /note="MIP18 family-like"
FT /evidence="ECO:0000259|Pfam:PF01883"
FT DOMAIN 543..602
FT /note="Gamma-butyrobetaine hydroxylase-like N-terminal"
FT /evidence="ECO:0000259|Pfam:PF06155"
FT REGION 192..262
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 503..530
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 202..223
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 224..238
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 239..255
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 503..526
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 637 AA; 69339 MW; B1CB9F2BBDA3D29C CRC64;
MNRDDGRQAA VDRNVDGEEL PSAAFHTSAD ACRIQRLRDE VLDQLRTVID PDLHKDIVAL
GFVRDLEIHE HAGSVKFRLR LTTPACPVKD VFVATCTARL RALEWVHQVD IQLESQKPSG
STASRSAGDG LKCVSFVLAV TSCKGGVGKS TVAVNLAFML RRLGAKVGLL DADLYGPSLP
VLLPLPDTDV YFEEESEGEP SEEHTSEVVF RPKRSKDRGH SRANSSRGSP IAFEPTRSQR
GETDTKKKHS AGDQDVENAQ PKLRPLVHNG VKIMSYGFIR NSGSQGFSAL RGPFASSVIE
QLLTGTAWRD LDYLVIDFPP GTGDIHITLS QTVKIDACVV VTTPQTLSTA DAERGIKMFN
ELGIPTICVV ENMAHFVCDG CQKKHILFPG QQNVEKLADL AEAPHVVQIP LDPRLSEVVG
DEASAGDQPT KNAQSAGETC TFPVVERLRQ VPEDKVYSVF HDLAAIVVRE LSTLRYGYVG
PSVTLTGDSC VQIGLPRRIH RTRADDSEKR WTSSTGDPDD DHVAAAGKAS TSDPHAVSID
VCTVSLRRLR DACECGICTE EAEKVPKSGT RATSPAELAL TEVLHASNRS LIFVWDDDHR
TALPLQTLER LAHAEDEIRS RASGSVCTAG AQPELEW
//
