ID F0VC13_NEOCL Unreviewed; 641 AA.
AC F0VC13;
DT 03-MAY-2011, integrated into UniProtKB/TrEMBL.
DT 03-MAY-2011, sequence version 1.
DT 27-MAR-2024, entry version 53.
DE SubName: Full=Peroxisomal multifunctional enzyme type 2,putative {ECO:0000313|EMBL:CEL68456.1};
DE SubName: Full=Putative peroxisomal multifunctional enzyme type 2 {ECO:0000313|EMBL:CBZ51147.1};
GN ORFNames=BN1204_042220 {ECO:0000313|EMBL:CEL68456.1}, NCLIV_042220
GN {ECO:0000313|EMBL:CBZ51147.1};
OS Neospora caninum (strain Liverpool).
OC Eukaryota; Sar; Alveolata; Apicomplexa; Conoidasida; Coccidia;
OC Eucoccidiorida; Eimeriorina; Sarcocystidae; Neospora.
OX NCBI_TaxID=572307 {ECO:0000313|EMBL:CBZ51147.1, ECO:0000313|Proteomes:UP000007494};
RN [1] {ECO:0000313|EMBL:CBZ51147.1}
RP NUCLEOTIDE SEQUENCE.
RC STRAIN=Liverpool {ECO:0000313|EMBL:CBZ51147.1};
RA Aslett M.;
RL Submitted (FEB-2011) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|EMBL:CBZ51147.1}
RP NUCLEOTIDE SEQUENCE.
RC STRAIN=Liverpool {ECO:0000313|EMBL:CBZ51147.1};
RA Reid A.J., Sohal A., Harris D., Quail M., Sanders M., Berriman M.,
RA Wastling J.M., Pain A.;
RT "Comparative genomics and transcriptomics of Neospora caninum and
RT Toxoplasma gondii.";
RL Submitted (MAR-2011) to the EMBL/GenBank/DDBJ databases.
RN [3] {ECO:0000313|Proteomes:UP000007494}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Liverpool {ECO:0000313|Proteomes:UP000007494};
RX PubMed=22457617; DOI=10.1371/journal.ppat.1002567;
RA Reid A.J., Vermont S.J., Cotton J.A., Harris D., Hill-Cawthorne G.A.,
RA Konen-Waisman S., Latham S.M., Mourier T., Norton R., Quail M.A.,
RA Sanders M., Shanmugam D., Sohal A., Wasmuth J.D., Brunk B., Grigg M.E.,
RA Howard J.C., Parkinson J., Roos D.S., Trees A.J., Berriman M., Pain A.,
RA Wastling J.M.;
RT "Comparative genomics of the apicomplexan parasites Toxoplasma gondii and
RT Neospora caninum: Coccidia differing in host range and transmission
RT strategy.";
RL PLoS Pathog. 8:e1002567-e1002567(2012).
RN [4] {ECO:0000313|EMBL:CEL68456.1}
RP NUCLEOTIDE SEQUENCE.
RC STRAIN=Liverpool {ECO:0000313|EMBL:CEL68456.1};
RX PubMed=25875305; DOI=10.1371/journal.pone.0124473;
RA Ramaprasad A., Mourier T., Naeem R., Malas T.B., Moussa E., Panigrahi A.,
RA Vermont S.J., Otto T.D., Wastling J., Pain A.;
RT "Comprehensive Evaluation of Toxoplasma gondii VEG and Neospora caninum LIV
RT Genomes with Tachyzoite Stage Transcriptome and Proteome Defines Novel
RT Transcript Features.";
RL PLoS ONE 10:e0124473-e0124473(2015).
CC -!- SUBCELLULAR LOCATION: Peroxisome {ECO:0000256|ARBA:ARBA00004275}.
CC -!- SIMILARITY: Belongs to the short-chain dehydrogenases/reductases (SDR)
CC family. {ECO:0000256|ARBA:ARBA00006484}.
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DR EMBL; FR823385; CBZ51147.1; -; Genomic_DNA.
DR EMBL; LN714484; CEL68456.1; -; Genomic_DNA.
DR RefSeq; XP_003881180.1; XM_003881131.1.
DR AlphaFoldDB; F0VC13; -.
DR GeneID; 13440132; -.
DR VEuPathDB; ToxoDB:NCLIV_042220; -.
DR eggNOG; KOG4170; Eukaryota.
DR InParanoid; F0VC13; -.
DR OrthoDB; 2140828at2759; -.
DR Proteomes; UP000007494; Chromosome IX.
DR GO; GO:0005777; C:peroxisome; IEA:UniProtKB-SubCell.
DR GO; GO:0016491; F:oxidoreductase activity; IEA:UniProtKB-KW.
DR CDD; cd05353; hydroxyacyl-CoA-like_DH_SDR_c-like; 1.
DR Gene3D; 1.10.287.4290; -; 1.
DR Gene3D; 3.40.50.720; NAD(P)-binding Rossmann-like Domain; 1.
DR Gene3D; 3.30.1050.10; SCP2 sterol-binding domain; 2.
DR InterPro; IPR036291; NAD(P)-bd_dom_sf.
DR InterPro; IPR020904; Sc_DH/Rdtase_CS.
DR InterPro; IPR003033; SCP2_sterol-bd_dom.
DR InterPro; IPR036527; SCP2_sterol-bd_dom_sf.
DR InterPro; IPR002347; SDR_fam.
DR PANTHER; PTHR45024; DEHYDROGENASES, SHORT CHAIN; 1.
DR PANTHER; PTHR45024:SF2; SCP2 DOMAIN-CONTAINING PROTEIN; 1.
DR Pfam; PF00106; adh_short; 1.
DR Pfam; PF02036; SCP2; 2.
DR PRINTS; PR00081; GDHRDH.
DR PRINTS; PR00080; SDRFAMILY.
DR SMART; SM00822; PKS_KR; 1.
DR SUPFAM; SSF51735; NAD(P)-binding Rossmann-fold domains; 1.
DR SUPFAM; SSF55718; SCP-like; 2.
DR PROSITE; PS00061; ADH_SHORT; 1.
PE 3: Inferred from homology;
KW Oxidoreductase {ECO:0000256|ARBA:ARBA00023002};
KW Peroxisome {ECO:0000256|ARBA:ARBA00023140};
KW Reference proteome {ECO:0000313|Proteomes:UP000007494}.
FT DOMAIN 351..445
FT /note="SCP2"
FT /evidence="ECO:0000259|Pfam:PF02036"
FT DOMAIN 536..630
FT /note="SCP2"
FT /evidence="ECO:0000259|Pfam:PF02036"
FT REGION 474..522
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 641 AA; 68458 MW; D1B5416F360E8B70 CRC64;
MPVRFDGQVA IVTGAGGGLG RSYALLLAAR GAKVLVNDVG AALSGGASDA SKAKPPADQV
VAEIRARGGE AAADYNSVLD GQKIIDHALS LFGRVDILIN NAGVLRDTSF MKMTEQDWNL
VLDVHVKGAY ACTKAAWPVM QKQNYGRIIM TASAAGLYGN FGQANYSAAK SALVGFTKTL
AFEGAKKNIL VNCIAPLAGT RMTATVLPPD LVEAMKPDYV APLVAFLCSK ECRDSGQVLE
VGAGWVASVR WQRNIGHSFA PPLSPDDIAR EWKQIRDFSG DVAYPASLQD SMLMVMQRLQ
QEPKQAKITG VEQRDALNGK AEKQAGAAAV GGSTPIGKAG LIFKLMAAYI RNAPDARQKL
QDKVDSVFGF NVTDGKTTRS WSINLKKGNA GGGVEEGLHS APDVVFTMAG EHFVSVCLGK
LNPQMAFVQG KMKIKGSMQK ATKFTPSLFP PIPKELVDMD DAGKAVEAYM KASNVPLSQP
PRGSDGEPPA QAKQQAGEPA NSKAATGRGG APEAPSPRAK QLKSMTLYEV MKRHLATAEG
EQLVKKIKSV YRLNILPKKG AAPVKVILDL KNMPPTIREE DDREHAACDC TITLLDEDFV
KLALGKMNPQ LAFIQGKIKL KGSMQAALKF TPDIFPKTSR L
//
