ID F0VEH2_NEOCL Unreviewed; 2382 AA.
AC F0VEH2;
DT 03-MAY-2011, integrated into UniProtKB/TrEMBL.
DT 03-MAY-2011, sequence version 1.
DT 27-MAR-2024, entry version 54.
DE SubName: Full=Putative tubulin-tyrosine ligase family protein {ECO:0000313|EMBL:CBZ52116.1};
DE SubName: Full=Tubulin-tyrosine ligase family protein, putative {ECO:0000313|EMBL:CEL66078.1};
GN ORFNames=BN1204_019050 {ECO:0000313|EMBL:CEL66078.1}, NCLIV_019050
GN {ECO:0000313|EMBL:CBZ52116.1};
OS Neospora caninum (strain Liverpool).
OC Eukaryota; Sar; Alveolata; Apicomplexa; Conoidasida; Coccidia;
OC Eucoccidiorida; Eimeriorina; Sarcocystidae; Neospora.
OX NCBI_TaxID=572307 {ECO:0000313|EMBL:CBZ52116.1, ECO:0000313|Proteomes:UP000007494};
RN [1] {ECO:0000313|EMBL:CBZ52116.1}
RP NUCLEOTIDE SEQUENCE.
RC STRAIN=Liverpool {ECO:0000313|EMBL:CBZ52116.1};
RA Aslett M.;
RL Submitted (FEB-2011) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|EMBL:CBZ52116.1}
RP NUCLEOTIDE SEQUENCE.
RC STRAIN=Liverpool {ECO:0000313|EMBL:CBZ52116.1};
RA Reid A.J., Sohal A., Harris D., Quail M., Sanders M., Berriman M.,
RA Wastling J.M., Pain A.;
RT "Comparative genomics and transcriptomics of Neospora caninum and
RT Toxoplasma gondii.";
RL Submitted (MAR-2011) to the EMBL/GenBank/DDBJ databases.
RN [3] {ECO:0000313|Proteomes:UP000007494}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Liverpool {ECO:0000313|Proteomes:UP000007494};
RX PubMed=22457617; DOI=10.1371/journal.ppat.1002567;
RA Reid A.J., Vermont S.J., Cotton J.A., Harris D., Hill-Cawthorne G.A.,
RA Konen-Waisman S., Latham S.M., Mourier T., Norton R., Quail M.A.,
RA Sanders M., Shanmugam D., Sohal A., Wasmuth J.D., Brunk B., Grigg M.E.,
RA Howard J.C., Parkinson J., Roos D.S., Trees A.J., Berriman M., Pain A.,
RA Wastling J.M.;
RT "Comparative genomics of the apicomplexan parasites Toxoplasma gondii and
RT Neospora caninum: Coccidia differing in host range and transmission
RT strategy.";
RL PLoS Pathog. 8:e1002567-e1002567(2012).
RN [4] {ECO:0000313|EMBL:CEL66078.1}
RP NUCLEOTIDE SEQUENCE.
RC STRAIN=Liverpool {ECO:0000313|EMBL:CEL66078.1};
RX PubMed=25875305; DOI=10.1371/journal.pone.0124473;
RA Ramaprasad A., Mourier T., Naeem R., Malas T.B., Moussa E., Panigrahi A.,
RA Vermont S.J., Otto T.D., Wastling J., Pain A.;
RT "Comprehensive Evaluation of Toxoplasma gondii VEG and Neospora caninum LIV
RT Genomes with Tachyzoite Stage Transcriptome and Proteome Defines Novel
RT Transcript Features.";
RL PLoS ONE 10:e0124473-e0124473(2015).
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DR EMBL; FR823387; CBZ52116.1; -; Genomic_DNA.
DR EMBL; LN714480; CEL66078.1; -; Genomic_DNA.
DR RefSeq; XP_003882148.1; XM_003882099.1.
DR GeneID; 13444982; -.
DR VEuPathDB; ToxoDB:NCLIV_019050; -.
DR eggNOG; KOG2158; Eukaryota.
DR InParanoid; F0VEH2; -.
DR OrthoDB; 215823at2759; -.
DR Proteomes; UP000007494; Chromosome VI.
DR GO; GO:0016874; F:ligase activity; IEA:UniProtKB-KW.
DR GO; GO:0036211; P:protein modification process; IEA:InterPro.
DR Gene3D; 3.30.470.20; ATP-grasp fold, B domain; 1.
DR InterPro; IPR004344; TTL/TTLL_fam.
DR PANTHER; PTHR12241; TUBULIN POLYGLUTAMYLASE; 1.
DR PANTHER; PTHR12241:SF154; TUBULIN POLYGLUTAMYLASE TTLL11; 1.
DR Pfam; PF03133; TTL; 1.
DR SUPFAM; SSF56059; Glutathione synthetase ATP-binding domain-like; 1.
DR PROSITE; PS51221; TTL; 1.
PE 4: Predicted;
KW Ligase {ECO:0000313|EMBL:CBZ52116.1};
KW Reference proteome {ECO:0000313|Proteomes:UP000007494}.
FT REGION 1..61
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 598..619
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 652..855
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1243..1474
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1519..1644
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1656..1725
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1777..1799
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1909..1935
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 2159..2271
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 17..61
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 658..684
FT /note="Acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 712..730
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 774..820
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1249..1307
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1386..1402
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1419..1474
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1556..1576
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1583..1641
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1656..1699
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1709..1724
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1919..1935
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 2177..2192
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 2382 AA; 257695 MW; 2D428DAC72B335C5 CRC64;
MMPFPTVGAL PPAGAGPTMN NRSTIWRPPG VTHTTPPGLS NGTAAESHPP QPLNLSTGYQ
CPPTRPLQPV LQCRFVAGTG HGTQGAPAFG AFSAPNAGYF AGAPVTQGPS QMLPATNAGS
WRNPGSTEQP PMTRHCSPTF LLQSPGNHPG GGYGHQSFAK IHREGLPQAP IFRTSTPTLI
QGQPLPRLPN SAPKQDSISL GIPELQRNQT PQQPGFCMQS QQVAATQASH PPQQRPRAPT
QVELPLTHLA GNPVRQYPQS DLRQDRPLPH VAVRDVDRDA RHRFLSPSSQ RVRLTPSDSC
LTGQLAGQTH GIVPGAQSVS SVGGQAVHPG NQLRHSASLA TDSGRPHLPH LTVQQSMDMA
KKQSVHGFPS TPSAPASDGV LFAPFAAQKA LANFDVKPDY RKPTGDFIAN MRPNLCEPRL
GQADMLHPNY SFFVGQGMLA ASYTSPETLL HGHGNRLASQ AGPAMGSVPV QPHTTQKEAH
NADGHSTLSP VYPDKVSHTR LIPSPGHNEQ YGGLFVPSSE AKERGAATLV PARVTQSPAS
LVAWQSWRRL PHQDIRWPQQ QIEAGGGTFC KRAEGSEEGK PTETPISCYG SAHTLELGRE
QRDQGDPKPS PIAYQSGYGK LTLEGVEDVP KEETGECREG EDWSCVDCAR GPGEVAVEEE
PPVEDQVTGD TESEVEEDAA KEFEDDAYPL ESSTLSGSPD AEGDRSRSDS VTAPHSEAGS
PANGSPRPCQ SHSEEAEALS EEEDEDSDST THEEIPMPWE NDPWVDVQIP SPRQADAWQP
SAAASISASM SGSAPSQARS PSPGSVGNAV AATTKNSKAT RASGHDQERG GKAKGAKGYT
GQSHDGEPGR KGEDNALRGT MACAIPWNEV VLNTKMCRAE RPLINTIGHR LGWSRQDQVS
TKGNIVWLGG SVPDHEHLQF MKPLQLVNRF PGMWDMTKKR MLSRILSLYQ QLYPDLFDFS
PETWSLPEDR DVIKRILHNK NQEVFILKPD GGAMGNGVQL VSRFKDIDAM VLRGDGNYIM
QRYVHNPYLM NKRKFDFRIY CMLFSVNGTP KAYISKLGMA RFCTEQYRAP TRRNIDNPFM
HLTNYSINKD NTTSFVRSTD LHDDSNSKRM LKDVLEDLAK DGVNIVNVWD QIKSITARTV
VCLYPWLNLR YRHVYKVKDT EPSRCFQLLG LDILLDTHEK CWLLEVNSNP SLRIDYFDSK
YEGIDVQLES AMDRHIKEPV VSEGLGLAYR LLLQHRRRGA AGVVEKGKAS RVSSSTPPVS
HSSRGALRAS GSRSSLATRG LSQPKTTSPE VSSATPSVPS RDRSSDSFCS AGRGEGAAAQ
CAQATSGADS PLAQGAATGR AQGTPREGDA SGAPCQPASG SGPVDGGEGG IRRLESSNLA
TTLPGKEVRE ARREDREGGL CVKRAASVRA SKRLGKRSSS AASRRDRGKG TLESLADQRD
MRSARRGEAP RDAGVNERRT TQKSEEEAAD DIHGDVELGM EQAVEKVRAF LAHMGTSGGS
SLAALVACGE SAGTVLRPPA RMCLSPEPRP VGKEPGRWGN GDGRSAGERE GRKSSALSHG
LTSRLTTTSS SRAPSRKRAV ASHASESGSE HRSRSRGRMQ AARAHSETGR RGREPTRAAD
ERDTGSAKPD LETKEVDIME QGKDGQFSVS ALSLSRSASV ETAETPTSPL SCRDDGSSLT
QSTASFPLQS SQPRTPSPRT PLDSLEEREN AWPSSSSSPE EALQASVLAT ARPDALPEAE
QLACELDWLD VAYKEMEKCM DGFNVLGLRF ASSREKGVGG ATSRDSATED GKKKFPPGPY
KPFLRKDRMA AKKVQSAVKA SYTKLHKDIL RPLSGEHAKP QHCWIDLASS VNALVAETTS
VLRFQLLFER LIKFPKGITL QRAGLLEACR IVKLPDILRK IQVPIGNPPR PGCRSGVRSS
AFPSHTHPTQ ARSYSNDAGQ SFAFGRSNSR AHLQGNEAVL PCGSSLLSSV STKSLLAAGP
AGGPSQVFPG LQRPRLGAGG QMPLGAASSS TASVSRMPSV ALLPHERRRR LGLPDVEALW
YYHLQSVRKQ LQMQESSYGL GLLETWYVFE SIALICFPFL PSKAKLLEAF LNPTREKGYS
NALSVSLLGG GVEKAEVLAA DRRVDGTLRS QIAFAKDLEE ALRKVEEEER LALPISKQGT
LKRKTSKTAH RSPALVEGIA SEDERRYSSR STETETVAEP PQGQERGPEC LLSRLGSDGN
RPDASGQLSE GEGDRRSASL NLGDGCLPTD TGTSRSESQD GRRGFDSGRR LTSLPTRLRR
KLFSGEDEGL GSLAGPLEGK ARTKEGTGFA ALTEKTTHAR TPAPETPAWY EGFCAAWPDV
GEYVCRHVPP EDRREAMERL VDYFQLRWDY HNYCVMLQGG SV
//
