ID F0VEL6_NEOCL Unreviewed; 1257 AA.
AC F0VEL6;
DT 03-MAY-2011, integrated into UniProtKB/TrEMBL.
DT 03-MAY-2011, sequence version 1.
DT 27-MAR-2024, entry version 52.
DE SubName: Full=Lysine decarboxylase, putative {ECO:0000313|EMBL:CEL66124.1};
DE SubName: Full=Putative lysine decarboxylase {ECO:0000313|EMBL:CBZ52160.1};
GN ORFNames=BN1204_019490 {ECO:0000313|EMBL:CEL66124.1}, NCLIV_019490
GN {ECO:0000313|EMBL:CBZ52160.1};
OS Neospora caninum (strain Liverpool).
OC Eukaryota; Sar; Alveolata; Apicomplexa; Conoidasida; Coccidia;
OC Eucoccidiorida; Eimeriorina; Sarcocystidae; Neospora.
OX NCBI_TaxID=572307 {ECO:0000313|EMBL:CBZ52160.1, ECO:0000313|Proteomes:UP000007494};
RN [1] {ECO:0000313|EMBL:CBZ52160.1}
RP NUCLEOTIDE SEQUENCE.
RC STRAIN=Liverpool {ECO:0000313|EMBL:CBZ52160.1};
RA Aslett M.;
RL Submitted (FEB-2011) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|EMBL:CBZ52160.1}
RP NUCLEOTIDE SEQUENCE.
RC STRAIN=Liverpool {ECO:0000313|EMBL:CBZ52160.1};
RA Reid A.J., Sohal A., Harris D., Quail M., Sanders M., Berriman M.,
RA Wastling J.M., Pain A.;
RT "Comparative genomics and transcriptomics of Neospora caninum and
RT Toxoplasma gondii.";
RL Submitted (MAR-2011) to the EMBL/GenBank/DDBJ databases.
RN [3] {ECO:0000313|Proteomes:UP000007494}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Liverpool {ECO:0000313|Proteomes:UP000007494};
RX PubMed=22457617; DOI=10.1371/journal.ppat.1002567;
RA Reid A.J., Vermont S.J., Cotton J.A., Harris D., Hill-Cawthorne G.A.,
RA Konen-Waisman S., Latham S.M., Mourier T., Norton R., Quail M.A.,
RA Sanders M., Shanmugam D., Sohal A., Wasmuth J.D., Brunk B., Grigg M.E.,
RA Howard J.C., Parkinson J., Roos D.S., Trees A.J., Berriman M., Pain A.,
RA Wastling J.M.;
RT "Comparative genomics of the apicomplexan parasites Toxoplasma gondii and
RT Neospora caninum: Coccidia differing in host range and transmission
RT strategy.";
RL PLoS Pathog. 8:e1002567-e1002567(2012).
RN [4] {ECO:0000313|EMBL:CEL66124.1}
RP NUCLEOTIDE SEQUENCE.
RC STRAIN=Liverpool {ECO:0000313|EMBL:CEL66124.1};
RX PubMed=25875305; DOI=10.1371/journal.pone.0124473;
RA Ramaprasad A., Mourier T., Naeem R., Malas T.B., Moussa E., Panigrahi A.,
RA Vermont S.J., Otto T.D., Wastling J., Pain A.;
RT "Comprehensive Evaluation of Toxoplasma gondii VEG and Neospora caninum LIV
RT Genomes with Tachyzoite Stage Transcriptome and Proteome Defines Novel
RT Transcript Features.";
RL PLoS ONE 10:e0124473-e0124473(2015).
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DR EMBL; FR823388; CBZ52160.1; -; Genomic_DNA.
DR EMBL; LN714481; CEL66124.1; -; Genomic_DNA.
DR RefSeq; XP_003882192.1; XM_003882143.1.
DR AlphaFoldDB; F0VEL6; -.
DR GeneID; 13443925; -.
DR VEuPathDB; ToxoDB:NCLIV_019490; -.
DR eggNOG; ENOG502QWPE; Eukaryota.
DR InParanoid; F0VEL6; -.
DR OrthoDB; 246721at2759; -.
DR Proteomes; UP000007494; Chromosome VIIa.
DR GO; GO:0005737; C:cytoplasm; IEA:InterPro.
DR GO; GO:0016831; F:carboxy-lyase activity; IEA:InterPro.
DR GO; GO:0006520; P:amino acid metabolic process; IEA:InterPro.
DR CDD; cd00615; Orn_deC_like; 1.
DR Gene3D; 3.90.100.10; Orn/Lys/Arg decarboxylase, C-terminal domain; 1.
DR Gene3D; 3.40.640.10; Type I PLP-dependent aspartate aminotransferase-like (Major domain); 1.
DR InterPro; IPR011193; Orn/lys/arg_de-COase.
DR InterPro; IPR000310; Orn/Lys/Arg_deCO2ase_major_dom.
DR InterPro; IPR036633; Prn/Lys/Arg_de-COase_C_sf.
DR InterPro; IPR015424; PyrdxlP-dep_Trfase.
DR InterPro; IPR015421; PyrdxlP-dep_Trfase_major.
DR PANTHER; PTHR45229:SF3; BIODEGRADATIVE ARGININE DECARBOXYLASE; 1.
DR PANTHER; PTHR45229; CONSTITUTIVE ORNITHINE DECARBOXYLASE; 1.
DR Pfam; PF01276; OKR_DC_1; 2.
DR SUPFAM; SSF55904; Ornithine decarboxylase C-terminal domain; 1.
DR SUPFAM; SSF53383; PLP-dependent transferases; 1.
PE 4: Predicted;
KW Pyridoxal phosphate {ECO:0000256|ARBA:ARBA00022898};
KW Reference proteome {ECO:0000313|Proteomes:UP000007494}.
FT DOMAIN 472..700
FT /note="Orn/Lys/Arg decarboxylases family 1 pyridoxal-P
FT attachment site"
FT /evidence="ECO:0000259|Pfam:PF01276"
FT DOMAIN 747..938
FT /note="Orn/Lys/Arg decarboxylases family 1 pyridoxal-P
FT attachment site"
FT /evidence="ECO:0000259|Pfam:PF01276"
FT REGION 49..147
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1001..1053
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1157..1257
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 55..72
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 81..99
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1025..1039
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1169..1247
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 1257 AA; 138963 MW; D5AB780FCDD4DB10 CRC64;
MLERRGTLRY GAARRLRQFG SRDSILLTPG ASFSMQSSSG LFLPQLGAAE PRSLSRDSDS
PRDFDVDSAM RTNPRHMRGG YPGQGDRDRG ERERSRSYLG HAPLGRGLSP ANGGDGREDS
GGYGGRGQLA GRGGRDRDDA SEGDSALGRG LYWAGEKSRG ERGDARLADM TSALSITTED
DFAAGGPNAE HAWLRKADTF TQADEDLVSS ETTYVAMLRE ELWQALSAHV AMWRKEKIEA
GLNCLEQIEW FWGAEGMQKV HEVRALVKDN KMDSAGVVIS SVTASMSSVT GSMQGRHHCF
YVLVVVPPCT FRNRDHRVNL AAELRRIASK EQSQDSSLVY RIVEVDSIRR ALLATIVNPD
ILAVVLQDNV PIEHSHSSHA LVGFEAFVRG IDVFVETPVT KMRAGAPVLA TVIQSIAQCR
SNIDVFCVCT AMGLATLEPV SHLVKRAFFP NDDHSDLHEA ILAGVRSKMR CPFFEALRRY
AERPIGVFHA LAISRGNSVR RSKWIQGLIE FYGVNLFKAE SSATCGGLDS LLDPHGSLLD
AQNLAARAYD ANYAFFVTNG TSTSNKIVLQ AVLRPGDVVL VDRDCHKSHH YGFVLAGSSP
CYLDAYPLHR FSMYGGVPLE AIKRTLLAYR SAGRVAEVKL LVLTNCTFDG IVYNVKRVVE
ECLAIAPHLV FLFDEAWFSY AMFHPILKRR TAMHAANEIR RCLMEGRYHR RFQELLETLG
TDDLTSVDAE TLVKTRLYPD PRRMRVRVYA THSIHKSLTA LRQGSMILVN DDLFESHVHT
PFKEAYYTHM STSPNYQILA TIDVGRSQME LEGYGLVERQ IEAAFFIRRL LTRDLLVRKY
FTVLSPRDMI PAAMRKHSKA LLGEEALQCE MNLQTLEQVW LTDDEFVLDP TRITLFTGLS
GLDGDTFKVK WLMDKYGIQI NKTSRNSVLF MTNIGTTRSS CVFLKACIRS CAQELEMHRL
MSSTRELEEV NDAIRALVED CPDLPNFSAF HPAFKKTLFP HDVCEPPNEP SPAAEGGASE
GSGDGAKPAR ERERGDGDQK GATAGSTPGE DALSLVRDGD LRAAFYLAYD EDVVRYLSLR
ETKEAILRGE QLVATTFVIP YPPGFPVAVP GQVLTLALVD FLLKLDVKEI HGFDHKLGFR
LFTEGILNDQ LRQRRAAERE KTDLQGMRLL PSAPQNVNVT VSPPCGATVE SEASPPSVSA
GRETPDNAAK SSSSANGNEL DSNHAKTGST STNDTRRSDT SSSPPPSGRE GKREPNP
//
