ID F0VFE4_NEOCL Unreviewed; 691 AA.
AC F0VFE4;
DT 03-MAY-2011, integrated into UniProtKB/TrEMBL.
DT 03-MAY-2011, sequence version 1.
DT 27-MAR-2024, entry version 47.
DE SubName: Full=Polo kinase {ECO:0000313|EMBL:CEL66412.1};
GN ORFNames=BN1204_022270 {ECO:0000313|EMBL:CEL66412.1}, NCLIV_022270
GN {ECO:0000313|EMBL:CBZ52438.1};
OS Neospora caninum (strain Liverpool).
OC Eukaryota; Sar; Alveolata; Apicomplexa; Conoidasida; Coccidia;
OC Eucoccidiorida; Eimeriorina; Sarcocystidae; Neospora.
OX NCBI_TaxID=572307 {ECO:0000313|EMBL:CBZ52438.1, ECO:0000313|Proteomes:UP000007494};
RN [1] {ECO:0000313|EMBL:CBZ52438.1}
RP NUCLEOTIDE SEQUENCE.
RC STRAIN=Liverpool {ECO:0000313|EMBL:CBZ52438.1};
RA Aslett M.;
RL Submitted (FEB-2011) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|EMBL:CBZ52438.1}
RP NUCLEOTIDE SEQUENCE.
RC STRAIN=Liverpool {ECO:0000313|EMBL:CBZ52438.1};
RA Reid A.J., Sohal A., Harris D., Quail M., Sanders M., Berriman M.,
RA Wastling J.M., Pain A.;
RT "Comparative genomics and transcriptomics of Neospora caninum and
RT Toxoplasma gondii.";
RL Submitted (MAR-2011) to the EMBL/GenBank/DDBJ databases.
RN [3] {ECO:0000313|Proteomes:UP000007494}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Liverpool {ECO:0000313|Proteomes:UP000007494};
RX PubMed=22457617; DOI=10.1371/journal.ppat.1002567;
RA Reid A.J., Vermont S.J., Cotton J.A., Harris D., Hill-Cawthorne G.A.,
RA Konen-Waisman S., Latham S.M., Mourier T., Norton R., Quail M.A.,
RA Sanders M., Shanmugam D., Sohal A., Wasmuth J.D., Brunk B., Grigg M.E.,
RA Howard J.C., Parkinson J., Roos D.S., Trees A.J., Berriman M., Pain A.,
RA Wastling J.M.;
RT "Comparative genomics of the apicomplexan parasites Toxoplasma gondii and
RT Neospora caninum: Coccidia differing in host range and transmission
RT strategy.";
RL PLoS Pathog. 8:e1002567-e1002567(2012).
RN [4] {ECO:0000313|EMBL:CEL66412.1}
RP NUCLEOTIDE SEQUENCE.
RC STRAIN=Liverpool {ECO:0000313|EMBL:CEL66412.1};
RX PubMed=25875305; DOI=10.1371/journal.pone.0124473;
RA Ramaprasad A., Mourier T., Naeem R., Malas T.B., Moussa E., Panigrahi A.,
RA Vermont S.J., Otto T.D., Wastling J., Pain A.;
RT "Comprehensive Evaluation of Toxoplasma gondii VEG and Neospora caninum LIV
RT Genomes with Tachyzoite Stage Transcriptome and Proteome Defines Novel
RT Transcript Features.";
RL PLoS ONE 10:e0124473-e0124473(2015).
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DR EMBL; FR823388; CBZ52438.1; -; Genomic_DNA.
DR EMBL; LN714481; CEL66412.1; -; Genomic_DNA.
DR RefSeq; XP_003882470.1; XM_003882421.1.
DR AlphaFoldDB; F0VFE4; -.
DR GeneID; 13444439; -.
DR VEuPathDB; ToxoDB:NCLIV_022270; -.
DR eggNOG; KOG0575; Eukaryota.
DR InParanoid; F0VFE4; -.
DR OrthoDB; 202777at2759; -.
DR Proteomes; UP000007494; Chromosome VIIa.
DR GO; GO:0005524; F:ATP binding; IEA:InterPro.
DR GO; GO:0004672; F:protein kinase activity; IEA:InterPro.
DR GO; GO:0016310; P:phosphorylation; IEA:UniProtKB-KW.
DR Gene3D; 1.10.510.10; Transferase(Phosphotransferase) domain 1; 1.
DR InterPro; IPR027916; Kinase-like_dom_Apicomplexa.
DR InterPro; IPR011009; Kinase-like_dom_sf.
DR InterPro; IPR000719; Prot_kinase_dom.
DR PANTHER; PTHR24345; SERINE/THREONINE-PROTEIN KINASE PLK; 1.
DR PANTHER; PTHR24345:SF0; SERINE_THREONINE-PROTEIN KINASE PLK1; 1.
DR Pfam; PF14531; Kinase-like; 1.
DR SMART; SM00220; S_TKc; 1.
DR SUPFAM; SSF56112; Protein kinase-like (PK-like); 1.
DR PROSITE; PS50011; PROTEIN_KINASE_DOM; 1.
PE 4: Predicted;
KW Kinase {ECO:0000313|EMBL:CEL66412.1};
KW Reference proteome {ECO:0000313|Proteomes:UP000007494};
KW Transferase {ECO:0000313|EMBL:CEL66412.1}.
FT DOMAIN 350..677
FT /note="Protein kinase"
FT /evidence="ECO:0000259|PROSITE:PS50011"
FT REGION 67..163
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 191..255
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 67..86
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 114..129
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 201..216
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 691 AA; 76447 MW; 9AD70E22C91F2D23 CRC64;
MRRPKSGCTA GSFVNGLAVH RLWLLVLFSA LWFTPAILSP SRAAGPPRAF FPLHAQLSRI
FFPAKRTNGA STGSSSSQQL VEMEPTQPES LPSEPLPPST INARQRPERR QRLQSGSLTE
ASVSSENHGA RLPAQVDVSP DTPDVPPGGS MQQDLPTVDP AAGLSPQTTH LGAPWHFLRN
QMRSAARKAR SVSQSVTISE NRVNRHHRDS LETRSPTFHT EPETGRLTAR RQRLMTSPPH
IDSDDGPGKG TAAPNRIQSG TFLVCRLLTT DMSAGHAELQ KRLGARTGGT RNRLQAEECE
HAHGAHFALQ LGDRRQKFSR APIEFALDAT FPRETDVQFK SDISRKIVTL RRGRVLGVGS
RCIVVEVMRV ETGDKWALKA FVVPRHQFPT HGTPPPWDTF NKEAFAIQQL KHTVPVVVYR
NLRFLVPTDV LTLQGDKTEA LRNRHEIGPA FFATYLLFPL AEGSLSDVIE VMFPETKASN
AVVLRDNEAQ ALGARLTFSL QIVRLTALLH GQGVVHGDLQ AKSFFLCQDG SLFLGGFRHL
VRAGDPYQSP RPETVGTRCT PPEVLTPPKN AKFTFSLNAW GVGCILYQLW CGVLPFDLSP
KPETTTRVIL PHLLTPPYLL KKRFGKGSNS ASPAKFLRFR GCVQNMPVEM HDLIGRMLQE
NPRSRLLPTQ AVGDPVFKRV EEQSLVQEVQ I
//
