ID F0VFU8_NEOCL Unreviewed; 970 AA.
AC F0VFU8;
DT 03-MAY-2011, integrated into UniProtKB/TrEMBL.
DT 03-MAY-2011, sequence version 1.
DT 24-JAN-2024, entry version 56.
DE SubName: Full=ATP-dependent chaperone ClpB, related {ECO:0000313|EMBL:CBZ52592.1};
GN ORFNames=BN1204_023810 {ECO:0000313|EMBL:CEL66570.1}, NCLIV_023810
GN {ECO:0000313|EMBL:CBZ52592.1};
OS Neospora caninum (strain Liverpool).
OC Eukaryota; Sar; Alveolata; Apicomplexa; Conoidasida; Coccidia;
OC Eucoccidiorida; Eimeriorina; Sarcocystidae; Neospora.
OX NCBI_TaxID=572307 {ECO:0000313|EMBL:CBZ52592.1, ECO:0000313|Proteomes:UP000007494};
RN [1] {ECO:0000313|EMBL:CBZ52592.1}
RP NUCLEOTIDE SEQUENCE.
RC STRAIN=Liverpool {ECO:0000313|EMBL:CBZ52592.1};
RA Aslett M.;
RL Submitted (FEB-2011) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|EMBL:CBZ52592.1}
RP NUCLEOTIDE SEQUENCE.
RC STRAIN=Liverpool {ECO:0000313|EMBL:CBZ52592.1};
RA Reid A.J., Sohal A., Harris D., Quail M., Sanders M., Berriman M.,
RA Wastling J.M., Pain A.;
RT "Comparative genomics and transcriptomics of Neospora caninum and
RT Toxoplasma gondii.";
RL Submitted (MAR-2011) to the EMBL/GenBank/DDBJ databases.
RN [3] {ECO:0000313|Proteomes:UP000007494}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Liverpool {ECO:0000313|Proteomes:UP000007494};
RX PubMed=22457617; DOI=10.1371/journal.ppat.1002567;
RA Reid A.J., Vermont S.J., Cotton J.A., Harris D., Hill-Cawthorne G.A.,
RA Konen-Waisman S., Latham S.M., Mourier T., Norton R., Quail M.A.,
RA Sanders M., Shanmugam D., Sohal A., Wasmuth J.D., Brunk B., Grigg M.E.,
RA Howard J.C., Parkinson J., Roos D.S., Trees A.J., Berriman M., Pain A.,
RA Wastling J.M.;
RT "Comparative genomics of the apicomplexan parasites Toxoplasma gondii and
RT Neospora caninum: Coccidia differing in host range and transmission
RT strategy.";
RL PLoS Pathog. 8:e1002567-e1002567(2012).
RN [4] {ECO:0000313|EMBL:CEL66570.1}
RP NUCLEOTIDE SEQUENCE.
RC STRAIN=Liverpool {ECO:0000313|EMBL:CEL66570.1};
RX PubMed=25875305; DOI=10.1371/journal.pone.0124473;
RA Ramaprasad A., Mourier T., Naeem R., Malas T.B., Moussa E., Panigrahi A.,
RA Vermont S.J., Otto T.D., Wastling J., Pain A.;
RT "Comprehensive Evaluation of Toxoplasma gondii VEG and Neospora caninum LIV
RT Genomes with Tachyzoite Stage Transcriptome and Proteome Defines Novel
RT Transcript Features.";
RL PLoS ONE 10:e0124473-e0124473(2015).
CC -!- SIMILARITY: Belongs to the ClpA/ClpB family.
CC {ECO:0000256|RuleBase:RU004432}.
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DR EMBL; FR823388; CBZ52592.1; -; Genomic_DNA.
DR EMBL; LN714481; CEL66570.1; -; Genomic_DNA.
DR RefSeq; XP_003882624.1; XM_003882575.1.
DR AlphaFoldDB; F0VFU8; -.
DR GeneID; 13444751; -.
DR VEuPathDB; ToxoDB:NCLIV_023810; -.
DR eggNOG; KOG1051; Eukaryota.
DR InParanoid; F0VFU8; -.
DR OrthoDB; 35211at2759; -.
DR Proteomes; UP000007494; Chromosome VIIa.
DR GO; GO:0005524; F:ATP binding; IEA:UniProtKB-KW.
DR GO; GO:0016887; F:ATP hydrolysis activity; IEA:InterPro.
DR CDD; cd00009; AAA; 1.
DR CDD; cd19499; RecA-like_ClpB_Hsp104-like; 1.
DR Gene3D; 1.10.8.60; -; 2.
DR Gene3D; 1.10.1780.10; Clp, N-terminal domain; 1.
DR Gene3D; 3.40.50.300; P-loop containing nucleotide triphosphate hydrolases; 2.
DR InterPro; IPR003593; AAA+_ATPase.
DR InterPro; IPR003959; ATPase_AAA_core.
DR InterPro; IPR019489; Clp_ATPase_C.
DR InterPro; IPR036628; Clp_N_dom_sf.
DR InterPro; IPR004176; Clp_R_dom.
DR InterPro; IPR001270; ClpA/B.
DR InterPro; IPR018368; ClpA/B_CS1.
DR InterPro; IPR028299; ClpA/B_CS2.
DR InterPro; IPR041546; ClpA/ClpB_AAA_lid.
DR InterPro; IPR027417; P-loop_NTPase.
DR PANTHER; PTHR11638; ATP-DEPENDENT CLP PROTEASE; 1.
DR PANTHER; PTHR11638:SF18; HEAT SHOCK PROTEIN 104; 1.
DR Pfam; PF00004; AAA; 1.
DR Pfam; PF07724; AAA_2; 1.
DR Pfam; PF17871; AAA_lid_9; 1.
DR Pfam; PF02861; Clp_N; 2.
DR Pfam; PF10431; ClpB_D2-small; 1.
DR PRINTS; PR00300; CLPPROTEASEA.
DR SMART; SM00382; AAA; 2.
DR SMART; SM01086; ClpB_D2-small; 1.
DR SUPFAM; SSF81923; Double Clp-N motif; 1.
DR SUPFAM; SSF52540; P-loop containing nucleoside triphosphate hydrolases; 2.
DR PROSITE; PS51903; CLP_R; 1.
DR PROSITE; PS00870; CLPAB_1; 1.
DR PROSITE; PS00871; CLPAB_2; 1.
PE 3: Inferred from homology;
KW ATP-binding {ECO:0000256|ARBA:ARBA00022840, ECO:0000256|RuleBase:RU004432};
KW Chaperone {ECO:0000256|ARBA:ARBA00023186, ECO:0000256|RuleBase:RU004432};
KW Nucleotide-binding {ECO:0000256|ARBA:ARBA00022741,
KW ECO:0000256|RuleBase:RU004432};
KW Reference proteome {ECO:0000313|Proteomes:UP000007494};
KW Repeat {ECO:0000256|ARBA:ARBA00022737, ECO:0000256|PROSITE-
KW ProRule:PRU01251}; Signal {ECO:0000256|SAM:SignalP}.
FT SIGNAL 1..39
FT /evidence="ECO:0000256|SAM:SignalP"
FT CHAIN 40..970
FT /evidence="ECO:0000256|SAM:SignalP"
FT /id="PRO_5007655054"
FT DOMAIN 54..202
FT /note="Clp R"
FT /evidence="ECO:0000259|PROSITE:PS51903"
FT REGION 39..60
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 207..234
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 488..525
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 214..230
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 970 AA; 106884 MW; F9CB0D6D82BF909E CRC64;
MAGARRVPTG SRAASARRLM LAAAFAIFAL TWQTRGVEAG TSSSGSTPAP GGKLDKPASI
SRDAREQLDQ AEVLAMYMHH RHITPVHFLT VLLEVQGDYS ITKSLQECGG NLYELKKALS
NVLIKLPTSS EVYIVDEVES TAQLKRVALR ALNIAQKDKK QTIGMEHLIL SLFEERNLRT
MLEQVGCNVK VFLEHSTAMY ETKFKEDVAN RSKKKQGSTS ASSTSESTPE NSDEEFVKSF
GVDMTQLAAD GKLEPVVGRN KEIKEVITVL SRKGKGNPCL IGEPGVGKTA VVEGLAQRLI
EGMVPKSLEN KILFAVDLGA LIAGATYRGE FEKRMKALLR YAVGQEGRVI LFIDEIHMLM
GAGKSDGTVD AANLLKPPMA RGEIRLVGAT TQEEYKIIER DAAMERRLKP ILVEEPTTDR
AIYILRKLKE KFERHHEMTI SDEAIVSAVM LSHKYIKNRK LPDKAIDLLD EAAATKRVKW
DLRTVDDDEM ASEKKQKEKL EEEHRKVEEQ DKKRIEGQHH GAGTEEELKL LEKEIEQEAL
EEEQELVLTA DDVAVVISSW TGIPVAKLTD DEKGKILRLS DLLHSRVIGQ EDAVKAVADA
MVRARAGLSR EGMPVGSFLF LGPTGVGKTE LAKALAAEMF HSEKNLIRID MSEFSEAHSV
SRLIGSPPGY VGHEAGGQLT EAVRRRPHSV VLFDEIEKGH QQILNIMLQM LDEGRLTDGK
GLLVDFTNCV IILTSNVGAQ YIISAYEQGE KDSRSALATF DPKSGSLEQF AEATKAAQVA
AESDDAASAK TDKKGAVLDK NKKSGNWKKE ARRKILSEIA GSGLLKPEVV NRFSGVIIFE
PMKPSDVRKI LSIQSKDLKE ALARKGIELV IDGSAEEFIV QRSYTHKFGA RPLKRFVDNQ
IGAKMAPWIL SGYLQPGMRV TVVASKRNKN TLEAHVCKVV MGKCDRTTRK ARVLASVAKK
DDSSPDDPGR
//