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Database: UniProt
Entry: F0VFU8_NEOCL
LinkDB: F0VFU8_NEOCL
Original site: F0VFU8_NEOCL 
ID   F0VFU8_NEOCL            Unreviewed;       970 AA.
AC   F0VFU8;
DT   03-MAY-2011, integrated into UniProtKB/TrEMBL.
DT   03-MAY-2011, sequence version 1.
DT   24-JAN-2024, entry version 56.
DE   SubName: Full=ATP-dependent chaperone ClpB, related {ECO:0000313|EMBL:CBZ52592.1};
GN   ORFNames=BN1204_023810 {ECO:0000313|EMBL:CEL66570.1}, NCLIV_023810
GN   {ECO:0000313|EMBL:CBZ52592.1};
OS   Neospora caninum (strain Liverpool).
OC   Eukaryota; Sar; Alveolata; Apicomplexa; Conoidasida; Coccidia;
OC   Eucoccidiorida; Eimeriorina; Sarcocystidae; Neospora.
OX   NCBI_TaxID=572307 {ECO:0000313|EMBL:CBZ52592.1, ECO:0000313|Proteomes:UP000007494};
RN   [1] {ECO:0000313|EMBL:CBZ52592.1}
RP   NUCLEOTIDE SEQUENCE.
RC   STRAIN=Liverpool {ECO:0000313|EMBL:CBZ52592.1};
RA   Aslett M.;
RL   Submitted (FEB-2011) to the EMBL/GenBank/DDBJ databases.
RN   [2] {ECO:0000313|EMBL:CBZ52592.1}
RP   NUCLEOTIDE SEQUENCE.
RC   STRAIN=Liverpool {ECO:0000313|EMBL:CBZ52592.1};
RA   Reid A.J., Sohal A., Harris D., Quail M., Sanders M., Berriman M.,
RA   Wastling J.M., Pain A.;
RT   "Comparative genomics and transcriptomics of Neospora caninum and
RT   Toxoplasma gondii.";
RL   Submitted (MAR-2011) to the EMBL/GenBank/DDBJ databases.
RN   [3] {ECO:0000313|Proteomes:UP000007494}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=Liverpool {ECO:0000313|Proteomes:UP000007494};
RX   PubMed=22457617; DOI=10.1371/journal.ppat.1002567;
RA   Reid A.J., Vermont S.J., Cotton J.A., Harris D., Hill-Cawthorne G.A.,
RA   Konen-Waisman S., Latham S.M., Mourier T., Norton R., Quail M.A.,
RA   Sanders M., Shanmugam D., Sohal A., Wasmuth J.D., Brunk B., Grigg M.E.,
RA   Howard J.C., Parkinson J., Roos D.S., Trees A.J., Berriman M., Pain A.,
RA   Wastling J.M.;
RT   "Comparative genomics of the apicomplexan parasites Toxoplasma gondii and
RT   Neospora caninum: Coccidia differing in host range and transmission
RT   strategy.";
RL   PLoS Pathog. 8:e1002567-e1002567(2012).
RN   [4] {ECO:0000313|EMBL:CEL66570.1}
RP   NUCLEOTIDE SEQUENCE.
RC   STRAIN=Liverpool {ECO:0000313|EMBL:CEL66570.1};
RX   PubMed=25875305; DOI=10.1371/journal.pone.0124473;
RA   Ramaprasad A., Mourier T., Naeem R., Malas T.B., Moussa E., Panigrahi A.,
RA   Vermont S.J., Otto T.D., Wastling J., Pain A.;
RT   "Comprehensive Evaluation of Toxoplasma gondii VEG and Neospora caninum LIV
RT   Genomes with Tachyzoite Stage Transcriptome and Proteome Defines Novel
RT   Transcript Features.";
RL   PLoS ONE 10:e0124473-e0124473(2015).
CC   -!- SIMILARITY: Belongs to the ClpA/ClpB family.
CC       {ECO:0000256|RuleBase:RU004432}.
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DR   EMBL; FR823388; CBZ52592.1; -; Genomic_DNA.
DR   EMBL; LN714481; CEL66570.1; -; Genomic_DNA.
DR   RefSeq; XP_003882624.1; XM_003882575.1.
DR   AlphaFoldDB; F0VFU8; -.
DR   GeneID; 13444751; -.
DR   VEuPathDB; ToxoDB:NCLIV_023810; -.
DR   eggNOG; KOG1051; Eukaryota.
DR   InParanoid; F0VFU8; -.
DR   OrthoDB; 35211at2759; -.
DR   Proteomes; UP000007494; Chromosome VIIa.
DR   GO; GO:0005524; F:ATP binding; IEA:UniProtKB-KW.
DR   GO; GO:0016887; F:ATP hydrolysis activity; IEA:InterPro.
DR   CDD; cd00009; AAA; 1.
DR   CDD; cd19499; RecA-like_ClpB_Hsp104-like; 1.
DR   Gene3D; 1.10.8.60; -; 2.
DR   Gene3D; 1.10.1780.10; Clp, N-terminal domain; 1.
DR   Gene3D; 3.40.50.300; P-loop containing nucleotide triphosphate hydrolases; 2.
DR   InterPro; IPR003593; AAA+_ATPase.
DR   InterPro; IPR003959; ATPase_AAA_core.
DR   InterPro; IPR019489; Clp_ATPase_C.
DR   InterPro; IPR036628; Clp_N_dom_sf.
DR   InterPro; IPR004176; Clp_R_dom.
DR   InterPro; IPR001270; ClpA/B.
DR   InterPro; IPR018368; ClpA/B_CS1.
DR   InterPro; IPR028299; ClpA/B_CS2.
DR   InterPro; IPR041546; ClpA/ClpB_AAA_lid.
DR   InterPro; IPR027417; P-loop_NTPase.
DR   PANTHER; PTHR11638; ATP-DEPENDENT CLP PROTEASE; 1.
DR   PANTHER; PTHR11638:SF18; HEAT SHOCK PROTEIN 104; 1.
DR   Pfam; PF00004; AAA; 1.
DR   Pfam; PF07724; AAA_2; 1.
DR   Pfam; PF17871; AAA_lid_9; 1.
DR   Pfam; PF02861; Clp_N; 2.
DR   Pfam; PF10431; ClpB_D2-small; 1.
DR   PRINTS; PR00300; CLPPROTEASEA.
DR   SMART; SM00382; AAA; 2.
DR   SMART; SM01086; ClpB_D2-small; 1.
DR   SUPFAM; SSF81923; Double Clp-N motif; 1.
DR   SUPFAM; SSF52540; P-loop containing nucleoside triphosphate hydrolases; 2.
DR   PROSITE; PS51903; CLP_R; 1.
DR   PROSITE; PS00870; CLPAB_1; 1.
DR   PROSITE; PS00871; CLPAB_2; 1.
PE   3: Inferred from homology;
KW   ATP-binding {ECO:0000256|ARBA:ARBA00022840, ECO:0000256|RuleBase:RU004432};
KW   Chaperone {ECO:0000256|ARBA:ARBA00023186, ECO:0000256|RuleBase:RU004432};
KW   Nucleotide-binding {ECO:0000256|ARBA:ARBA00022741,
KW   ECO:0000256|RuleBase:RU004432};
KW   Reference proteome {ECO:0000313|Proteomes:UP000007494};
KW   Repeat {ECO:0000256|ARBA:ARBA00022737, ECO:0000256|PROSITE-
KW   ProRule:PRU01251}; Signal {ECO:0000256|SAM:SignalP}.
FT   SIGNAL          1..39
FT                   /evidence="ECO:0000256|SAM:SignalP"
FT   CHAIN           40..970
FT                   /evidence="ECO:0000256|SAM:SignalP"
FT                   /id="PRO_5007655054"
FT   DOMAIN          54..202
FT                   /note="Clp R"
FT                   /evidence="ECO:0000259|PROSITE:PS51903"
FT   REGION          39..60
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          207..234
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          488..525
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        214..230
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   970 AA;  106884 MW;  F9CB0D6D82BF909E CRC64;
     MAGARRVPTG SRAASARRLM LAAAFAIFAL TWQTRGVEAG TSSSGSTPAP GGKLDKPASI
     SRDAREQLDQ AEVLAMYMHH RHITPVHFLT VLLEVQGDYS ITKSLQECGG NLYELKKALS
     NVLIKLPTSS EVYIVDEVES TAQLKRVALR ALNIAQKDKK QTIGMEHLIL SLFEERNLRT
     MLEQVGCNVK VFLEHSTAMY ETKFKEDVAN RSKKKQGSTS ASSTSESTPE NSDEEFVKSF
     GVDMTQLAAD GKLEPVVGRN KEIKEVITVL SRKGKGNPCL IGEPGVGKTA VVEGLAQRLI
     EGMVPKSLEN KILFAVDLGA LIAGATYRGE FEKRMKALLR YAVGQEGRVI LFIDEIHMLM
     GAGKSDGTVD AANLLKPPMA RGEIRLVGAT TQEEYKIIER DAAMERRLKP ILVEEPTTDR
     AIYILRKLKE KFERHHEMTI SDEAIVSAVM LSHKYIKNRK LPDKAIDLLD EAAATKRVKW
     DLRTVDDDEM ASEKKQKEKL EEEHRKVEEQ DKKRIEGQHH GAGTEEELKL LEKEIEQEAL
     EEEQELVLTA DDVAVVISSW TGIPVAKLTD DEKGKILRLS DLLHSRVIGQ EDAVKAVADA
     MVRARAGLSR EGMPVGSFLF LGPTGVGKTE LAKALAAEMF HSEKNLIRID MSEFSEAHSV
     SRLIGSPPGY VGHEAGGQLT EAVRRRPHSV VLFDEIEKGH QQILNIMLQM LDEGRLTDGK
     GLLVDFTNCV IILTSNVGAQ YIISAYEQGE KDSRSALATF DPKSGSLEQF AEATKAAQVA
     AESDDAASAK TDKKGAVLDK NKKSGNWKKE ARRKILSEIA GSGLLKPEVV NRFSGVIIFE
     PMKPSDVRKI LSIQSKDLKE ALARKGIELV IDGSAEEFIV QRSYTHKFGA RPLKRFVDNQ
     IGAKMAPWIL SGYLQPGMRV TVVASKRNKN TLEAHVCKVV MGKCDRTTRK ARVLASVAKK
     DDSSPDDPGR
//
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