ID F0VGM4_NEOCL Unreviewed; 1458 AA.
AC F0VGM4;
DT 03-MAY-2011, integrated into UniProtKB/TrEMBL.
DT 03-MAY-2011, sequence version 1.
DT 24-JAN-2024, entry version 39.
DE RecName: Full=C2 domain-containing protein {ECO:0000259|PROSITE:PS50004};
GN ORFNames=NCLIV_026570 {ECO:0000313|EMBL:CBZ52868.1};
OS Neospora caninum (strain Liverpool).
OC Eukaryota; Sar; Alveolata; Apicomplexa; Conoidasida; Coccidia;
OC Eucoccidiorida; Eimeriorina; Sarcocystidae; Neospora.
OX NCBI_TaxID=572307 {ECO:0000313|EMBL:CBZ52868.1, ECO:0000313|Proteomes:UP000007494};
RN [1] {ECO:0000313|Proteomes:UP000007494}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Liverpool {ECO:0000313|Proteomes:UP000007494};
RX PubMed=22457617; DOI=10.1371/journal.ppat.1002567;
RA Reid A.J., Vermont S.J., Cotton J.A., Harris D., Hill-Cawthorne G.A.,
RA Konen-Waisman S., Latham S.M., Mourier T., Norton R., Quail M.A.,
RA Sanders M., Shanmugam D., Sohal A., Wasmuth J.D., Brunk B., Grigg M.E.,
RA Howard J.C., Parkinson J., Roos D.S., Trees A.J., Berriman M., Pain A.,
RA Wastling J.M.;
RT "Comparative genomics of the apicomplexan parasites Toxoplasma gondii and
RT Neospora caninum: Coccidia differing in host range and transmission
RT strategy.";
RL PLoS Pathog. 8:e1002567-e1002567(2012).
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DR EMBL; FR823389; CBZ52868.1; -; Genomic_DNA.
DR RefSeq; XP_003882900.1; XM_003882851.1.
DR GeneID; 13442819; -.
DR VEuPathDB; ToxoDB:NCLIV_026570; -.
DR eggNOG; KOG1326; Eukaryota.
DR InParanoid; F0VGM4; -.
DR OrthoDB; 991411at2759; -.
DR Proteomes; UP000007494; Chromosome VIIb.
DR GO; GO:0016020; C:membrane; IEA:UniProtKB-KW.
DR CDD; cd00030; C2; 2.
DR CDD; cd08374; C2F_Ferlin; 1.
DR Gene3D; 2.60.40.150; C2 domain; 5.
DR InterPro; IPR000008; C2_dom.
DR InterPro; IPR035892; C2_domain_sf.
DR InterPro; IPR037725; C2F_Ferlin.
DR InterPro; IPR037721; Ferlin.
DR PANTHER; PTHR12546; FER-1-LIKE; 1.
DR PANTHER; PTHR12546:SF33; SPERM VESICLE FUSION PROTEIN FER-1; 1.
DR Pfam; PF00168; C2; 5.
DR SMART; SM00239; C2; 5.
DR SUPFAM; SSF49562; C2 domain (Calcium/lipid-binding domain, CaLB); 5.
DR PROSITE; PS50004; C2; 5.
PE 4: Predicted;
KW Membrane {ECO:0000256|SAM:Phobius};
KW Reference proteome {ECO:0000313|Proteomes:UP000007494};
KW Transmembrane {ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|SAM:Phobius}.
FT TRANSMEM 1430..1453
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 1..111
FT /note="C2"
FT /evidence="ECO:0000259|PROSITE:PS50004"
FT DOMAIN 161..280
FT /note="C2"
FT /evidence="ECO:0000259|PROSITE:PS50004"
FT DOMAIN 552..678
FT /note="C2"
FT /evidence="ECO:0000259|PROSITE:PS50004"
FT DOMAIN 1063..1186
FT /note="C2"
FT /evidence="ECO:0000259|PROSITE:PS50004"
FT DOMAIN 1221..1350
FT /note="C2"
FT /evidence="ECO:0000259|PROSITE:PS50004"
FT REGION 1389..1409
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 1458 AA; 164360 MW; 7E9991B78C54FF1B CRC64;
MGKTKIYSVG FTVHEAQNLV TEKGQPVDPL VVVRCCGREY RTEVKYAKSN VVSWDESHAW
TDLCLTDEEW EAAYITFEVQ AANAFWRNTL LGLVSVQLRL IQLRKTHQIR KALPLQHPDD
TDVHGSLRVT IFACAPGEAP PSPGEEEVVE EEDNNDYDDL RKAVIDTNQV VEREAGSRLY
HVYVTAYRVE DLPTSSKGTR DPFVTCEFAG CKLKSMQARG CCSHTFNECF RFPVVTPLPE
DAILIKVWDW NFMRADELIA VSPFVNVAYS IHRLGQDIFF GAANSPDASE ASDGGRGHLA
SFFFMMRRFS KRHRGTLWFN LYGFDDKEVA QATKVAGQGG RLVANCYLGR ILLSARAERL
TKEDDLMPAH TVAARPYETP PVIPLALLAD IYEVQGAPGE KVSVEIWCGP ARARTKWVMG
LESKAAQRAG AAPQALNRAI EGALGVANYL MGEVPEGEDR FPFDNFEGRV EDLRLVVPED
TKQQWDVIIS VHVRGSTKGF MGDTRIAFQR LKMSKVPVHT HNNPRTPVWV PLISTPPFES
MKPAPAILMC IEKSKVESFA RSKRKHVTAV DYQLRAYVYA ARNLLSPSGA LPNPFVQVAC
AGNARETEVF EQTSSPVFMD CLLLDITMMT DPVSRLPTVA PIVVTLYEQR SWGTQFLGRA
TCHYDRLRGR LKPGEAPTVA EPRWIKLRGG KYANRHLGDV LLMLELIRKR DAQLIPAFPM
RPVVNMCTLT FSCLGLRSLY MTQRAKRLDY VSIRKGEDVK AELRRIRGPV IRVSVSSFAS
AGRGNNEAIL RYERNLPEDP TIVNKHWTTV TKAANTDIFK VAYMEIDVPV DPIYDPRLVV
QVYDRKQKPK YFIGEYSMSL VPLMPWVLDQ QGAIEAVAPL NDFTDTVDLK HIGGLMRGFH
GSSKKSGTGQ IGLEALSAAD RETADAHKEL TLAQSRFATY DPDNKRLDVR RNAGILCNMD
WRHRNSLMSF RGRASELLLV WFVLFAEGKR AADKKTKEQY ARPSVDSTLE QFLDDVTFPS
DSLKKSVMGD IDVTGFVKFF VNLTHHDEPN PHVDPAAVEL ASSEDRMRRN LRGEEAYPKL
MKIRVYVIRA ISLYVGDDRI VPNPYLLFNL GDKSDTLRAE AKSNTHNPEF FTVWEKDVMF
PDDSQFELQV WSAHEGVSGG LEDIYIGSTC IDLEERWFSK EWQKSMSKNQ VPMEYRPLKQ
MPGGSFKGTV EMWVELMDFQ KAGEVPKFDL QSPAATEVEI RVIVWGARNL AVKILGKDFI
DAMIRCNLDC TGYRGTQPAA QQTDVHYYSK TGAAIFNWRM VYSRVQMPVS TCVLQIAAYD
NRNMGQASFV GEVNLELRRY LERVASTLNS IDVDAELKLI NRSRESADIS TFGFVQVSLQ
FISQSEATSK PVGLGRDSPN RDPRLTTPQE GRKWEDVLGS AGLRVDYRPL WYWVRVAAVV
FLCIWVFVVA FLYPSLLG
//
