ID F0VH54_NEOCL Unreviewed; 928 AA.
AC F0VH54;
DT 03-MAY-2011, integrated into UniProtKB/TrEMBL.
DT 03-MAY-2011, sequence version 1.
DT 24-JAN-2024, entry version 58.
DE SubName: Full=ATP-dependent Clp protease, Hsp 100, ATP-binding subunit ClpB, putative {ECO:0000313|EMBL:CEL67032.1};
GN ORFNames=BN1204_028370 {ECO:0000313|EMBL:CEL67032.1}, NCLIV_028370
GN {ECO:0000313|EMBL:CBZ53048.1};
OS Neospora caninum (strain Liverpool).
OC Eukaryota; Sar; Alveolata; Apicomplexa; Conoidasida; Coccidia;
OC Eucoccidiorida; Eimeriorina; Sarcocystidae; Neospora.
OX NCBI_TaxID=572307 {ECO:0000313|EMBL:CBZ53048.1, ECO:0000313|Proteomes:UP000007494};
RN [1] {ECO:0000313|EMBL:CBZ53048.1}
RP NUCLEOTIDE SEQUENCE.
RC STRAIN=Liverpool {ECO:0000313|EMBL:CBZ53048.1};
RA Aslett M.;
RL Submitted (FEB-2011) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|EMBL:CBZ53048.1}
RP NUCLEOTIDE SEQUENCE.
RC STRAIN=Liverpool {ECO:0000313|EMBL:CBZ53048.1};
RA Reid A.J., Sohal A., Harris D., Quail M., Sanders M., Berriman M.,
RA Wastling J.M., Pain A.;
RT "Comparative genomics and transcriptomics of Neospora caninum and
RT Toxoplasma gondii.";
RL Submitted (MAR-2011) to the EMBL/GenBank/DDBJ databases.
RN [3] {ECO:0000313|Proteomes:UP000007494}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Liverpool {ECO:0000313|Proteomes:UP000007494};
RX PubMed=22457617; DOI=10.1371/journal.ppat.1002567;
RA Reid A.J., Vermont S.J., Cotton J.A., Harris D., Hill-Cawthorne G.A.,
RA Konen-Waisman S., Latham S.M., Mourier T., Norton R., Quail M.A.,
RA Sanders M., Shanmugam D., Sohal A., Wasmuth J.D., Brunk B., Grigg M.E.,
RA Howard J.C., Parkinson J., Roos D.S., Trees A.J., Berriman M., Pain A.,
RA Wastling J.M.;
RT "Comparative genomics of the apicomplexan parasites Toxoplasma gondii and
RT Neospora caninum: Coccidia differing in host range and transmission
RT strategy.";
RL PLoS Pathog. 8:e1002567-e1002567(2012).
RN [4] {ECO:0000313|EMBL:CEL67032.1}
RP NUCLEOTIDE SEQUENCE.
RC STRAIN=Liverpool {ECO:0000313|EMBL:CEL67032.1};
RX PubMed=25875305; DOI=10.1371/journal.pone.0124473;
RA Ramaprasad A., Mourier T., Naeem R., Malas T.B., Moussa E., Panigrahi A.,
RA Vermont S.J., Otto T.D., Wastling J., Pain A.;
RT "Comprehensive Evaluation of Toxoplasma gondii VEG and Neospora caninum LIV
RT Genomes with Tachyzoite Stage Transcriptome and Proteome Defines Novel
RT Transcript Features.";
RL PLoS ONE 10:e0124473-e0124473(2015).
CC -!- SIMILARITY: Belongs to the ClpA/ClpB family.
CC {ECO:0000256|RuleBase:RU004432}.
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DR EMBL; FR823389; CBZ53048.1; -; Genomic_DNA.
DR EMBL; LN714482; CEL67032.1; -; Genomic_DNA.
DR RefSeq; XP_003883080.1; XM_003883031.1.
DR AlphaFoldDB; F0VH54; -.
DR GeneID; 13443157; -.
DR VEuPathDB; ToxoDB:NCLIV_028370; -.
DR eggNOG; KOG1051; Eukaryota.
DR InParanoid; F0VH54; -.
DR OrthoDB; 35211at2759; -.
DR Proteomes; UP000007494; Chromosome VIIb.
DR GO; GO:0005524; F:ATP binding; IEA:UniProtKB-KW.
DR GO; GO:0016887; F:ATP hydrolysis activity; IEA:InterPro.
DR GO; GO:0008233; F:peptidase activity; IEA:UniProtKB-KW.
DR GO; GO:0006508; P:proteolysis; IEA:UniProtKB-KW.
DR CDD; cd00009; AAA; 1.
DR CDD; cd19499; RecA-like_ClpB_Hsp104-like; 1.
DR Gene3D; 1.10.8.60; -; 1.
DR Gene3D; 1.10.1780.10; Clp, N-terminal domain; 1.
DR Gene3D; 3.40.50.300; P-loop containing nucleotide triphosphate hydrolases; 3.
DR InterPro; IPR003593; AAA+_ATPase.
DR InterPro; IPR003959; ATPase_AAA_core.
DR InterPro; IPR019489; Clp_ATPase_C.
DR InterPro; IPR036628; Clp_N_dom_sf.
DR InterPro; IPR004176; Clp_R_dom.
DR InterPro; IPR001270; ClpA/B.
DR InterPro; IPR018368; ClpA/B_CS1.
DR InterPro; IPR028299; ClpA/B_CS2.
DR InterPro; IPR041546; ClpA/ClpB_AAA_lid.
DR InterPro; IPR027417; P-loop_NTPase.
DR PANTHER; PTHR11638; ATP-DEPENDENT CLP PROTEASE; 1.
DR PANTHER; PTHR11638:SF18; HEAT SHOCK PROTEIN 104; 1.
DR Pfam; PF00004; AAA; 1.
DR Pfam; PF07724; AAA_2; 1.
DR Pfam; PF17871; AAA_lid_9; 1.
DR Pfam; PF02861; Clp_N; 2.
DR Pfam; PF10431; ClpB_D2-small; 1.
DR PRINTS; PR00300; CLPPROTEASEA.
DR SMART; SM00382; AAA; 2.
DR SMART; SM01086; ClpB_D2-small; 1.
DR SUPFAM; SSF81923; Double Clp-N motif; 1.
DR SUPFAM; SSF52540; P-loop containing nucleoside triphosphate hydrolases; 2.
DR PROSITE; PS51903; CLP_R; 1.
DR PROSITE; PS00870; CLPAB_1; 1.
DR PROSITE; PS00871; CLPAB_2; 1.
PE 3: Inferred from homology;
KW ATP-binding {ECO:0000256|ARBA:ARBA00022840, ECO:0000256|RuleBase:RU004432};
KW Chaperone {ECO:0000256|ARBA:ARBA00023186, ECO:0000256|RuleBase:RU004432};
KW Coiled coil {ECO:0000256|SAM:Coils};
KW Hydrolase {ECO:0000313|EMBL:CEL67032.1};
KW Nucleotide-binding {ECO:0000256|ARBA:ARBA00022741,
KW ECO:0000256|RuleBase:RU004432}; Protease {ECO:0000313|EMBL:CEL67032.1};
KW Reference proteome {ECO:0000313|Proteomes:UP000007494};
KW Repeat {ECO:0000256|ARBA:ARBA00022737, ECO:0000256|PROSITE-
KW ProRule:PRU01251}.
FT DOMAIN 1..145
FT /note="Clp R"
FT /evidence="ECO:0000259|PROSITE:PS51903"
FT REGION 877..928
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COILED 470..524
FT /evidence="ECO:0000256|SAM:Coils"
FT COMPBIAS 896..919
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 928 AA; 104299 MW; 3257698826BB2DC7 CRC64;
MDADAWTTLV KKAFLAGQEV CRERRNPQLD PLHLFEAMLR DKQSFASQVL SQCPGDFAQL
KEDVHRAVLK FPQQNPPPDF PSPNHALMAV LRHGKEIQRQ LNDSLMSADS LFLALVQEKS
IRGLLTEAGF MMKQIEEKAK SVRGLRKISS SDDDANFEAL KKYGTDFTDL AEKGKLDPVI
GREDEIRRVI RILCRRTKNN PVLIGEPGVG KSAIVEGLAR RIVENDVPSN LRCRLVSLDV
GALISGAKYR GEFEERLTAV LKEVKDAAGK VILFIDEIHV ILGAGKTEGA LDAANLLKPM
LARGELRCIG ATTLDEYRKH VEKDAAFERR FQQVHVREPS VQATISILRG LKDRYASHHG
VRILDSALVE AAQLADRYIT ARFLPDKAID LMDEACAIAR VQVDSKPEAV DVLERQKVQL
EVEVLALEKE KDPASQKRLA EVRQHLGEIA DALRPLYLQY QQEKGRIDEL GKLAQKQDEL
KAKIDRAQRV GDLDLVAELR FDALPGVEAR FKKLQAEQEE YERTHKPLLT EVVGPEQIAD
VVQRWTNIPV HKLTQTETER LLAFGKTLAE QVIGQPQAVE AVSQAILRSA AGLSKRNKPI
GSFLFLGPTG VGKTELCKRV AESLFDTKER LVRFDMSEYM EQHSVSRLIG APPGYVGHDE
GGQLTEEIRR NPYSVVLFDE VEKAHSQVWN VLLQVLDDGR LTDSQGRTVD FSNTIIILTS
NLGAAFLLEA AQRVGTEEQL AAEAAAKEMV MMEVRKFFKP EMLNRLDDIV IFKALTNVNL
RQVMNLQMEE VRERLAEKRI ELTLTDRATD HVVHEAFDPA YGARPLKRFV ERHIVSDLSL
KLLKGEIVPD SRVLCDWDEK RRAWVWETTT AVESTASVRK TPGHPVEAEM DAESLSPDSR
TLSLGSRTDS YTNRSSAMHE TNAKKFRY
//