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Database: UniProt
Entry: F0VH54_NEOCL
LinkDB: F0VH54_NEOCL
Original site: F0VH54_NEOCL 
ID   F0VH54_NEOCL            Unreviewed;       928 AA.
AC   F0VH54;
DT   03-MAY-2011, integrated into UniProtKB/TrEMBL.
DT   03-MAY-2011, sequence version 1.
DT   24-JAN-2024, entry version 58.
DE   SubName: Full=ATP-dependent Clp protease, Hsp 100, ATP-binding subunit ClpB, putative {ECO:0000313|EMBL:CEL67032.1};
GN   ORFNames=BN1204_028370 {ECO:0000313|EMBL:CEL67032.1}, NCLIV_028370
GN   {ECO:0000313|EMBL:CBZ53048.1};
OS   Neospora caninum (strain Liverpool).
OC   Eukaryota; Sar; Alveolata; Apicomplexa; Conoidasida; Coccidia;
OC   Eucoccidiorida; Eimeriorina; Sarcocystidae; Neospora.
OX   NCBI_TaxID=572307 {ECO:0000313|EMBL:CBZ53048.1, ECO:0000313|Proteomes:UP000007494};
RN   [1] {ECO:0000313|EMBL:CBZ53048.1}
RP   NUCLEOTIDE SEQUENCE.
RC   STRAIN=Liverpool {ECO:0000313|EMBL:CBZ53048.1};
RA   Aslett M.;
RL   Submitted (FEB-2011) to the EMBL/GenBank/DDBJ databases.
RN   [2] {ECO:0000313|EMBL:CBZ53048.1}
RP   NUCLEOTIDE SEQUENCE.
RC   STRAIN=Liverpool {ECO:0000313|EMBL:CBZ53048.1};
RA   Reid A.J., Sohal A., Harris D., Quail M., Sanders M., Berriman M.,
RA   Wastling J.M., Pain A.;
RT   "Comparative genomics and transcriptomics of Neospora caninum and
RT   Toxoplasma gondii.";
RL   Submitted (MAR-2011) to the EMBL/GenBank/DDBJ databases.
RN   [3] {ECO:0000313|Proteomes:UP000007494}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=Liverpool {ECO:0000313|Proteomes:UP000007494};
RX   PubMed=22457617; DOI=10.1371/journal.ppat.1002567;
RA   Reid A.J., Vermont S.J., Cotton J.A., Harris D., Hill-Cawthorne G.A.,
RA   Konen-Waisman S., Latham S.M., Mourier T., Norton R., Quail M.A.,
RA   Sanders M., Shanmugam D., Sohal A., Wasmuth J.D., Brunk B., Grigg M.E.,
RA   Howard J.C., Parkinson J., Roos D.S., Trees A.J., Berriman M., Pain A.,
RA   Wastling J.M.;
RT   "Comparative genomics of the apicomplexan parasites Toxoplasma gondii and
RT   Neospora caninum: Coccidia differing in host range and transmission
RT   strategy.";
RL   PLoS Pathog. 8:e1002567-e1002567(2012).
RN   [4] {ECO:0000313|EMBL:CEL67032.1}
RP   NUCLEOTIDE SEQUENCE.
RC   STRAIN=Liverpool {ECO:0000313|EMBL:CEL67032.1};
RX   PubMed=25875305; DOI=10.1371/journal.pone.0124473;
RA   Ramaprasad A., Mourier T., Naeem R., Malas T.B., Moussa E., Panigrahi A.,
RA   Vermont S.J., Otto T.D., Wastling J., Pain A.;
RT   "Comprehensive Evaluation of Toxoplasma gondii VEG and Neospora caninum LIV
RT   Genomes with Tachyzoite Stage Transcriptome and Proteome Defines Novel
RT   Transcript Features.";
RL   PLoS ONE 10:e0124473-e0124473(2015).
CC   -!- SIMILARITY: Belongs to the ClpA/ClpB family.
CC       {ECO:0000256|RuleBase:RU004432}.
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DR   EMBL; FR823389; CBZ53048.1; -; Genomic_DNA.
DR   EMBL; LN714482; CEL67032.1; -; Genomic_DNA.
DR   RefSeq; XP_003883080.1; XM_003883031.1.
DR   AlphaFoldDB; F0VH54; -.
DR   GeneID; 13443157; -.
DR   VEuPathDB; ToxoDB:NCLIV_028370; -.
DR   eggNOG; KOG1051; Eukaryota.
DR   InParanoid; F0VH54; -.
DR   OrthoDB; 35211at2759; -.
DR   Proteomes; UP000007494; Chromosome VIIb.
DR   GO; GO:0005524; F:ATP binding; IEA:UniProtKB-KW.
DR   GO; GO:0016887; F:ATP hydrolysis activity; IEA:InterPro.
DR   GO; GO:0008233; F:peptidase activity; IEA:UniProtKB-KW.
DR   GO; GO:0006508; P:proteolysis; IEA:UniProtKB-KW.
DR   CDD; cd00009; AAA; 1.
DR   CDD; cd19499; RecA-like_ClpB_Hsp104-like; 1.
DR   Gene3D; 1.10.8.60; -; 1.
DR   Gene3D; 1.10.1780.10; Clp, N-terminal domain; 1.
DR   Gene3D; 3.40.50.300; P-loop containing nucleotide triphosphate hydrolases; 3.
DR   InterPro; IPR003593; AAA+_ATPase.
DR   InterPro; IPR003959; ATPase_AAA_core.
DR   InterPro; IPR019489; Clp_ATPase_C.
DR   InterPro; IPR036628; Clp_N_dom_sf.
DR   InterPro; IPR004176; Clp_R_dom.
DR   InterPro; IPR001270; ClpA/B.
DR   InterPro; IPR018368; ClpA/B_CS1.
DR   InterPro; IPR028299; ClpA/B_CS2.
DR   InterPro; IPR041546; ClpA/ClpB_AAA_lid.
DR   InterPro; IPR027417; P-loop_NTPase.
DR   PANTHER; PTHR11638; ATP-DEPENDENT CLP PROTEASE; 1.
DR   PANTHER; PTHR11638:SF18; HEAT SHOCK PROTEIN 104; 1.
DR   Pfam; PF00004; AAA; 1.
DR   Pfam; PF07724; AAA_2; 1.
DR   Pfam; PF17871; AAA_lid_9; 1.
DR   Pfam; PF02861; Clp_N; 2.
DR   Pfam; PF10431; ClpB_D2-small; 1.
DR   PRINTS; PR00300; CLPPROTEASEA.
DR   SMART; SM00382; AAA; 2.
DR   SMART; SM01086; ClpB_D2-small; 1.
DR   SUPFAM; SSF81923; Double Clp-N motif; 1.
DR   SUPFAM; SSF52540; P-loop containing nucleoside triphosphate hydrolases; 2.
DR   PROSITE; PS51903; CLP_R; 1.
DR   PROSITE; PS00870; CLPAB_1; 1.
DR   PROSITE; PS00871; CLPAB_2; 1.
PE   3: Inferred from homology;
KW   ATP-binding {ECO:0000256|ARBA:ARBA00022840, ECO:0000256|RuleBase:RU004432};
KW   Chaperone {ECO:0000256|ARBA:ARBA00023186, ECO:0000256|RuleBase:RU004432};
KW   Coiled coil {ECO:0000256|SAM:Coils};
KW   Hydrolase {ECO:0000313|EMBL:CEL67032.1};
KW   Nucleotide-binding {ECO:0000256|ARBA:ARBA00022741,
KW   ECO:0000256|RuleBase:RU004432}; Protease {ECO:0000313|EMBL:CEL67032.1};
KW   Reference proteome {ECO:0000313|Proteomes:UP000007494};
KW   Repeat {ECO:0000256|ARBA:ARBA00022737, ECO:0000256|PROSITE-
KW   ProRule:PRU01251}.
FT   DOMAIN          1..145
FT                   /note="Clp R"
FT                   /evidence="ECO:0000259|PROSITE:PS51903"
FT   REGION          877..928
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COILED          470..524
FT                   /evidence="ECO:0000256|SAM:Coils"
FT   COMPBIAS        896..919
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   928 AA;  104299 MW;  3257698826BB2DC7 CRC64;
     MDADAWTTLV KKAFLAGQEV CRERRNPQLD PLHLFEAMLR DKQSFASQVL SQCPGDFAQL
     KEDVHRAVLK FPQQNPPPDF PSPNHALMAV LRHGKEIQRQ LNDSLMSADS LFLALVQEKS
     IRGLLTEAGF MMKQIEEKAK SVRGLRKISS SDDDANFEAL KKYGTDFTDL AEKGKLDPVI
     GREDEIRRVI RILCRRTKNN PVLIGEPGVG KSAIVEGLAR RIVENDVPSN LRCRLVSLDV
     GALISGAKYR GEFEERLTAV LKEVKDAAGK VILFIDEIHV ILGAGKTEGA LDAANLLKPM
     LARGELRCIG ATTLDEYRKH VEKDAAFERR FQQVHVREPS VQATISILRG LKDRYASHHG
     VRILDSALVE AAQLADRYIT ARFLPDKAID LMDEACAIAR VQVDSKPEAV DVLERQKVQL
     EVEVLALEKE KDPASQKRLA EVRQHLGEIA DALRPLYLQY QQEKGRIDEL GKLAQKQDEL
     KAKIDRAQRV GDLDLVAELR FDALPGVEAR FKKLQAEQEE YERTHKPLLT EVVGPEQIAD
     VVQRWTNIPV HKLTQTETER LLAFGKTLAE QVIGQPQAVE AVSQAILRSA AGLSKRNKPI
     GSFLFLGPTG VGKTELCKRV AESLFDTKER LVRFDMSEYM EQHSVSRLIG APPGYVGHDE
     GGQLTEEIRR NPYSVVLFDE VEKAHSQVWN VLLQVLDDGR LTDSQGRTVD FSNTIIILTS
     NLGAAFLLEA AQRVGTEEQL AAEAAAKEMV MMEVRKFFKP EMLNRLDDIV IFKALTNVNL
     RQVMNLQMEE VRERLAEKRI ELTLTDRATD HVVHEAFDPA YGARPLKRFV ERHIVSDLSL
     KLLKGEIVPD SRVLCDWDEK RRAWVWETTT AVESTASVRK TPGHPVEAEM DAESLSPDSR
     TLSLGSRTDS YTNRSSAMHE TNAKKFRY
//
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