ID F0VHC8_NEOCL Unreviewed; 1249 AA.
AC F0VHC8;
DT 03-MAY-2011, integrated into UniProtKB/TrEMBL.
DT 03-MAY-2011, sequence version 1.
DT 24-JAN-2024, entry version 69.
DE SubName: Full=Putative SET domain containing protein {ECO:0000313|EMBL:CBZ53122.1};
GN ORFNames=NCLIV_029100 {ECO:0000313|EMBL:CBZ53122.1};
OS Neospora caninum (strain Liverpool).
OC Eukaryota; Sar; Alveolata; Apicomplexa; Conoidasida; Coccidia;
OC Eucoccidiorida; Eimeriorina; Sarcocystidae; Neospora.
OX NCBI_TaxID=572307 {ECO:0000313|EMBL:CBZ53122.1, ECO:0000313|Proteomes:UP000007494};
RN [1] {ECO:0000313|Proteomes:UP000007494}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Liverpool {ECO:0000313|Proteomes:UP000007494};
RX PubMed=22457617; DOI=10.1371/journal.ppat.1002567;
RA Reid A.J., Vermont S.J., Cotton J.A., Harris D., Hill-Cawthorne G.A.,
RA Konen-Waisman S., Latham S.M., Mourier T., Norton R., Quail M.A.,
RA Sanders M., Shanmugam D., Sohal A., Wasmuth J.D., Brunk B., Grigg M.E.,
RA Howard J.C., Parkinson J., Roos D.S., Trees A.J., Berriman M., Pain A.,
RA Wastling J.M.;
RT "Comparative genomics of the apicomplexan parasites Toxoplasma gondii and
RT Neospora caninum: Coccidia differing in host range and transmission
RT strategy.";
RL PLoS Pathog. 8:e1002567-e1002567(2012).
CC -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000256|PROSITE-ProRule:PRU00358}.
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DR EMBL; FR823389; CBZ53122.1; -; Genomic_DNA.
DR RefSeq; XP_003883154.1; XM_003883105.1.
DR AlphaFoldDB; F0VHC8; -.
DR GeneID; 13443310; -.
DR VEuPathDB; ToxoDB:NCLIV_029100; -.
DR eggNOG; KOG1082; Eukaryota.
DR InParanoid; F0VHC8; -.
DR OrthoDB; 5481936at2759; -.
DR Proteomes; UP000007494; Chromosome VIIb.
DR GO; GO:0005694; C:chromosome; IEA:UniProtKB-KW.
DR GO; GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
DR GO; GO:0042054; F:histone methyltransferase activity; IEA:InterPro.
DR GO; GO:0008270; F:zinc ion binding; IEA:InterPro.
DR Gene3D; 2.170.270.10; SET domain; 1.
DR Gene3D; 2.30.280.10; SRA-YDG; 1.
DR InterPro; IPR003616; Post-SET_dom.
DR InterPro; IPR007728; Pre-SET_dom.
DR InterPro; IPR015947; PUA-like_sf.
DR InterPro; IPR001214; SET_dom.
DR InterPro; IPR046341; SET_dom_sf.
DR InterPro; IPR036987; SRA-YDG_sf.
DR InterPro; IPR003105; SRA_YDG.
DR PANTHER; PTHR45660; HISTONE-LYSINE N-METHYLTRANSFERASE SETMAR; 1.
DR PANTHER; PTHR45660:SF13; HISTONE-LYSINE N-METHYLTRANSFERASE SETMAR; 1.
DR Pfam; PF05033; Pre-SET; 1.
DR Pfam; PF02182; SAD_SRA; 1.
DR Pfam; PF00856; SET; 1.
DR SMART; SM00317; SET; 1.
DR SMART; SM00466; SRA; 1.
DR SUPFAM; SSF88697; PUA domain-like; 1.
DR SUPFAM; SSF82199; SET domain; 1.
DR PROSITE; PS50868; POST_SET; 1.
DR PROSITE; PS50280; SET; 1.
DR PROSITE; PS51015; YDG; 1.
PE 4: Predicted;
KW Chromosome {ECO:0000256|ARBA:ARBA00022454};
KW Nucleus {ECO:0000256|ARBA:ARBA00023242, ECO:0000256|PROSITE-
KW ProRule:PRU00358}; Reference proteome {ECO:0000313|Proteomes:UP000007494};
KW S-adenosyl-L-methionine {ECO:0000256|ARBA:ARBA00022691};
KW Transferase {ECO:0000256|ARBA:ARBA00022679}.
FT DOMAIN 181..330
FT /note="YDG"
FT /evidence="ECO:0000259|PROSITE:PS51015"
FT DOMAIN 1046..1173
FT /note="SET"
FT /evidence="ECO:0000259|PROSITE:PS50280"
FT DOMAIN 1177..1193
FT /note="Post-SET"
FT /evidence="ECO:0000259|PROSITE:PS50868"
FT REGION 1..25
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 82..102
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 318..597
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 318..344
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 387..401
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 439..466
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 509..549
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 1249 AA; 138304 MW; 5173AF93541D0BAB CRC64;
MNAAARSDAA RRDGAAGTVP RVQLPNTKMV VEILDDPEEA ENQEEAADGV AVILSDPDSE
EEEERLRQLQ KLFKEHCRRR RLRGEQNEAR EPTCDSGKGG KVSDRVEEIG ERCLDMERGV
EEYEDFFQLN ADEKALWLAL KFIHLYQRCT EKVATPGTMS RSLRKMKETV ENLFPSNVIG
PGSLRLMPGF RCLYTGQLSA VGLHCAFNDR MCIGHDDESL PTVTSLLLND DRIEDNNDII
IVYGEENDGK GYGAYPGDQM LFIGGTNTRN YSLWNAWKLE YPVRVVRGYK CKSKYAPSFG
FRYDGLYRVV EMLADSNNSP SAFHRPSRSP ASAASPSSSD TGDSRVRRPL SRRRPVDPVS
PGQDAPLSRR ADRGASDRPI APAWEQTETE IRKERPRTAK TENCDSAFPP AILPSMRPWL
SPFSGRGAAD PARPQGVSPT VSDGEQPQPP SGSTSRSLSF SRLAAVSPES SDPDGDSDAS
SARRCATLAR GRDDPARKYS LGGARQPWSV LSGRSSFSDA AASRGGTSSS ESRRPTSPVP
TQKPGLWSEG EHSSSRGPFG SAAVFEKLEK EPVNSPRSTP EQGSPSGGGA AAGGPYGKRE
RQQLEGRRIY KFVLVSIHRD IYLAPESKLP DRDIAIFSHH VFEDDKGLKK VKALAHHQYR
AHYKIQEQLQ ASLPTFSRST KVVQVWSDLP FPFALAVPPV LKLPGQSQSI LSNFVCIMAS
AYKIYTEIKR AMDPSASEIP SGALLAVQQY QAAVSLSASP SSLLSKTCSR TGPRCSALPS
RSRLPPVAPP SWALCGLLPL KVLLTLFDLE LQELSPASKA RLIEQARVDC KRHPPGYLES
KRDNALPSFS KSPEELAELL AQLKNKPRVP GRHRPLVWRE SQTEILVTAE LAKIFAHQLL
PQSATCGMYS TIELCSPLPD SWSPWQDISQ GKEKFPVPAV NDVDDLPPPV DFSYQVRNVC
FSRLPNFCML CLCAGCVPPD KDTSIWERIE VEGYSSGLRD PETGRVYCAG SNLSFVKETS
TLAVCTSYCL CDKTVCTNRY PEDLAYPVMV AKTKLAGWEL RTQVEIPAGA FIMQYVGEIM
CRATMEGRSR HNSRRGYHNY CMEIVQDEWD WEDNWKLPCI DSLFLGNASR FLNHSCEPNV
EVRNIWRGPL LPVVGVFSRR AIKAGEALTY AYGAGYETIK CWCGAKTCKG YIGDGTSVEK
KEEGKRADRE LRKKVRNAAD VVVVEGTEFE LVELSDDETQ QKKHAAHRR
//
