ID F0VI36_NEOCL Unreviewed; 3771 AA.
AC F0VI36;
DT 03-MAY-2011, integrated into UniProtKB/TrEMBL.
DT 03-MAY-2011, sequence version 1.
DT 27-MAR-2024, entry version 54.
DE SubName: Full=Putative tRNA-splicing endonuclease positive effector {ECO:0000313|EMBL:CBZ53397.1};
DE SubName: Full=tRNA-splicing endonuclease positive effector,putative {ECO:0000313|EMBL:CEL67384.1};
GN ORFNames=BN1204_031840 {ECO:0000313|EMBL:CEL67384.1}, NCLIV_031840
GN {ECO:0000313|EMBL:CBZ53397.1};
OS Neospora caninum (strain Liverpool).
OC Eukaryota; Sar; Alveolata; Apicomplexa; Conoidasida; Coccidia;
OC Eucoccidiorida; Eimeriorina; Sarcocystidae; Neospora.
OX NCBI_TaxID=572307 {ECO:0000313|EMBL:CBZ53397.1, ECO:0000313|Proteomes:UP000007494};
RN [1] {ECO:0000313|EMBL:CBZ53397.1}
RP NUCLEOTIDE SEQUENCE.
RC STRAIN=Liverpool {ECO:0000313|EMBL:CBZ53397.1};
RA Aslett M.;
RL Submitted (FEB-2011) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|EMBL:CBZ53397.1}
RP NUCLEOTIDE SEQUENCE.
RC STRAIN=Liverpool {ECO:0000313|EMBL:CBZ53397.1};
RA Reid A.J., Sohal A., Harris D., Quail M., Sanders M., Berriman M.,
RA Wastling J.M., Pain A.;
RT "Comparative genomics and transcriptomics of Neospora caninum and
RT Toxoplasma gondii.";
RL Submitted (MAR-2011) to the EMBL/GenBank/DDBJ databases.
RN [3] {ECO:0000313|Proteomes:UP000007494}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Liverpool {ECO:0000313|Proteomes:UP000007494};
RX PubMed=22457617; DOI=10.1371/journal.ppat.1002567;
RA Reid A.J., Vermont S.J., Cotton J.A., Harris D., Hill-Cawthorne G.A.,
RA Konen-Waisman S., Latham S.M., Mourier T., Norton R., Quail M.A.,
RA Sanders M., Shanmugam D., Sohal A., Wasmuth J.D., Brunk B., Grigg M.E.,
RA Howard J.C., Parkinson J., Roos D.S., Trees A.J., Berriman M., Pain A.,
RA Wastling J.M.;
RT "Comparative genomics of the apicomplexan parasites Toxoplasma gondii and
RT Neospora caninum: Coccidia differing in host range and transmission
RT strategy.";
RL PLoS Pathog. 8:e1002567-e1002567(2012).
RN [4] {ECO:0000313|EMBL:CEL67384.1}
RP NUCLEOTIDE SEQUENCE.
RC STRAIN=Liverpool {ECO:0000313|EMBL:CEL67384.1};
RX PubMed=25875305; DOI=10.1371/journal.pone.0124473;
RA Ramaprasad A., Mourier T., Naeem R., Malas T.B., Moussa E., Panigrahi A.,
RA Vermont S.J., Otto T.D., Wastling J., Pain A.;
RT "Comprehensive Evaluation of Toxoplasma gondii VEG and Neospora caninum LIV
RT Genomes with Tachyzoite Stage Transcriptome and Proteome Defines Novel
RT Transcript Features.";
RL PLoS ONE 10:e0124473-e0124473(2015).
CC ---------------------------------------------------------------------------
CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC ---------------------------------------------------------------------------
DR EMBL; FR823390; CBZ53397.1; -; Genomic_DNA.
DR EMBL; LN714483; CEL67384.1; -; Genomic_DNA.
DR RefSeq; XP_003883429.1; XM_003883380.1.
DR GeneID; 13442571; -.
DR VEuPathDB; ToxoDB:NCLIV_031840; -.
DR eggNOG; KOG1801; Eukaryota.
DR InParanoid; F0VI36; -.
DR OrthoDB; 208118at2759; -.
DR Proteomes; UP000007494; Chromosome VIII.
DR GO; GO:0004519; F:endonuclease activity; IEA:UniProtKB-KW.
DR GO; GO:0004386; F:helicase activity; IEA:InterPro.
DR CDD; cd18808; SF1_C_Upf1; 1.
DR Gene3D; 3.40.50.300; P-loop containing nucleotide triphosphate hydrolases; 2.
DR InterPro; IPR045055; DNA2/NAM7-like.
DR InterPro; IPR041679; DNA2/NAM7-like_C.
DR InterPro; IPR041677; DNA2/NAM7_AAA_11.
DR InterPro; IPR027417; P-loop_NTPase.
DR InterPro; IPR047187; SF1_C_Upf1.
DR PANTHER; PTHR10887; DNA2/NAM7 HELICASE FAMILY; 1.
DR PANTHER; PTHR10887:SF525; HELICASE SENATAXIN-RELATED; 1.
DR Pfam; PF13086; AAA_11; 2.
DR Pfam; PF13087; AAA_12; 1.
DR SUPFAM; SSF52540; P-loop containing nucleoside triphosphate hydrolases; 1.
PE 4: Predicted;
KW Endonuclease {ECO:0000313|EMBL:CBZ53397.1};
KW Hydrolase {ECO:0000313|EMBL:CBZ53397.1};
KW Nuclease {ECO:0000313|EMBL:CBZ53397.1};
KW Reference proteome {ECO:0000313|Proteomes:UP000007494}.
FT DOMAIN 2802..3110
FT /note="DNA2/NAM7 helicase helicase"
FT /evidence="ECO:0000259|Pfam:PF13086"
FT DOMAIN 3173..3216
FT /note="DNA2/NAM7 helicase helicase"
FT /evidence="ECO:0000259|Pfam:PF13086"
FT DOMAIN 3330..3615
FT /note="DNA2/NAM7 helicase-like C-terminal"
FT /evidence="ECO:0000259|Pfam:PF13087"
FT REGION 72..109
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 187..216
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 246..289
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 373..393
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 483..530
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 720..756
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 936..975
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1145..1185
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1235..1255
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1280..1341
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1368..1418
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1518..1851
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1869..2034
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 2132..2167
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 2247..2276
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 2315..2394
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 2502..2543
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 2635..2666
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 2748..2777
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 2853..2885
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 3238..3306
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 3519..3583
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 3713..3771
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 88..109
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 189..209
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 246..278
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 373..390
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 493..530
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 729..748
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1151..1172
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1369..1396
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1403..1418
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1603..1618
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1685..1735
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1736..1780
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1791..1805
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1806..1821
FT /note="Pro residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1822..1851
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1881..1915
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1923..1940
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1942..1976
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1996..2010
FT /note="Pro residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 2013..2033
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 2338..2371
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 2635..2649
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 2853..2871
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 3526..3541
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 3567..3583
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 3713..3733
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 3771 AA; 405795 MW; 44506C1125B0855C CRC64;
MTLPDEDENI LFSEVVDFSI FPLSPGRRRE LRATAELPSI SDLLGVKDVR DDDEVAAAIW
EAYDRLYTQF SAPRSSSPSP RLSPSLPPSS PSSSSSFSPS TSSSSSSVSP PPVCGAASVH
VFCSPQHVRD GFRVLFSFAF EAETGERSPR ESLVLAALSA SLLRCPACVV AYVAGCRQFL
LALQSGESRD RKNPQRPRSE EPHEAGDSLA DGEDSDEEGS LLCARLQKKI LAWDLLRLLA
VLAADRDRRE EEDRREEAAG KKADFDIGDR EDPGGQKTGK EADISLSGDT AGNRERCSLL
SLVRTGVQTA LDKKAEVDKG CCLATKEDAA SPRTPAPSSG PASENALCLC FPEKNLQTLL
RRLSQHRSTL SSDLSSRVSA SRQPSLSFRP SPCSSAPPLP SCSSVDLPSV CTLLEVLLDS
ARLLYVDFDL PLKSLQEDLR DFGSSIPALF LPLLRNQECL PARDRGLETG VCGDCSGPCS
SPSLSSVGHA EGSADGEKPR EGRQVRRAED AGFEEEGSGK EGDEEAPRKE KERLWLRMTT
SAFCSLRGLT PETRERLSGH RRTLRSLVVA LPSLLASSPV DLSSARCSEL WEASVSSSGF
AASAALPPST LLLPLLPSPV FCVGILLYAL LLRPCGVAPL LLSFQTHALP AVRLAACAAL
HIAAVRRPSL LLPPSSPSAS SCAASSASAS SLAFPVSSAA PSSFATGSKS DPVTICEEAG
CVDEDGETQG DGDYSKGERH RGEASCDERR FASPPASPMS ALVSVVQMWV TLLHILSVRL
GQATQEMAAC LQRCRNGAWT GDPEMEDVED NVVSSLHHLV LILRALHSLF VVVLSPDSTP
AVAEPIARVG EEVFNFATRL PPSSSLFPFC PFSSSSAATS SNPGSSSVSL SLPAADSLSL
FDASPPSSAS SVPLFSSSSL PSSLSSSCCL ASSSVPSSPS ERHVLESHTG ARQLPHGTRP
WRQSPTVPGE RGCGEDAGQP ARFPALGSVA AVIQEELSAC ASHEKGLLLG AAEDELGCLD
SASLAKSRGE TRRAGCQDAA RSDALFPPST FFEREEDRAV LLREGLYLLL PFPSGLTRGE
AGRTGDEARG SVELLLDRNS AAIALGGLPR VLKTLARGLV ELWGQLEVHS CLSERRAFSR
TGAGFRGGDL REAPASEEEG ARGEEDQSRP GLSEERGSQV GNARRARGFP EEAAVVLGSV
SACLSAELTV EILVLKTLLV AVSLLYKLVR SPARSSLLSS PASRPPRHAS AAELSTETFS
LMSEMACRAR GRRRELAEAL SLAQPGGERR ESRQDGNPQR RNSSPRTGAE RRSRDTRGGL
SAAKGGESGL PEGAQEEGEV GREKRIFAGM VWACELLERM SSSIARFLPG REEGREKDGD
AGKEGKPKER VAARANRGGK RIQTVGEAKE SSESEGACED AAVSRLRAEI LGASSEERDP
HGCHPSCSSS SSRVAASPFL SAAPLLPSPA SRAREAAGAR AVGATRWVCH STQDASTTAA
GKTGDSVPFS IRQEQEIILV SDSEEEAQPP RLRSSAPRRP HTHFAVVLGD SDRRASAAAS
LRAGDQEHAR GGNARGQGET RLLSSPPRAG RGGAAEARQP AGTGSTGVAS TLSGRETSAA
EGASLEEPTS RVSKEQGGSA AFSRRDFCGP GDAPGVELIL SDEEESEQGQ LHAQRAGEDT
QEQGRGSSEG ARERVVTLDW DFPEDDETRR EVELRQERKR ERARERPRSP RAQTKRQRTA
DLSTVDFLAS CVSSPSPWTS RASSASSSGS ASPRSSSRSS PCREIRSRAR SPSSRCSSVV
SVRPSPSSSP SPPPSPSCPS PSPAVSSRSS SRSSSLSSAS SSSFSTSLSC SGAAGGVDIS
ALWADAEAAR DMQAAAQEAR TAREAAEKLR RRQEAGVKKK ASWTGRTREQ ARDDACPSRC
FTPSDSAPGS QRSASASHAE LTSVRAEDEA RTGRKGDMFL GSSRERKGEH AKEGRGSPPE
SQGSFRNHPT HDRAPPASSS PHPGPSPSLP QPAGALRHSS LSSLSSRPSL PRPVSAQVAS
VVAAARAQAA DTRWRAQRLL QARLEGLRSR REDWRRGGGV SELLTTHRWE KSSTHPFGSL
AVFPGAAFQK SKLKAVAEKI GFEGPVVRRK ADTRREGVTT PGEKETGVEE EAQVERTGEE
ERAKRESRKA EQIRRMRREL EKGLCEKESG PAESATLKRH ILLAPSGGDV RAHRQRSRKP
AWMSAEEWEK EKLRAWVQQE VDDAQTREVR EKKAQEQSMQ NEQAEQQATQ RAQEEALKRK
HALDRARIIT ETDAGLDQFL WRLLHVDVHS IARGDEEGGL HREKPQSVSP PSSPPPSTSS
SSSSSPSSSS SSSSLSSSSS SSFSSSAPGA REARHSSAHE SRRGDGACVN AQSVQRASAL
SPAEAKAPPA RSKYSLELLT SRVRAQRHLP NRYRNVEEYK SLLAPLLFLE LIFQLKQAFR
EQNLEPRLCV LEELREGKQW MLGRLSMSRI FPQLAAFART PGRQRNVSSR LREPPSFSSA
ADAARGSDRG GEPDTCGPSS SFSGERGEAA ECFFPPFGVH ELLLLLPVGS AYTRLLDTAR
GDREGDPESA EQTTVDHAQL LMRRYAGKSF AAIAREPVQS WFLLGLVDRV EDTSPTGFSA
SGSQGKSGIH ADSDSERSAA EKSSGGSQFI LRLPHLVSSD LSPAASHQMK RVPLEHVAVN
TSWVAVSLTQ LTTAVREIQA VFLSQLSPRF PFLLNPLPLK LSLAPVLPSA SSPSPSPSAS
LPASPSPSSA PSADSKRQTR GAALAAVWFK QAVDRQLRSG RLNPSQAEAI RDVLTTETKV
GLIQGPPGTG KTQAIQSLLA IIYSRLRDQQ GLRAKEGSNQ PSFSRSLRSS GALNPPGRHM
ASPGAAREGL RKKILVCAPS NAAVDEIAER LLAHGLQHPM TGETFTPACL RIGNLDRVRE
SVRSITLEAQ VKRLRSAHES QMETSFQASL QELREKKKVL IQQHQCVRFL LSRFSSLDLS
RLNSAPYLDD LVAAMLASSF AKSFSGEARG EETLRSLLPS LACLGLFGLK DLRATLDAQL
EDVNARFACL FDERRQDRSA LFPACRQQVI LATDIVFATL SSSAHEYLCP YTLTLTSVAS
SPGRGASLSR GFSSAPASLA LSSCLPGLPR FATQEQKMTF LQAQFYAASP PFSYAYLIVD
EAGQASELSC LIPLRLAPER CILVGDPQQL PSTIFSALAE KRGLGRSLLE RLALCAEEDR
QREARPSEER GEERRWARQT ASKEARAEDS KQADEGDGLY TRRPAEKNEG FPTEEPEGER
RDEERQKRLV KAGVSLALGA TNRPHGTQAL KVNLLTTQYR MRAEIARFPS EAFYDGRLET
SPSVSLRPRL PCFRLHWLFA PVKFFRVPSL EDRGSLGSSS LANYEEARFV VSLLRTLYLH
FCGRPQSEHH TRHLGYSPSF SSPAPSSFAS RSQKLSDVGV ITPYRQQVAL LQQMLAEDLV
LGLARDRPEI NTVDAFQGRE KSIIIISFVR AAGPAALAAR TGDDPASYGL REKHRGPKGT
GNEAGKESPS VKGRKAGIAP RTASDLPETS PGASPVSLGP SSSSSFSTLG FVADFRRLNV
ALTRARDALW IVGDDETLKT HPSFRRFLAY VQSLPGDAYI DLLDLPKPLR RAMQFRRRDA
GRGSLDLSAQ KHRCPDAPRS GAAGRMKLWR DEEEGLLSEF FGAVEEDFRQ TKKLENGEGQ
RQKPGEAARG HATLRDSGET TGGFARTRGG NDAEPQTEGR PGRPREEKKR K
//