ID F0VKV7_NEOCL Unreviewed; 1853 AA.
AC F0VKV7;
DT 03-MAY-2011, integrated into UniProtKB/TrEMBL.
DT 03-MAY-2011, sequence version 1.
DT 27-MAR-2024, entry version 45.
DE SubName: Full=Signal peptidase {ECO:0000313|EMBL:CEL69424.1};
GN ORFNames=BN1204_051350 {ECO:0000313|EMBL:CEL69424.1}, NCLIV_051350
GN {ECO:0000313|EMBL:CBZ54708.1};
OS Neospora caninum (strain Liverpool).
OC Eukaryota; Sar; Alveolata; Apicomplexa; Conoidasida; Coccidia;
OC Eucoccidiorida; Eimeriorina; Sarcocystidae; Neospora.
OX NCBI_TaxID=572307 {ECO:0000313|EMBL:CBZ54708.1, ECO:0000313|Proteomes:UP000007494};
RN [1] {ECO:0000313|EMBL:CBZ54708.1}
RP NUCLEOTIDE SEQUENCE.
RC STRAIN=Liverpool {ECO:0000313|EMBL:CBZ54708.1};
RA Aslett M.;
RL Submitted (FEB-2011) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|EMBL:CBZ54708.1}
RP NUCLEOTIDE SEQUENCE.
RC STRAIN=Liverpool {ECO:0000313|EMBL:CBZ54708.1};
RA Reid A.J., Sohal A., Harris D., Quail M., Sanders M., Berriman M.,
RA Wastling J.M., Pain A.;
RT "Comparative genomics and transcriptomics of Neospora caninum and
RT Toxoplasma gondii.";
RL Submitted (MAR-2011) to the EMBL/GenBank/DDBJ databases.
RN [3] {ECO:0000313|Proteomes:UP000007494}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Liverpool {ECO:0000313|Proteomes:UP000007494};
RX PubMed=22457617; DOI=10.1371/journal.ppat.1002567;
RA Reid A.J., Vermont S.J., Cotton J.A., Harris D., Hill-Cawthorne G.A.,
RA Konen-Waisman S., Latham S.M., Mourier T., Norton R., Quail M.A.,
RA Sanders M., Shanmugam D., Sohal A., Wasmuth J.D., Brunk B., Grigg M.E.,
RA Howard J.C., Parkinson J., Roos D.S., Trees A.J., Berriman M., Pain A.,
RA Wastling J.M.;
RT "Comparative genomics of the apicomplexan parasites Toxoplasma gondii and
RT Neospora caninum: Coccidia differing in host range and transmission
RT strategy.";
RL PLoS Pathog. 8:e1002567-e1002567(2012).
RN [4] {ECO:0000313|EMBL:CEL69424.1}
RP NUCLEOTIDE SEQUENCE.
RC STRAIN=Liverpool {ECO:0000313|EMBL:CEL69424.1};
RX PubMed=25875305; DOI=10.1371/journal.pone.0124473;
RA Ramaprasad A., Mourier T., Naeem R., Malas T.B., Moussa E., Panigrahi A.,
RA Vermont S.J., Otto T.D., Wastling J., Pain A.;
RT "Comprehensive Evaluation of Toxoplasma gondii VEG and Neospora caninum LIV
RT Genomes with Tachyzoite Stage Transcriptome and Proteome Defines Novel
RT Transcript Features.";
RL PLoS ONE 10:e0124473-e0124473(2015).
CC -!- SIMILARITY: Belongs to the NEMF family.
CC {ECO:0000256|ARBA:ARBA00008318}.
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DR EMBL; FR823391; CBZ54708.1; -; Genomic_DNA.
DR EMBL; LN714485; CEL69424.1; -; Genomic_DNA.
DR RefSeq; XP_003884738.1; XM_003884689.1.
DR GeneID; 13446413; -.
DR VEuPathDB; ToxoDB:NCLIV_051350; -.
DR eggNOG; KOG2030; Eukaryota.
DR InParanoid; F0VKV7; -.
DR OrthoDB; 129892at2759; -.
DR Proteomes; UP000007494; Chromosome X.
DR GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-KW.
DR GO; GO:0072344; P:rescue of stalled ribosome; IEA:UniProt.
DR Gene3D; 2.30.310.10; ibrinogen binding protein from staphylococcus aureus domain; 1.
DR InterPro; IPR021846; NFACT-C.
DR InterPro; IPR008532; NFACT_RNA-bd.
DR PANTHER; PTHR15239; NUCLEAR EXPORT MEDIATOR FACTOR NEMF; 1.
DR PANTHER; PTHR15239:SF6; RIBOSOME QUALITY CONTROL COMPLEX SUBUNIT NEMF; 1.
DR Pfam; PF11923; NFACT-C; 1.
DR Pfam; PF05670; NFACT-R_1; 1.
DR Pfam; PF05833; NFACT_N; 1.
PE 3: Inferred from homology;
KW Coiled coil {ECO:0000256|ARBA:ARBA00023054, ECO:0000256|SAM:Coils};
KW Cytoplasm {ECO:0000256|ARBA:ARBA00022490};
KW Reference proteome {ECO:0000313|Proteomes:UP000007494}.
FT DOMAIN 649..767
FT /note="NFACT RNA-binding"
FT /evidence="ECO:0000259|Pfam:PF05670"
FT DOMAIN 1736..1825
FT /note="NFACT protein C-terminal"
FT /evidence="ECO:0000259|Pfam:PF11923"
FT REGION 365..415
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 804..860
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 965..1020
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1203..1415
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1436..1455
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1468..1514
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1529..1720
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COILED 472..506
FT /evidence="ECO:0000256|SAM:Coils"
FT COILED 617..644
FT /evidence="ECO:0000256|SAM:Coils"
FT COMPBIAS 365..390
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 391..406
FT /note="Acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 810..850
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 965..981
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1232..1247
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1284..1305
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1343..1366
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1390..1405
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1472..1487
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1546..1591
FT /note="Acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1592..1651
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1662..1680
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 1853 AA; 202724 MW; 78D040CA86F56922 CRC64;
MAPTKQRVGA LDVRALVASI RPAVLGLRVT NVYDFSSGGG RGAGSSSYIV KLAGKDSKIF
LFIHAGFRLY TTEWKKDKGA LPSPFCMRLR KSLRGKKLED IHQHGADRVV LLTFGKGENT
LRLIVELYVS GNIVLTDHTN LILAVLRRHT LSAPSAEGGP QGPQETEQRI AVNEYYRLDS
PERSLLRDGV RPVDFTADVV RRQLVAIAEE SGPRTETKPR PPITWSQAVA RLAPFVSPAV
AVHALLVATQ GDETAKKRVL TQDRLDEAVH VLRRAVVECL RTLCAVSSSA DFLGSGPLPP
EVATQSLASP PVEGYILATR RASLPSEAQK SLSFSLLYDY EDFAPVVLRQ FADFPVLASP
QDIQREREER ASDAVQRSQV EKRTEGHEEV KEDDKEEEEA DEKEEEEKEA RMEARNDGDV
AAAVAAVHGG VAEGTRVLLH FRDINVCVDE YFSSVDVQKG ERAEALARHE ALSRVEKIRS
DQAQRMQQLE EEAASLLEEA QAVEANVGLV EQIIQLLRAA LATGVDWDEL GRQMKQQAKE
GHPLAVHVQE LRLEKQRALL LLEAPGEEAS GATTVVSIDI TLSAHGNAQL LHSQVKQLKA
KTLKTSSATA AALAAADRKA QRTLKQKEQQ VLQAQQQLQK VRKAFWFEKF HWFISSDHYL
VLAGRDAQQN EILFRRYLRA NDVYVHADVH GAATCIIKNT GETDPGKTEE PPVPLATLQQ
CGEFAVCRSS AWNTKTPAAA WWVYGHQVSK SAPSGLYLST GSFMIRGRRN FIQIHRLEMG
FGLLFRLADE ASVARHVAAR KRLQLEEDDN KTPPSSSSSS SSSSSSSSSS SSSSSSSSSS
SSSSSSAVPE EESRARGGVK ANVCGEKKNL RIGFVEPAAQ SRSGPGELTW ERKQRNPAEF
LREIDIEQCA GVNAIREVLA SGGARDAEGS AAPDGAAAVL AHLERQEVRQ RQLQEQLNQV
KHQLEEQLRT ASRSPSIGTQ SARREGRYAR GSVEFSPATL NEDAQASRDT SVGRRIRRRH
PTGRLSVQDI AELRGEAADA ELVEMRQAVL AEQARSQEAA ASRPEAGALN GVAGVPAAPS
SCAAEVDVGD LRPLHQEMLQ RQYSAETHRL LMAEKLREVV LQRGAEGVVR AERARSRRAS
KLAKSDGDDC HVTFSPDPPK VVEKTITALH VDFDGLPPEV IPRHEEPASP LLVQIEEELR
EARETEASEQ IPWALRRRPT GWPAWVPPEE AETQAESDRD SRPGHAREAE GGPLSSREVS
PDAPVGDSAP SGPGEGGEIS RQAASATPGV SGLAKTPSPS LRASRDENEM QAAENWSGKR
GACRPTGSAG TGRDAVAKQG SDRRSPSAFS ERSTLSAQSL TLADSRISRR MSVDGGPPPV
GFTEETLPTP RELLSRSSID FQNSGGDDAE ESVDDQEIHI IVRRLSIKEE KELFRCRSAD
HGPTPKGFSS GDVPSAKDLL TLQQYLSDKL ASPVRSEEDD ETTSAGTRRS RRAVSEGNAP
LFAERGVGGR LKERPKELFL DACASPLASG EGWQEDASAN VGESEPCEGQ EEEDEEELQE
EEASPSDEEA DTTEDDQDAD DAVEEEVKEE ELEAGTVPRK RISAAERRRL KKGDRGEKGE
REEKEEKTNR EEEEEGGKEK KAKDPRLQPV PRGKKGKLAK MKKKYREQDE EEKKYKMSLI
GAEEIKQPGP KETGNTAAPA AGAAKKLPGR KAAQQREERR ELKEFFEEEG EEKLAEQCSQ
IDLLTASPFP EDALLCVVPV TAPYSAMSKY KFKAKLVPGS MKKGNAGQAV LRHFLQQVED
IRLKHLIKSV TLAEVALSMI GDVRVSVPGI QKQLTAARRQ KQAQKKTTFA VDA
//
