ID F0VPR8_NEOCL Unreviewed; 2263 AA.
AC F0VPR8;
DT 03-MAY-2011, integrated into UniProtKB/TrEMBL.
DT 03-MAY-2011, sequence version 1.
DT 27-MAR-2024, entry version 53.
DE SubName: Full=GI16562, related {ECO:0000313|EMBL:CBZ55715.1};
GN ORFNames=NCLIV_061400 {ECO:0000313|EMBL:CBZ55715.1};
OS Neospora caninum (strain Liverpool).
OC Eukaryota; Sar; Alveolata; Apicomplexa; Conoidasida; Coccidia;
OC Eucoccidiorida; Eimeriorina; Sarcocystidae; Neospora.
OX NCBI_TaxID=572307 {ECO:0000313|EMBL:CBZ55715.1, ECO:0000313|Proteomes:UP000007494};
RN [1] {ECO:0000313|Proteomes:UP000007494}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Liverpool {ECO:0000313|Proteomes:UP000007494};
RX PubMed=22457617; DOI=10.1371/journal.ppat.1002567;
RA Reid A.J., Vermont S.J., Cotton J.A., Harris D., Hill-Cawthorne G.A.,
RA Konen-Waisman S., Latham S.M., Mourier T., Norton R., Quail M.A.,
RA Sanders M., Shanmugam D., Sohal A., Wasmuth J.D., Brunk B., Grigg M.E.,
RA Howard J.C., Parkinson J., Roos D.S., Trees A.J., Berriman M., Pain A.,
RA Wastling J.M.;
RT "Comparative genomics of the apicomplexan parasites Toxoplasma gondii and
RT Neospora caninum: Coccidia differing in host range and transmission
RT strategy.";
RL PLoS Pathog. 8:e1002567-e1002567(2012).
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DR EMBL; FR823393; CBZ55715.1; -; Genomic_DNA.
DR RefSeq; XP_003885741.1; XM_003885692.1.
DR GeneID; 13441146; -.
DR VEuPathDB; ToxoDB:NCLIV_061400; -.
DR eggNOG; KOG1113; Eukaryota.
DR InParanoid; F0VPR8; -.
DR OrthoDB; 228292at2759; -.
DR Proteomes; UP000007494; Chromosome XII.
DR GO; GO:0005509; F:calcium ion binding; IEA:InterPro.
DR CDD; cd00038; CAP_ED; 4.
DR Gene3D; 1.10.238.10; EF-hand; 1.
DR Gene3D; 2.60.120.10; Jelly Rolls; 6.
DR InterPro; IPR018488; cNMP-bd_CS.
DR InterPro; IPR000595; cNMP-bd_dom.
DR InterPro; IPR018490; cNMP-bd_dom_sf.
DR InterPro; IPR011992; EF-hand-dom_pair.
DR InterPro; IPR002048; EF_hand_dom.
DR InterPro; IPR014710; RmlC-like_jellyroll.
DR PANTHER; PTHR11635; CAMP-DEPENDENT PROTEIN KINASE REGULATORY CHAIN; 1.
DR PANTHER; PTHR11635:SF152; CAMP-DEPENDENT PROTEIN KINASE TYPE II REGULATORY SUBUNIT; 1.
DR Pfam; PF00027; cNMP_binding; 5.
DR SMART; SM00100; cNMP; 5.
DR SUPFAM; SSF51206; cAMP-binding domain-like; 6.
DR SUPFAM; SSF47473; EF-hand; 2.
DR PROSITE; PS00888; CNMP_BINDING_1; 1.
DR PROSITE; PS00889; CNMP_BINDING_2; 2.
DR PROSITE; PS50042; CNMP_BINDING_3; 6.
DR PROSITE; PS50222; EF_HAND_2; 2.
PE 4: Predicted;
KW Magnesium {ECO:0000256|ARBA:ARBA00022842};
KW Reference proteome {ECO:0000313|Proteomes:UP000007494}.
FT DOMAIN 586..621
FT /note="EF-hand"
FT /evidence="ECO:0000259|PROSITE:PS50222"
FT DOMAIN 804..904
FT /note="Cyclic nucleotide-binding"
FT /evidence="ECO:0000259|PROSITE:PS50042"
FT DOMAIN 929..1037
FT /note="Cyclic nucleotide-binding"
FT /evidence="ECO:0000259|PROSITE:PS50042"
FT DOMAIN 1131..1235
FT /note="Cyclic nucleotide-binding"
FT /evidence="ECO:0000259|PROSITE:PS50042"
FT DOMAIN 1289..1388
FT /note="Cyclic nucleotide-binding"
FT /evidence="ECO:0000259|PROSITE:PS50042"
FT DOMAIN 1646..1681
FT /note="EF-hand"
FT /evidence="ECO:0000259|PROSITE:PS50222"
FT DOMAIN 1923..1991
FT /note="Cyclic nucleotide-binding"
FT /evidence="ECO:0000259|PROSITE:PS50042"
FT DOMAIN 2006..2127
FT /note="Cyclic nucleotide-binding"
FT /evidence="ECO:0000259|PROSITE:PS50042"
FT REGION 55..110
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 122..141
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 156..507
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 524..569
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1056..1106
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1428..1630
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 2128..2165
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 2184..2263
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 63..89
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 156..445
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 450..477
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 543..569
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1056..1080
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1452..1474
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1481..1496
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1529..1552
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1582..1596
FT /note="Acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1614..1630
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 2184..2207
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 2263 AA; 257078 MW; 2D02BC1222C3C349 CRC64;
MPVAAPAGAD CDGVEEAETV RMRVSESSWT LDRDRVLVRQ VELLRRLAGV EEKFTFPRPG
AVSEVEESEK GEKKRRGDGK WRSGEEAGSS RDEPAASYRF SPEMEATMRA AEASIRCDAA
GIKEKVESEA ERKAERERFM GEVRKEQERV AREMRRQVDE MRKQMEKEKL EMVRRMEEER
RRRREAMEEE ERREQKKKLE RQKEEEAYWK EREARRKKAE EEEERRRRER EEEISKRCEE
RERRFREEEE ELERRRQQRI REEEEERRLR DERRRREEAE DEERRQRRKQ EEEREAERRR
NQLKEREELA RRRQKEEEEE EDRRRKQREQ EEEERRRKQR EQEEEEERRR RRRAEEEEEE
RRRKQREQEE EEERRRRRRA EEEEEERRRK QREQEEEEER RRRRRAEEEE EERRRKQREQ
EEEEERGRQF RQAEERARRE AEPARQTLPS DALDGQSEAA TNGETASTRN QEALPASSPS
YADGPPAHPE SGAEQPPGPL GRMAKRNASL AGAIAPSKMK EITSCSAAED ENQGAAVHFD
EDDSPSTSVS TATVTGADDA STDSENESVV SASYSPRSAL KHKIHDKYNS LANAFKYMDN
RRTGAVTLHQ FADFLDESGL DYPFSTVHDL YRQLSQPAEM LTEGLLYRNM DGDATLVQLG
RRLEDIFGNM GVPFEAEQIA PTGRVTKDAF FRVSAKAGLT SQNAEALWKS IDVLGSGHLQ
LESVLLLLED NVELAEVKRI EEEVAKMEGG LMSFFGRSSP PPSPQPKCKR HESCGRPLAL
TRKLSLGFTE AEATIDNVLE GSTTWDVLFP LTRLAMIKKM TKTVYEPEQR IQEAQDSKCP
LYIVMTGSVQ LLQPGLLLET VAEEKSAPQI LFSEEMLEGK PNPYAVKALT KTKVFAFKRE
DFEKHFKHER IKRTRDVAAN MALIKIVPVL NKLSEVQARR LARTFGEETF EDGEAIFKEF
DEPDNFYLVK KGEAAVVKYK KDAATNEMEE VTFRIYQRGD YFGEISIIRD QTRTATVKAR
GLCTVLSLPK EDFNAQLRKF ETSFIGRAGR VYTAQGHVDK RKKSQKKRET ETKPTSIEEP
DDGTDGAGVL SDALGDERRT GGSGATIEEM LATEQTKLRD ECMLLLEAVP VLKDLPLERR
KEIVKAMSLE CFYPNTPIIL QGEESQNFYV LKTGTVAAEL YVGPGKPFRK IQEYNSTCYF
GEMSIIKNEP RGCYITAKSP VQLYSLTGEK FRELLEDYYP AFTEYAQAQY EQETLKRQAT
FQLKTDDQER AQPTADYGHI MNLLVKVPVI NMLDEDALQA LARAFKVECY QEREVIIHEG
TLAENFYIIF SGDVSVQKVV DDAPVEIVVL HAGEYLGEIA FLNEQPRTAS CVAKTDVKLL
SLTRSDFQVH LGALSDEFLQ QAESKYGASK QEEIPDWLVE AGEQGAFYDP SASSGKAEEE
DEEPGGAFCG TIDLDREKEM YNKKKERKNS GIGKKKSEAT AGDTASGDEK AKAGEGAPGE
HGAAGDGSRR KSGEPESTGE VAWAAGAEGA EKKNKKKKEE REEGDESTKK KGTKSQAKRR
MSLAGGAALL AAAAAAQSAS GEGWEEEEED EQAERDEKKE EDEKKKDKKK KKKKKDKDDG
EDATEQVPVE DRVGEIRDLV RGTLKNKYGS IAQAFQQIDG NNSENVDFDE FAEFVRDLRV
QSLKKKDIQI LFDDLCQPLK GTLTVGNLYR NIDKKDQLTK AEINLRWVEI FGGSRKAFKA
VANLSAGEEC TEENFIKVAE AAGVSEENAK SIWTELDKAQ TGHMHTRIIC SYMAGELTAE
EAAAKEEEHA SFGTRLWNFF GGSGSDDENE KSANNLTTQG DEEKIKEALK WEDMAIVQRD
DHRAYPTCTK RLVEVLVKKE GFMYLQLLQL RYVASTMRRE CLTKGVRVME AGDEACMVFC
AWGEFKIVQA GLFGESEIGV VGPDECFGLS ELVNDTPLTA SLVTEVDNSV LWVLERDTYH
DLIRDMLEAR RAVVPVIEHF LKSVPIIKDM SDTEILHVAA ACKIETFSPH QTVFRAGMAG
DMFCFIFKGE ITMLKPMGAG QEPIELGRLQ AGVYFGEMAV IKNQRRTASI IAATDLTLFC
LDKGSFERVL GRVKGKMIER AESLYKRQDV ATTDPKEGED SASASPAAAA AAGGGFSPGD
QFEKKRTRKS SLALLQYAKI REVGNSEGEG EKKGGGDEEE ESEARWAMAQ DPEIIHRPPP
LSAAPKKSAL RTTSGKSVGM KKNSVFFDEE TLLPSPPSSD EDA
//
