ID F0VQL8_NEOCL Unreviewed; 794 AA.
AC F0VQL8;
DT 03-MAY-2011, integrated into UniProtKB/TrEMBL.
DT 03-MAY-2011, sequence version 1.
DT 27-MAR-2024, entry version 47.
DE SubName: Full=Zinc finger, C3HC4 type (RING finger) domain-containing protein {ECO:0000313|EMBL:CEL70762.1};
GN ORFNames=BN1204_064410 {ECO:0000313|EMBL:CEL70762.1}, NCLIV_064410
GN {ECO:0000313|EMBL:CBZ56015.1};
OS Neospora caninum (strain Liverpool).
OC Eukaryota; Sar; Alveolata; Apicomplexa; Conoidasida; Coccidia;
OC Eucoccidiorida; Eimeriorina; Sarcocystidae; Neospora.
OX NCBI_TaxID=572307 {ECO:0000313|EMBL:CBZ56015.1, ECO:0000313|Proteomes:UP000007494};
RN [1] {ECO:0000313|EMBL:CBZ56015.1}
RP NUCLEOTIDE SEQUENCE.
RC STRAIN=Liverpool {ECO:0000313|EMBL:CBZ56015.1};
RA Aslett M.;
RL Submitted (FEB-2011) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|EMBL:CBZ56015.1}
RP NUCLEOTIDE SEQUENCE.
RC STRAIN=Liverpool {ECO:0000313|EMBL:CBZ56015.1};
RA Reid A.J., Sohal A., Harris D., Quail M., Sanders M., Berriman M.,
RA Wastling J.M., Pain A.;
RT "Comparative genomics and transcriptomics of Neospora caninum and
RT Toxoplasma gondii.";
RL Submitted (MAR-2011) to the EMBL/GenBank/DDBJ databases.
RN [3] {ECO:0000313|Proteomes:UP000007494}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Liverpool {ECO:0000313|Proteomes:UP000007494};
RX PubMed=22457617; DOI=10.1371/journal.ppat.1002567;
RA Reid A.J., Vermont S.J., Cotton J.A., Harris D., Hill-Cawthorne G.A.,
RA Konen-Waisman S., Latham S.M., Mourier T., Norton R., Quail M.A.,
RA Sanders M., Shanmugam D., Sohal A., Wasmuth J.D., Brunk B., Grigg M.E.,
RA Howard J.C., Parkinson J., Roos D.S., Trees A.J., Berriman M., Pain A.,
RA Wastling J.M.;
RT "Comparative genomics of the apicomplexan parasites Toxoplasma gondii and
RT Neospora caninum: Coccidia differing in host range and transmission
RT strategy.";
RL PLoS Pathog. 8:e1002567-e1002567(2012).
RN [4] {ECO:0000313|EMBL:CEL70762.1}
RP NUCLEOTIDE SEQUENCE.
RC STRAIN=Liverpool {ECO:0000313|EMBL:CEL70762.1};
RX PubMed=25875305; DOI=10.1371/journal.pone.0124473;
RA Ramaprasad A., Mourier T., Naeem R., Malas T.B., Moussa E., Panigrahi A.,
RA Vermont S.J., Otto T.D., Wastling J., Pain A.;
RT "Comprehensive Evaluation of Toxoplasma gondii VEG and Neospora caninum LIV
RT Genomes with Tachyzoite Stage Transcriptome and Proteome Defines Novel
RT Transcript Features.";
RL PLoS ONE 10:e0124473-e0124473(2015).
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DR EMBL; FR823393; CBZ56015.1; -; Genomic_DNA.
DR EMBL; LN714487; CEL70762.1; -; Genomic_DNA.
DR RefSeq; XP_003886041.1; XM_003885992.1.
DR AlphaFoldDB; F0VQL8; -.
DR GeneID; 13445238; -.
DR VEuPathDB; ToxoDB:NCLIV_064410; -.
DR eggNOG; KOG0828; Eukaryota.
DR InParanoid; F0VQL8; -.
DR OrthoDB; 51730at2759; -.
DR Proteomes; UP000007494; Chromosome XII.
DR GO; GO:0016020; C:membrane; IEA:UniProtKB-KW.
DR GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
DR Gene3D; 3.30.40.10; Zinc/RING finger domain, C3HC4 (zinc finger); 1.
DR InterPro; IPR001841; Znf_RING.
DR InterPro; IPR013083; Znf_RING/FYVE/PHD.
DR PANTHER; PTHR22763; RING ZINC FINGER PROTEIN; 1.
DR PANTHER; PTHR22763:SF165; TRANSMEMBRANE E3 UBIQUITIN-PROTEIN LIGASE 1; 1.
DR Pfam; PF13639; zf-RING_2; 1.
DR SMART; SM00184; RING; 1.
DR SUPFAM; SSF57850; RING/U-box; 1.
DR PROSITE; PS50089; ZF_RING_2; 1.
PE 4: Predicted;
KW Membrane {ECO:0000256|SAM:Phobius};
KW Metal-binding {ECO:0000256|PROSITE-ProRule:PRU00175};
KW Reference proteome {ECO:0000313|Proteomes:UP000007494};
KW Transmembrane {ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|SAM:Phobius};
KW Zinc {ECO:0000256|PROSITE-ProRule:PRU00175};
KW Zinc-finger {ECO:0000256|PROSITE-ProRule:PRU00175}.
FT TRANSMEM 550..568
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 606..631
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 651..674
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 686..705
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 745..787
FT /note="RING-type"
FT /evidence="ECO:0000259|PROSITE:PS50089"
FT REGION 1..57
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 89..111
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 308..449
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 365..424
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 426..445
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 794 AA; 86556 MW; 1CB80822A8763D48 CRC64;
MILPFPNGIV GDGRTPSPSG QGGGNSGRAT AAAGGGARNW PLRGAGDASP GPPGREERSS
AACIAFSLSL LLILFLFNLD SIVDSFGPSS PRASAGQQRG SDGASGSNSN SLSMYYQANK
REQSPLHVGM DRTKRYSLQF NSEFFFFVFD PTDLNGTTPS QLATGDLGNW NSQGPGNDLS
NAFPYSTQSL SLLTSGAATL YLYTTRTIFQ SVRMALLRIH LNVGSAFSSS TPLAFPFGFF
DAFSGLFVDR DLYLTGVDFR DIPKANFQGS SLASKLPVVR GLPVPPGSVD ATWCTYTASL
KLNFEPGLGK SARETDESSV AELSQRAAQN SDAAASVAAG VPGPPRRLDA PGNSAVESPA
SGAPRSRPLA QSSVSQQEST TSPGTLPPRR ATASRSSSGR RMPAQSSSES LLTAKETPTA
GSPEAESMNR EDDAGGERPR DGGEPQGDLV GELVSSDCGF YIYFRAWEID YIALASHITS
VTLVFNVKTL VEMRFFWKQM QHTEGIGGLG STSSLALLQR VSIIGQAWQA ALDIFEVVAM
FRVAMQLQIM MAYFSILIMF KAILFGALEV RYLFMVWNAR QQSNPQELDA TGRALTHFYR
NFYGSLAFLV LFLYYVFPVF PPICLVLYFM WLPQIAWDVW KGQRNSMDLQ FVAGISLCRL
VFPTYLFGYP VSLFQESFVG VTLPNYPVLV CIVVVVTLQV LLMLAQRRFG SRFFVPLDHL
PHVYNYHRPL PASLANDAEE GLPECAICMN PIARKSRHRS ITPCDHLFHD KCLQQWMEVK
MECPNCRGAL PPFP
//
