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Database: UniProt
Entry: F0X741_GROCL
LinkDB: F0X741_GROCL
Original site: F0X741_GROCL 
ID   F0X741_GROCL            Unreviewed;       666 AA.
AC   F0X741;
DT   03-MAY-2011, integrated into UniProtKB/TrEMBL.
DT   03-MAY-2011, sequence version 1.
DT   08-MAY-2019, entry version 34.
DE   SubName: Full=Alkaline serine protease {ECO:0000313|EMBL:EFX06237.1};
GN   ORFNames=CMQ_6558 {ECO:0000313|EMBL:EFX06237.1};
OS   Grosmannia clavigera (strain kw1407 / UAMH 11150) (Blue stain fungus)
OS   (Graphiocladiella clavigera).
OC   Eukaryota; Fungi; Dikarya; Ascomycota; Pezizomycotina;
OC   Sordariomycetes; Sordariomycetidae; Ophiostomatales; Ophiostomataceae;
OC   Grosmannia.
OX   NCBI_TaxID=655863 {ECO:0000313|Proteomes:UP000007796};
RN   [1] {ECO:0000313|EMBL:EFX06237.1, ECO:0000313|Proteomes:UP000007796}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=kw1407 / UAMH 11150 {ECO:0000313|Proteomes:UP000007796};
RX   PubMed=21262841; DOI=10.1073/pnas.1011289108;
RA   DiGuistini S., Wang Y., Liao N.Y., Taylor G., Tanguay P., Feau N.,
RA   Henrissat B., Chan S.K., Hesse-Orce U., Alamouti S.M., Tsui C.K.M.,
RA   Docking R.T., Levasseur A., Haridas S., Robertson G., Birol I.,
RA   Holt R.A., Marra M.A., Hamelin R.C., Hirst M., Jones S.J.M.,
RA   Bohlmann J., Breuil C.;
RT   "Genome and transcriptome analyses of the mountain pine beetle-fungal
RT   symbiont Grosmannia clavigera, a lodgepole pine pathogen.";
RL   Proc. Natl. Acad. Sci. U.S.A. 108:2504-2509(2011).
CC   -!- COFACTOR:
CC       Name=Ca(2+); Xref=ChEBI:CHEBI:29108;
CC         Evidence={ECO:0000256|PROSITE-ProRule:PRU01032};
CC       Note=Binds 1 Ca(2+) ion per subunit. {ECO:0000256|PROSITE-
CC       ProRule:PRU01032};
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DR   EMBL; GL629729; EFX06237.1; -; Genomic_DNA.
DR   RefSeq; XP_014175719.1; XM_014320244.1.
DR   MEROPS; S53.007; -.
DR   EnsemblFungi; EFX06237; EFX06237; CMQ_6558.
DR   GeneID; 25980004; -.
DR   InParanoid; F0X741; -.
DR   OrthoDB; 1294880at2759; -.
DR   Proteomes; UP000007796; Unassembled WGS sequence.
DR   GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-UniRule.
DR   GO; GO:0004252; F:serine-type endopeptidase activity; IEA:UniProtKB-UniRule.
DR   CDD; cd04056; Peptidases_S53; 1.
DR   CDD; cd11377; Pro-peptidase_S53; 1.
DR   InterPro; IPR036852; Peptidase_S8/S53_dom_sf.
DR   InterPro; IPR015366; S53_propep.
DR   InterPro; IPR030400; Sedolisin_dom.
DR   Pfam; PF09286; Pro-kuma_activ; 1.
DR   SMART; SM00944; Pro-kuma_activ; 1.
DR   SUPFAM; SSF52743; SSF52743; 1.
DR   PROSITE; PS51695; SEDOLISIN; 1.
PE   4: Predicted;
KW   Calcium {ECO:0000256|PROSITE-ProRule:PRU01032};
KW   Complete proteome {ECO:0000313|Proteomes:UP000007796};
KW   Hydrolase {ECO:0000256|PROSITE-ProRule:PRU01032};
KW   Metal-binding {ECO:0000256|PROSITE-ProRule:PRU01032};
KW   Protease {ECO:0000256|PROSITE-ProRule:PRU01032,
KW   ECO:0000313|EMBL:EFX06237.1};
KW   Reference proteome {ECO:0000313|Proteomes:UP000007796};
KW   Serine protease {ECO:0000256|PROSITE-ProRule:PRU01032};
KW   Signal {ECO:0000256|SAM:SignalP}.
FT   SIGNAL        1     16       {ECO:0000256|SAM:SignalP}.
FT   CHAIN        17    666       {ECO:0000256|SAM:SignalP}.
FT                                /FTId=PRO_5003260200.
FT   DOMAIN      228    666       Peptidase S53. {ECO:0000259|PROSITE:
FT                                PS51695}.
FT   ACT_SITE    308    308       Charge relay system.
FT                                {ECO:0000256|PROSITE-ProRule:PRU01032}.
FT   ACT_SITE    312    312       Charge relay system.
FT                                {ECO:0000256|PROSITE-ProRule:PRU01032}.
FT   ACT_SITE    584    584       Charge relay system.
FT                                {ECO:0000256|PROSITE-ProRule:PRU01032}.
FT   METAL       625    625       Calcium. {ECO:0000256|PROSITE-ProRule:
FT                                PRU01032}.
FT   METAL       626    626       Calcium; via carbonyl oxygen.
FT                                {ECO:0000256|PROSITE-ProRule:PRU01032}.
FT   METAL       644    644       Calcium; via carbonyl oxygen.
FT                                {ECO:0000256|PROSITE-ProRule:PRU01032}.
FT   METAL       646    646       Calcium. {ECO:0000256|PROSITE-ProRule:
FT                                PRU01032}.
SQ   SEQUENCE   666 AA;  72331 MW;  7BE71F53AFE68F02 CRC64;
     MLKTLLLAAT AGLALASPVS RREVPATHTL HERHAPHWAE HWSKRSKVPD DAVLPMRIGL
     TQQNLAAGHD RLMEISTPGS ANYGKHMTPE EVHDFFAPSA ASVDAVTAWI TGHGIAADRI
     GLSVNRQWLQ FDATTAEAED LLYAEFYVFE HASGASDVST EAYHVPEAVR EHIDYVTPGV
     RLRVRRTEKT TTLGSGAVRA RTNFGGVRPL KTKLSSFPHP NSSSCSTYVT ANCTRNQYNI
     PVGTTAAKGN EMGIFESLDV HYSRNDLDVY FSTLYPHIPN GTYPEERLID GAIGATEDTT
     DFVPIELEAP LDFDAAMPLI YPQGAVLFQE DDEYYATHGS TFMGFWNTFL DAIDGSYCTY
     SAFNETGDCT DPACKDPVYP NPNSGGYKGK LQCGVYTPTN VISISYGNSE GYWPDYYIKR
     QCNEWLKLGL QGTTVLMSSN DDGVGKWCNG PSGNVFDPDF GATCPYILAV GSTEWNRAAD
     ATGSEAPNEP LVEVATARFA SGGGFSNVFD VPDYQNDSVA AYFAQVESSL PFQGYNHYVH
     DGNFSNVTDG LYNRGGRGYP DVSAVGDRQV IYANGSWWLY GGTSLAAPVF GSVLTLINEE
     RIAAGKKSLG FIHNIIYKHP EAFNDITSGS NPGCGTSGFP AAKGWDPVTG LGSPNYPKLR
     EILLAA
//
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