ID F0X7A1_GROCL Unreviewed; 450 AA.
AC F0X7A1;
DT 03-MAY-2011, integrated into UniProtKB/TrEMBL.
DT 03-MAY-2011, sequence version 1.
DT 27-MAR-2024, entry version 35.
DE SubName: Full=Aldehyde dehydrogenase mitochondrial {ECO:0000313|EMBL:EFX06616.1};
GN ORFNames=CMQ_6937 {ECO:0000313|EMBL:EFX06616.1};
OS Grosmannia clavigera (strain kw1407 / UAMH 11150) (Blue stain fungus)
OS (Graphiocladiella clavigera).
OC Eukaryota; Fungi; Dikarya; Ascomycota; Pezizomycotina; Sordariomycetes;
OC Sordariomycetidae; Ophiostomatales; Ophiostomataceae; Leptographium.
OX NCBI_TaxID=655863 {ECO:0000313|Proteomes:UP000007796};
RN [1] {ECO:0000313|EMBL:EFX06616.1, ECO:0000313|Proteomes:UP000007796}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=kw1407 / UAMH 11150 {ECO:0000313|Proteomes:UP000007796};
RX PubMed=21262841; DOI=10.1073/pnas.1011289108;
RA DiGuistini S., Wang Y., Liao N.Y., Taylor G., Tanguay P., Feau N.,
RA Henrissat B., Chan S.K., Hesse-Orce U., Alamouti S.M., Tsui C.K.M.,
RA Docking R.T., Levasseur A., Haridas S., Robertson G., Birol I., Holt R.A.,
RA Marra M.A., Hamelin R.C., Hirst M., Jones S.J.M., Bohlmann J., Breuil C.;
RT "Genome and transcriptome analyses of the mountain pine beetle-fungal
RT symbiont Grosmannia clavigera, a lodgepole pine pathogen.";
RL Proc. Natl. Acad. Sci. U.S.A. 108:2504-2509(2011).
CC -!- CATALYTIC ACTIVITY:
CC Reaction=an aldehyde + H2O + NAD(+) = a carboxylate + 2 H(+) + NADH;
CC Xref=Rhea:RHEA:16185, ChEBI:CHEBI:15377, ChEBI:CHEBI:15378,
CC ChEBI:CHEBI:17478, ChEBI:CHEBI:29067, ChEBI:CHEBI:57540,
CC ChEBI:CHEBI:57945; EC=1.2.1.3;
CC Evidence={ECO:0000256|ARBA:ARBA00024149};
CC -!- SIMILARITY: Belongs to the aldehyde dehydrogenase family.
CC {ECO:0000256|ARBA:ARBA00009986}.
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DR EMBL; GL629729; EFX06616.1; -; Genomic_DNA.
DR RefSeq; XP_014176098.1; XM_014320623.1.
DR AlphaFoldDB; F0X7A1; -.
DR STRING; 655863.F0X7A1; -.
DR GeneID; 25980425; -.
DR eggNOG; KOG2450; Eukaryota.
DR HOGENOM; CLU_005391_0_1_1; -.
DR InParanoid; F0X7A1; -.
DR OrthoDB; 216092at2759; -.
DR Proteomes; UP000007796; Unassembled WGS sequence.
DR GO; GO:0016620; F:oxidoreductase activity, acting on the aldehyde or oxo group of donors, NAD or NADP as acceptor; IEA:InterPro.
DR InterPro; IPR016161; Ald_DH/histidinol_DH.
DR InterPro; IPR016163; Ald_DH_C.
DR InterPro; IPR016162; Ald_DH_N.
DR InterPro; IPR015590; Aldehyde_DH_dom.
DR PANTHER; PTHR11699:SF206; ALDEHYDE DEHYDROGENASE DOMAIN-CONTAINING PROTEIN; 1.
DR PANTHER; PTHR11699; ALDEHYDE DEHYDROGENASE-RELATED; 1.
DR Pfam; PF00171; Aldedh; 2.
DR SUPFAM; SSF53720; ALDH-like; 1.
PE 3: Inferred from homology;
KW Reference proteome {ECO:0000313|Proteomes:UP000007796}.
FT DOMAIN 19..252
FT /note="Aldehyde dehydrogenase"
FT /evidence="ECO:0000259|Pfam:PF00171"
FT DOMAIN 254..444
FT /note="Aldehyde dehydrogenase"
FT /evidence="ECO:0000259|Pfam:PF00171"
SQ SEQUENCE 450 AA; 48555 MW; 6BD3AB1DAD042C6D CRC64;
MAALDPKSFN KLYLNGQYVA AQNKETYSLK NPKDNSAVTD CVPIAGAADV DAAVEYAEAA
FRGPWSKFTG IQRTECFMRL VALLDEELTP ILTLDSQTSG IPVSLAPVRE RNYIRNCLIY
YAGWTDKHKG DYYPADDGFV KLVRHEPLGV CAAINPFNAP LATLFLKVAP ALATGNVIIV
KPSEKTPLGT LAAAALFARA GFPPGVVQVV TGFGATGALL AEHMRIRKVS FTGSVATGKR
IQVAAAQSNL KRLCVAASRL YVEKSAAPRF IEAYTARMKA AAGDLGDPQD PDVRLGPMVD
ADQLERVRAM VERGRAEAEL VVGGLQHGTT GCFMQPTVFL NPRDDAEIYR NEIFGPVAII
KTFESEDEVL RLANDTEFGL MAGVFTRDIT RALRLSSAIE AGVVGINCVS LQSLQAPFGG
KKQSGVGREF GEYALRLYTE PKTVLINMAV
//
