ID F0X8G2_GROCL Unreviewed; 625 AA.
AC F0X8G2;
DT 03-MAY-2011, integrated into UniProtKB/TrEMBL.
DT 03-MAY-2011, sequence version 1.
DT 27-MAR-2024, entry version 38.
DE SubName: Full=Glucose-methanol-choline oxidoreductase {ECO:0000313|EMBL:EFX05262.1};
GN ORFNames=CMQ_3331 {ECO:0000313|EMBL:EFX05262.1};
OS Grosmannia clavigera (strain kw1407 / UAMH 11150) (Blue stain fungus)
OS (Graphiocladiella clavigera).
OC Eukaryota; Fungi; Dikarya; Ascomycota; Pezizomycotina; Sordariomycetes;
OC Sordariomycetidae; Ophiostomatales; Ophiostomataceae; Leptographium.
OX NCBI_TaxID=655863 {ECO:0000313|Proteomes:UP000007796};
RN [1] {ECO:0000313|EMBL:EFX05262.1, ECO:0000313|Proteomes:UP000007796}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=kw1407 / UAMH 11150 {ECO:0000313|Proteomes:UP000007796};
RX PubMed=21262841; DOI=10.1073/pnas.1011289108;
RA DiGuistini S., Wang Y., Liao N.Y., Taylor G., Tanguay P., Feau N.,
RA Henrissat B., Chan S.K., Hesse-Orce U., Alamouti S.M., Tsui C.K.M.,
RA Docking R.T., Levasseur A., Haridas S., Robertson G., Birol I., Holt R.A.,
RA Marra M.A., Hamelin R.C., Hirst M., Jones S.J.M., Bohlmann J., Breuil C.;
RT "Genome and transcriptome analyses of the mountain pine beetle-fungal
RT symbiont Grosmannia clavigera, a lodgepole pine pathogen.";
RL Proc. Natl. Acad. Sci. U.S.A. 108:2504-2509(2011).
CC -!- COFACTOR:
CC Name=FAD; Xref=ChEBI:CHEBI:57692;
CC Evidence={ECO:0000256|ARBA:ARBA00001974,
CC ECO:0000256|PIRSR:PIRSR000137-2};
CC -!- SIMILARITY: Belongs to the GMC oxidoreductase family.
CC {ECO:0000256|ARBA:ARBA00010790}.
CC ---------------------------------------------------------------------------
CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC ---------------------------------------------------------------------------
DR EMBL; GL629735; EFX05262.1; -; Genomic_DNA.
DR RefSeq; XP_014174744.1; XM_014319269.1.
DR AlphaFoldDB; F0X8G2; -.
DR STRING; 655863.F0X8G2; -.
DR GeneID; 25976420; -.
DR eggNOG; KOG1238; Eukaryota.
DR HOGENOM; CLU_002865_6_2_1; -.
DR InParanoid; F0X8G2; -.
DR OrthoDB; 858083at2759; -.
DR Proteomes; UP000007796; Unassembled WGS sequence.
DR GO; GO:0050660; F:flavin adenine dinucleotide binding; IEA:InterPro.
DR GO; GO:0016614; F:oxidoreductase activity, acting on CH-OH group of donors; IEA:InterPro.
DR Gene3D; 3.50.50.60; FAD/NAD(P)-binding domain; 1.
DR Gene3D; 3.30.560.10; Glucose Oxidase, domain 3; 1.
DR InterPro; IPR036188; FAD/NAD-bd_sf.
DR InterPro; IPR012132; GMC_OxRdtase.
DR InterPro; IPR000172; GMC_OxRdtase_N.
DR InterPro; IPR007867; GMC_OxRtase_C.
DR PANTHER; PTHR11552; GLUCOSE-METHANOL-CHOLINE GMC OXIDOREDUCTASE; 1.
DR PANTHER; PTHR11552:SF210; GLUCOSE-METHANOL-CHOLINE OXIDOREDUCTASE N-TERMINAL DOMAIN-CONTAINING PROTEIN-RELATED; 1.
DR Pfam; PF05199; GMC_oxred_C; 1.
DR Pfam; PF00732; GMC_oxred_N; 1.
DR PIRSF; PIRSF000137; Alcohol_oxidase; 1.
DR SUPFAM; SSF54373; FAD-linked reductases, C-terminal domain; 1.
DR SUPFAM; SSF51905; FAD/NAD(P)-binding domain; 1.
DR PROSITE; PS00624; GMC_OXRED_2; 1.
PE 3: Inferred from homology;
KW FAD {ECO:0000256|PIRSR:PIRSR000137-2};
KW Flavoprotein {ECO:0000256|PIRSR:PIRSR000137-2};
KW Reference proteome {ECO:0000313|Proteomes:UP000007796}.
FT DOMAIN 296..310
FT /note="Glucose-methanol-choline oxidoreductase N-terminal"
FT /evidence="ECO:0000259|PROSITE:PS00624"
FT BINDING 245
FT /ligand="FAD"
FT /ligand_id="ChEBI:CHEBI:57692"
FT /evidence="ECO:0000256|PIRSR:PIRSR000137-2"
SQ SEQUENCE 625 AA; 66968 MW; F5A22B7E00AE9E78 CRC64;
MGSTGEDQAA TFDYIIAGGG TAGVVVAARL SEDPSIKVLL IEAGADHSKD PLVLTPGLVA
GVYGKKEYDW NFSSVPQPTL HGRAINQARG RMLGGCSGIN FMMAVYPSRA ILDAWGALGN
KGWSFDELEP YFRKFATTEP PSALTTSTCR VAGHYDDAIT QTETGPLQIS YGEGHSPNNS
AWFDTFANLG LRMTSDPRGG SAVGAFQNTA TIDPKTKTRS FAVTAYLTEK VLARTNLTIW
TEAVVTKILL ESPSAHTADP DVVAVAKGVR VRSGNGGETG KERDVFARAE VILAAGTLQT
PQLLELSGIG GRDILEKHAI PVVVDNPNVG EHLQDHAVVC QSFEVAPGTL SGDILRDPDL
LNALVQQYQT DGQGPMGQSA ISCAYAPLLD ADGPLSAEAR QAFFDAHSDS GEEEHGLVRK
LLSGPGEPSV QFLLFPTQVS IRKNPSSMAE IIVPSQPENY LTIMSVLNHP FSRGQVHITS
GNIDDLPVWD PHYNSESIDM EILARAVRFV ETFAYTKPFA GLLMPPGEGK RMPDICADDL
DQAREIVRQA QISIFHVCGS CVMKPKDKGG VVDGKLRVYG VSNLRIVDAS IFPIEPLGNI
QTTVYAVAEK AADIIKQGRQ GHSSN
//
