ID F0XIG8_GROCL Unreviewed; 377 AA.
AC F0XIG8;
DT 03-MAY-2011, integrated into UniProtKB/TrEMBL.
DT 03-MAY-2011, sequence version 1.
DT 27-MAR-2024, entry version 33.
DE SubName: Full=C-3 sterol dehydrogenase c-4 decarboxylase {ECO:0000313|EMBL:EFX02520.1};
GN ORFNames=CMQ_5881 {ECO:0000313|EMBL:EFX02520.1};
OS Grosmannia clavigera (strain kw1407 / UAMH 11150) (Blue stain fungus)
OS (Graphiocladiella clavigera).
OC Eukaryota; Fungi; Dikarya; Ascomycota; Pezizomycotina; Sordariomycetes;
OC Sordariomycetidae; Ophiostomatales; Ophiostomataceae; Leptographium.
OX NCBI_TaxID=655863 {ECO:0000313|Proteomes:UP000007796};
RN [1] {ECO:0000313|EMBL:EFX02520.1, ECO:0000313|Proteomes:UP000007796}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=kw1407 / UAMH 11150 {ECO:0000313|Proteomes:UP000007796};
RX PubMed=21262841; DOI=10.1073/pnas.1011289108;
RA DiGuistini S., Wang Y., Liao N.Y., Taylor G., Tanguay P., Feau N.,
RA Henrissat B., Chan S.K., Hesse-Orce U., Alamouti S.M., Tsui C.K.M.,
RA Docking R.T., Levasseur A., Haridas S., Robertson G., Birol I., Holt R.A.,
RA Marra M.A., Hamelin R.C., Hirst M., Jones S.J.M., Bohlmann J., Breuil C.;
RT "Genome and transcriptome analyses of the mountain pine beetle-fungal
RT symbiont Grosmannia clavigera, a lodgepole pine pathogen.";
RL Proc. Natl. Acad. Sci. U.S.A. 108:2504-2509(2011).
CC -!- SUBCELLULAR LOCATION: Endoplasmic reticulum membrane
CC {ECO:0000256|ARBA:ARBA00004406}; Peripheral membrane protein
CC {ECO:0000256|ARBA:ARBA00004406}.
CC -!- SIMILARITY: Belongs to the 3-beta-HSD family.
CC {ECO:0000256|ARBA:ARBA00009219}.
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DR EMBL; GL629771; EFX02520.1; -; Genomic_DNA.
DR RefSeq; XP_014172002.1; XM_014316527.1.
DR AlphaFoldDB; F0XIG8; -.
DR STRING; 655863.F0XIG8; -.
DR GeneID; 25979252; -.
DR eggNOG; KOG1430; Eukaryota.
DR HOGENOM; CLU_007383_6_8_1; -.
DR InParanoid; F0XIG8; -.
DR OrthoDB; 1133at2759; -.
DR Proteomes; UP000007796; Unassembled WGS sequence.
DR GO; GO:0003854; F:3-beta-hydroxy-delta5-steroid dehydrogenase activity; IEA:InterPro.
DR GO; GO:0006694; P:steroid biosynthetic process; IEA:InterPro.
DR Gene3D; 3.40.50.720; NAD(P)-binding Rossmann-like Domain; 1.
DR InterPro; IPR002225; 3Beta_OHSteriod_DH/Estase.
DR InterPro; IPR036291; NAD(P)-bd_dom_sf.
DR PANTHER; PTHR43245; BIFUNCTIONAL POLYMYXIN RESISTANCE PROTEIN ARNA; 1.
DR PANTHER; PTHR43245:SF51; SHORT CHAIN DEHYDROGENASE_REDUCTASE FAMILY 42E, MEMBER 2; 1.
DR Pfam; PF01073; 3Beta_HSD; 1.
DR SUPFAM; SSF51735; NAD(P)-binding Rossmann-fold domains; 1.
PE 3: Inferred from homology;
KW Reference proteome {ECO:0000313|Proteomes:UP000007796}.
FT DOMAIN 11..291
FT /note="3-beta hydroxysteroid dehydrogenase/isomerase"
FT /evidence="ECO:0000259|Pfam:PF01073"
SQ SEQUENCE 377 AA; 41303 MW; EBBBB0983E757C27 CRC64;
MASGPKLGSV LVIGGCGFLG HHVVNLLLQD YVPSKSVTAI SVVDLRCDRN RRPDADGVRY
FEADITNSER LVEIFEEVRP DVVVHTASPA PQASSNVSDA LFYKVNVEGT RGVIDASKKA
GVRCLVYTSS ASVVSDNKSD LINADERWPV IRGKDQTEYY SETKAAAEEL VLAANDRTTA
GGLLTCAIRP SGIMGEGDTM LLYHMVGVYR QRRHNVQIGD NNNLFDFTYV LNIAHAHLLA
AQALRATVTA ATAPLDHERV DGEAFFQSPT TVPCTFGIFG HTVWKYAGNQ DSLDKVWVLS
RGTGLVLGLA SEIVFSILRK PPTFNRQRIV YTCMTRYYDI SKAKRLLGYK PIVSLEEGIK
RGVAWFMAQD AAKAVKA
//
