ID F0XIJ5_GROCL Unreviewed; 896 AA.
AC F0XIJ5;
DT 03-MAY-2011, integrated into UniProtKB/TrEMBL.
DT 03-MAY-2011, sequence version 1.
DT 27-MAR-2024, entry version 38.
DE SubName: Full=Chromosome condensation protein {ECO:0000313|EMBL:EFX02529.1};
GN ORFNames=CMQ_5890 {ECO:0000313|EMBL:EFX02529.1};
OS Grosmannia clavigera (strain kw1407 / UAMH 11150) (Blue stain fungus)
OS (Graphiocladiella clavigera).
OC Eukaryota; Fungi; Dikarya; Ascomycota; Pezizomycotina; Sordariomycetes;
OC Sordariomycetidae; Ophiostomatales; Ophiostomataceae; Leptographium.
OX NCBI_TaxID=655863 {ECO:0000313|Proteomes:UP000007796};
RN [1] {ECO:0000313|EMBL:EFX02529.1, ECO:0000313|Proteomes:UP000007796}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=kw1407 / UAMH 11150 {ECO:0000313|Proteomes:UP000007796};
RX PubMed=21262841; DOI=10.1073/pnas.1011289108;
RA DiGuistini S., Wang Y., Liao N.Y., Taylor G., Tanguay P., Feau N.,
RA Henrissat B., Chan S.K., Hesse-Orce U., Alamouti S.M., Tsui C.K.M.,
RA Docking R.T., Levasseur A., Haridas S., Robertson G., Birol I., Holt R.A.,
RA Marra M.A., Hamelin R.C., Hirst M., Jones S.J.M., Bohlmann J., Breuil C.;
RT "Genome and transcriptome analyses of the mountain pine beetle-fungal
RT symbiont Grosmannia clavigera, a lodgepole pine pathogen.";
RL Proc. Natl. Acad. Sci. U.S.A. 108:2504-2509(2011).
CC -!- FUNCTION: Fluoride channel required for the rapid expulsion of
CC cytoplasmic fluoride. {ECO:0000256|ARBA:ARBA00002598}.
CC -!- CATALYTIC ACTIVITY:
CC Reaction=fluoride(in) = fluoride(out); Xref=Rhea:RHEA:76159,
CC ChEBI:CHEBI:17051; Evidence={ECO:0000256|ARBA:ARBA00035585};
CC PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:76160;
CC Evidence={ECO:0000256|ARBA:ARBA00035585};
CC -!- SUBCELLULAR LOCATION: Membrane {ECO:0000256|ARBA:ARBA00004141}; Multi-
CC pass membrane protein {ECO:0000256|ARBA:ARBA00004141}.
CC -!- SIMILARITY: Belongs to the fluoride channel Fluc/FEX (TC 1.A.43)
CC family. {ECO:0000256|ARBA:ARBA00035120}.
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DR EMBL; GL629771; EFX02529.1; -; Genomic_DNA.
DR RefSeq; XP_014172011.1; XM_014316536.1.
DR AlphaFoldDB; F0XIJ5; -.
DR STRING; 655863.F0XIJ5; -.
DR GeneID; 25979262; -.
DR eggNOG; ENOG502QT5F; Eukaryota.
DR HOGENOM; CLU_322894_0_0_1; -.
DR InParanoid; F0XIJ5; -.
DR OrthoDB; 162264at2759; -.
DR Proteomes; UP000007796; Unassembled WGS sequence.
DR GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-KW.
DR GO; GO:1903425; F:fluoride transmembrane transporter activity; IEA:UniProt.
DR Gene3D; 2.60.40.640; -; 1.
DR InterPro; IPR014752; Arrestin-like_C.
DR InterPro; IPR003691; FluC.
DR PANTHER; PTHR28259; FLUORIDE EXPORT PROTEIN 1-RELATED; 1.
DR PANTHER; PTHR28259:SF1; FLUORIDE EXPORT PROTEIN 1-RELATED; 1.
DR Pfam; PF02537; CRCB; 2.
PE 3: Inferred from homology;
KW Cell membrane {ECO:0000256|ARBA:ARBA00022475};
KW Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|SAM:Phobius};
KW Reference proteome {ECO:0000313|Proteomes:UP000007796};
KW Transmembrane {ECO:0000256|ARBA:ARBA00022692, ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW ECO:0000256|SAM:Phobius}.
FT TRANSMEM 539..563
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 618..640
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 674..706
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 726..749
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 761..780
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 787..810
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 830..849
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 861..882
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT REGION 435..505
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 584..613
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 445..465
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 476..498
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 596..613
FT /note="Pro residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 896 AA; 95198 MW; 54345503E6BB7EDF CRC64;
MKFFVQVEEH LNGRAFGPGD EVRGRVEVPA DMDAAAAGRR VPDVSVVFQG TVRLSIVPQT
SLDAVAQVPN AASQRTHTYT LFSHSVTATP KPSIATDGRI VYTAPFTFRF PTSSTCCDSG
SSCALPPSID LNTAKVHANV VYSVTASARR LKQSGLQLLP QSWRRPLHAQ QVLTFAPDLP
VTVSSAQPAA GEVDHAVSAD AIALSRMHIP KTTFLGNGND DDDESIPHTL PPPYTSSMAQ
ALELVMPQPA VISPGSGGVA LGVFLRTPAD LLPPGSSGAI LRGVRVQLRR ETAARIGSLV
ARAAPVSWPL WSVEGAVPMG RERVDITAVC GGVWATQCCV PAAARPSFRS CYLSQSYTIE
VEVSVSASPN STDIRYIHSS IDVVVSDPPP EYCTQTTSVP NQDPYSTVDL QVGMGAPSNW
SSPSVAEGGH AEMELQQAAR DGSSRHSGPH YEGYTPDRFE DLNEVRSPPP VENPDEAATY
RHRSIEEDVE DERRRCRKPE SKHARVHAPR TELYTVGHLV FFSLLGTLAR LGLDALTNYA
GAPVTFGVLW SNFAGTAVMG FLAELAPAIN RHLAVESTPD SRNVAAAALS SPSASSPTPS
PSPSPSPSPS PPRKLPPVPL YIGLATGFCG SFTSFSTFML DAFEAMANSL KAPRYHQNEG
GSSSPVSRGV GDDIMALLAV LLLTIAMCAS ALKMGAHLAV FVARWWPLPP PPSPHSSSAW
SRHFRLGLNA SAVFLGFGCW LGAVLMAIFP PYGTGFGSWR GDAVFALVFA PLGTLLRFGL
GLRLNGIFAA FPLGTFAANA IGTAILAMAW DLQHAQPSTG IATSITACQL LQGVLDGFCG
CLTTVSTWMA ELNGLRRRHA YVYGATTVST GLGLLVVIVG PLRWTVGWHE PTCQGR
//
