ID F0XMB8_GROCL Unreviewed; 1623 AA.
AC F0XMB8;
DT 03-MAY-2011, integrated into UniProtKB/TrEMBL.
DT 03-MAY-2011, sequence version 1.
DT 27-MAR-2024, entry version 51.
DE SubName: Full=Guanyl-nucleotide exchange factor {ECO:0000313|EMBL:EFX01000.1};
GN ORFNames=CMQ_5942 {ECO:0000313|EMBL:EFX01000.1};
OS Grosmannia clavigera (strain kw1407 / UAMH 11150) (Blue stain fungus)
OS (Graphiocladiella clavigera).
OC Eukaryota; Fungi; Dikarya; Ascomycota; Pezizomycotina; Sordariomycetes;
OC Sordariomycetidae; Ophiostomatales; Ophiostomataceae; Leptographium.
OX NCBI_TaxID=655863 {ECO:0000313|Proteomes:UP000007796};
RN [1] {ECO:0000313|EMBL:EFX01000.1, ECO:0000313|Proteomes:UP000007796}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=kw1407 / UAMH 11150 {ECO:0000313|Proteomes:UP000007796};
RX PubMed=21262841; DOI=10.1073/pnas.1011289108;
RA DiGuistini S., Wang Y., Liao N.Y., Taylor G., Tanguay P., Feau N.,
RA Henrissat B., Chan S.K., Hesse-Orce U., Alamouti S.M., Tsui C.K.M.,
RA Docking R.T., Levasseur A., Haridas S., Robertson G., Birol I., Holt R.A.,
RA Marra M.A., Hamelin R.C., Hirst M., Jones S.J.M., Bohlmann J., Breuil C.;
RT "Genome and transcriptome analyses of the mountain pine beetle-fungal
RT symbiont Grosmannia clavigera, a lodgepole pine pathogen.";
RL Proc. Natl. Acad. Sci. U.S.A. 108:2504-2509(2011).
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DR EMBL; GL629794; EFX01000.1; -; Genomic_DNA.
DR RefSeq; XP_014170482.1; XM_014315007.1.
DR STRING; 655863.F0XMB8; -.
DR GeneID; 25979320; -.
DR eggNOG; KOG0929; Eukaryota.
DR HOGENOM; CLU_004694_0_0_1; -.
DR InParanoid; F0XMB8; -.
DR OrthoDB; 4248238at2759; -.
DR Proteomes; UP000007796; Unassembled WGS sequence.
DR GO; GO:0005085; F:guanyl-nucleotide exchange factor activity; IEA:InterPro.
DR GO; GO:0032012; P:regulation of ARF protein signal transduction; IEA:InterPro.
DR CDD; cd00171; Sec7; 1.
DR Gene3D; 1.10.1000.11; Arf Nucleotide-binding Site Opener,domain 2; 1.
DR Gene3D; 2.30.29.30; Pleckstrin-homology domain (PH domain)/Phosphotyrosine-binding domain (PTB); 1.
DR InterPro; IPR011993; PH-like_dom_sf.
DR InterPro; IPR001849; PH_domain.
DR InterPro; IPR023394; Sec7_C_sf.
DR InterPro; IPR000904; Sec7_dom.
DR InterPro; IPR035999; Sec7_dom_sf.
DR PANTHER; PTHR10663:SF402; ARF GUANINE NUCLEOTIDE EXCHANGE FACTOR SYT1; 1.
DR PANTHER; PTHR10663; GUANYL-NUCLEOTIDE EXCHANGE FACTOR; 1.
DR Pfam; PF00169; PH; 1.
DR Pfam; PF01369; Sec7; 1.
DR SMART; SM00233; PH; 1.
DR SMART; SM00222; Sec7; 1.
DR SUPFAM; SSF50729; PH domain-like; 1.
DR SUPFAM; SSF48425; Sec7 domain; 1.
DR PROSITE; PS50003; PH_DOMAIN; 1.
DR PROSITE; PS50190; SEC7; 1.
PE 4: Predicted;
KW Coiled coil {ECO:0000256|SAM:Coils};
KW Reference proteome {ECO:0000313|Proteomes:UP000007796}.
FT DOMAIN 508..667
FT /note="SEC7"
FT /evidence="ECO:0000259|PROSITE:PS50190"
FT DOMAIN 794..923
FT /note="PH"
FT /evidence="ECO:0000259|PROSITE:PS50003"
FT REGION 200..236
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 272..470
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 489..521
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1096..1146
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1162..1260
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1276..1303
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1313..1332
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1340..1378
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1413..1448
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1483..1623
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COILED 985..1012
FT /evidence="ECO:0000256|SAM:Coils"
FT COMPBIAS 272..309
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 342..356
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 367..388
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 407..451
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 489..510
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1099..1146
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1162..1178
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1186..1213
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1222..1244
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1531..1553
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1554..1572
FT /note="Acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1574..1589
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 1623 AA; 176153 MW; D408545DC2A15B71 CRC64;
MPFLRRRGVM ASESDMRRHT SFFNPLAISK QASPPPIRPE TAIPESEVRK YSIQLPRFSS
NVVAAAEQDR ANAGGLDSLS LNTIAPSFPA PPITPPVDSI HQGEATRGAM SIESDMDRPE
SPPIQEQTPK HHRFSILRFR NASDSQLAAR ARQQALAEEM PPMPRPPEII TTAPTLELGS
AAERLPGHRS AVRVRKSGEL ARIDDEGTPG GSGTSFRSWP KRDRRKSMVV QSTTDGKHSA
VAFDESTFNQ HGNPMLPEYG DDSGSALALP ATRLSESSRS DGSSADRVYG STTTTTHTVQ
TTTTFFRLPR RKNANPPPLF PIGHLPQKGR PITPSDTPVP AKRSYEGSTR NDISASSHAG
GLYVLGEGQS TPTQSRPSSQ NKALSTPSGV GPSPALVIFQ KGNHSPASAF FRPSSRNSGR
SSPTRTTPVP SSAAAMHLRG RSSTLSSLGR DSLEGNHPPP TVRSSSSATG RKSFGDLLGF
SRLRQNSELS VRPGSLAPGT PSNNSLHLPR DSITLPERRD DDTPAKYLAR LEEVVSRSVI
ASALSKSADQ FSQAVLRSYM RSFRFFGDPM DMAIRKLLME AELPKETQQI DRCLQAFANR
YHECNPGIYN SPDQAYFIAF SLLILHTDVF NKNNKHKMQK QDYLKNTRGE GIFDEILEVF
YDNITYTPFI HVEDELDING DRIITHKAKR KYIFPNGNVD MAKKTSKEPI DPYTLIIDNK
LDILRPNFQD AMQLEDPYSY IGTASSLNMK ELQSTFFRTG ILQIVSARSR PDAFMTLKTV
TNPEEAHPGI VDIKITKVGL LWRKEAKRKK ARSPWQEWGA ILTGAQLYFF RNTTWVKSLI
HQYEGHVRHG HDGIPVIFKP PLEEFKPDAL ISTDGAVALL DSSYKKHKHA FTYVRRGGDE
EVLLADNEEE MNDWLAKLNY AAAFRTSGVR IRGAIGSLYE GQNRRVLRRL GSAEGQAVQT
PSGEVTITRS RIDQKMAEDI LAARRDIMRQ KVADANEKLA GVEKKLEVQL RNSRHLQIMS
PIQPKTREQM LHSAARMATQ VQWTRVEMWR LKCHRDILEM DLDEEHQAVG LGSEHALESG
AALAGAVAVA PGLGGVAAEG SSSTVNQLEQ KPGLSREDSL ASSASTVLQC SPRPTTHCGS
LASGSGGSGS VIGVVTDLPL SDASATPSSA TPTVSTQHNR HKSAEHTPTT AGSPGVRKAS
VSSAVSAGSH SALVTPSRAA RRPSLPNEST LQRQTPTTAV PAEDSQLDHT PEPNDEDADE
QTLLQKTGLL EPGLSLVGAE AGSGRPALAE ESSTPLATGT QHHYPASLHS LPQAQGMSQQ
SSPSQHDKNK IRRSLHRTLR EGAGHLSHHR GKKTRETTSA GGSDDAAGEP GVLERGSGSF
VVHGKKASVI SFGGDLQSIL PSDERLRQRM SLQQSSMTTG NGQGDAAQSL AEEAEGEGVR
GSTPAGNNDF RAMVLQHDRN QERRESAAST STATARSFRE LHKKYSSVRA ASKSSTGGRS
ASRRDDGESE AAVSSGLEGG HTPLTPALEE SEGSGEKHFP RRGRGRMADD ESQDDSDAVT
DDDEDDYDND SIYSVNEDVP SQFFTSEPPA SPRARTPEVG DDESALELDS GSATGLAAQT
IHA
//
