ID   F0XN02_GROCL            Unreviewed;       648 AA.
AC   F0XN02;
DT   03-MAY-2011, integrated into UniProtKB/TrEMBL.
DT   03-MAY-2011, sequence version 1.
DT   27-MAR-2024, entry version 45.
DE   SubName: Full=Fumarate reductase {ECO:0000313|EMBL:EFX00817.1};
GN   ORFNames=CMQ_1898 {ECO:0000313|EMBL:EFX00817.1};
OS   Grosmannia clavigera (strain kw1407 / UAMH 11150) (Blue stain fungus)
OS   (Graphiocladiella clavigera).
OC   Eukaryota; Fungi; Dikarya; Ascomycota; Pezizomycotina; Sordariomycetes;
OC   Sordariomycetidae; Ophiostomatales; Ophiostomataceae; Leptographium.
OX   NCBI_TaxID=655863 {ECO:0000313|Proteomes:UP000007796};
RN   [1] {ECO:0000313|EMBL:EFX00817.1, ECO:0000313|Proteomes:UP000007796}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=kw1407 / UAMH 11150 {ECO:0000313|Proteomes:UP000007796};
RX   PubMed=21262841; DOI=10.1073/pnas.1011289108;
RA   DiGuistini S., Wang Y., Liao N.Y., Taylor G., Tanguay P., Feau N.,
RA   Henrissat B., Chan S.K., Hesse-Orce U., Alamouti S.M., Tsui C.K.M.,
RA   Docking R.T., Levasseur A., Haridas S., Robertson G., Birol I., Holt R.A.,
RA   Marra M.A., Hamelin R.C., Hirst M., Jones S.J.M., Bohlmann J., Breuil C.;
RT   "Genome and transcriptome analyses of the mountain pine beetle-fungal
RT   symbiont Grosmannia clavigera, a lodgepole pine pathogen.";
RL   Proc. Natl. Acad. Sci. U.S.A. 108:2504-2509(2011).
CC   -!- COFACTOR:
CC       Name=FAD; Xref=ChEBI:CHEBI:57692;
CC         Evidence={ECO:0000256|ARBA:ARBA00001974};
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DR   EMBL; GL629795; EFX00817.1; -; Genomic_DNA.
DR   RefSeq; XP_014170299.1; XM_014314824.1.
DR   AlphaFoldDB; F0XN02; -.
DR   STRING; 655863.F0XN02; -.
DR   GeneID; 25974826; -.
DR   eggNOG; KOG0537; Eukaryota.
DR   eggNOG; KOG2404; Eukaryota.
DR   HOGENOM; CLU_011398_4_5_1; -.
DR   InParanoid; F0XN02; -.
DR   OrthoDB; 1605658at2759; -.
DR   Proteomes; UP000007796; Unassembled WGS sequence.
DR   GO; GO:0010181; F:FMN binding; IEA:InterPro.
DR   GO; GO:0016491; F:oxidoreductase activity; IEA:UniProtKB-KW.
DR   Gene3D; 3.10.120.10; Cytochrome b5-like heme/steroid binding domain; 1.
DR   Gene3D; 3.50.50.60; FAD/NAD(P)-binding domain; 1.
DR   Gene3D; 3.90.700.10; Succinate dehydrogenase/fumarate reductase flavoprotein, catalytic domain; 1.
DR   InterPro; IPR001199; Cyt_B5-like_heme/steroid-bd.
DR   InterPro; IPR036400; Cyt_B5-like_heme/steroid_sf.
DR   InterPro; IPR003953; FAD-binding_2.
DR   InterPro; IPR036188; FAD/NAD-bd_sf.
DR   InterPro; IPR010960; Flavocytochrome_c.
DR   InterPro; IPR027477; Succ_DH/fumarate_Rdtase_cat_sf.
DR   NCBIfam; TIGR01813; flavo_cyto_c; 1.
DR   PANTHER; PTHR43400; FUMARATE REDUCTASE; 1.
DR   PANTHER; PTHR43400:SF8; HYPOTHETICAL FUMARATE REDUCTASE (EUROFUNG); 1.
DR   Pfam; PF00173; Cyt-b5; 1.
DR   Pfam; PF00890; FAD_binding_2; 1.
DR   SMART; SM01117; Cyt-b5; 1.
DR   SUPFAM; SSF55856; Cytochrome b5-like heme/steroid binding domain; 1.
DR   SUPFAM; SSF51905; FAD/NAD(P)-binding domain; 1.
DR   SUPFAM; SSF56425; Succinate dehydrogenase/fumarate reductase flavoprotein, catalytic domain; 1.
DR   PROSITE; PS50255; CYTOCHROME_B5_2; 1.
PE   4: Predicted;
KW   Flavoprotein {ECO:0000256|ARBA:ARBA00022630};
KW   Oxidoreductase {ECO:0000256|ARBA:ARBA00023002};
KW   Reference proteome {ECO:0000313|Proteomes:UP000007796}.
FT   DOMAIN          564..640
FT                   /note="Cytochrome b5 heme-binding"
FT                   /evidence="ECO:0000259|PROSITE:PS50255"
FT   REGION          487..555
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        525..549
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   648 AA;  68880 MW;  0895EDDCB4454147 CRC64;
     MAPRVIVVGG GLSGLSAAHT VYLAGGNVVV VDKQSFFGGN STKATSGING ALTRTQVELN
     INDSVKQFYD DTLKSARDKA RPDLIRVLTY NSAAAVEWLQ DVFNLDLTLV SRLGGHSQPR
     THRGHDAKFP GMAITYALMQ RLEELAEAEP ERVQIIKKAR VTSLNKEGNL VTGVTYEANG
     ESATLDGPVV LATGGYAADF TETSLIKKYR PDTYDLATTN GAHATGDGQK MVMAIGGNGI
     DLEKVQVHPT GLVDPKDPGA KTKFLAAEAL RGEGGLLLNG DGDRFCDELG HRDYVSGMMW
     KEKDNGKFPI RLILNSKASN VLDFHTRHYS GRGLMRKMTG KELAKDIGCT PEHLQKTFTT
     YNAIADGKQK DPWGKKFFHN GPLDVNDDFH VALMEPVLHF TMGGVEIDQH SQVLNQEHKP
     FEGLFACGEL AGGVHGANRL GGSSLLGCVV YGRVAGDSAS NFLFQNVLKS AGSGVGGTAS
     QRLGQISLHI DPSQPGKISV EWGSAKKGSN DDDEGSGSGG AGGSGSVGGP SSSSSSSSSS
     SSSGAGSSTA AAAKAGPKVF SIPEKEFSLE EIAKHNKKED LWVVVKGVVL DLTNWLDEHP
     GGPQAIMNFM GRDASEEFEM LHDDEVIPKY APDQVIGRVQ GVEPTLEI
//