ID F0XUV5_GROCL Unreviewed; 695 AA.
AC F0XUV5;
DT 03-MAY-2011, integrated into UniProtKB/TrEMBL.
DT 03-MAY-2011, sequence version 1.
DT 27-MAR-2024, entry version 56.
DE SubName: Full=DNA mismatch repair protein {ECO:0000313|EMBL:EFW98903.1};
GN ORFNames=CMQ_4755 {ECO:0000313|EMBL:EFW98903.1};
OS Grosmannia clavigera (strain kw1407 / UAMH 11150) (Blue stain fungus)
OS (Graphiocladiella clavigera).
OC Eukaryota; Fungi; Dikarya; Ascomycota; Pezizomycotina; Sordariomycetes;
OC Sordariomycetidae; Ophiostomatales; Ophiostomataceae; Leptographium.
OX NCBI_TaxID=655863 {ECO:0000313|Proteomes:UP000007796};
RN [1] {ECO:0000313|EMBL:EFW98903.1, ECO:0000313|Proteomes:UP000007796}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=kw1407 / UAMH 11150 {ECO:0000313|Proteomes:UP000007796};
RX PubMed=21262841; DOI=10.1073/pnas.1011289108;
RA DiGuistini S., Wang Y., Liao N.Y., Taylor G., Tanguay P., Feau N.,
RA Henrissat B., Chan S.K., Hesse-Orce U., Alamouti S.M., Tsui C.K.M.,
RA Docking R.T., Levasseur A., Haridas S., Robertson G., Birol I., Holt R.A.,
RA Marra M.A., Hamelin R.C., Hirst M., Jones S.J.M., Bohlmann J., Breuil C.;
RT "Genome and transcriptome analyses of the mountain pine beetle-fungal
RT symbiont Grosmannia clavigera, a lodgepole pine pathogen.";
RL Proc. Natl. Acad. Sci. U.S.A. 108:2504-2509(2011).
CC -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000256|ARBA:ARBA00004123}.
CC -!- SIMILARITY: Belongs to the DNA mismatch repair MutL/HexB family.
CC {ECO:0000256|ARBA:ARBA00006082}.
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DR EMBL; GL630006; EFW98903.1; -; Genomic_DNA.
DR RefSeq; XP_014168386.1; XM_014312911.1.
DR AlphaFoldDB; F0XUV5; -.
DR STRING; 655863.F0XUV5; -.
DR GeneID; 25978001; -.
DR eggNOG; KOG1979; Eukaryota.
DR HOGENOM; CLU_004131_2_0_1; -.
DR InParanoid; F0XUV5; -.
DR OrthoDB; 5475669at2759; -.
DR Proteomes; UP000007796; Unassembled WGS sequence.
DR GO; GO:0032300; C:mismatch repair complex; IEA:InterPro.
DR GO; GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
DR GO; GO:0005524; F:ATP binding; IEA:InterPro.
DR GO; GO:0016887; F:ATP hydrolysis activity; IEA:InterPro.
DR GO; GO:0140664; F:ATP-dependent DNA damage sensor activity; IEA:InterPro.
DR GO; GO:0030983; F:mismatched DNA binding; IEA:InterPro.
DR GO; GO:0061982; P:meiosis I cell cycle process; IEA:UniProt.
DR GO; GO:0006298; P:mismatch repair; IEA:InterPro.
DR CDD; cd16926; HATPase_MutL-MLH-PMS-like; 1.
DR CDD; cd03483; MutL_Trans_MLH1; 1.
DR Gene3D; 3.30.230.10; -; 1.
DR Gene3D; 3.30.565.10; Histidine kinase-like ATPase, C-terminal domain; 1.
DR InterPro; IPR014762; DNA_mismatch_repair_CS.
DR InterPro; IPR013507; DNA_mismatch_S5_2-like.
DR InterPro; IPR036890; HATPase_C_sf.
DR InterPro; IPR032189; Mlh1_C.
DR InterPro; IPR002099; MutL/Mlh/PMS.
DR InterPro; IPR038973; MutL/Mlh/Pms-like.
DR InterPro; IPR020568; Ribosomal_Su5_D2-typ_SF.
DR InterPro; IPR014721; Ribsml_uS5_D2-typ_fold_subgr.
DR NCBIfam; TIGR00585; mutl; 1.
DR PANTHER; PTHR10073; DNA MISMATCH REPAIR PROTEIN MLH, PMS, MUTL; 1.
DR PANTHER; PTHR10073:SF12; DNA MISMATCH REPAIR PROTEIN MLH1; 1.
DR Pfam; PF01119; DNA_mis_repair; 1.
DR Pfam; PF13589; HATPase_c_3; 1.
DR Pfam; PF16413; Mlh1_C; 1.
DR SMART; SM01340; DNA_mis_repair; 1.
DR SUPFAM; SSF55874; ATPase domain of HSP90 chaperone/DNA topoisomerase II/histidine kinase; 1.
DR SUPFAM; SSF54211; Ribosomal protein S5 domain 2-like; 1.
DR PROSITE; PS00058; DNA_MISMATCH_REPAIR_1; 1.
PE 3: Inferred from homology;
KW DNA damage {ECO:0000256|ARBA:ARBA00022763};
KW DNA repair {ECO:0000256|ARBA:ARBA00023204};
KW Nucleus {ECO:0000256|ARBA:ARBA00023242};
KW Reference proteome {ECO:0000313|Proteomes:UP000007796}.
FT DOMAIN 217..336
FT /note="DNA mismatch repair protein S5"
FT /evidence="ECO:0000259|SMART:SM01340"
FT REGION 620..647
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 622..640
FT /note="Acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 695 AA; 76508 MW; 639FC5E1856D5D38 CRC64;
MVWALDPDVV NKIAAGEIII APVHALKELV ENAVDAGSTM LEVLVKDGGL KLLQITDNGC
GIDKGDLPIL CERFTTSKLQ TFDDLGSIAT YGFRGEALAS ISHIAHLTVT TRTRDDVSAW
RACYEAGRLA PPKPGQDAEP KRVAGRQGTQ IAVEDLFYNV PTRRRAFRSA ADEHNKIVDM
LGRYAVHCAG VAFSCKKHGE SSASIAVPAV ATTVDRIRHV YGGAMAAELL ALDTADVRWG
FRARGQASSA NHSLKRTTLL LFINNRCVES ANIRKALDDL YATFLPRHGH PFVYLSLDID
PQRVDVNVHP TKREVHFLNE DEITRAVCDH IASKLADVDT SRTFATQTLL PTRLPAPSPA
LAVKKTPARP YENNLVRTDS NLRKITSMFT PTSPMTVSCP AAAETAPSDA SVHPGRQPAY
DVVEREPSVN WLRSVRELKE AVVADAHGGL TDLFRHYSFV GIVDDRRRLA AIQSGVKLYL
LDYGRACFEL FYQLGLNDFG NFGLIRFSPP LDLAQLLRMA LRLAPGNDGH TPSPDDTSAV
DAVLAQLVER RQMLLEYFSL ELTPTGELLS IPMLIKGYTP PLTKLPHFLL RLGPAVCWTD
EKACFDTLLR ELARFYVPEQ LPNEDDDDGG VDDDDGDGDD SDGEMRARRA HVRHAVEHVF
LPAFKAQLIC TASLMQAGLV EVANLKGLYR VFERC
//
