ID F0YFB7_AURAN Unreviewed; 1189 AA.
AC F0YFB7;
DT 03-MAY-2011, integrated into UniProtKB/TrEMBL.
DT 03-MAY-2011, sequence version 1.
DT 27-MAR-2024, entry version 54.
DE RecName: Full=Chloride channel protein {ECO:0000256|RuleBase:RU361221};
GN ORFNames=AURANDRAFT_72054 {ECO:0000313|EMBL:EGB06162.1};
OS Aureococcus anophagefferens (Harmful bloom alga).
OC Eukaryota; Sar; Stramenopiles; Ochrophyta; Pelagophyceae; Pelagomonadales;
OC Aureococcus.
OX NCBI_TaxID=44056 {ECO:0000313|Proteomes:UP000002729};
RN [1] {ECO:0000313|EMBL:EGB06162.1, ECO:0000313|Proteomes:UP000002729}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=CCMP 1984 {ECO:0000313|Proteomes:UP000002729};
RX PubMed=21368207; DOI=10.1073/pnas.1016106108;
RA Gobler C.J., Berry D.L., Dyhrman S.T., Wilhelm S.W., Salamov A.,
RA Lobanov A.V., Zhang Y., Collier J.L., Wurch L.L., Kustka A.B., Dill B.D.,
RA Shah M., VerBerkmoes N.C., Kuo A., Terry A., Pangilinan J., Lindquist E.A.,
RA Lucas S., Paulsen I.T., Hattenrath-Lehmann T.K., Talmage S.C., Walker E.A.,
RA Koch F., Burson A.M., Marcoval M.A., Tang Y.Z., Lecleir G.R., Coyne K.J.,
RA Berg G.M., Bertrand E.M., Saito M.A., Gladyshev V.N., Grigoriev I.V.;
RT "Niche of harmful alga Aureococcus anophagefferens revealed through
RT ecogenomics.";
RL Proc. Natl. Acad. Sci. U.S.A. 108:4352-4357(2011).
CC -!- SUBCELLULAR LOCATION: Membrane {ECO:0000256|ARBA:ARBA00004141,
CC ECO:0000256|RuleBase:RU361221}; Multi-pass membrane protein
CC {ECO:0000256|ARBA:ARBA00004141, ECO:0000256|RuleBase:RU361221}. Nucleus
CC {ECO:0000256|ARBA:ARBA00004123}.
CC -!- SIMILARITY: Belongs to the chloride channel (TC 2.A.49) family.
CC {ECO:0000256|RuleBase:RU361221}.
CC -!- CAUTION: Lacks conserved residue(s) required for the propagation of
CC feature annotation. {ECO:0000256|RuleBase:RU361221}.
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DR EMBL; GL833136; EGB06162.1; -; Genomic_DNA.
DR RefSeq; XP_009039115.1; XM_009040867.1.
DR AlphaFoldDB; F0YFB7; -.
DR EnsemblProtists; EGB06162; EGB06162; AURANDRAFT_72054.
DR GeneID; 20228524; -.
DR KEGG; aaf:AURANDRAFT_72054; -.
DR eggNOG; KOG0474; Eukaryota.
DR InParanoid; F0YFB7; -.
DR Proteomes; UP000002729; Unassembled WGS sequence.
DR GO; GO:0016020; C:membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
DR GO; GO:0003677; F:DNA binding; IEA:UniProtKB-KW.
DR GO; GO:0003700; F:DNA-binding transcription factor activity; IEA:InterPro.
DR GO; GO:0005247; F:voltage-gated chloride channel activity; IEA:UniProtKB-UniRule.
DR Gene3D; 1.10.3080.10; Clc chloride channel; 1.
DR InterPro; IPR000644; CBS_dom.
DR InterPro; IPR046342; CBS_dom_sf.
DR InterPro; IPR014743; Cl-channel_core.
DR InterPro; IPR001807; Cl-channel_volt-gated.
DR InterPro; IPR001289; NFYA.
DR PANTHER; PTHR11689; CHLORIDE CHANNEL PROTEIN CLC FAMILY MEMBER; 1.
DR PANTHER; PTHR11689:SF136; H(+)_CL(-) EXCHANGE TRANSPORTER 6; 1.
DR Pfam; PF00571; CBS; 1.
DR Pfam; PF00654; Voltage_CLC; 1.
DR PRINTS; PR00762; CLCHANNEL.
DR SUPFAM; SSF54631; CBS-domain pair; 1.
DR SUPFAM; SSF81340; Clc chloride channel; 1.
DR PROSITE; PS51371; CBS; 1.
DR PROSITE; PS51152; NFYA_HAP2_2; 1.
PE 3: Inferred from homology;
KW CBS domain {ECO:0000256|ARBA:ARBA00023122, ECO:0000256|PROSITE-
KW ProRule:PRU00703}; Chloride {ECO:0000256|RuleBase:RU361221};
KW DNA-binding {ECO:0000256|ARBA:ARBA00023125};
KW Ion transport {ECO:0000256|RuleBase:RU361221};
KW Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|RuleBase:RU361221};
KW Nucleus {ECO:0000256|ARBA:ARBA00023242};
KW Reference proteome {ECO:0000313|Proteomes:UP000002729};
KW Repeat {ECO:0000256|ARBA:ARBA00022737};
KW Transcription {ECO:0000256|ARBA:ARBA00023163};
KW Transcription regulation {ECO:0000256|ARBA:ARBA00023015};
KW Transmembrane {ECO:0000256|ARBA:ARBA00022692,
KW ECO:0000256|RuleBase:RU361221};
KW Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW ECO:0000256|RuleBase:RU361221}; Transport {ECO:0000256|RuleBase:RU361221}.
FT TRANSMEM 171..193
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU361221"
FT TRANSMEM 233..255
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU361221"
FT TRANSMEM 276..298
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU361221"
FT TRANSMEM 304..325
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU361221"
FT TRANSMEM 346..371
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU361221"
FT TRANSMEM 442..463
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU361221"
FT TRANSMEM 484..502
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU361221"
FT DOMAIN 740..797
FT /note="CBS"
FT /evidence="ECO:0000259|PROSITE:PS51371"
FT REGION 31..67
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 113..135
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 801..820
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 883..907
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 932..1101
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1122..1189
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 936..957
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1053..1074
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1122..1147
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 1189 AA; 124133 MW; 58531FFBBB02AE80 CRC64;
MRTASASSAR GDLALMSVGA SLNGDELTEG LLAADGRGRG PAAPPGRRRS ASESFPERLP
SRDGSVGTSV GAWAAGFARR GSLDPFAREV VDGERAAARR AALGGSSRDL AGLGDVEGAA
PAAPPGSPAA PPKSRTEVQL LSSFEALDYG PSMSAYRRAR RRDRRRAEGD ALVAFATLLA
VGCIVGTCGF CVARGTTSFQ ARRCAEIDRR ARRLELARYG PSGAVTPGGV ARVLAASAGL
AVASALLVVG VEAAAAGSGI PEAKAYLNGV NYSRYLALRC GAVKAVAVVL SVASGLVVGR
EGPLIHVGAV VGNALATWPG ANRLARLRGV NWTWQHRFRH DAWKREFVAC GAAAGVAAAF
GSPIGGVAFA LEEATTFWDA ALTARAFAAT GAATATLWTF EAKFPLGDVD DGRRRVRSSF
WRLLKFGSFG DQPAYDLRDL PLMVLGLGVL GGVVGAAFCH CNVRLSRWRR RRVLGRPARR
VAEVGAAALL TAGVMAALPA LVGSCRAATP QWACSATENG HYCGDYYGRG ARGGAGGNAT
ACAYECWDRS TYERGGCGEG FFDAAATLSM RPSDGAIAAL FHDDDVAFGA AALAAYAAAA
FALAALTYGV AVPSGLFVPS ILIGGALGRL AGEAYRALDL VPGGVHVRPG VWAVCGAAAV
LAGAGVTRLT MTITVIVFET TGLSDLAPPL MGVVCVAKTL ADALGGPRSI YDAHVALKCI
PYLDDESNGD DGDAVVGDVM ATAVRCVPDV APHAAALSCL EDTRHNAFPV LAAGDGAFVG
LVSRRELAAL LAHVAALAAD PRRPRGPAGP APADAFSSSL QSRVAPLPPR AVAALEAAAP
PLDRLDLRPY VDVAPVTVPP HCPVPRAFRI FKALGVRHLP AGARASPASP LRRRRAPPRA
RPTVRDVVPL PGQSIDEALE EAELRYIEDF PEEFQDDERA PAAVDAPRPE RAAPRSKPDA
DGAAPPAAEP LAGASPPRRR RRQAVPPLAP AAAPPPPTGG GAPRVEDEDR ERVPLGPRAA
RLAAAERRTR ELEGRAAASA PSRGVERGAG KYQSRLLGDR RDAAKFDRPP DERAAPPPAA
RADGAPEPGW DRPLNPRQVA RIRKRRRDLD VLRSVGRLPA WLDPREGRRV AKPKTESRQR
HASSRPRTEK GVFMTRAQLD AEGYARDPAT GDWSKRGPAV RVDTTTRPS
//
