ID F0YK38_AURAN Unreviewed; 4335 AA.
AC F0YK38;
DT 03-MAY-2011, integrated into UniProtKB/TrEMBL.
DT 03-MAY-2011, sequence version 1.
DT 27-MAR-2024, entry version 49.
DE RecName: Full=Calmodulin {ECO:0008006|Google:ProtNLM};
GN ORFNames=AURANDRAFT_72500 {ECO:0000313|EMBL:EGB04517.1};
OS Aureococcus anophagefferens (Harmful bloom alga).
OC Eukaryota; Sar; Stramenopiles; Ochrophyta; Pelagophyceae; Pelagomonadales;
OC Aureococcus.
OX NCBI_TaxID=44056 {ECO:0000313|Proteomes:UP000002729};
RN [1] {ECO:0000313|EMBL:EGB04517.1, ECO:0000313|Proteomes:UP000002729}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=CCMP 1984 {ECO:0000313|Proteomes:UP000002729};
RX PubMed=21368207; DOI=10.1073/pnas.1016106108;
RA Gobler C.J., Berry D.L., Dyhrman S.T., Wilhelm S.W., Salamov A.,
RA Lobanov A.V., Zhang Y., Collier J.L., Wurch L.L., Kustka A.B., Dill B.D.,
RA Shah M., VerBerkmoes N.C., Kuo A., Terry A., Pangilinan J., Lindquist E.A.,
RA Lucas S., Paulsen I.T., Hattenrath-Lehmann T.K., Talmage S.C., Walker E.A.,
RA Koch F., Burson A.M., Marcoval M.A., Tang Y.Z., Lecleir G.R., Coyne K.J.,
RA Berg G.M., Bertrand E.M., Saito M.A., Gladyshev V.N., Grigoriev I.V.;
RT "Niche of harmful alga Aureococcus anophagefferens revealed through
RT ecogenomics.";
RL Proc. Natl. Acad. Sci. U.S.A. 108:4352-4357(2011).
CC -!- COFACTOR:
CC Name=L-ascorbate; Xref=ChEBI:CHEBI:38290;
CC Evidence={ECO:0000256|ARBA:ARBA00001961};
CC ---------------------------------------------------------------------------
CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC ---------------------------------------------------------------------------
DR EMBL; GL833150; EGB04517.1; -; Genomic_DNA.
DR RefSeq; XP_009040770.1; XM_009042522.1.
DR EnsemblProtists; EGB04517; EGB04517; AURANDRAFT_72500.
DR GeneID; 20228738; -.
DR KEGG; aaf:AURANDRAFT_72500; -.
DR InParanoid; F0YK38; -.
DR OrthoDB; 55822at2759; -.
DR Proteomes; UP000002729; Unassembled WGS sequence.
DR GO; GO:0005509; F:calcium ion binding; IEA:InterPro.
DR GO; GO:0051213; F:dioxygenase activity; IEA:UniProtKB-KW.
DR GO; GO:0005506; F:iron ion binding; IEA:InterPro.
DR GO; GO:0031418; F:L-ascorbic acid binding; IEA:InterPro.
DR GO; GO:0016705; F:oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen; IEA:InterPro.
DR CDD; cd00201; WW; 1.
DR Gene3D; 2.20.70.10; -; 1.
DR Gene3D; 1.25.10.10; Leucine-rich Repeat Variant; 3.
DR Gene3D; 2.60.120.620; q2cbj1_9rhob like domain; 1.
DR InterPro; IPR011989; ARM-like.
DR InterPro; IPR016024; ARM-type_fold.
DR InterPro; IPR000225; Armadillo.
DR InterPro; IPR045499; DUF6492.
DR InterPro; IPR018247; EF_Hand_1_Ca_BS.
DR InterPro; IPR002048; EF_hand_dom.
DR InterPro; IPR005123; Oxoglu/Fe-dep_dioxygenase.
DR InterPro; IPR006620; Pro_4_hyd_alph.
DR InterPro; IPR044862; Pro_4_hyd_alph_FE2OG_OXY.
DR InterPro; IPR001202; WW_dom.
DR InterPro; IPR036020; WW_dom_sf.
DR PANTHER; PTHR12907; EGL NINE HOMOLOG-RELATED; 1.
DR PANTHER; PTHR12907:SF26; HIF PROLYL HYDROXYLASE, ISOFORM C; 1.
DR Pfam; PF13640; 2OG-FeII_Oxy_3; 1.
DR Pfam; PF20102; DUF6492; 1.
DR Pfam; PF00397; WW; 1.
DR SMART; SM00185; ARM; 4.
DR SMART; SM00702; P4Hc; 1.
DR SMART; SM00456; WW; 1.
DR SUPFAM; SSF48371; ARM repeat; 3.
DR SUPFAM; SSF51045; WW domain; 1.
DR PROSITE; PS00018; EF_HAND_1; 1.
DR PROSITE; PS50222; EF_HAND_2; 1.
DR PROSITE; PS51471; FE2OG_OXY; 1.
DR PROSITE; PS50020; WW_DOMAIN_2; 1.
PE 4: Predicted;
KW Dioxygenase {ECO:0000256|ARBA:ARBA00022964};
KW Iron {ECO:0000256|ARBA:ARBA00023004};
KW Metal-binding {ECO:0000256|ARBA:ARBA00022723};
KW Oxidoreductase {ECO:0000256|ARBA:ARBA00023002};
KW Reference proteome {ECO:0000313|Proteomes:UP000002729}.
FT DOMAIN 16..51
FT /note="EF-hand"
FT /evidence="ECO:0000259|PROSITE:PS50222"
FT DOMAIN 1111..1135
FT /note="WW"
FT /evidence="ECO:0000259|PROSITE:PS50020"
FT DOMAIN 4230..4330
FT /note="Fe2OG dioxygenase"
FT /evidence="ECO:0000259|PROSITE:PS51471"
FT REGION 1152..1175
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1156..1175
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 4335 AA; 468231 MW; 55EFD40AD1C8453D CRC64;
MLSHIGSREH NGKVQVSIDE VFDRFQQLDV DASGKVSKRE LERFLAGDDV QHTFIVVFET
ADIGISWDDS GGGGVKNQRR TNLDNLFYEP FVIVHDFAQT LDLEIDTSRR KHVPKGILVA
GSTPNLRASL ARLLTKIDAW FEPADGGPTL PLPNPVVKRQ LLVAKLDTRA YAFISDIVDA
LGDALFVAAP QQFRLGCVED SKRPLTLSPP DDGRCDTSLH RHLGFGNVPT EIHAYSVESQ
AVTKCECSHR ICSQSSIGIE TRALLWLEFD EFRKLYMTHL FDDAALNELR TRVKIRFRSE
EEIKALAEER AMIQRRAKLK LELEMRREAN RAIRERQKRK NADSYYRDCD GNLRRGRDKP
ALKTVSTQME PTEYETTVST NMAITRRMRR RLIREKQVRK RKAVCATEHK VDVFRAMEDT
RVVSQRRQQV VRLLQEAGYT NVRASSLDDR IGTIVCHDVP HPSFSGRAYG RLILRSQVTN
HPIFHGLVRV PLIANHPLHA FELLAFARDI RRPSAAAWHA FCMPPLCRGI ARQRYREAAR
AHDRSEIVHP AVWGSFVAST ATFYDANYTS PTLYGYTMQR QVLDAGSRPQ RTDGLCPLRR
IPRGGGCVDP IVGIRSGFDE LAEPCHVCLG GDTTHEHVSK VFLTLHTDLT TRTALAHDRH
VRHNRAEVLI KSVPCGAVTK LTLLCDDSVA HLHHLFRATS VHGVADIALF HIPTEHGLVE
LDIEASNEAG INDGMELPNR GTIPLFKYGL NQAGARAVLF HGCHTSMWSM IHVFISNNLL
LERLESALDF VPHLDGAPRT LPGSDLVQHG LWDVFVLQVS QQKLYAQQDE AAEQQFCRDL
EKREMEHHHA IMLAARQARC SSARTSACNS PRPFHLVAPA SAKWANSRHN NSPGILSIPK
KIDPRRVSAV MGRPRIHEYA GLEMRRVLRA ALARAKRGSK FEPEQRFRKA RADCEGFTLQ
RSSRYIWNFP RDEYLCMGLL ELDGKGMEIE FYEGTDRCTM LLRLSEDAKG EFEKFSLGNR
EQRADLARRA EGEDADEESA EFDADCAEME RTANTVGAPT LRFFEDIVKG LDNAMIEKYE
LWSSQIRHPE HWSIADPPSA EVAQYQDTIA RTDAQGRTFF VDHNTKTTSW TRPSPGTPMS
LETDEQLARR LQMEEESSAS AVSAPSSGNT MSDEELARML QTEEDASSEI EPKEPLAKDR
RLAILKVCGS TLAVFADESR PKAELRVELI ASTLLESSSQ GKLRSMKDEI FRWKVTIAGI
TSANLGTESI VEGGKTGRGE IEFAAADDAE RAAWIGWPDN TVSLQETHAI LHMCIVAGAN
MPKSADLVAK AFKPLLSAAP TPERAQALKT LAKALGADGT TSPQLGALVK ALRSCGALAS
VAECLKSAPG QESAARCTYF AARAETYTAR TLVDERVELL LLPLLIAPDD GLQQWAAAAL
APVLAGDPFR ASKSIIEAGG VFTIVALLSS SSPDVRSHAL AALISLCSGV IEAAWPKSAV
GSEEAKGLLC KLVDGAIDAG ICHSIIALLE VRDDVRVATA ALEAVIALSY SSKSFRRVLR
SEIGGDVRLS TQLVTACGDR RFGAHALRVM ADACYCVDEQ TGAEDRVESA AASDAARGLF
AAGALPVAIE ALGTEFETSM ELNQSLLLEA STLQGAEARG YASPGNSKRD DGARIAAALL
AHAPGAAEEC LVGSQARMVA ALVSVVAFEL APSLAVREGK PRAVAALPAL TLCVSASARQ
HDARPAVEAA QAGILELLAT HNFFDASLGY SLDHTPCRGL VATRSAMLVH ALIMACWRDS
NEGSLLVLAL AAPPNGHTLS RLCGLLDGLV STGLAISDAG PPHPHLVDSL MTAILLALGS
LCGAARPYGR AAHPSEKLCK RDVVQSLGCG LAIAAGLSHE SREVQPCEKR RAAARLLASL
LRSDCEQPND SISTTAEPHH AIAEALAQSG LVGVAAACLT DDDAIIRADA VDAFTVLSTY
ALREDRDVAL GAAALGDNLS RGIVASDAAA KHSSSGCTPE LVPLRATIAV EKALQALGAA
CCRGGVAARD AVAFSTGCAG AFISLTRAPL SAPSDFGVRC AAICLTAIAA LAKDAEGRAS
ALADAGACDA VALALVAAMR DKDGSIASLQ TAALSAMSAF SSFHSPRQAF TTTETPVLAA
LFLCIVQVDD APSFECGHLA LSTLVHFAHP TVTVSEPQTA SKLATAAKQC KIVAALTHVL
NGAWRPFCVD TAQHDLVMRY AHELITALAN APATMEGPTD IDTLDGDTCP LDVLVNDRTA
AVSSVYASES TRLPDEAISA AKKKFPSSAE LVASDEKQHF EQRYGAWLLR RGTTNDSKLR
HKTTALAGAD MAALVSLITA PEPLDDAERI TAHLSAVDCA CTALEDIIVE DAAGTTAALA
IQGGVLTRLL MLAPRSPAAA MCLVALCEAS VHFMCAVCRD SDLAVLALAI TLMSRNRLST
ALGRLAIIAV AEATVESTTD INATQPGALV LISMLAPRLH DATDGHDHLF RVDSDFFPSG
GPPSLPASMS SLLDAIAVDD SSRIRCVDAF SKGVTLLLDT AAVNAIAKAT PALLRVLLAL
PPGSLRARAR RAIAIIAAEI AEATRYLLGA GAVEAAVRLV VEAKGTPGKT AASDAAFGCT
LLASLVSNAK SRAARAALAH DGLMPALVTC VVQATAYKTS PLAFAALSLV VNLADAGDDA
AAHVASSDDL LQALATLAAE IVSPVTTGLP LNAASCNQIY DDGSVHREHT DKKVHIKQDP
PPKATRQNRM HIAEKALLAL ANIAIGPRAQ REALANVNGI LHVAVGILRN AKPGIAQAAA
ARLVASLLEA HVNLDAEADD ATFTAATLCG ALTIMTEREL HAETALRLVH ALNALLCYAQ
GADALQSSQP TSVLAMLLKV TMTRYPDVAE ACAAQINTLC YDAYHRKALK TEHVVTLVDA
LKVPEATALQ FHCLAVLNSI AHTDAGCDMS DVINDGGPAI CVLGAGKAAV APSARRLAAI
LGADLNSIKR NYKRNNPGLF VPTLISRNAK CSALEGVESL KRSKAGEEQA NPKFPVEEAK
KECRAPADDS QNKCAGGPRA KMCVLLFRIE GTVELEISSP KHGAEFDKTA IRINGGIDVD
VSVLAGTRKD YMHDAFGLSV CLHVNGSAFA GALDCVAVGL DEHGCILSCD LTPIMRPGCG
GATEVTSAPI LVKIKDKMSS QESVSGLHSV GSRPRVTLVL TQLPLTIDDA HRALMLIASI
RAHELCERKR IHELLVVVPD AHVFALDILK QVNHCLAISI VEESSLFDGM IQSTWPKYAL
QMALKLVVAQ RVTTKYYITL DADNIVVGPL DLTELFPGGK GVFAAEPRSI HPHWWDGSSQ
VLGLNEDASP DAMSWGFRMW WSEYTLYRLA LDKRDIFWEL HTPSTTEPLC NAIWFQEELP
WNSRSAFENK SCIFSLAPMT AALSPSEMVW MRSAKARKGL RNDGGDAAQS WRRARVLEDD
ADPSYHPRLD RAERRLEHEA AAVRVLVDTG EVVAVDEEAA LLEVDSVDLL VRGKRLDHAV
ARALRGHEEV ELVLVAVRGR RAREDGGLLE VPRDGLAVAE AHGARPPRAG RVRELEVDAA
HNRRAPVYCR TPTRPSPMGD VLDGREVLEP RGRDPVAAVV SARAALGGVA PSHEGVGLAR
VKEVLPRAPR CVELDVLLLD ATLSRVRRRR RERPKRLQTM RTQRQRHAVL EVLGPRPRRV
PRSLLAPAGS GPGPSHTPRY FGAGGGTLTR CWSVPFSGFY SRANAAAERR AAAAQNAIIE
WSDWTSDSHP TRRTRIRAHR TQRFESILRR YLYIGVKMVS NSNSRVVQLT LDDRLEISPT
LFSVRLTVPR KWYAKQIFVL VMAFVSRLKD KRGADLSASD LEVFIAGESV SLKRSVEEAL
CGISNVHVRR RPSPMSARRE MLHRGETTHV QAIVESMAAV HETSVSATAA MLGLSKYQTC
ESLRRALLCH GWAACATVLP LLGEGIETAH LTSARQAYRC SLTSGLGHEA SREALHRKAV
RLVSASCAAA RRLAARPGGR EVLSATGVFP YLWEPGTMEA QLAESESILA GRVAKEAIRL
ELSRQRQMTP AKSLRTMTAA RIVQGHSDAA LGLAEKGFCI LEDVLSTSDC RVLYNHFNSA
LQRGELFGPV SSDACNNGSF SLSIPTMAGA GPEPDSNVIK REIGRHPVKK EAFAKAFALR
SALRALVGLP AELMDRLNCK GGRALVSVNV PPTVMCACYP AFTGACYYKH KDWYPYETSN
HRDLTIVLYP NIGWTEEDGG ELIIHGADGA IEVIGPLAGR AVVFFSRTIW HEVRPTNTRS
RFAFTIWLDR APQGK
//
