ID F0YKG5_AURAN Unreviewed; 713 AA.
AC F0YKG5;
DT 03-MAY-2011, integrated into UniProtKB/TrEMBL.
DT 03-MAY-2011, sequence version 1.
DT 27-MAR-2024, entry version 39.
DE RecName: Full=Presenilin {ECO:0008006|Google:ProtNLM};
GN ORFNames=AURANDRAFT_67233 {ECO:0000313|EMBL:EGB04402.1};
OS Aureococcus anophagefferens (Harmful bloom alga).
OC Eukaryota; Sar; Stramenopiles; Ochrophyta; Pelagophyceae; Pelagomonadales;
OC Aureococcus.
OX NCBI_TaxID=44056 {ECO:0000313|Proteomes:UP000002729};
RN [1] {ECO:0000313|EMBL:EGB04402.1, ECO:0000313|Proteomes:UP000002729}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=CCMP 1984 {ECO:0000313|Proteomes:UP000002729};
RX PubMed=21368207; DOI=10.1073/pnas.1016106108;
RA Gobler C.J., Berry D.L., Dyhrman S.T., Wilhelm S.W., Salamov A.,
RA Lobanov A.V., Zhang Y., Collier J.L., Wurch L.L., Kustka A.B., Dill B.D.,
RA Shah M., VerBerkmoes N.C., Kuo A., Terry A., Pangilinan J., Lindquist E.A.,
RA Lucas S., Paulsen I.T., Hattenrath-Lehmann T.K., Talmage S.C., Walker E.A.,
RA Koch F., Burson A.M., Marcoval M.A., Tang Y.Z., Lecleir G.R., Coyne K.J.,
RA Berg G.M., Bertrand E.M., Saito M.A., Gladyshev V.N., Grigoriev I.V.;
RT "Niche of harmful alga Aureococcus anophagefferens revealed through
RT ecogenomics.";
RL Proc. Natl. Acad. Sci. U.S.A. 108:4352-4357(2011).
CC -!- SUBCELLULAR LOCATION: Endoplasmic reticulum membrane
CC {ECO:0000256|ARBA:ARBA00004477}; Multi-pass membrane protein
CC {ECO:0000256|ARBA:ARBA00004477}. Membrane
CC {ECO:0000256|ARBA:ARBA00004141}; Multi-pass membrane protein
CC {ECO:0000256|ARBA:ARBA00004141}.
CC -!- SIMILARITY: Belongs to the peptidase A22A family.
CC {ECO:0000256|ARBA:ARBA00008604}.
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DR EMBL; GL833152; EGB04402.1; -; Genomic_DNA.
DR RefSeq; XP_009040959.1; XM_009042711.1.
DR AlphaFoldDB; F0YKG5; -.
DR EnsemblProtists; EGB04402; EGB04402; AURANDRAFT_67233.
DR GeneID; 20226133; -.
DR KEGG; aaf:AURANDRAFT_67233; -.
DR eggNOG; KOG2736; Eukaryota.
DR InParanoid; F0YKG5; -.
DR OrthoDB; 205653at2759; -.
DR Proteomes; UP000002729; Unassembled WGS sequence.
DR GO; GO:0005789; C:endoplasmic reticulum membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0005794; C:Golgi apparatus; IEA:UniProtKB-KW.
DR GO; GO:0042500; F:aspartic endopeptidase activity, intramembrane cleaving; IEA:InterPro.
DR GO; GO:0007219; P:Notch signaling pathway; IEA:UniProtKB-KW.
DR GO; GO:0016485; P:protein processing; IEA:InterPro.
DR Gene3D; 1.10.472.100; Presenilin; 1.
DR InterPro; IPR022051; DUF3611.
DR InterPro; IPR001108; Peptidase_A22A.
DR InterPro; IPR006639; Preselin/SPP.
DR InterPro; IPR042524; Presenilin_C.
DR PANTHER; PTHR10202; PRESENILIN; 1.
DR PANTHER; PTHR10202:SF13; PRESENILIN-2; 1.
DR Pfam; PF12263; DUF3611; 1.
DR Pfam; PF01080; Presenilin; 2.
DR SMART; SM00730; PSN; 1.
PE 3: Inferred from homology;
KW Endoplasmic reticulum {ECO:0000256|ARBA:ARBA00022824};
KW Golgi apparatus {ECO:0000256|ARBA:ARBA00023034};
KW Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|SAM:Phobius};
KW Notch signaling pathway {ECO:0000256|ARBA:ARBA00022976};
KW Reference proteome {ECO:0000313|Proteomes:UP000002729};
KW Signal {ECO:0000256|SAM:SignalP};
KW Transmembrane {ECO:0000256|ARBA:ARBA00022692, ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW ECO:0000256|SAM:Phobius}.
FT SIGNAL 1..18
FT /evidence="ECO:0000256|SAM:SignalP"
FT CHAIN 19..713
FT /note="Presenilin"
FT /evidence="ECO:0000256|SAM:SignalP"
FT /id="PRO_5003264690"
FT TRANSMEM 81..100
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 112..132
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 449..469
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 481..500
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 512..531
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 538..558
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 564..585
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 654..674
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 680..700
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
SQ SEQUENCE 713 AA; 74521 MW; 2BAE5C88384AD9EC CRC64;
MVASRSLLVC GLLAAASGFV VPAAHRRHAP RLRAAAKDDG GLGQAIDAAA SEMASAPAIA
AATLPANRRS LALWRVGWCS WWSQVILSVI SAVVLVFARV STPATANSVA GALGNGFLFA
SLGAGFAFAS AYDPYEENLW LDDGDEEALT FGNEQLTLSG EGNAFGDSTV ADVADDYRFP
ISYVADAILG FGIPPPIRDD ARIADILDAD QAFALLEAVT SLDAAEVEDA YVAFDLARVA
GLLEAPLAEV FAACVDEGFG LPHGVETQLR REQYEALRSR FGFAAYAPDP LDKVYEDFGF
KPLDETAEPL DPEARKMPEY VQDADRPTYQ DGAPETYCDM RSCAGFPGQL TNSLRPRLRV
PLRCASMRAR SSVTKAAVAS RAPPPKRHGF DAGDASYALA SFGAVVRPVS ATMLVASFFV
VTVRVETGSL VVYDDDPADS GLERVGKGAA NAGVVVCALL AATLAVLALY KFRCTRILRG
YMMLSSGLLL GLLGGVLVLA SLEELGLEFA DLASFGLCAY NGAVLGVLAI YEPAYLRFPK
AATQAALVVV AVVMAWQLSH YPPVTSWCLL VALAAYDAFA VLAPCGPLRW LVQLMGETGE
PLPGLLYEAD LDGDGDGAGA GAGAPSSVKL GLGDFVFYSV LVSNAFSSHA ASGAACFVAT
LLGLGVTFLL LALHRAPLPA LPVSIAAGVA SYVLVEYAVL PLAGALRAAR AVA
//
